GREMLIN Database
YOAE - UPF0053 inner membrane protein YoaE
UniProt: P0AEC0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13517
Length: 518 (391)
Sequences: 641 (435)
Seq/√Len: 22.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
310_I408_L6.3581.00
440_V507_I5.0281.00
200_L248_T4.5011.00
375_V384_L4.2541.00
477_H483_D4.1021.00
493_T508_V3.8681.00
439_L504_L3.5511.00
439_L495_I3.4661.00
440_V449_L3.3001.00
467_V505_V3.2861.00
471_V505_V3.2621.00
318_G321_E3.2281.00
336_V369_A3.0921.00
313_V322_I3.0581.00
288_M418_I2.9370.99
386_G389_R2.8980.99
449_L453_L2.8250.99
416_E425_A2.8050.99
397_I408_L2.6580.99
484_V493_T2.5800.98
334_F350_A2.5750.98
312_W337_C2.4910.98
471_V494_I2.4870.98
440_V467_V2.4490.98
337_C344_I2.4440.98
475_N485_I2.4330.98
498_N503_D2.4060.97
493_T506_R2.3750.97
162_V166_A2.3500.97
143_A147_A2.2720.96
449_L507_I2.1840.95
338_R366_I2.1760.95
173_K176_T2.1580.95
162_V208_H2.1390.95
165_M181_Q2.1330.95
484_V491_H2.1280.95
486_D491_H2.1240.95
395_F448_A2.1080.95
384_L476_G2.0810.94
491_H508_V2.0790.94
352_E370_S2.0600.94
173_K203_E2.0530.94
434_D506_R1.9750.92
164_A199_S1.9290.91
298_R302_G1.8720.90
129_V446_L1.8250.89
471_V475_N1.8060.88
379_L384_L1.8060.88
348_V385_L1.8040.88
162_V165_M1.8030.88
384_L409_V1.7850.88
324_E328_S1.7620.87
312_W341_L1.7520.87
289_I333_L1.7470.87
424_D427_E1.7240.86
311_S334_F1.6810.84
139_F150_M1.6790.84
450_Q461_D1.6760.84
291_G351_K1.6580.84
139_F168_M1.6420.83
434_D439_L1.6380.83
333_L399_T1.6320.83
162_V173_K1.6070.82
173_K195_M1.6000.81
176_T195_M1.5940.81
491_H510_E1.5670.80
338_R343_E1.5620.80
437_G509_K1.5480.79
423_P427_E1.5150.77
471_V492_I1.5140.77
169_L173_K1.5010.77
412_L425_A1.4920.76
344_I397_I1.4910.76
142_D146_T1.4890.76
310_I405_V1.4750.76
139_F166_A1.4740.75
316_N338_R1.4720.75
310_I341_L1.4670.75
137_A193_L1.4640.75
292_V418_I1.4610.75
155_P159_A1.4460.74
344_I384_L1.4440.74
419_A422_F1.4360.73
166_A177_R1.4320.73
342_D404_V1.4310.73
333_L412_L1.4210.73
287_Y451_Q1.4130.72
402_F468_A1.4030.72
162_V169_L1.3970.71
305_T380_D1.3780.70
172_S202_A1.3690.70
345_I483_D1.3650.70
170_L177_R1.3330.68
168_M199_S1.3320.68
352_E400_N1.3280.67
434_D437_G1.3180.67
170_L176_T1.3070.66
464_I473_S1.3000.66
317_L321_E1.2870.65
468_A472_I1.2870.65
327_L359_E1.2800.64
317_L322_I1.2730.64
486_D489_P1.2710.64
349_R394_S1.2690.64
146_T149_G1.2690.64
139_F169_L1.2630.63
127_V472_I1.2630.63
156_V160_A1.2620.63
139_F143_A1.2600.63
297_S414_V1.2600.63
411_P422_F1.2590.63
303_I381_P1.2380.62
254_R260_R1.2300.61
147_A212_G1.2240.61
291_G421_E1.2220.61
388_L411_P1.2200.61
130_T409_V1.2180.61
496_E503_D1.2110.60
422_F445_D1.2110.60
382_I389_R1.2100.60
169_L202_A1.2040.60
297_S441_K1.2020.59
136_D140_S1.2010.59
140_S144_V1.1960.59
332_S351_K1.1930.59
139_F200_L1.1900.59
143_A174_P1.1890.59
147_A150_M1.1850.58
335_P397_I1.1810.58
379_L387_V1.1790.58
268_A275_P1.1730.58
159_A165_M1.1690.57
296_A468_A1.1620.57
300_L308_G1.1530.56
377_E401_E1.1520.56
388_L498_N1.1500.56
173_K199_S1.1450.56
301_R340_E1.1400.55
154_L157_M1.1300.55
470_L487_V1.1250.54
399_T466_T1.1240.54
139_F245_R1.1220.54
333_L394_S1.1180.54
310_I412_L1.1110.53
422_F425_A1.1020.53
209_I252_I1.1000.53
198_L466_T1.0970.52
317_L325_Q1.0960.52
165_M169_L1.0950.52
139_F165_M1.0850.52
472_I502_V1.0830.51
133_V376_P1.0820.51
139_F146_T1.0720.51
412_L422_F1.0700.51
139_F204_G1.0690.51
397_I454_D1.0680.50
286_R385_L1.0670.50
166_A170_L1.0640.50
262_A485_I1.0570.50
298_R438_W1.0540.50
161_V195_M1.0530.49
168_M173_K1.0530.49
184_T188_L1.0460.49
422_F427_E1.0440.49
337_C387_V1.0430.49
166_A169_L1.0420.49
269_D272_M1.0340.48
238_H495_I1.0310.48
295_L405_V1.0260.48
129_V313_V1.0250.48
166_A208_H1.0220.47
311_S466_T1.0220.47
149_G293_L1.0210.47
396_V426_D1.0140.47
240_S279_G1.0130.47
264_V282_A1.0120.47
231_A234_N1.0120.47
405_V414_V1.0120.47
155_P163_I1.0110.47
195_M203_E1.0100.47
214_L220_F1.0090.46
254_R325_Q1.0090.46
439_L506_R1.0080.46
140_S199_S1.0000.46
145_I323_R0.9990.46
157_M215_Y0.9910.45
341_L438_W0.9910.45
379_L389_R0.9900.45
175_L179_V0.9900.45
265_Q468_A0.9870.45
131_Q140_S0.9850.45
394_S412_L0.9840.45
489_P510_E0.9750.44
364_A367_A0.9730.44
337_C392_R0.9680.44
292_V295_L0.9650.43
348_V368_S0.9650.43
157_M174_P0.9640.43
143_A493_T0.9630.43
415_L424_D0.9620.43
396_V475_N0.9610.43
395_F411_P0.9600.43
158_M207_F0.9590.43
313_V365_A0.9580.43
213_Y339_G0.9580.43
268_A272_M0.9570.43
272_M445_D0.9560.43
140_S178_F0.9520.43
333_L427_E0.9510.43
236_I499_D0.9500.42
185_V189_C0.9480.42
490_L509_K0.9480.42
198_L499_D0.9460.42
302_G414_V0.9460.42
276_I463_D0.9460.42
336_V442_G0.9450.42
265_Q269_D0.9440.42
400_N403_G0.9400.42
495_I506_R0.9390.42
145_I217_A0.9380.42
162_V177_R0.9380.42
157_M161_V0.9340.41
490_L507_I0.9330.41
348_V369_A0.9300.41
186_V190_L0.9280.41
139_F248_T0.9260.41
252_I369_A0.9240.41
446_L503_D0.9210.41
186_V218_I0.9180.40
158_M165_M0.9160.40
268_A271_P0.9150.40
212_G215_Y0.9120.40
353_L488_G0.9070.40
130_T209_I0.9060.40
221_S254_R0.8980.39
425_A459_A0.8980.39
354_L385_L0.8950.39
335_P424_D0.8940.39
140_S505_V0.8940.39
278_E390_R0.8900.39
157_M212_G0.8900.39
160_A203_E0.8890.39
142_D149_G0.8810.38
150_M166_A0.8800.38
295_L312_W0.8790.38
165_M208_H0.8780.38
432_I439_L0.8780.38
203_E293_L0.8780.38
307_R403_G0.8770.38
147_A162_V0.8760.38
344_I418_I0.8710.37
313_V484_V0.8650.37
147_A203_E0.8630.37
372_A389_R0.8620.37
171_A212_G0.8610.37
139_F147_A0.8560.36
350_A507_I0.8520.36
412_L416_E0.8500.36
349_R411_P0.8500.36
304_M492_I0.8460.36
295_L382_I0.8450.36
147_A178_F0.8440.36
384_L397_I0.8440.36
212_G249_A0.8430.36
157_M160_A0.8430.36
436_D509_K0.8420.36
142_D164_A0.8380.35
433_T436_D0.8360.35
150_M169_L0.8330.35
153_H176_T0.8330.35
170_L199_S0.8330.35
139_F145_I0.8310.35
166_A181_Q0.8270.35
265_Q297_S0.8270.35
139_F208_H0.8250.34
409_V414_V0.8250.34
332_S427_E0.8230.34
283_E352_E0.8200.34
416_E427_E0.8200.34
193_L389_R0.8200.34
370_S392_R0.8180.34
144_V147_A0.8170.34
382_I387_V0.8170.34
145_I199_S0.8170.34
240_S267_D0.8150.34
354_L372_A0.8150.34
158_M162_V0.8100.34
137_A331_H0.8100.34
331_H426_D0.8080.33
388_L396_V0.8060.33
143_A203_E0.8050.33
352_E392_R0.8040.33
362_D454_D0.7990.33
341_L458_L0.7970.33
288_M292_V0.7950.33
139_F142_D0.7930.33
314_D339_G0.7900.32
140_S227_F0.7880.32
177_R195_M0.7840.32
162_V179_V0.7810.32
507_I514_H0.7780.32
394_S423_P0.7760.32
388_L393_G0.7750.31
245_R248_T0.7750.31
275_P279_G0.7740.31
372_A386_G0.7730.31
207_F248_T0.7710.31
169_L208_H0.7700.31
182_H225_E0.7690.31
286_R303_I0.7670.31
155_P212_G0.7640.31
128_V199_S0.7630.31
311_S331_H0.7610.31
352_E492_I0.7610.31
150_M204_G0.7600.31
412_L417_A0.7570.30
145_I168_M0.7550.30
431_I440_V0.7530.30
261_Q365_A0.7520.30
401_E466_T0.7520.30
154_L212_G0.7500.30
136_D212_G0.7490.30
147_A157_M0.7490.30
415_L418_I0.7480.30
242_L266_H0.7480.30
146_T220_F0.7470.30
204_G305_T0.7460.30
160_A249_A0.7450.30
450_Q459_A0.7420.30
315_A345_I0.7420.30
176_T203_E0.7410.30
331_H334_F0.7380.29
295_L323_R0.7360.29
335_P350_A0.7350.29
332_S440_V0.7340.29
192_F418_I0.7310.29
360_G367_A0.7310.29
149_G437_G0.7280.29
400_N448_A0.7270.29
343_E425_A0.7260.29
208_H223_I0.7250.29
163_I442_G0.7210.28
296_A317_L0.7140.28
189_C219_G0.7130.28
265_Q274_M0.7120.28
385_L422_F0.7100.28
471_V502_V0.7090.28
406_Q417_A0.7080.28
208_H212_G0.7060.28
433_T471_V0.7060.28
341_L470_L0.7050.28
159_A274_M0.7050.28
287_Y400_N0.7050.28
146_T203_E0.7040.27
446_L450_Q0.7040.27
142_D207_F0.7030.27
300_L402_F0.7020.27
412_L427_E0.7010.27
294_T497_A0.7010.27
147_A215_Y0.6980.27
277_P399_T0.6960.27
197_G221_S0.6950.27
139_F162_V0.6940.27
385_L408_L0.6920.27
145_I188_L0.6920.27
307_R342_D0.6920.27
483_D494_I0.6920.27
294_T402_F0.6900.27
171_A179_V0.6900.27
205_F508_V0.6900.27
337_C438_W0.6870.27
172_S198_L0.6860.26
323_R327_L0.6850.26
282_A478_I0.6850.26
285_E415_L0.6840.26
139_F203_E0.6820.26
242_L279_G0.6810.26
146_T207_F0.6810.26
272_M277_P0.6770.26
337_C412_L0.6760.26
330_P350_A0.6750.26
343_E454_D0.6740.26
267_D453_L0.6710.26
400_N462_D0.6690.26
173_K178_F0.6680.26
349_R501_R0.6660.25
163_I400_N0.6650.25
345_I474_A0.6640.25
173_K177_R0.6630.25
340_E485_I0.6630.25
164_A234_N0.6620.25
291_G295_L0.6620.25
421_E447_H0.6620.25
143_A166_A0.6610.25
294_T306_P0.6610.25
174_P202_A0.6610.25
160_A248_T0.6600.25
162_V242_L0.6600.25
311_S343_E0.6580.25
179_V208_H0.6580.25
193_L224_I0.6570.25
200_L245_R0.6570.25
190_L218_I0.6570.25
150_M162_V0.6570.25
386_G396_V0.6550.25
159_A162_V0.6550.25
440_V497_A0.6540.25
272_M275_P0.6540.25
301_R381_P0.6540.25
449_L494_I0.6540.25
253_L266_H0.6520.25
209_I253_L0.6520.25
165_M204_G0.6520.25
475_N483_D0.6510.25
344_I392_R0.6510.25
337_C375_V0.6480.25
471_V485_I0.6480.25
194_L281_F0.6430.24
194_L199_S0.6400.24
131_Q252_I0.6400.24
412_L426_D0.6380.24
466_T477_H0.6360.24
274_M310_I0.6350.24
335_P408_L0.6350.24
280_A475_N0.6340.24
142_D168_M0.6340.24
381_P414_V0.6330.24
174_P179_V0.6320.24
460_D486_D0.6310.24
234_N240_S0.6290.24
137_A225_E0.6290.24
186_V189_C0.6280.24
205_F324_E0.6280.24
170_L216_A0.6270.23
157_M162_V0.6260.23
130_T177_R0.6240.23
307_R401_E0.6230.23
449_L467_V0.6220.23
134_I221_S0.6220.23
138_V290_N0.6200.23
219_G291_G0.6170.23
178_F215_Y0.6170.23
169_L176_T0.6170.23
181_Q208_H0.6150.23
161_V172_S0.6150.23
139_F149_G0.6140.23
178_F213_Y0.6120.23
154_L174_P0.6110.23
169_L203_E0.6090.23
136_D147_A0.6080.23
313_V371_P0.6070.23
312_W438_W0.6070.23
179_V215_Y0.6060.22
266_H347_I0.6040.22
175_L178_F0.6030.22
125_F131_Q0.6030.22
190_L229_Q0.6030.22
481_V507_I0.6020.22
468_A501_R0.6010.22
386_G498_N0.6000.22
308_G404_V0.6000.22
431_I444_T0.5980.22
254_R365_A0.5980.22
347_I504_L0.5940.22
136_D215_Y0.5920.22
334_F438_W0.5900.22
306_P395_F0.5890.22
495_I503_D0.5880.22
454_D485_I0.5880.22
154_L170_L0.5860.22
167_V174_P0.5850.21
362_D367_A0.5840.21
344_I402_F0.5820.21
193_L225_E0.5820.21
142_D215_Y0.5790.21
238_H340_E0.5780.21
178_F183_P0.5770.21
337_C426_D0.5760.21
128_V140_S0.5750.21
370_S443_G0.5740.21
464_I475_N0.5730.21
139_F175_L0.5730.21
272_M345_I0.5730.21
416_E420_G0.5720.21
264_V267_D0.5720.21
348_V370_S0.5700.21
222_I227_F0.5700.21
385_L492_I0.5700.21
232_R236_I0.5680.21
161_V249_A0.5680.21
312_W417_A0.5660.21
147_A154_L0.5650.21
323_R343_E0.5630.21
150_M157_M0.5630.21
342_D418_I0.5620.20
188_L225_E0.5610.20
165_M168_M0.5610.20
289_I394_S0.5600.20
143_A161_V0.5600.20
361_V367_A0.5600.20
129_V236_I0.5600.20
132_I161_V0.5590.20
251_A470_L0.5580.20
365_A422_F0.5580.20
194_L245_R0.5570.20
322_I377_E0.5560.20
134_I324_E0.5550.20
150_M165_M0.5530.20
395_F408_L0.5530.20
149_G251_A0.5520.20
471_V480_R0.5520.20
252_I382_I0.5520.20
337_C384_L0.5510.20
174_P212_G0.5500.20
333_L396_V0.5490.20
190_L204_G0.5470.20
168_M203_E0.5460.20
306_P421_E0.5460.20
143_A508_V0.5460.20
256_M441_K0.5460.20
141_L151_V0.5440.20
201_V343_E0.5430.20
375_V410_T0.5430.20
394_S409_V0.5420.20
267_D279_G0.5420.20
236_I458_L0.5410.20
184_T189_C0.5410.20
139_F212_G0.5400.20
312_W497_A0.5390.19
138_V281_F0.5390.19
399_T461_D0.5380.19
164_A205_F0.5380.19
365_A497_A0.5380.19
143_A163_I0.5370.19
264_V300_L0.5370.19
377_E405_V0.5360.19
332_S475_N0.5350.19
336_V414_V0.5350.19
366_I370_S0.5340.19
198_L214_L0.5320.19
333_L429_P0.5310.19
392_R502_V0.5310.19
396_V404_V0.5300.19
136_D139_F0.5290.19
400_N409_V0.5270.19
136_D200_L0.5270.19
401_E469_G0.5260.19
396_V409_V0.5260.19
334_F473_S0.5250.19
401_E416_E0.5240.19
344_I374_I0.5240.19
193_L229_Q0.5230.19
142_D147_A0.5230.19
412_L424_D0.5230.19
260_R334_F0.5210.19
399_T500_Y0.5200.19
373_I396_V0.5200.19
169_L174_P0.5200.19
376_P379_L0.5180.19
292_V422_F0.5180.19
329_S392_R0.5170.19
354_L415_L0.5170.19
297_S324_E0.5160.19
309_E409_V0.5160.19
243_P247_R0.5160.19
432_I435_G0.5140.18
259_K283_E0.5130.18
335_P344_I0.5130.18
145_I229_Q0.5130.18
352_E426_D0.5130.18
333_L337_C0.5130.18
165_M227_F0.5120.18
290_N444_T0.5090.18
264_V406_Q0.5090.18
299_S382_I0.5080.18
448_A488_G0.5080.18
133_V484_V0.5080.18
205_F512_P0.5060.18
147_A202_A0.5040.18
302_G306_P0.5040.18
313_V325_Q0.5040.18
174_P195_M0.5010.18
146_T152_N0.5010.18
329_S371_P0.5000.18
288_M353_L0.5000.18
441_K499_D0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hg0A 2 0.4382 100 0.7 Contact Map
3lhhA 1 0.2413 100 0.86 Contact Map
3ocoA 2 0.2606 100 0.867 Contact Map
3ocmA 5 0.2876 100 0.868 Contact Map
2v8qE 1 0.4324 99.9 0.871 Contact Map
3oi8A 2 0.3012 99.9 0.872 Contact Map
3lv9A 2 0.251 99.9 0.878 Contact Map
3kxrA 3 0.3108 99.9 0.881 Contact Map
4iysA 2 0.2741 99.9 0.885 Contact Map
3t4nC 1 0.4459 99.9 0.886 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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