DCUS - ECOLI - GREMLIN Contacts

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DCUS - Sensor histidine kinase DcuS

UniProt:	P0AEC8	Sequences: MRHSLPYRMLRKRPMKLSTTVILMVSAVLFSVLLVVHLIYFSQISDMTRDGLANKALAVARTLADSPEIRQGLQKKPQESGIQAIAEAVRKRNDLLFIVVTDMQSLRYSHPEAQRIGQPFKGDDILKALNGEENVAINRGFLAQALRVFTPIYDENHKQIGVVAIGLELSRVTQQINDSRWSIIWSVLFGMLVGLIGTCILVKVLKKILFGLEPYEISTLFEQRQAMLQSIKEGVVAVDDRGEVTLINDAAQELLNYRKSQDDEKLSTLSHSWSQVVDVSEVLRDGTPRRDEEITIKDRLLLINTVPVRSNGVIIGAISTFRDKTEVRKLMQRLDGLVNYADALRERSHEFMNKLHVILGLLHLKSYKQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFLISKINRATDLGHTLILNSESQLPDSGSEDQVATLITTLGNLIENALEALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKGSERGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIPWDGERSNR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12465
Length:	543 (506)
Sequences:	10236 (8898)
Seq/√Len:	395.6

ECOLI - DCUS DPIB ATOS RCSC RCSD BARA ARCB NARX EVGS TORS NARQ ZRAS CREC PHOR PHOQ BAES CUSS GLRK ENVZ QSEC CPXA NTRB YEDV RSTB
BACSU - DCTS MALK CITS YYCG RESE PHOR KINE KINA KINC YCLK KIND YKOH CSSS YVRG
HALSA - Q9HQ16 O51970 Q9HR10 Q9HRE4 Q9HQG5 Q9HRG1 Q9HNM2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
523_E	526_I	4.416	1.00
474_N	529_Q	4.210	1.00
362_L	374_I	4.154	1.00
485_I	520_V	3.795	1.00
508_K	512_E	3.771	1.00
233_E	322_R	3.539	1.00
519_A	531_F	3.401	1.00
450_L	476_D	3.382	1.00
418_N	461_T	3.374	1.00
416_I	457_E	3.274	1.00
221_F	225_Q	3.252	1.00
438_T	510_Q	3.084	1.00
468_W	533_Q	3.051	1.00
239_D	243_E	3.050	1.00
511_V	532_V	3.033	1.00
507_V	518_I	3.023	1.00
220_L	223_Q	2.908	1.00
481_A	484_K	2.896	1.00
471_C	532_V	2.894	1.00
459_S	474_N	2.853	1.00
430_D	514_L	2.797	1.00
461_T	472_E	2.774	1.00
520_V	530_F	2.738	1.00
250_A	253_E	2.701	1.00
475_D	479_G	2.672	1.00
510_Q	514_L	2.665	1.00
480_I	484_K	2.650	1.00
418_N	459_S	2.606	1.00
472_E	529_Q	2.587	1.00
416_I	459_S	2.575	1.00
293_E	296_I	2.484	1.00
472_E	531_F	2.436	1.00
450_L	456_G	2.431	1.00
470_H	533_Q	2.427	1.00
522_S	528_T	2.403	1.00
457_E	476_D	2.402	1.00
463_H	470_H	2.377	1.00
461_T	474_N	2.363	1.00
365_K	369_Q	2.352	1.00
438_T	511_V	2.344	1.00
511_V	516_G	2.249	1.00
485_I	522_S	2.222	1.00
215_Y	218_S	2.191	1.00
464_Y	536_W	2.191	1.00
521_E	529_Q	2.179	1.00
218_S	221_F	2.173	1.00
449_A	494_S	2.172	1.00
264_E	268_T	2.167	1.00
102_D	106_L	2.154	1.00
414_T	457_E	2.153	1.00
489_F	518_I	2.150	1.00
439_L	471_C	2.139	1.00
234_G	321_F	2.130	1.00
438_T	507_V	2.125	1.00
292_E	295_T	2.102	1.00
450_L	458_I	2.085	1.00
522_S	526_I	2.080	1.00
456_G	476_D	2.080	1.00
220_L	225_Q	2.061	1.00
359_L	378_A	2.043	1.00
327_V	331_M	2.038	1.00
236_V	251_A	2.027	1.00
231_I	235_V	2.026	1.00
470_H	531_F	2.020	1.00
404_K	440_G	1.921	1.00
487_H	490_D	1.907	1.00
234_G	254_L	1.899	1.00
399_G	436_I	1.895	1.00
512_E	517_S	1.890	1.00
198_T	202_V	1.881	1.00
517_S	533_Q	1.878	1.00
431_Q	434_T	1.874	1.00
394_S	462_L	1.869	1.00
361_L	370_L	1.863	1.00
480_I	488_I	1.857	1.00
405_I	409_T	1.805	1.00
216_E	220_L	1.792	1.00
430_D	435_L	1.788	1.00
236_V	319_S	1.775	1.00
463_H	472_E	1.765	1.00
482_P	485_I	1.752	1.00
434_T	437_T	1.749	1.00
434_T	510_Q	1.730	1.00
220_L	224_R	1.727	1.00
328_R	331_M	1.725	1.00
359_L	379_N	1.723	1.00
419_S	462_L	1.717	1.00
329_K	333_R	1.714	1.00
516_G	534_I	1.694	1.00
521_E	531_F	1.693	1.00
265_K	268_T	1.685	1.00
225_Q	229_Q	1.673	1.00
522_S	525_G	1.667	1.00
439_L	443_I	1.660	1.00
448_E	496_K	1.645	1.00
281_E	285_D	1.633	1.00
224_R	228_L	1.625	1.00
249_D	253_E	1.621	1.00
87_E	90_R	1.614	1.00
217_I	220_L	1.605	1.00
205_L	208_I	1.591	1.00
494_S	497_G	1.591	1.00
446_A	458_I	1.563	1.00
236_V	244_V	1.543	1.00
444_E	448_E	1.539	1.00
329_K	332_Q	1.536	1.00
484_K	493_V	1.512	1.00
383_E	433_A	1.499	1.00
438_T	532_V	1.478	1.00
221_F	224_R	1.474	1.00
519_A	533_Q	1.461	1.00
331_M	335_D	1.460	1.00
511_V	518_I	1.457	1.00
484_K	487_H	1.446	1.00
489_F	520_V	1.443	1.00
326_E	329_K	1.424	1.00
469_L	536_W	1.421	1.00
439_L	473_V	1.402	1.00
408_A	447_L	1.400	1.00
307_P	316_G	1.400	1.00
234_G	248_N	1.399	1.00
237_A	316_G	1.395	1.00
161_G	168_E	1.392	1.00
38_L	42_S	1.383	1.00
357_V	361_L	1.372	1.00
251_A	255_L	1.371	1.00
481_A	524_P	1.369	1.00
424_P	464_Y	1.364	1.00
151_P	161_G	1.360	1.00
362_L	375_L	1.342	1.00
488_I	520_V	1.340	1.00
442_L	532_V	1.339	1.00
382_Q	386_G	1.335	1.00
358_I	374_I	1.331	1.00
397_I	462_L	1.330	1.00
252_Q	259_K	1.326	1.00
488_I	530_F	1.316	1.00
399_G	432_V	1.314	1.00
247_I	252_Q	1.313	1.00
394_S	398_A	1.309	1.00
437_T	510_Q	1.308	1.00
125_I	129_L	1.305	1.00
360_G	364_L	1.304	1.00
64_A	68_E	1.301	1.00
257_Y	261_Q	1.296	1.00
375_L	379_N	1.283	1.00
119_P	122_G	1.278	1.00
52_L	56_A	1.277	1.00
480_I	528_T	1.271	1.00
345_R	350_E	1.265	1.00
56_A	60_A	1.264	1.00
224_R	227_M	1.262	1.00
490_D	493_V	1.256	1.00
372_D	376_K	1.254	1.00
249_D	252_Q	1.249	1.00
218_S	223_Q	1.245	1.00
336_G	339_N	1.240	1.00
357_V	377_T	1.236	1.00
362_L	371_E	1.235	1.00
459_S	476_D	1.230	1.00
252_Q	258_R	1.230	1.00
408_A	415_L	1.226	1.00
78_Q	81_G	1.223	1.00
97_F	166_G	1.222	1.00
465_R	470_H	1.217	1.00
350_E	353_N	1.215	1.00
468_W	517_S	1.215	1.00
348_S	353_N	1.211	1.00
310_S	313_V	1.207	1.00
520_V	528_T	1.206	1.00
482_P	523_E	1.199	1.00
60_A	64_A	1.196	1.00
400_F	443_I	1.194	1.00
451_G	455_G	1.183	1.00
435_L	514_L	1.178	1.00
203_K	207_K	1.174	1.00
334_L	337_L	1.172	1.00
291_D	296_I	1.170	1.00
519_A	532_V	1.163	1.00
487_H	493_V	1.161	1.00
158_K	161_G	1.161	1.00
49_R	53_A	1.160	1.00
489_F	530_F	1.160	1.00
403_S	440_G	1.154	1.00
480_I	520_V	1.153	1.00
351_F	354_K	1.153	1.00
423_L	462_L	1.146	1.00
400_F	436_I	1.143	1.00
480_I	485_I	1.125	1.00
484_K	495_T	1.124	1.00
353_N	449_A	1.122	1.00
442_L	507_V	1.116	1.00
290_R	293_E	1.113	1.00
335_D	338_V	1.111	1.00
395_P	432_V	1.110	1.00
277_V	281_E	1.103	1.00
218_S	222_E	1.101	1.00
408_A	458_I	1.090	1.00
340_Y	344_L	1.080	1.00
396_V	400_F	1.080	1.00
82_I	86_A	1.080	1.00
280_S	284_R	1.078	1.00
420_E	463_H	1.076	1.00
338_V	342_D	1.073	1.00
361_L	373_Y	1.068	1.00
258_R	261_Q	1.062	1.00
442_L	530_F	1.055	1.00
399_G	403_S	1.053	1.00
304_N	307_P	1.045	1.00
394_S	419_S	1.042	1.00
327_V	334_L	1.040	1.00
247_I	251_A	1.038	1.00
238_V	319_S	1.038	1.00
324_K	328_R	1.033	1.00
161_G	165_I	1.032	1.00
289_R	292_E	1.032	1.00
434_T	513_N	1.031	1.00
338_V	341_A	1.030	1.00
511_V	534_I	1.026	1.00
56_A	59_V	1.024	1.00
353_N	360_G	1.021	1.00
350_E	354_K	1.020	1.00
118_Q	122_G	1.018	1.00
228_L	246_L	1.017	1.00
208_I	212_L	1.014	1.00
97_F	110_H	1.013	1.00
127_K	132_E	1.012	1.00
480_I	522_S	1.011	1.00
328_R	332_Q	1.009	1.00
448_E	494_S	1.008	1.00
347_R	388_L	1.008	1.00
278_D	281_E	1.005	1.00
202_V	206_K	1.003	1.00
361_L	374_I	1.001	1.00
395_P	399_G	0.998	1.00
309_R	314_I	0.997	1.00
299_R	302_L	0.996	1.00
351_F	381_Y	0.996	1.00
442_L	473_V	0.995	1.00
443_I	460_V	0.994	1.00
438_T	514_L	0.992	1.00
401_L	417_L	0.992	1.00
374_I	378_A	0.987	1.00
124_D	127_K	0.985	1.00
407_R	410_D	0.981	1.00
238_V	244_V	0.980	1.00
404_K	447_L	0.978	1.00
330_L	334_L	0.977	1.00
216_E	221_F	0.977	1.00
59_V	62_T	0.976	1.00
373_Y	377_T	0.974	1.00
234_G	251_A	0.971	1.00
362_L	378_A	0.970	1.00
398_A	402_I	0.968	1.00
237_A	318_I	0.965	1.00
462_L	471_C	0.963	1.00
420_E	423_L	0.961	1.00
77_P	81_G	0.960	1.00
42_S	46_D	0.958	1.00
223_Q	227_M	0.957	1.00
398_A	417_L	0.956	1.00
352_M	381_Y	0.955	1.00
413_H	450_L	0.955	1.00
357_V	373_Y	0.955	1.00
401_L	405_I	0.954	1.00
502_V	506_L	0.954	1.00
112_E	115_R	0.954	1.00
228_L	248_N	0.953	1.00
480_I	504_L	0.953	1.00
51_G	54_N	0.951	1.00
494_S	500_R	0.951	1.00
467_G	536_W	0.951	1.00
435_L	532_V	0.949	1.00
149_F	162_V	0.947	1.00
393_K	494_S	0.945	1.00
397_I	460_V	0.942	1.00
451_G	454_P	0.942	1.00
436_I	440_G	0.940	1.00
349_H	441_N	0.940	1.00
123_D	127_K	0.935	1.00
215_Y	223_Q	0.934	1.00
228_L	235_V	0.932	1.00
55_K	58_A	0.929	1.00
418_N	463_H	0.928	1.00
480_I	486_D	0.922	1.00
307_P	314_I	0.922	1.00
449_A	496_K	0.918	1.00
138_N	141_F	0.918	1.00
295_T	299_R	0.917	1.00
60_A	63_L	0.915	1.00
215_Y	220_L	0.908	1.00
412_G	454_P	0.907	1.00
350_E	506_L	0.905	1.00
291_D	294_I	0.905	1.00
67_P	70_R	0.905	1.00
126_L	130_N	0.901	1.00
37_H	41_F	0.900	1.00
196_I	200_I	0.898	1.00
359_L	362_L	0.895	1.00
468_W	535_P	0.893	1.00
450_L	455_G	0.893	1.00
333_R	336_G	0.892	1.00
354_K	381_Y	0.891	1.00
153_Y	159_Q	0.888	1.00
50_D	53_A	0.886	1.00
350_E	437_T	0.885	1.00
237_A	246_L	0.883	1.00
352_M	389_L	0.883	1.00
101_T	107_R	0.883	1.00
343_A	348_S	0.879	1.00
404_K	443_I	0.879	1.00
346_E	491_K	0.877	1.00
141_F	145_A	0.877	1.00
124_D	128_A	0.874	1.00
390_G	434_T	0.871	1.00
177_N	180_R	0.870	1.00
84_A	87_E	0.869	1.00
42_S	45_S	0.864	1.00
99_V	107_R	0.863	1.00
215_Y	221_F	0.863	1.00
344_L	353_N	0.861	1.00
204_V	208_I	0.860	1.00
342_D	346_E	0.859	1.00
235_V	320_T	0.857	1.00
177_N	181_W	0.856	1.00
330_L	333_R	0.856	1.00
363_H	375_L	0.853	1.00
271_H	274_S	0.851	1.00
254_L	301_L	0.849	1.00
245_T	316_G	0.849	1.00
377_T	380_N	0.847	1.00
248_N	251_A	0.845	1.00
352_M	382_Q	0.844	1.00
332_Q	335_D	0.844	1.00
370_L	373_Y	0.842	1.00
302_L	322_R	0.839	1.00
36_V	40_Y	0.839	1.00
509_Q	512_E	0.839	1.00
516_G	535_P	0.837	1.00
491_K	509_Q	0.835	1.00
460_V	473_V	0.835	1.00
154_D	158_K	0.830	1.00
143_A	147_R	0.830	1.00
57_L	61_R	0.827	1.00
358_I	378_A	0.826	1.00
443_I	458_I	0.826	1.00
437_T	440_G	0.826	1.00
236_V	248_N	0.822	1.00
237_A	248_N	0.820	1.00
359_L	382_Q	0.820	1.00
351_F	355_L	0.820	1.00
439_L	532_V	0.819	1.00
388_L	392_I	0.819	1.00
448_E	495_T	0.815	1.00
432_V	436_I	0.813	1.00
343_A	347_R	0.812	1.00
66_S	69_I	0.812	1.00
403_S	407_R	0.809	1.00
351_F	385_I	0.809	1.00
48_T	51_G	0.806	1.00
194_G	198_T	0.806	1.00
83_Q	87_E	0.804	1.00
404_K	407_R	0.799	1.00
354_K	492_G	0.799	1.00
125_I	128_A	0.798	1.00
81_G	84_A	0.797	1.00
482_P	486_D	0.794	1.00
216_E	223_Q	0.792	1.00
238_V	242_G	0.790	1.00
353_N	357_V	0.789	1.00
399_G	402_I	0.788	1.00
180_R	184_I	0.788	1.00
26_S	29_L	0.784	1.00
243_E	265_K	0.782	1.00
148_V	151_P	0.780	1.00
310_S	314_I	0.780	1.00
350_E	384_E	0.776	1.00
356_H	359_L	0.775	1.00
353_N	364_L	0.774	1.00
168_E	171_R	0.774	1.00
34_L	38_L	0.772	1.00
342_D	491_K	0.770	1.00
255_L	301_L	0.769	1.00
422_Q	464_Y	0.769	1.00
40_Y	44_I	0.767	1.00
387_S	500_R	0.766	1.00
182_S	185_W	0.764	1.00
409_T	412_G	0.763	1.00
437_T	506_L	0.762	1.00
344_L	356_H	0.761	1.00
353_N	389_L	0.761	1.00
41_F	45_S	0.759	1.00
352_M	386_G	0.758	1.00
237_A	251_A	0.758	1.00
153_Y	161_G	0.757	1.00
161_G	169_L	0.755	1.00
85_I	88_A	0.754	1.00
221_F	227_M	0.750	1.00
348_S	352_M	0.749	1.00
299_R	323_D	0.748	1.00
340_Y	346_E	0.748	1.00
237_A	245_T	0.747	1.00
383_E	387_S	0.745	1.00
397_I	439_L	0.745	1.00
48_T	52_L	0.743	1.00
364_L	370_L	0.742	1.00
344_L	347_R	0.742	1.00
99_V	110_H	0.741	1.00
336_G	340_Y	0.741	1.00
446_A	473_V	0.741	1.00
481_A	488_I	0.740	1.00
347_R	351_F	0.737	1.00
218_S	224_R	0.736	1.00
475_D	527_F	0.736	1.00
223_Q	228_L	0.736	1.00
343_A	353_N	0.734	1.00
389_L	500_R	0.733	1.00
325_T	329_K	0.733	1.00
192_L	196_I	0.729	1.00
478_P	528_T	0.729	1.00
51_G	55_K	0.729	1.00
532_V	535_P	0.728	1.00
145_A	148_V	0.728	1.00
292_E	296_I	0.726	1.00
231_I	234_G	0.726	1.00
219_T	223_Q	0.726	1.00
289_R	294_I	0.725	1.00
343_A	389_L	0.722	1.00
348_S	449_A	0.721	1.00
465_R	468_W	0.717	1.00
389_L	393_K	0.717	1.00
239_D	245_T	0.717	1.00
45_S	49_R	0.714	1.00
377_T	389_L	0.710	1.00
305_T	308_V	0.710	1.00
434_T	514_L	0.709	1.00
478_P	497_G	0.707	1.00
88_A	92_R	0.706	1.00
387_S	434_T	0.705	1.00
305_T	317_A	0.704	1.00
237_A	319_S	0.701	1.00
283_L	286_G	0.701	1.00
142_L	145_A	0.701	1.00
229_Q	249_D	0.700	1.00
123_D	126_L	0.700	1.00
383_E	386_G	0.700	1.00
302_L	327_V	0.699	1.00
407_R	444_E	0.699	1.00
151_P	162_V	0.699	1.00
52_L	55_K	0.698	1.00
257_Y	296_I	0.698	1.00
335_D	339_N	0.696	1.00
86_A	90_R	0.695	1.00
494_S	498_S	0.695	1.00
59_V	63_L	0.691	1.00
355_L	361_L	0.688	0.99
218_S	225_Q	0.688	0.99
59_V	64_A	0.687	0.99
345_R	353_N	0.686	0.99
53_A	57_L	0.686	0.99
449_A	478_P	0.685	0.99
486_D	490_D	0.685	0.99
345_R	384_E	0.685	0.99
349_H	353_N	0.684	0.99
233_E	250_A	0.683	0.99
407_R	411_L	0.683	0.99
149_F	164_A	0.683	0.99
400_F	404_K	0.683	0.99
58_A	62_T	0.682	0.99
441_N	449_A	0.682	0.99
251_A	254_L	0.682	0.99
351_F	361_L	0.680	0.99
85_I	89_V	0.680	0.99
355_L	385_I	0.680	0.99
97_F	111_P	0.679	0.99
397_I	400_F	0.679	0.99
398_A	401_L	0.678	0.99
359_L	363_H	0.677	0.99
236_V	321_F	0.676	0.99
361_L	377_T	0.675	0.99
413_H	447_L	0.675	0.99
411_L	447_L	0.674	0.99
163_V	168_E	0.673	0.99
278_D	282_V	0.673	0.99
99_V	105_S	0.672	0.99
279_V	283_L	0.671	0.99
353_N	448_E	0.671	0.99
127_K	131_G	0.670	0.99
281_E	286_G	0.670	0.99
151_P	160_I	0.670	0.99
194_G	197_G	0.669	0.99
386_G	390_G	0.669	0.99
445_N	503_G	0.669	0.99
396_V	430_D	0.668	0.99
327_V	330_L	0.667	0.99
63_L	66_S	0.666	0.99
376_K	399_G	0.666	0.99
489_F	508_K	0.666	0.99
282_V	317_A	0.663	0.99
181_W	185_W	0.663	0.99
251_A	321_F	0.662	0.99
207_K	210_F	0.661	0.99
350_E	441_N	0.661	0.99
492_G	502_V	0.660	0.99
227_M	232_K	0.660	0.99
188_L	192_L	0.658	0.99
310_S	315_I	0.656	0.99
102_D	108_Y	0.655	0.99
449_A	495_T	0.654	0.99
341_A	345_R	0.654	0.99
507_V	511_V	0.654	0.99
345_R	348_S	0.654	0.99
353_N	356_H	0.653	0.99
250_A	254_L	0.653	0.99
143_A	168_E	0.652	0.99
391_K	491_K	0.652	0.99
261_Q	296_I	0.652	0.99
63_L	67_P	0.651	0.99
305_T	319_S	0.650	0.99
450_L	494_S	0.649	0.99
504_L	530_F	0.648	0.99
138_N	149_F	0.648	0.99
285_D	288_P	0.646	0.99
223_Q	237_A	0.646	0.99
55_K	59_V	0.646	0.99
54_N	57_L	0.646	0.99
407_R	447_L	0.645	0.99
223_Q	246_L	0.645	0.99
331_M	334_L	0.643	0.99
345_R	502_V	0.643	0.99
389_L	448_E	0.640	0.99
61_R	64_A	0.638	0.99
388_L	393_K	0.637	0.99
147_R	150_T	0.636	0.99
245_T	248_N	0.633	0.99
360_G	378_A	0.632	0.99
480_I	530_F	0.627	0.99
239_D	263_D	0.627	0.99
370_L	392_I	0.626	0.99
141_F	147_R	0.626	0.99
424_P	427_G	0.626	0.99
146_L	149_F	0.625	0.99
234_G	255_L	0.624	0.99
228_L	237_A	0.621	0.99
154_D	160_I	0.621	0.99
77_P	80_S	0.621	0.99
346_E	353_N	0.621	0.99
511_V	517_S	0.620	0.99
79_E	82_I	0.620	0.99
343_A	494_S	0.620	0.99
347_R	356_H	0.620	0.99
279_V	282_V	0.619	0.99
235_V	248_N	0.619	0.99
441_N	506_L	0.619	0.99
292_E	328_R	0.619	0.99
337_L	340_Y	0.618	0.99
236_V	247_I	0.618	0.99
276_V	279_V	0.617	0.99
379_N	383_E	0.616	0.99
107_R	110_H	0.616	0.99
353_N	381_Y	0.616	0.99
413_H	476_D	0.614	0.99
102_D	105_S	0.613	0.99
354_K	506_L	0.613	0.99
238_V	266_L	0.613	0.99
351_F	384_E	0.611	0.99
97_F	101_T	0.609	0.99
18_S	203_K	0.609	0.99
413_H	455_G	0.609	0.99
145_A	153_Y	0.609	0.99
406_N	410_D	0.608	0.99
327_V	333_R	0.608	0.99
140_G	147_R	0.607	0.99
87_E	91_K	0.605	0.99
234_G	238_V	0.605	0.99
414_T	455_G	0.605	0.99
326_E	330_L	0.604	0.99
406_N	409_T	0.603	0.99
378_A	382_Q	0.603	0.99
178_D	181_W	0.603	0.99
340_Y	348_S	0.602	0.99
343_A	346_E	0.602	0.99
345_R	351_F	0.599	0.99
434_T	438_T	0.599	0.99
231_I	320_T	0.598	0.99
384_E	392_I	0.597	0.99
396_V	404_K	0.597	0.99
64_A	67_P	0.596	0.99
349_H	354_K	0.596	0.99
248_N	325_T	0.593	0.99
234_G	323_D	0.593	0.99
172_V	176_I	0.593	0.99
226_A	230_S	0.591	0.98
397_I	417_L	0.591	0.98
435_L	511_V	0.591	0.98
465_R	533_Q	0.589	0.98
82_I	89_V	0.588	0.98
29_L	32_V	0.587	0.98
381_Y	387_S	0.584	0.98
101_T	164_A	0.584	0.98
235_V	246_L	0.583	0.98
183_I	186_S	0.583	0.98
291_D	295_T	0.583	0.98
448_E	500_R	0.582	0.98
220_L	227_M	0.582	0.98
346_E	356_H	0.581	0.98
481_A	495_T	0.581	0.98
412_G	455_G	0.581	0.98
169_L	173_T	0.581	0.98
464_Y	469_L	0.580	0.98
43_Q	47_M	0.580	0.98
316_G	321_F	0.579	0.98
244_V	248_N	0.579	0.98
470_H	519_A	0.579	0.98
420_E	464_Y	0.578	0.98
353_N	450_L	0.577	0.98
356_H	502_V	0.577	0.98
391_K	509_Q	0.577	0.98
347_R	382_Q	0.576	0.98
394_S	425_D	0.574	0.98
303_I	321_F	0.574	0.98
511_V	514_L	0.574	0.98
215_Y	219_T	0.573	0.98
145_A	166_G	0.572	0.98
518_I	532_V	0.572	0.98
306_V	318_I	0.572	0.98
227_M	230_S	0.571	0.98
433_A	436_I	0.571	0.98
448_E	497_G	0.571	0.98
140_G	143_A	0.571	0.98
161_G	164_A	0.571	0.98
115_R	118_Q	0.571	0.98
107_R	111_P	0.571	0.98
435_L	534_I	0.570	0.98
402_I	406_N	0.568	0.98
393_K	500_R	0.568	0.98
491_K	505_A	0.568	0.98
441_N	444_E	0.568	0.98
238_V	305_T	0.567	0.98
353_N	500_R	0.567	0.98
244_V	251_A	0.567	0.98
350_E	381_Y	0.565	0.98
472_E	521_E	0.565	0.98
65_D	69_I	0.565	0.98
360_G	437_T	0.563	0.98
243_E	263_D	0.559	0.98
240_D	313_V	0.559	0.98
337_L	341_A	0.559	0.98
82_I	109_S	0.558	0.98
441_N	500_R	0.558	0.98
199_C	203_K	0.558	0.98
439_L	460_V	0.557	0.98
402_I	405_I	0.556	0.98
492_G	500_R	0.555	0.98
356_H	377_T	0.555	0.98
150_T	153_Y	0.554	0.98
165_I	168_E	0.553	0.98
399_G	404_K	0.553	0.98
345_R	356_H	0.553	0.98
413_H	458_I	0.552	0.98
170_S	174_Q	0.552	0.98
491_K	502_V	0.551	0.98
448_E	498_S	0.551	0.98
164_A	168_E	0.551	0.98
377_T	384_E	0.551	0.98
396_V	401_L	0.550	0.98
282_V	305_T	0.550	0.98
290_R	295_T	0.550	0.98
65_D	68_E	0.549	0.98
350_E	498_S	0.549	0.98
298_D	302_L	0.549	0.98
415_L	458_I	0.549	0.98
340_Y	353_N	0.546	0.97
50_D	54_N	0.546	0.97
350_E	507_V	0.546	0.97
46_D	49_R	0.546	0.97
408_A	413_H	0.544	0.97
146_L	150_T	0.543	0.97
361_L	494_S	0.542	0.97
277_V	280_S	0.541	0.97
147_R	166_G	0.541	0.97
141_F	149_F	0.540	0.97
289_R	295_T	0.540	0.97
138_N	147_R	0.537	0.97
492_G	505_A	0.536	0.97
346_E	494_S	0.536	0.97
413_H	494_S	0.535	0.97
356_H	361_L	0.535	0.97
58_A	61_R	0.535	0.97
211_G	214_P	0.534	0.97
380_N	436_I	0.534	0.97
239_D	316_G	0.533	0.97
424_P	536_W	0.530	0.97
389_L	392_I	0.530	0.97
182_S	190_G	0.529	0.97
88_A	91_K	0.527	0.97
370_L	374_I	0.527	0.97
427_G	430_D	0.527	0.97
282_V	287_T	0.526	0.97
343_A	444_E	0.526	0.97
200_I	204_V	0.526	0.97
54_N	58_A	0.526	0.97
468_W	536_W	0.526	0.97
53_A	56_A	0.526	0.97
161_G	166_G	0.525	0.97
354_K	385_I	0.525	0.97
450_L	478_P	0.525	0.97
161_G	167_L	0.522	0.97
61_R	65_D	0.522	0.97
55_K	60_A	0.521	0.97
84_A	88_A	0.521	0.97
278_D	283_L	0.521	0.97
374_I	377_T	0.521	0.97
343_A	351_F	0.521	0.97
81_G	85_I	0.521	0.97
395_P	398_A	0.520	0.97
146_L	169_L	0.520	0.97
345_R	352_M	0.519	0.97
340_Y	345_R	0.519	0.97
404_K	444_E	0.519	0.97
162_V	166_G	0.518	0.97
309_R	315_I	0.518	0.97
423_L	427_G	0.518	0.97
162_V	165_I	0.518	0.97
370_L	377_T	0.517	0.97
449_A	497_G	0.517	0.97
440_G	444_E	0.516	0.96
397_I	419_S	0.516	0.96
264_E	269_L	0.515	0.96
353_N	385_I	0.514	0.96
339_N	346_E	0.514	0.96
479_G	527_F	0.512	0.96
377_T	382_Q	0.512	0.96
217_I	221_F	0.512	0.96
127_K	130_N	0.512	0.96
401_L	415_L	0.511	0.96
348_S	448_E	0.509	0.96
71_Q	75_K	0.509	0.96
378_A	381_Y	0.509	0.96
449_A	476_D	0.509	0.96
252_Q	257_Y	0.507	0.96
507_V	532_V	0.507	0.96
232_K	235_V	0.507	0.96
89_V	93_N	0.506	0.96
472_E	532_V	0.505	0.96
351_F	388_L	0.504	0.96
227_M	237_A	0.504	0.96
403_S	436_I	0.504	0.96
371_E	378_A	0.503	0.96
343_A	352_M	0.503	0.96
263_D	268_T	0.503	0.96
187_V	191_M	0.502	0.96
495_T	500_R	0.502	0.96
179_S	183_I	0.502	0.96
380_N	384_E	0.501	0.96
240_D	314_I	0.501	0.96
102_D	109_S	0.501	0.96
420_E	462_L	0.500	0.96
182_S	186_S	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4i5sA	2	0.5967	100	0.456	Contact Map
3a0rA	2	0.5672	100	0.46	Contact Map
4gczA	2	0.6059	100	0.469	Contact Map
4r3aA	1	0.547	100	0.567	Contact Map
2c2aA	2	0.3904	100	0.608	Contact Map
4q20A	2	0.3738	100	0.612	Contact Map
4e01A	3	0.4936	100	0.622	Contact Map
4mpcA	2	0.5212	100	0.623	Contact Map
4bixA	2	0.3886	100	0.623	Contact Map
3jz3A	2	0.2578	100	0.623	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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