GREMLIN Database
YNAI - Low conductance mechanosensitive channel YnaI
UniProt: P0AEB5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13924
Length: 343 (307)
Sequences: 8138 (6186)
Seq/√Len: 353.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_T130_L4.6551.00
252_G315_D4.4631.00
314_I318_Q3.7061.00
259_R263_K3.6711.00
197_A207_T3.6451.00
186_R193_E3.4741.00
253_V320_H3.3941.00
280_Q287_N3.3631.00
256_E260_E3.0181.00
188_P191_N2.9501.00
316_I319_S2.9261.00
255_V311_L2.8301.00
265_H308_D2.8061.00
316_I320_H2.7711.00
282_A287_N2.7531.00
242_G285_S2.6791.00
258_V313_I2.6451.00
184_W193_E2.5531.00
260_E264_N2.3881.00
279_N289_M2.3421.00
312_K315_D2.3391.00
161_K165_S2.3271.00
257_A316_I2.3051.00
260_E316_I2.2881.00
315_D319_S2.2811.00
253_V256_E2.2611.00
220_L224_I2.2121.00
278_F286_L2.1641.00
240_T289_M2.1621.00
176_D202_R2.0661.00
257_A320_H2.0211.00
198_E205_K1.9601.00
184_W195_T1.9551.00
292_C309_V1.9441.00
185_I196_V1.9341.00
262_L290_V1.9061.00
306_Q310_Y1.8991.00
243_L254_I1.8911.00
244_R323_D1.8821.00
186_R227_E1.8681.00
186_R229_P1.8471.00
184_W209_F1.8351.00
255_V259_R1.8271.00
261_M316_I1.8201.00
47_F51_T1.8081.00
261_M312_K1.7871.00
264_N312_K1.7841.00
241_I313_I1.7621.00
296_T301_E1.7341.00
240_T287_N1.7311.00
254_I288_I1.7261.00
197_A213_P1.7121.00
186_R191_N1.7021.00
208_T214_L1.6661.00
238_T289_M1.6601.00
283_D287_N1.6491.00
242_G287_N1.6491.00
269_D272_Q1.6421.00
154_L157_G1.6261.00
99_N123_K1.5871.00
248_A253_V1.5821.00
317_V322_A1.5801.00
245_Y281_F1.5701.00
188_P225_S1.5321.00
283_D329_Q1.5091.00
204_T218_N1.5011.00
308_D312_K1.4941.00
84_S134_Y1.4701.00
162_D165_S1.4661.00
24_I28_F1.4561.00
257_A260_E1.4261.00
242_G284_S1.4221.00
252_G256_E1.4131.00
267_A308_D1.3991.00
188_P224_I1.3961.00
267_A301_E1.3931.00
253_V257_A1.3861.00
312_K316_I1.3821.00
252_G311_L1.3731.00
265_H312_K1.3681.00
33_G36_K1.3671.00
302_W306_Q1.3581.00
19_S23_L1.3501.00
246_E326_F1.3451.00
84_S138_F1.3401.00
243_L251_V1.3361.00
126_I130_L1.3071.00
243_L247_D1.3011.00
301_E304_A1.2991.00
88_V92_I1.2841.00
242_G282_A1.2761.00
18_G22_A1.2631.00
23_L27_S1.2131.00
27_S31_R1.2061.00
144_G147_T1.2051.00
294_T305_A1.2001.00
263_K270_Q1.1931.00
256_E259_R1.1901.00
180_S231_R1.1881.00
307_Q311_L1.1861.00
255_V307_Q1.1861.00
194_G206_I1.1841.00
179_F204_T1.1771.00
265_H309_V1.1741.00
265_H268_I1.1621.00
304_A308_D1.1581.00
260_E263_K1.1541.00
220_L225_S1.1431.00
183_D231_R1.1421.00
220_L223_S1.1411.00
151_I160_G1.1371.00
237_I292_C1.1281.00
45_V51_T1.1121.00
196_V206_I1.1111.00
148_F151_I1.1071.00
214_L227_E1.1011.00
103_K119_S1.0981.00
244_R247_D1.0951.00
15_I19_S1.0871.00
235_R302_W1.0841.00
326_F330_T1.0811.00
283_D327_P1.0811.00
163_I169_S1.0761.00
276_V290_V1.0731.00
95_F123_K1.0721.00
242_G326_F1.0711.00
187_S221_F1.0651.00
87_A137_H1.0621.00
15_I22_A1.0621.00
264_N316_I1.0571.00
77_V81_I1.0561.00
254_I317_V1.0491.00
87_A130_L1.0421.00
205_K213_P1.0401.00
254_I258_V1.0341.00
91_T95_F1.0331.00
172_M222_S1.0331.00
80_F83_T1.0311.00
245_Y326_F1.0271.00
28_F32_R1.0271.00
192_I225_S1.0231.00
36_K41_L1.0221.00
303_L307_Q1.0191.00
242_G245_Y1.0191.00
243_L317_V1.0161.00
247_D323_D1.0071.00
159_A164_L1.0061.00
247_D251_V1.0051.00
317_V324_F1.0051.00
284_S326_F1.0051.00
280_Q310_Y1.0021.00
240_T280_Q0.9911.00
211_N293_F0.9881.00
279_N287_N0.9871.00
258_V290_V0.9851.00
278_F310_Y0.9831.00
252_G255_V0.9831.00
151_I155_A0.9771.00
79_D83_T0.9701.00
177_R180_S0.9671.00
257_A319_S0.9531.00
258_V262_L0.9501.00
247_D254_I0.9491.00
45_V53_I0.9461.00
93_K97_L0.9431.00
27_S30_F0.9411.00
281_F286_L0.9401.00
257_A322_A0.9351.00
246_E314_I0.9331.00
257_A317_V0.9321.00
36_K40_F0.9241.00
135_G140_M0.9231.00
134_Y138_F0.9191.00
242_G283_D0.9171.00
50_Y54_I0.9121.00
49_I53_I0.9121.00
62_N66_E0.9111.00
22_A26_M0.8991.00
43_H46_Q0.8961.00
156_V164_L0.8941.00
75_P79_D0.8911.00
277_Y307_Q0.8901.00
267_A305_A0.8891.00
31_R34_N0.8881.00
208_T212_R0.8831.00
237_I306_Q0.8831.00
31_R35_R0.8751.00
262_L268_I0.8711.00
267_A304_A0.8691.00
20_C24_I0.8661.00
236_R293_F0.8651.00
28_F31_R0.8641.00
19_S22_A0.8601.00
246_E323_D0.8561.00
241_I258_V0.8541.00
245_Y286_L0.8481.00
281_F310_Y0.8471.00
55_S59_S0.8461.00
282_A285_S0.8441.00
203_I215_Y0.8351.00
50_Y53_I0.8311.00
213_P231_R0.8251.00
192_I214_L0.8231.00
212_R227_E0.8211.00
102_E105_Q0.8191.00
51_T58_G0.8161.00
244_R325_A0.8151.00
23_L30_F0.8151.00
261_M309_V0.8141.00
210_D236_R0.8111.00
245_Y324_F0.8111.00
259_R274_L0.8101.00
146_L155_A0.8091.00
251_V288_I0.8081.00
32_R35_R0.8061.00
76_G80_F0.8041.00
284_S329_Q0.8041.00
45_V49_I0.8041.00
311_L315_D0.8021.00
239_T310_Y0.8011.00
254_I322_A0.8001.00
309_V313_I0.7981.00
61_I65_I0.7921.00
152_G156_V0.7921.00
29_W33_G0.7901.00
259_R276_V0.7881.00
285_S326_F0.7881.00
245_Y284_S0.7861.00
53_I57_V0.7841.00
22_A30_F0.7841.00
23_L28_F0.7841.00
53_I56_A0.7821.00
149_G152_G0.7801.00
257_A261_M0.7801.00
127_I131_V0.7781.00
252_G259_R0.7731.00
254_I257_A0.7721.00
268_I292_C0.7701.00
18_G36_K0.7691.00
237_I302_W0.7691.00
185_I206_I0.7671.00
251_V255_V0.7651.00
46_Q50_Y0.7601.00
16_I19_S0.7601.00
20_C30_F0.7561.00
238_T291_Y0.7561.00
261_M265_H0.7561.00
176_D203_I0.7541.00
43_H47_F0.7511.00
262_L276_V0.7511.00
259_R262_L0.7501.00
28_F34_N0.7451.00
195_T207_T0.7441.00
240_T279_N0.7441.00
22_A34_N0.7431.00
64_V68_Y0.7381.00
193_E229_P0.7381.00
323_D330_T0.7341.00
243_L322_A0.7331.00
50_Y58_G0.7321.00
185_I221_F0.7311.00
262_L309_V0.7301.00
165_S223_S0.7290.99
62_N65_I0.7250.99
188_P220_L0.7240.99
113_T174_Y0.7240.99
165_S219_S0.7230.99
124_I128_V0.7230.99
16_I30_F0.7230.99
207_T211_N0.7220.99
27_S32_R0.7210.99
123_K127_I0.7170.99
156_V168_F0.7170.99
243_L288_I0.7170.99
54_I58_G0.7160.99
326_F329_Q0.7120.99
77_V80_F0.7120.99
36_K42_F0.7120.99
61_I64_V0.7070.99
95_F99_N0.7060.99
23_L26_M0.7060.99
21_A24_I0.7050.99
152_G155_A0.7010.99
178_P205_K0.6990.99
286_L314_I0.6970.99
303_L306_Q0.6930.99
91_T126_I0.6920.99
74_T77_V0.6900.99
278_F288_I0.6900.99
207_T213_P0.6880.99
258_V276_V0.6830.99
116_R120_R0.6780.99
277_Y303_L0.6780.99
26_M31_R0.6760.99
187_S216_V0.6750.99
176_D205_K0.6710.99
22_A32_R0.6700.99
64_V67_N0.6680.99
275_L291_Y0.6640.99
57_V60_I0.6640.99
87_A91_T0.6620.99
284_S328_S0.6610.99
22_A25_L0.6600.99
160_G168_F0.6580.99
163_I222_S0.6580.99
45_V50_Y0.6570.99
143_S147_T0.6550.99
27_S35_R0.6530.99
53_I62_N0.6530.99
33_G40_F0.6510.99
251_V286_L0.6500.99
23_L36_K0.6500.99
148_F153_G0.6490.99
56_A60_I0.6470.99
86_I89_I0.6460.99
101_F105_Q0.6450.99
16_I20_C0.6440.99
47_F50_Y0.6430.99
19_S32_R0.6420.99
324_F328_S0.6410.99
72_F76_G0.6410.99
18_G23_L0.6400.99
116_R198_E0.6400.99
57_V61_I0.6380.99
30_F33_G0.6360.99
25_L28_F0.6350.99
251_V314_I0.6330.99
279_N306_Q0.6330.99
41_L45_V0.6320.99
15_I18_G0.6300.99
130_L134_Y0.6300.99
255_V288_I0.6260.98
281_F313_I0.6260.98
24_I27_S0.6250.98
26_M30_F0.6250.98
99_N119_S0.6250.98
251_V278_F0.6210.98
133_L136_E0.6190.98
187_S192_I0.6180.98
19_S26_M0.6170.98
45_V58_G0.6150.98
158_M163_I0.6130.98
86_I90_L0.6120.98
317_V320_H0.6100.98
256_E263_K0.6100.98
169_S222_S0.6090.98
16_I23_L0.6080.98
245_Y285_S0.6050.98
244_R330_T0.6050.98
51_T56_A0.6050.98
254_I320_H0.6030.98
19_S24_I0.6000.98
150_G161_K0.6000.98
26_M32_R0.6000.98
281_F314_I0.5990.98
15_I28_F0.5990.98
119_S123_K0.5980.98
120_R123_K0.5950.98
53_I65_I0.5920.98
234_N272_Q0.5910.98
323_D328_S0.5900.98
254_I261_M0.5870.98
47_F53_I0.5850.98
45_V60_I0.5820.98
164_L168_F0.5820.98
284_S327_P0.5810.98
290_V313_I0.5790.97
244_R328_S0.5790.97
278_F281_F0.5790.97
59_S62_N0.5780.97
245_Y283_D0.5770.97
26_M29_W0.5760.97
162_D219_S0.5760.97
219_S222_S0.5760.97
307_Q310_Y0.5750.97
30_F34_N0.5740.97
32_R36_K0.5730.97
242_G281_F0.5720.97
246_E318_Q0.5710.97
92_I96_L0.5700.97
51_T55_S0.5690.97
179_F221_F0.5680.97
18_G28_F0.5670.97
236_R291_Y0.5620.97
44_A48_L0.5610.97
72_F77_V0.5600.97
247_D286_L0.5600.97
158_M161_K0.5590.97
178_P226_V0.5590.97
23_L33_G0.5580.97
325_A328_S0.5580.97
42_F50_Y0.5560.97
25_L29_W0.5550.97
168_F222_S0.5530.97
22_A33_G0.5510.97
30_F36_K0.5510.97
40_F45_V0.5490.97
176_D215_Y0.5480.96
98_I126_I0.5480.96
262_L292_C0.5470.96
308_D311_L0.5460.96
258_V317_V0.5450.96
155_A160_G0.5450.96
275_L279_N0.5450.96
84_S88_V0.5450.96
237_I294_T0.5440.96
18_G30_F0.5430.96
111_D114_S0.5420.96
56_A59_S0.5400.96
162_D166_N0.5390.96
65_I68_Y0.5390.96
60_I67_N0.5360.96
129_V132_L0.5350.96
175_F178_P0.5340.96
17_F20_C0.5340.96
24_I31_R0.5340.96
95_F127_I0.5330.96
51_T64_V0.5290.96
89_I92_I0.5280.96
192_I227_E0.5280.96
111_D177_R0.5280.96
179_F185_I0.5270.96
60_I64_V0.5270.96
147_T150_G0.5260.96
51_T54_I0.5260.96
205_K215_Y0.5260.96
102_E106_I0.5250.96
195_T209_F0.5250.96
44_A47_F0.5240.95
255_V276_V0.5240.95
23_L31_R0.5210.95
17_F24_I0.5210.95
110_R114_S0.5200.95
200_G205_K0.5190.95
263_K274_L0.5180.95
305_A308_D0.5180.95
150_G154_L0.5170.95
152_G159_A0.5160.95
154_L162_D0.5150.95
263_K273_T0.5150.95
47_F58_G0.5140.95
18_G24_I0.5120.95
200_G203_I0.5120.95
130_L133_L0.5100.95
179_F226_V0.5080.95
100_Q105_Q0.5080.95
251_V254_I0.5080.95
49_I57_V0.5080.95
53_I60_I0.5070.95
209_F291_Y0.5050.95
43_H49_I0.5050.95
282_A326_F0.5040.94
141_S144_G0.5030.94
29_W35_R0.5030.94
179_F218_N0.5030.94
88_V134_Y0.5030.94
161_K219_S0.5010.94
23_L34_N0.5000.94
244_R324_F0.5000.94
150_G153_G0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5ajiA 3 0.7638 100 0.261 Contact Map
4hw9A 3 0.7376 100 0.264 Contact Map
3udcA 3 0.7376 100 0.296 Contact Map
1nz9A 1 0.1458 26.5 0.951 Contact Map
2e6zA 1 0.1545 22.2 0.953 Contact Map
2qn6B 1 0.2624 19.2 0.954 Contact Map
3cnrA 1 0.2478 17.2 0.955 Contact Map
2aalA 3 0.2915 15.3 0.956 Contact Map
4hfiA 3 0.344 12.9 0.958 Contact Map
3j9pD 4 0.7114 12.6 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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