GREMLIN Database
CYSW - Sulfate transport system permease protein CysW
UniProt: P0AEB0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10198
Length: 291 (243)
Sequences: 75706 (48840)
Seq/√Len: 3133.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
189_Q193_R3.8071.00
67_W71_M3.2211.00
181_I190_M3.1461.00
166_V170_L2.9181.00
186_S189_Q2.5571.00
64_H67_W2.5071.00
180_A190_M2.4971.00
93_R177_D2.4571.00
79_V154_I2.4441.00
65_A238_Q2.4251.00
75_I150_V2.4071.00
168_V202_A2.3661.00
177_D195_T2.3061.00
187_G190_M2.3021.00
233_L241_L2.2981.00
45_A53_V2.2911.00
54_L58_A2.2911.00
63_L67_W2.2821.00
51_M54_L2.2561.00
188_W192_R2.2461.00
77_V207_V2.1791.00
51_M55_Q2.0841.00
96_F99_R2.0651.00
165_L203_L2.0601.00
247_N250_G2.0511.00
185_A189_Q1.9761.00
189_Q192_R1.9381.00
92_T170_L1.8881.00
39_I43_V1.8771.00
267_F271_M1.8661.00
176_E198_N1.8491.00
169_M199_I1.8451.00
43_V47_S1.8431.00
71_M146_W1.8231.00
161_V206_G1.8231.00
85_I191_F1.8011.00
64_H68_L1.7951.00
177_D190_M1.7911.00
180_A185_A1.7821.00
85_I199_I1.7341.00
181_I187_G1.7001.00
103_L166_V1.6851.00
177_D181_I1.6741.00
238_Q242_L1.6621.00
73_A211_N1.6471.00
71_M75_I1.6451.00
85_I165_L1.6431.00
76_A214_A1.5901.00
87_L162_V1.5881.00
84_G161_V1.5821.00
81_L207_V1.5291.00
91_V162_V1.5211.00
55_Q250_G1.5181.00
174_S177_D1.4741.00
36_V40_Y1.4731.00
55_Q58_A1.4701.00
230_G233_L1.4301.00
82_V86_L1.4081.00
88_A165_L1.4001.00
98_G101_L1.3991.00
24_G28_L1.3991.00
40_Y44_Q1.3981.00
95_N99_R1.3781.00
161_V210_T1.3741.00
218_F222_S1.3741.00
49_G52_P1.3721.00
92_T166_V1.3361.00
146_W232_T1.3271.00
80_N210_T1.3061.00
174_S178_E1.3021.00
50_L54_L1.3001.00
169_M195_T1.2881.00
205_Y209_L1.2831.00
233_L238_Q1.2671.00
42_F256_A1.2571.00
196_L203_L1.2551.00
165_L206_G1.2541.00
144_F147_P1.2541.00
93_R174_S1.2391.00
180_A194_V1.2381.00
186_S190_M1.2351.00
175_Q178_E1.2201.00
220_A224_V1.2131.00
142_I145_S1.2131.00
68_L71_M1.2101.00
28_L32_F1.2101.00
149_M221_V1.1991.00
89_W169_M1.1821.00
234_S237_L1.1581.00
242_L247_N1.1551.00
101_L104_T1.1501.00
61_D64_H1.1431.00
242_L245_D1.1381.00
55_Q59_D1.1351.00
142_I147_P1.1311.00
92_T169_M1.1301.00
85_I203_L1.1301.00
17_W21_F1.1251.00
75_I78_P1.1241.00
152_V224_V1.1221.00
78_P82_V1.1121.00
172_Q198_N1.1071.00
229_R232_T1.1001.00
225_S232_T1.0931.00
40_Y43_V1.0911.00
19_K23_I1.0911.00
218_F240_E1.0791.00
200_R204_L1.0741.00
240_E244_Q1.0731.00
158_C162_V1.0721.00
18_G22_L1.0691.00
101_L105_L1.0661.00
177_D187_G1.0611.00
79_V150_V1.0581.00
69_T235_L1.0471.00
21_F25_I1.0461.00
72_I234_S1.0451.00
125_Y148_G1.0381.00
81_L203_L1.0361.00
123_L127_S1.0341.00
238_Q241_L1.0271.00
18_G21_F1.0231.00
41_I256_A1.0231.00
76_A153_T1.0191.00
21_F24_G1.0141.00
86_L90_L1.0111.00
75_I79_V1.0051.00
76_A80_N0.9961.00
53_V256_A0.9951.00
185_A190_M0.9841.00
150_V154_I0.9811.00
70_V74_L0.9761.00
89_W191_F0.9761.00
217_E220_A0.9741.00
198_N201_W0.9731.00
233_L237_L0.9621.00
165_L202_A0.9511.00
164_E206_G0.9491.00
145_S232_T0.9381.00
57_L63_L0.9361.00
99_R170_L0.9321.00
268_L271_M0.9311.00
66_I235_L0.9301.00
143_M147_P0.9291.00
238_Q254_A0.9271.00
268_L272_L0.9261.00
89_W187_G0.9241.00
20_W24_G0.9161.00
71_M74_L0.9101.00
88_A92_T0.9091.00
44_Q47_S0.9061.00
74_L78_P0.8991.00
143_M146_W0.8981.00
31_A35_L0.8971.00
190_M193_R0.8971.00
88_A169_M0.8931.00
153_T214_A0.8911.00
97_P100_Q0.8881.00
84_G162_V0.8851.00
146_W150_V0.8801.00
52_P55_Q0.8791.00
33_I37_P0.8761.00
78_P207_V0.8741.00
121_Y224_V0.8711.00
187_G191_F0.8671.00
72_I146_W0.8661.00
261_M264_I0.8641.00
185_A193_R0.8631.00
147_P151_L0.8631.00
221_V234_S0.8581.00
107_D163_R0.8581.00
79_V82_V0.8571.00
76_A150_V0.8501.00
66_I70_V0.8491.00
23_I27_M0.8471.00
44_Q252_F0.8461.00
217_E221_V0.8451.00
121_Y152_V0.8411.00
263_I267_F0.8391.00
161_V165_L0.8361.00
199_I202_A0.8351.00
165_L199_I0.8341.00
67_W70_V0.8321.00
243_E251_S0.8321.00
168_V199_I0.8321.00
87_L158_C0.8281.00
190_M195_T0.8241.00
264_I268_L0.8221.00
118_G219_G0.8191.00
210_T214_A0.8171.00
192_R196_L0.8171.00
50_L53_V0.8121.00
62_M254_A0.8111.00
152_V220_A0.8101.00
191_F196_L0.8101.00
52_P249_V0.8021.00
222_S237_L0.8021.00
91_V103_L0.8011.00
200_R203_L0.7931.00
100_Q103_L0.7911.00
80_N84_G0.7891.00
114_P156_V0.7831.00
267_F270_S0.7811.00
145_S148_G0.7801.00
71_M147_P0.7751.00
225_S229_R0.7751.00
191_F195_T0.7741.00
41_I252_F0.7711.00
75_I154_I0.7671.00
44_Q48_K0.7611.00
80_N161_V0.7581.00
202_A206_G0.7571.00
122_L126_G0.7561.00
22_L25_I0.7551.00
72_I153_T0.7511.00
147_P150_V0.7511.00
84_G165_L0.7481.00
144_F148_G0.7431.00
195_T198_N0.7421.00
242_L250_G0.7351.00
237_L241_L0.7331.00
174_S181_I0.7301.00
68_L146_W0.7281.00
88_A162_V0.7261.00
73_A77_V0.7241.00
250_G254_A0.7181.00
91_V166_V0.7171.00
56_N257_L0.7161.00
57_L60_P0.7141.00
242_L254_A0.7141.00
90_L96_F0.7121.00
36_V39_I0.7101.00
91_V102_L0.7041.00
126_G143_M0.7011.00
80_N157_T0.6901.00
110_F159_P0.6891.00
55_Q247_N0.6871.00
65_A68_L0.6861.00
77_V211_N0.6851.00
172_Q199_I0.6851.00
54_L57_L0.6841.00
266_L270_S0.6841.00
107_D110_F0.6811.00
176_E194_V0.6811.00
83_F154_I0.6801.00
81_L165_L0.6781.00
262_A266_L0.6761.00
72_I149_M0.6761.00
97_P101_L0.6741.00
46_F49_G0.6671.00
225_S233_L0.6601.00
179_A183_L0.6601.00
22_L26_G0.6571.00
63_L66_I0.6561.00
269_K272_L0.6541.00
80_N214_A0.6531.00
27_M31_A0.6521.00
156_V159_P0.6511.00
69_T215_I0.6491.00
264_I267_F0.6491.00
41_I255_A0.6491.00
165_L169_M0.6481.00
157_T210_T0.6461.00
117_A155_F0.6451.00
148_G152_V0.6421.00
149_M153_T0.6401.00
31_A34_L0.6381.00
43_V46_F0.6341.00
83_F158_C0.6331.00
203_L206_G0.6331.00
25_I28_L0.6321.00
30_S34_L0.6311.00
95_N100_Q0.6311.00
72_I150_V0.6291.00
118_G223_V0.6241.00
144_F229_R0.6211.00
217_E234_S0.6191.00
17_W20_W0.6121.00
236_P258_L0.6111.00
252_F255_A0.6091.00
248_T252_F0.6081.00
123_L126_G0.6081.00
203_L207_V0.6071.00
94_F187_G0.6021.00
121_Y124_F0.6021.00
100_Q104_T0.6021.00
248_T251_S0.6001.00
114_P219_G0.5991.00
58_A61_D0.5981.00
112_V117_A0.5951.00
69_T236_P0.5941.00
190_M194_V0.5921.00
77_V81_L0.5911.00
80_N154_I0.5911.00
73_A215_I0.5911.00
239_I254_A0.5851.00
20_W23_I0.5831.00
164_E202_A0.5831.00
77_V214_A0.5791.00
179_A182_L0.5781.00
60_P63_L0.5741.00
219_G222_S0.5731.00
89_W195_T0.5701.00
56_N250_G0.5691.00
65_A235_L0.5691.00
82_V85_I0.5691.00
103_L163_R0.5671.00
213_R216_G0.5671.00
192_R195_T0.5661.00
35_L39_I0.5651.00
270_S273_Q0.5641.00
157_T213_R0.5641.00
88_A166_V0.5641.00
76_A154_I0.5631.00
98_G102_L0.5621.00
207_V210_T0.5611.00
87_L106_L0.5561.00
110_F160_F0.5561.00
59_D63_L0.5551.00
72_I76_A0.5551.00
149_M225_S0.5541.00
204_L207_V0.5531.00
90_L94_F0.5521.00
112_V116_V0.5491.00
148_G224_V0.5471.00
64_H71_M0.5471.00
99_R103_L0.5471.00
212_A216_G0.5461.00
241_L244_Q0.5411.00
261_M265_T0.5411.00
32_F36_V0.5361.00
153_T217_E0.5351.00
178_E181_I0.5351.00
96_F100_Q0.5341.00
115_V223_V0.5341.00
60_P64_H0.5331.00
26_G30_S0.5311.00
19_K22_L0.5311.00
186_S192_R0.5271.00
96_F102_L0.5251.00
24_G27_M0.5241.00
95_N174_S0.5211.00
258_L262_A0.5211.00
122_L143_M0.5201.00
105_L109_P0.5201.00
153_T221_V0.5161.00
29_V33_I0.5141.00
269_K273_Q0.5141.00
255_A258_L0.5141.00
250_G253_T0.5121.00
252_F256_A0.5111.00
206_G210_T0.5101.00
117_A121_Y0.5101.00
87_L90_L0.5101.00
73_A214_A0.5081.00
103_L170_L0.5071.00
219_G223_V0.5071.00
77_V82_V0.5061.00
89_W93_R0.5051.00
240_E243_E0.5031.00
68_L232_T0.5021.00
237_L240_E0.5021.00
104_T108_I0.5001.00
210_T213_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2onkC 2 0.8625 100 0.295 Contact Map
3d31C 2 0.8522 100 0.301 Contact Map
4tquM 1 0.9244 100 0.359 Contact Map
4tquN 1 0.8591 100 0.391 Contact Map
3rlfG 1 0.8832 100 0.4 Contact Map
3rlfF 1 0.9141 100 0.401 Contact Map
4ymuD 2 0.7354 100 0.499 Contact Map
3tuiA 2 0.7148 99.9 0.535 Contact Map
4pypA 1 0.6976 38.1 0.935 Contact Map
2mfrA 1 0.189 37.3 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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