GREMLIN Database
BARA - Signal transduction histidine-protein kinase BarA
UniProt: P0AEC5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11367
Length: 918 (763)
Sequences: 1331 (1104)
Seq/√Len: 40.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
695_E712_F10.0291.00
717_M729_A5.6831.00
674_D680_L5.2241.00
699_S723_D5.0781.00
366_F404_G4.9701.00
704_V729_A4.6891.00
501_S513_W4.6411.00
701_H705_E4.5861.00
697_C706_R4.4701.00
315_T334_I4.4171.00
461_Q502_F4.4101.00
364_I406_P4.2701.00
698_D702_Q3.7811.00
456_I460_D3.6831.00
404_G496_M3.5871.00
741_Q765_S3.5041.00
447_V514_F3.4481.00
321_T327_Q3.4411.00
766_D784_Y3.3531.00
680_L696_L3.3521.00
258_I262_T3.3221.00
725_D728_R3.3051.00
362_E404_G3.2651.00
757_E761_G3.2081.00
636_P642_L3.1851.00
272_M276_N3.1571.00
672_A683_I3.1441.00
353_K482_T3.0421.00
636_P646_L3.0411.00
417_V431_I3.0321.00
609_L613_L2.9871.00
680_L698_D2.9611.00
323_L327_Q2.9451.00
424_T452_T2.9451.00
310_G337_S2.8571.00
683_I747_V2.8381.00
730_C764_M2.8271.00
669_T693_H2.8261.00
686_L717_M2.8141.00
668_M785_K2.7831.00
472_D477_R2.7721.00
719_I727_I2.7411.00
686_L729_A2.7071.00
673_V697_C2.6881.00
715_I742_T2.6651.00
412_I493_V2.5711.00
474_S477_R2.5581.00
724_M728_R2.5021.00
269_L272_M2.4741.00
477_R480_G2.4641.00
701_H723_D2.4321.00
314_F682_L2.4311.00
720_Q750_H2.4301.00
493_V514_F2.4081.00
609_L612_A2.3531.00
457_P460_D2.3461.00
289_A293_K2.3391.00
737_P741_Q2.3041.00
362_E406_P2.3031.00
717_M730_C2.2451.00
471_A480_G2.1780.99
719_I759_L2.1740.99
382_S385_D2.1610.99
231_G237_K2.1550.99
297_L300_M2.1470.99
321_T330_H2.1450.99
642_L646_L2.1410.99
269_L273_E2.1370.99
750_H755_Q2.1240.99
241_N244_A2.1210.99
316_R773_E2.1070.99
312_I338_A2.1040.99
273_E276_N2.0840.99
475_I480_G2.0650.99
754_G757_E2.0640.99
505_Q508_R2.0460.99
365_P403_I2.0280.99
490_Q494_N2.0090.99
683_I717_M1.9870.99
258_I261_A1.9710.99
674_D696_L1.9670.99
674_D750_H1.9670.99
404_G518_L1.9620.99
720_Q755_Q1.9490.99
308_L314_F1.9400.99
205_P236_L1.9180.99
534_L561_L1.9180.99
300_M321_T1.9120.98
362_E366_F1.9110.98
672_A694_V1.9090.98
231_G234_D1.8920.98
673_V683_I1.8900.98
233_L240_I1.8870.98
482_T767_Y1.8800.98
255_Q262_T1.8750.98
759_L764_M1.8570.98
457_P506_P1.8310.98
756_K766_D1.8230.98
59_G64_N1.7990.98
367_P400_D1.7910.98
312_I315_T1.7910.98
732_L735_Q1.7710.97
314_F759_L1.7650.97
540_A577_Y1.7470.97
707_A742_T1.7420.97
412_I514_F1.7380.97
448_Q511_T1.7310.97
472_D480_G1.7270.97
347_D408_R1.7130.97
268_T272_M1.7060.97
706_R712_F1.6980.97
300_M348_V1.6830.97
300_M304_L1.6790.97
240_I243_M1.6730.96
730_C744_V1.6670.96
333_T337_S1.6670.96
280_D283_K1.6640.96
320_K689_D1.6470.96
766_D783_R1.6390.96
729_A733_I1.6240.96
408_R492_L1.6200.96
213_V243_M1.6180.96
15_L18_T1.6160.96
254_M261_A1.6030.95
751_A769_A1.6020.95
734_H765_S1.6010.95
324_T327_Q1.5970.95
255_Q261_A1.5710.95
751_A767_Y1.5690.95
269_L276_N1.5690.95
719_I764_M1.5610.95
456_I471_A1.5560.95
329_D681_K1.5550.95
704_V707_A1.5540.95
683_I729_A1.5470.94
298_A477_R1.5410.94
635_K642_L1.5400.94
282_A286_A1.5190.94
537_K578_D1.5190.94
748_T759_L1.5160.94
443_V517_N1.5150.94
276_N279_L1.5140.94
331_L676_N1.4970.93
686_L774_E1.4950.93
263_S268_T1.4880.93
669_T713_D1.4840.93
474_S480_G1.4780.93
538_R562_E1.4750.93
542_V572_L1.4600.93
728_R732_L1.4480.92
254_M258_I1.4460.92
294_S512_F1.4400.92
460_D471_A1.4380.92
668_M713_D1.4340.92
479_H757_E1.4310.92
310_G678_A1.4280.92
750_H759_L1.4270.92
299_N720_Q1.4240.92
670_V692_Q1.4220.92
673_V699_S1.4180.91
717_M720_Q1.4170.91
433_V447_V1.4150.91
304_L308_L1.4140.91
673_V703_A1.4130.91
717_M746_A1.4130.91
283_K287_Q1.4120.91
754_G767_Y1.4120.91
717_M755_Q1.4050.91
447_V518_L1.4040.91
714_L785_K1.4000.91
155_N158_G1.3990.91
476_S480_G1.3990.91
444_Q517_N1.3970.91
345_I354_L1.3910.91
216_I243_M1.3870.90
470_Q477_R1.3830.90
674_D699_S1.3790.90
237_K240_I1.3720.90
229_M234_D1.3690.90
682_L764_M1.3680.90
717_M747_V1.3640.90
418_G449_I1.3590.90
358_K720_Q1.3570.89
366_F403_I1.3530.89
145_S149_D1.3520.89
472_D720_Q1.3480.89
383_S421_I1.3430.89
751_A754_G1.3430.89
300_M674_D1.3410.89
376_V431_I1.3380.89
446_E515_H1.3370.89
669_T695_E1.3370.89
344_I407_L1.3310.89
412_I497_G1.3290.88
699_S724_M1.3250.88
475_I479_H1.3220.88
283_K286_A1.3200.88
432_L450_R1.3130.88
383_S418_G1.3090.88
209_M213_V1.2850.87
715_I729_A1.2840.87
268_T276_N1.2820.87
355_E413_I1.2720.86
232_E747_V1.2720.86
715_I744_V1.2690.86
318_T327_Q1.2680.86
255_Q258_I1.2680.86
612_A615_C1.2670.86
690_M774_E1.2630.86
719_I754_G1.2600.86
435_K445_I1.2570.85
289_A292_I1.2570.85
456_I502_F1.2550.85
309_N746_A1.2490.85
45_G52_L1.2410.85
633_L636_P1.2310.84
354_L357_G1.2310.84
237_K241_N1.2300.84
372_L431_I1.2300.84
727_I758_K1.2210.84
379_L414_T1.2200.84
316_R774_E1.2130.83
363_S519_D1.2110.83
225_V240_I1.2090.83
460_D463_R1.2080.83
380_A384_H1.2030.83
275_Q279_L1.2010.83
636_P643_L1.1930.82
728_R731_E1.1910.82
611_L614_P1.1890.82
310_G719_I1.1880.82
457_P471_A1.1880.82
704_V724_M1.1840.82
206_I344_I1.1760.81
348_V752_M1.1740.81
695_E706_R1.1740.81
503_H511_T1.1700.81
315_T319_L1.1700.81
470_Q480_G1.1690.81
311_V410_Q1.1690.81
733_I746_A1.1680.81
737_P765_S1.1630.81
304_L354_L1.1620.81
408_R411_Q1.1600.80
347_D357_G1.1590.80
475_I747_V1.1580.80
337_S678_A1.1540.80
297_L355_E1.1490.80
308_L335_E1.1470.80
731_E762_A1.1450.80
368_L445_I1.1440.80
471_A475_I1.1420.79
413_I674_D1.1420.79
373_D767_Y1.1360.79
583_G587_T1.1360.79
348_V353_K1.1350.79
432_L448_Q1.1340.79
389_E635_K1.1310.79
755_Q767_Y1.1300.79
716_L777_L1.1270.79
129_M134_P1.1270.79
311_V351_F1.1270.79
688_E694_V1.1260.78
737_P740_Q1.1240.78
310_G767_Y1.1210.78
333_T375_V1.1210.78
229_M237_K1.1200.78
364_I471_A1.1170.78
326_T685_A1.1160.78
224_R244_A1.1150.78
699_S729_A1.1120.78
308_L720_Q1.1120.78
632_C636_P1.1070.77
30_V34_Y1.1060.77
382_S683_I1.1020.77
407_L673_V1.1020.77
708_K736_L1.1010.77
224_R241_N1.0980.77
707_A715_I1.0980.77
673_V756_K1.0970.77
452_T456_I1.0960.77
240_I244_A1.0940.76
606_T609_L1.0920.76
546_S731_E1.0910.76
330_H717_M1.0880.76
560_P563_V1.0870.76
300_M353_K1.0870.76
297_L304_L1.0870.76
202_V205_P1.0850.76
374_E410_Q1.0850.76
383_S387_G1.0840.76
231_G682_L1.0830.76
272_M275_Q1.0750.75
290_A293_K1.0740.75
383_S388_L1.0710.75
362_E772_I1.0700.75
413_I417_V1.0670.75
320_K774_E1.0670.75
352_S484_L1.0650.74
268_T273_E1.0650.74
279_L282_A1.0650.74
68_I72_I1.0620.74
330_H345_I1.0600.74
684_G688_E1.0590.74
329_D333_T1.0580.74
130_I134_P1.0570.74
291_R295_E1.0530.74
714_L784_Y1.0510.73
467_A720_Q1.0440.73
730_C747_V1.0440.73
337_S737_P1.0440.73
449_I502_F1.0430.73
45_G56_T1.0430.73
312_I406_P1.0420.73
615_C618_Q1.0410.73
219_G222_D1.0400.73
746_A764_M1.0380.73
213_V240_I1.0370.72
345_I348_V1.0360.72
56_T59_G1.0350.72
146_P149_D1.0350.72
56_T158_G1.0340.72
434_E446_E1.0330.72
286_A748_T1.0320.72
727_I759_L1.0310.72
312_I334_I1.0300.72
310_G764_M1.0290.72
49_I53_A1.0270.72
502_F512_F1.0270.72
14_I22_G1.0220.71
540_A566_S1.0210.71
379_L421_I1.0200.71
267_E270_E1.0200.71
330_H686_L1.0180.71
23_L26_S1.0140.71
308_L345_I1.0140.71
402_V694_V1.0080.70
89_Y93_N1.0070.70
87_S95_L1.0040.70
356_A784_Y1.0030.70
257_N674_D1.0020.70
14_I17_P1.0020.70
695_E713_D1.0020.70
279_L489_T1.0000.70
314_F719_I0.9990.70
353_K470_Q0.9990.70
746_A767_Y0.9970.69
233_L237_K0.9950.69
337_S767_Y0.9940.69
59_G63_Q0.9920.69
147_S150_A0.9920.69
699_S732_L0.9870.69
707_A717_M0.9870.69
423_F480_G0.9850.68
379_L417_V0.9800.68
48_I53_A0.9750.68
374_E673_V0.9740.68
477_R725_D0.9720.67
270_E273_E0.9690.67
422_K481_G0.9670.67
312_I404_G0.9660.67
737_P747_V0.9640.67
88_V93_N0.9640.67
466_Q487_V0.9630.67
308_L338_A0.9620.67
388_L769_A0.9610.67
361_L496_M0.9610.67
228_F237_K0.9610.67
375_V417_V0.9600.66
294_S355_E0.9600.66
352_S489_T0.9590.66
470_Q479_H0.9590.66
514_F517_N0.9560.66
475_I728_R0.9550.66
609_L615_C0.9550.66
158_G162_L0.9510.66
310_G699_S0.9470.65
504_S507_N0.9470.65
300_M344_I0.9460.65
333_T767_Y0.9460.65
423_F470_Q0.9440.65
697_C702_Q0.9430.65
71_L75_L0.9430.65
446_E513_W0.9420.65
330_H488_I0.9420.65
303_E470_Q0.9410.65
250_Y262_T0.9390.65
288_E487_V0.9390.65
450_R511_T0.9370.65
423_F481_G0.9350.64
549_A565_Y0.9340.64
634_L646_L0.9310.64
344_I482_T0.9300.64
344_I464_L0.9300.64
409_L516_I0.9300.64
72_I413_I0.9290.64
707_A744_V0.9290.64
719_I746_A0.9280.64
337_S690_M0.9280.64
243_M246_S0.9270.64
89_Y95_L0.9260.64
53_A59_G0.9260.64
345_I764_M0.9240.63
263_S270_E0.9240.63
391_T430_D0.9230.63
720_Q727_I0.9190.63
719_I737_P0.9190.63
729_A755_Q0.9180.63
488_I495_E0.9180.63
566_S572_L0.9170.63
539_L556_L0.9170.63
679_N746_A0.9160.63
308_L333_T0.9150.63
311_V345_I0.9140.63
310_G747_V0.9140.63
188_I192_L0.9120.62
687_L777_L0.9120.62
232_E236_L0.9110.62
607_D611_L0.9100.62
243_M247_L0.9100.62
297_L752_M0.9090.62
330_H334_I0.9080.62
318_T321_T0.9070.62
684_G696_L0.9070.62
64_N158_G0.9070.62
538_R577_Y0.9070.62
716_L729_A0.9070.62
299_N330_H0.9060.62
750_H754_G0.9050.62
310_G737_P0.9030.62
286_A297_L0.9020.62
293_K311_V0.9000.61
707_A729_A0.8950.61
334_I682_L0.8940.61
707_A736_L0.8940.61
14_I28_F0.8940.61
679_N763_G0.8930.61
752_M755_Q0.8910.61
294_S346_N0.8890.60
304_L327_Q0.8860.60
70_Q75_L0.8860.60
368_L379_L0.8850.60
442_K517_N0.8840.60
609_L616_H0.8840.60
540_A572_L0.8830.60
315_T727_I0.8820.60
61_S64_N0.8820.60
333_T681_K0.8800.60
541_Y552_T0.8800.60
310_G323_L0.8790.60
344_I351_F0.8760.59
363_S404_G0.8750.59
347_D359_L0.8740.59
454_I479_H0.8730.59
333_T685_A0.8720.59
683_I764_M0.8710.59
276_N280_D0.8710.59
665_K692_Q0.8710.59
304_L502_F0.8700.59
53_A56_T0.8700.59
404_G409_L0.8700.59
82_I100_N0.8690.59
438_L520_L0.8690.59
399_P443_V0.8690.59
429_I738_H0.8680.59
552_T745_I0.8680.59
471_A477_R0.8680.59
299_N774_E0.8670.59
318_T323_L0.8630.58
229_M233_L0.8610.58
398_V445_I0.8590.58
717_M774_E0.8580.58
768_L781_L0.8580.58
419_N422_K0.8570.58
538_R578_D0.8570.58
470_Q486_L0.8570.58
412_I492_L0.8550.57
361_L416_L0.8550.57
718_D726_G0.8550.57
455_G481_G0.8540.57
144_E147_S0.8520.57
673_V680_L0.8520.57
474_S479_H0.8490.57
321_T324_T0.8480.57
714_L745_I0.8480.57
299_N311_V0.8470.57
41_L56_T0.8430.56
333_T678_A0.8430.56
411_Q492_L0.8430.56
456_I461_Q0.8420.56
327_Q474_S0.8390.56
59_G62_L0.8390.56
686_L707_A0.8370.56
683_I716_L0.8370.56
18_T25_L0.8370.56
330_H729_A0.8360.56
606_T610_M0.8340.56
388_L425_E0.8330.55
236_L243_M0.8330.55
686_L720_Q0.8330.55
314_F334_I0.8320.55
720_Q756_K0.8310.55
695_E710_M0.8310.55
257_N261_A0.8300.55
58_Y62_L0.8300.55
755_Q759_L0.8300.55
704_V732_L0.8290.55
611_L615_C0.8280.55
464_L773_E0.8280.55
670_V781_L0.8270.55
394_I398_V0.8260.55
423_F477_R0.8260.55
672_A687_L0.8250.55
53_A60_M0.8250.55
413_I447_V0.8250.55
500_I746_A0.8250.55
351_F500_I0.8230.55
614_P618_Q0.8230.55
311_V378_L0.8220.54
294_S510_S0.8220.54
442_K519_D0.8210.54
717_M764_M0.8210.54
362_E480_G0.8210.54
751_A772_I0.8200.54
153_S158_G0.8200.54
471_A487_V0.8190.54
404_G719_I0.8190.54
353_K480_G0.8160.54
47_S50_E0.8160.54
726_G749_A0.8130.54
676_N763_G0.8120.54
318_T331_L0.8120.54
691_V750_H0.8100.53
318_T333_T0.8100.53
388_L424_T0.8090.53
299_N467_A0.8090.53
309_N351_F0.8080.53
312_I342_L0.8080.53
419_N481_G0.8060.53
472_D479_H0.8060.53
213_V231_G0.8040.53
299_N686_L0.8010.53
338_A674_D0.7990.52
372_L490_Q0.7970.52
345_I752_M0.7960.52
48_I56_T0.7960.52
685_A766_D0.7950.52
755_Q758_K0.7930.52
756_K760_L0.7920.52
39_R42_E0.7910.52
680_L759_L0.7900.52
605_M609_L0.7900.52
694_V773_E0.7890.51
471_A479_H0.7880.51
556_L563_V0.7880.51
333_T381_H0.7870.51
310_G383_S0.7870.51
286_A764_M0.7860.51
751_A756_K0.7850.51
320_K333_T0.7820.51
314_F368_L0.7820.51
337_S408_R0.7810.51
692_Q713_D0.7810.51
404_G727_I0.7810.51
725_D734_H0.7810.51
311_V323_L0.7790.51
131_L134_P0.7780.50
315_T414_T0.7780.50
409_L518_L0.7780.50
361_L404_G0.7770.50
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686_L747_V0.5010.27
346_N350_D0.5010.27
416_L449_I0.5000.27
145_S150_A0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.3377 100 0.75 Contact Map
4bixA 2 0.2495 100 0.78 Contact Map
4e01A 3 0.3083 100 0.787 Contact Map
4mpcA 2 0.3606 100 0.789 Contact Map
4ctiA 2 0.2484 100 0.792 Contact Map
4gczA 2 0.3802 100 0.793 Contact Map
2q8gA 2 0.3475 100 0.796 Contact Map
2c2aA 2 0.2538 100 0.797 Contact Map
4q20A 2 0.2505 100 0.8 Contact Map
3jz3A 2 0.1743 100 0.802 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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