GREMLIN Database
DACA - D-alanyl-D-alanine carboxypeptidase DacA
UniProt: P0AEB2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10201
Length: 403 (364)
Sequences: 4097 (3218)
Seq/√Len: 168.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_D192_R3.6961.00
62_E65_A3.6941.00
97_L125_Q2.9981.00
128_V147_M2.9401.00
152_A161_L2.9311.00
101_G149_D2.8601.00
360_T372_Q2.8051.00
83_I147_M2.6991.00
51_L288_G2.6751.00
64_N67_V2.6541.00
239_D263_R2.5861.00
102_N122_P2.5661.00
198_G241_I2.5371.00
357_V374_P2.4921.00
264_L288_G2.4451.00
133_R214_E2.4381.00
165_Y168_A2.4291.00
171_L197_I2.4261.00
135_I147_M2.3821.00
237_N259_E2.3771.00
96_D150_F2.3771.00
85_Q165_Y2.3741.00
81_Y200_A2.2991.00
68_R188_Y2.2711.00
239_D256_S2.1981.00
66_D173_N2.1891.00
127_P130_Q2.1531.00
134_G140_G2.1211.00
77_M254_V2.1171.00
352_L377_V2.1131.00
258_T261_Q2.0841.00
135_I144_C2.0621.00
78_M174_T2.0611.00
314_S379_Q2.0421.00
155_Q179_V2.0331.00
49_Y61_A2.0041.00
157_A160_G1.9491.00
296_N299_K1.9461.00
54_Y265_I1.9451.00
93_K96_D1.9381.00
266_S281_S1.9361.00
192_R196_L1.9301.00
99_T125_Q1.9261.00
320_G378_L1.8601.00
154_S157_A1.8521.00
160_G164_S1.8061.00
78_M166_V1.7981.00
364_Q369_T1.7961.00
348_L358_V1.7741.00
92_F128_V1.7701.00
68_R173_N1.7701.00
280_E283_K1.7611.00
102_N106_A1.7301.00
257_A289_F1.7291.00
97_L127_P1.7261.00
198_G254_V1.7201.00
207_N210_S1.6991.00
98_V150_F1.6891.00
357_V360_T1.6841.00
152_A157_A1.6841.00
100_I146_A1.6681.00
340_S364_Q1.6661.00
169_L200_A1.6601.00
48_S191_A1.6491.00
369_T372_Q1.6411.00
48_S69_R1.6281.00
356_Q377_V1.6141.00
74_L254_V1.6091.00
98_V146_A1.5921.00
103_D149_D1.5851.00
80_S135_I1.5811.00
80_S136_N1.5781.00
51_L264_L1.5731.00
74_L194_M1.5701.00
171_L196_L1.5691.00
306_S316_R1.5621.00
199_Q265_I1.5481.00
322_D374_P1.5481.00
95_T129_S1.5481.00
137_L214_E1.5411.00
174_T189_S1.5301.00
175_H188_Y1.5281.00
79_T144_C1.5211.00
164_S168_A1.5191.00
101_G104_A1.5181.00
53_D262_M1.5181.00
200_A203_R1.5181.00
358_V377_V1.5181.00
86_A91_K1.4741.00
92_F150_F1.4731.00
47_E270_G1.4711.00
362_N372_Q1.4681.00
246_T249_A1.4641.00
235_S286_T1.4431.00
342_V362_N1.4221.00
129_S133_R1.4071.00
216_E223_R1.4011.00
353_Q380_E1.3891.00
191_A269_M1.3891.00
183_D248_K1.3881.00
71_P189_S1.3841.00
353_Q356_Q1.3811.00
317_A377_V1.3761.00
362_N369_T1.3751.00
80_S132_I1.3681.00
129_S211_I1.3651.00
177_Q186_G1.3581.00
83_I128_V1.3521.00
134_G143_A1.3501.00
354_K380_E1.3401.00
50_I65_A1.3341.00
129_S210_S1.3321.00
75_T187_Q1.3301.00
177_Q184_A1.3201.00
50_I192_R1.3181.00
100_I120_L1.3081.00
200_A204_D1.3051.00
340_S362_N1.2921.00
70_D183_D1.2721.00
194_M254_V1.2631.00
341_Y375_L1.2611.00
107_T145_V1.2611.00
118_M134_G1.2601.00
218_T223_R1.2571.00
70_D248_K1.2561.00
296_N326_Y1.2561.00
238_V255_A1.2551.00
161_L164_S1.2531.00
256_S263_R1.2531.00
88_K207_N1.2491.00
74_L269_M1.2451.00
133_R217_F1.2371.00
133_R137_L1.2371.00
258_T263_R1.2361.00
51_L266_S1.2341.00
94_E132_I1.2321.00
94_E129_S1.2301.00
255_A281_S1.2251.00
81_Y165_Y1.2231.00
166_V171_L1.2211.00
342_V360_T1.2171.00
209_Y256_S1.2051.00
199_Q203_R1.1971.00
318_S378_L1.1971.00
92_F147_M1.1891.00
50_I59_V1.1811.00
81_Y204_D1.1751.00
215_K232_W1.1691.00
293_E331_R1.1671.00
48_S64_N1.1661.00
104_A149_D1.1621.00
83_I135_I1.1521.00
139_S242_K1.1491.00
377_V380_E1.1471.00
87_M208_E1.1361.00
82_V86_A1.1341.00
384_G388_G1.1331.00
157_A161_L1.1321.00
273_T276_G1.1291.00
77_M198_G1.1281.00
49_Y63_Q1.1201.00
65_A192_R1.1171.00
313_D382_P1.1151.00
77_M241_I1.1111.00
249_A252_N1.1081.00
165_Y200_A1.1051.00
271_G280_E1.1001.00
52_I195_A1.0961.00
238_V285_L1.0791.00
57_G199_Q1.0651.00
282_K286_T1.0570.99
296_N324_D1.0490.99
86_A161_L1.0450.99
338_K364_Q1.0430.99
268_V281_S1.0420.99
159_V179_V1.0390.99
322_D376_V1.0380.99
144_C179_V1.0360.99
385_N388_G1.0340.99
177_Q187_Q1.0270.99
103_D156_D1.0260.99
159_V163_N1.0240.99
299_K324_D1.0200.99
66_D190_S1.0190.99
83_I92_F1.0180.99
100_I126_V1.0160.99
299_K302_K1.0120.99
235_S238_V1.0080.99
257_A285_L1.0020.99
319_L358_V1.0010.99
47_E69_R0.9960.99
333_R336_D0.9900.99
209_Y263_R0.9850.99
82_V165_Y0.9840.99
307_E319_L0.9840.99
53_D294_T0.9800.99
294_T328_T0.9790.99
212_Y241_I0.9750.99
166_V197_I0.9750.99
330_P333_R0.9740.99
306_S318_S0.9640.99
68_R190_S0.9630.99
210_S213_K0.9620.99
298_L321_V0.9560.99
255_A285_L0.9550.99
71_P269_M0.9540.99
105_W122_P0.9530.99
86_A151_A0.9520.99
87_M92_F0.9510.99
95_T127_P0.9510.99
77_M201_L0.9500.99
46_A271_G0.9490.99
300_V324_D0.9480.99
151_A161_L0.9480.99
259_E289_F0.9430.99
121_K124_M0.9420.99
145_V155_Q0.9380.99
139_S243_T0.9350.99
103_D155_Q0.9330.99
318_S379_Q0.9250.99
384_G392_D0.9240.99
173_N190_S0.9080.98
82_V151_A0.9070.98
202_I209_Y0.9060.98
140_G143_A0.9050.98
55_N294_T0.9040.98
317_A381_I0.9020.98
55_N326_Y0.9010.98
195_A267_A0.8990.98
98_V128_V0.8960.98
272_R276_G0.8950.98
163_N175_H0.8940.98
339_A363_F0.8900.98
120_L146_A0.8860.98
317_A352_L0.8850.98
312_G350_A0.8840.98
84_G208_E0.8820.98
364_Q367_G0.8810.98
73_S242_K0.8800.98
126_V130_Q0.8790.98
136_N212_Y0.8780.98
45_D280_E0.8760.98
50_I62_E0.8740.98
47_E67_V0.8730.98
100_I131_L0.8710.98
287_W292_F0.8700.98
175_H186_G0.8690.98
383_E389_K0.8630.98
325_V371_E0.8620.98
43_Q63_Q0.8600.98
259_E286_T0.8580.98
294_T326_Y0.8580.98
235_S257_A0.8570.98
94_E211_I0.8510.98
172_K192_R0.8480.98
189_S194_M0.8430.97
83_I151_A0.8430.97
325_V373_R0.8420.97
164_S167_N0.8420.97
50_I267_A0.8400.97
53_D328_T0.8390.97
219_F224_Q0.8350.97
268_V271_G0.8310.97
183_D246_T0.8310.97
78_M162_M0.8300.97
241_I256_S0.8300.97
253_L281_S0.8280.97
25_S29_A0.8280.97
209_Y212_Y0.8270.97
258_T289_F0.8250.97
237_N286_T0.8250.97
361_I373_R0.8240.97
287_W291_F0.8190.97
124_M222_I0.8170.97
351_P381_I0.8160.97
72_A249_A0.8150.97
201_L241_I0.8110.97
196_L199_Q0.8090.97
233_D282_K0.8080.97
87_M94_E0.8070.97
156_D160_G0.8060.97
356_Q380_E0.8040.97
254_V267_A0.8030.97
312_G381_I0.8030.97
82_V85_Q0.8030.97
85_Q204_D0.8000.96
309_V312_G0.7980.96
130_Q133_R0.7960.96
126_V131_L0.7950.96
50_I195_A0.7850.96
77_M136_N0.7810.96
55_N263_R0.7810.96
208_E212_Y0.7790.96
194_M269_M0.7700.96
88_K204_D0.7700.96
92_F96_D0.7690.96
117_L120_L0.7680.96
131_L143_A0.7660.95
84_G132_I0.7660.95
245_H251_Y0.7600.95
217_F224_Q0.7570.95
235_S282_K0.7540.95
216_E225_L0.7530.95
390_I394_I0.7530.95
99_T150_F0.7500.95
228_N253_L0.7490.95
166_V176_F0.7440.95
224_Q227_R0.7430.95
85_Q89_A0.7420.95
90_G93_K0.7410.95
348_L352_L0.7410.95
167_N172_K0.7400.95
309_V350_A0.7400.95
132_I211_I0.7390.95
133_R211_I0.7350.94
73_S244_G0.7320.94
52_I199_Q0.7310.94
194_M198_G0.7290.94
228_N255_A0.7280.94
198_G240_G0.7270.94
48_S269_M0.7270.94
229_G278_E0.7260.94
303_E318_S0.7260.94
138_Q227_R0.7250.94
202_I239_D0.7230.94
295_V334_M0.7220.94
78_M82_V0.7210.94
352_L358_V0.7200.94
86_A92_F0.7190.94
162_M166_V0.7190.94
101_G146_A0.7150.94
365_L368_K0.7150.94
80_S84_G0.7150.94
98_V131_L0.7150.94
336_D366_D0.7150.94
92_F98_V0.7150.94
78_M176_F0.7140.93
266_S285_L0.7140.93
116_S140_G0.7120.93
321_V375_L0.7120.93
163_N176_F0.7080.93
202_I263_R0.7010.93
246_T252_N0.7000.93
80_S212_Y0.6990.93
321_V325_V0.6950.93
201_L208_E0.6940.92
255_A266_S0.6940.92
74_L252_N0.6930.92
24_I29_A0.6900.92
52_I265_I0.6900.92
176_F194_M0.6900.92
24_I27_A0.6900.92
60_L292_F0.6890.92
166_V169_L0.6890.92
82_V162_M0.6890.92
62_E192_R0.6890.92
94_E97_L0.6890.92
169_L197_I0.6880.92
276_G280_E0.6870.92
69_R269_M0.6860.92
77_M197_I0.6810.92
301_G321_V0.6810.92
115_S119_F0.6800.92
126_V219_F0.6800.92
355_N377_V0.6780.92
78_M171_L0.6770.92
337_L365_L0.6760.92
73_S76_K0.6740.91
266_S284_L0.6730.91
159_V174_T0.6680.91
173_N193_D0.6680.91
107_T182_L0.6660.91
58_K328_T0.6650.91
262_M294_T0.6650.91
73_S139_S0.6620.91
70_D184_A0.6550.90
138_Q224_Q0.6540.90
118_M126_V0.6540.90
237_N257_A0.6460.90
365_L370_I0.6450.90
337_L370_I0.6450.90
319_L375_L0.6450.90
283_K286_T0.6440.89
52_I196_L0.6440.89
86_A89_A0.6430.89
130_Q217_F0.6410.89
85_Q168_A0.6400.89
107_T117_L0.6380.89
161_L165_Y0.6360.89
62_E66_D0.6320.89
194_M252_N0.6310.88
136_N208_E0.6310.88
208_E241_I0.6250.88
295_V329_I0.6240.88
118_M138_Q0.6240.88
131_L147_M0.6230.88
23_F28_H0.6230.88
91_K161_L0.6220.88
103_D107_T0.6220.88
312_G351_P0.6210.88
218_T221_G0.6210.88
116_S243_T0.6190.88
386_F390_I0.6190.88
235_S285_L0.6180.87
342_V345_S0.6180.87
262_M292_F0.6170.87
31_D35_K0.6150.87
339_A361_I0.6150.87
115_S142_D0.6140.87
78_M197_I0.6100.87
114_G117_L0.6100.87
338_K367_G0.6100.87
174_T193_D0.6090.87
30_D33_N0.6090.87
84_G207_N0.6070.86
44_I49_Y0.6050.86
35_K38_I0.6030.86
297_P327_L0.6020.86
388_G391_I0.5990.86
303_E306_S0.5990.86
212_Y240_G0.5980.86
175_H187_Q0.5980.86
137_L217_F0.5970.86
313_D388_G0.5970.86
360_T374_P0.5950.85
172_K196_L0.5940.85
27_A30_D0.5940.85
58_K368_K0.5940.85
73_S243_T0.5920.85
271_G276_G0.5910.85
311_F393_Y0.5900.85
245_H274_F0.5880.85
227_R245_H0.5870.85
311_F349_H0.5860.85
76_K141_N0.5850.84
189_S193_D0.5830.84
238_V257_A0.5830.84
212_Y256_S0.5810.84
92_F151_A0.5790.84
28_H31_D0.5780.84
341_Y361_I0.5760.84
42_P287_W0.5750.83
75_T189_S0.5750.83
229_G233_D0.5720.83
148_A155_Q0.5700.83
171_L193_D0.5700.83
230_L253_L0.5700.83
137_L211_I0.5680.83
253_L268_V0.5670.83
46_A280_E0.5670.83
201_L212_Y0.5670.83
165_Y169_L0.5670.83
146_A150_F0.5670.83
53_D56_S0.5660.82
26_A32_L0.5640.82
385_N389_K0.5630.82
220_N224_Q0.5630.82
208_E211_I0.5620.82
295_V298_L0.5620.82
163_N167_N0.5610.82
58_K333_R0.5610.82
74_L77_M0.5610.82
183_D249_A0.5590.82
235_S289_F0.5570.81
268_V284_L0.5570.81
187_Q252_N0.5570.81
235_S259_E0.5560.81
350_A381_I0.5560.81
202_I241_I0.5550.81
298_L363_F0.5530.81
151_A159_V0.5510.81
22_A28_H0.5510.81
82_V174_T0.5500.81
228_N231_L0.5480.80
72_A75_T0.5480.80
82_V161_L0.5470.80
310_W347_E0.5470.80
239_D258_T0.5460.80
180_H183_D0.5450.80
72_A244_G0.5430.80
68_R189_S0.5420.80
285_L288_G0.5410.80
388_G392_D0.5390.79
72_A243_T0.5380.79
204_D207_N0.5380.79
33_N37_M0.5380.79
343_L359_G0.5370.79
107_T114_G0.5360.79
355_N376_V0.5360.79
85_Q88_K0.5340.79
298_L361_I0.5340.79
253_L278_E0.5330.79
116_S242_K0.5330.79
134_G219_F0.5320.78
60_L264_L0.5320.78
329_I337_L0.5310.78
253_L266_S0.5310.78
291_F330_P0.5290.78
84_G211_I0.5270.78
64_N69_R0.5270.78
81_Y169_L0.5270.78
149_D155_Q0.5260.78
84_G212_Y0.5260.78
51_L284_L0.5250.78
52_I57_G0.5240.77
68_R175_H0.5230.77
183_D186_G0.5210.77
209_Y239_D0.5210.77
129_S207_N0.5200.77
243_T277_R0.5200.77
25_S31_D0.5190.77
59_V65_A0.5190.77
251_Y277_R0.5170.76
301_G320_G0.5160.76
72_A139_S0.5160.76
115_S180_H0.5160.76
126_V134_G0.5160.76
32_L36_T0.5150.76
134_G224_Q0.5140.76
24_I30_D0.5130.76
25_S28_H0.5130.76
54_Y199_Q0.5120.76
369_T373_R0.5120.76
94_E207_N0.5100.76
171_L190_S0.5090.75
23_F26_A0.5080.75
209_Y213_K0.5080.75
71_P187_Q0.5080.75
77_M84_G0.5080.75
117_L142_D0.5070.75
206_P209_Y0.5060.75
357_V376_V0.5060.75
229_G274_F0.5050.75
297_P363_F0.5050.75
309_V317_A0.5050.75
102_N105_W0.5050.75
54_Y263_R0.5050.75
73_S116_S0.5040.75
59_V192_R0.5030.75
305_A341_Y0.5030.75
278_E281_S0.5020.74
45_D276_G0.5010.74
195_A198_G0.5010.74
284_L288_G0.5010.74
262_M328_T0.5000.74
162_M176_F0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mzfA 1 0.871 100 0.259 Contact Map
3itaA 1 0.8635 100 0.275 Contact Map
4k91A 1 0.8511 100 0.275 Contact Map
3a3jA 1 0.8462 100 0.29 Contact Map
1xp4A 3 0.8362 100 0.292 Contact Map
3mfdA 1 0.7916 100 0.305 Contact Map
3hunA 1 0.804 100 0.394 Contact Map
1tvfA 1 0.8337 100 0.416 Contact Map
4pprA 1 0.7097 100 0.502 Contact Map
4ryeA 1 0.6328 100 0.506 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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