GREMLIN Database
USPA - Universal stress protein A
UniProt: P0AED0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11390
Length: 144 (130)
Sequences: 20793 (17136)
Seq/√Len: 1502.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_S85_L2.9661.00
7_L104_M2.8261.00
5_H35_S2.7541.00
92_G125_Q2.7381.00
22_K135_L2.4171.00
33_K83_E2.2621.00
5_H33_K2.2541.00
106_L135_L2.1801.00
85_L98_A2.0751.00
107_V132_V2.0421.00
35_S104_M1.9891.00
109_C126_L1.8961.00
87_G94_V1.8841.00
35_S98_A1.8781.00
111_H138_P1.8701.00
37_I98_A1.8291.00
124_R128_N1.7771.00
63_S67_H1.7701.00
99_I107_V1.7391.00
35_S83_E1.7261.00
39_V94_V1.7121.00
9_A95_L1.7041.00
8_I23_A1.6761.00
89_G94_V1.6651.00
9_A109_C1.5381.00
32_A105_D1.4901.00
94_V97_D1.4891.00
26_M30_Y1.4801.00
69_A72_E1.4241.00
96_V129_T1.4211.00
33_K81_I1.4141.00
66_T70_L1.3921.00
107_V130_V1.3891.00
59_Q63_S1.3461.00
100_K131_H1.3221.00
67_H71_T1.3211.00
8_I20_V1.2981.00
125_Q129_T1.2811.00
91_L122_S1.2611.00
87_G98_A1.2351.00
5_H105_D1.2211.00
23_A27_A1.2011.00
66_T69_A1.1951.00
98_A104_M1.1681.00
69_A73_L1.1641.00
99_I131_H1.1591.00
21_E73_L1.1561.00
65_E69_A1.1381.00
107_V126_L1.1351.00
99_I132_V1.1261.00
62_I66_T1.1221.00
71_T75_T1.1181.00
62_I65_E1.1061.00
5_H104_M1.0861.00
37_I87_G1.0771.00
111_H136_I1.0551.00
51_I54_N1.0511.00
39_V91_L1.0361.00
74_S78_G1.0251.00
12_L38_H1.0221.00
22_K137_V1.0211.00
65_E68_H1.0141.00
113_Q117_S1.0131.00
115_F118_K1.0071.00
96_V99_I1.0031.00
64_E68_H0.9901.00
99_I104_M0.9881.00
67_H84_T0.9841.00
38_H66_T0.9831.00
22_K26_M0.9811.00
40_D88_S0.9731.00
130_V134_M0.9701.00
63_S66_T0.9681.00
56_G60_K0.9641.00
71_T84_T0.9641.00
23_A108_V0.9571.00
20_V36_L0.9551.00
127_I136_I0.9541.00
60_K64_E0.9491.00
109_C123_A0.9441.00
74_S77_A0.9301.00
118_K124_R0.9281.00
111_H123_A0.9181.00
13_S16_S0.9151.00
25_S29_P0.9081.00
74_S84_T0.8891.00
71_T74_S0.8841.00
72_E76_N0.8791.00
21_E76_N0.8791.00
37_I95_L0.8781.00
23_A34_V0.8741.00
6_I106_L0.8601.00
22_K25_S0.8541.00
73_L77_A0.8381.00
74_S79_Y0.8381.00
10_V17_K0.8361.00
96_V130_V0.8321.00
58_M62_I0.8321.00
7_L37_I0.8291.00
73_L76_N0.8261.00
16_S19_L0.8211.00
27_A34_V0.8201.00
15_E139_L0.8151.00
7_L98_A0.8141.00
30_Y105_D0.8131.00
67_H70_L0.8091.00
54_N57_D0.8071.00
22_K133_D0.8051.00
40_D86_S0.7971.00
17_K69_A0.7941.00
90_D93_Q0.7941.00
108_V135_L0.7931.00
10_V36_L0.7911.00
17_K21_E0.7901.00
77_A80_P0.7881.00
24_V28_R0.7761.00
92_G122_S0.7751.00
72_E75_T0.7731.00
56_G59_Q0.7711.00
10_V20_V0.7621.00
94_V98_A0.7541.00
9_A110_G0.7451.00
96_V126_L0.7421.00
7_L107_V0.7371.00
18_V21_E0.7341.00
123_A136_I0.7311.00
68_H72_E0.7271.00
24_V80_P0.7261.00
24_V77_A0.7231.00
100_K132_V0.7191.00
58_M61_R0.7191.00
59_Q62_I0.7181.00
52_D55_L0.7161.00
70_L74_S0.7131.00
108_V137_V0.7091.00
17_K73_L0.7041.00
40_D59_Q0.7031.00
109_C136_I0.6961.00
60_K63_S0.6961.00
10_V19_L0.6951.00
27_A30_Y0.6931.00
57_D60_K0.6861.00
47_Y51_I0.6811.00
8_I19_L0.6761.00
8_I34_V0.6701.00
26_M29_P0.6691.00
37_I94_V0.6681.00
20_V24_V0.6681.00
15_E18_V0.6641.00
64_E67_H0.6621.00
61_R65_E0.6621.00
23_A32_A0.6621.00
70_L73_L0.6601.00
6_I108_V0.6571.00
82_T85_L0.6551.00
10_V16_S0.6541.00
6_I27_A0.6531.00
55_L59_Q0.6491.00
26_M108_V0.6481.00
25_S28_R0.6481.00
68_H71_T0.6481.00
55_L58_M0.6441.00
18_V139_L0.6441.00
95_L126_L0.6441.00
27_A32_A0.6441.00
119_L123_A0.6371.00
103_D132_V0.6301.00
36_L82_T0.6171.00
61_R64_E0.6161.00
36_L70_L0.6101.00
92_G129_T0.6031.00
67_H73_L0.6011.00
25_S77_A0.5991.00
28_R77_A0.5971.00
51_I55_L0.5961.00
43_Y46_L0.5851.00
28_R80_P0.5821.00
76_N79_Y0.5771.00
57_D61_R0.5741.00
92_G126_L0.5691.00
96_V125_Q0.5681.00
126_L134_M0.5671.00
85_L88_S0.5661.00
92_G96_V0.5651.00
89_G97_D0.5591.00
75_T78_G0.5571.00
112_H123_A0.5491.00
11_D16_S0.5431.00
93_Q97_D0.5421.00
47_Y52_D0.5281.00
5_H32_A0.5161.00
110_G137_V0.5121.00
69_A74_S0.5101.00
53_V57_D0.5011.00
18_V22_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jmvA 4 0.9722 99.9 0.172 Contact Map
3tnjA 2 0.9028 99.9 0.204 Contact Map
2dumA 2 0.9653 99.9 0.224 Contact Map
5ahwA 4 0.9722 99.9 0.229 Contact Map
4wnyA 2 0.8681 99.9 0.236 Contact Map
3s3tA 4 0.9514 99.8 0.239 Contact Map
1mjhA 2 0.9375 99.8 0.244 Contact Map
3fg9A 3 0.9375 99.8 0.245 Contact Map
3fdxA 2 0.8403 99.8 0.246 Contact Map
2z08A 4 0.8333 99.8 0.259 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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