CYSW - ECOLI - GREMLIN Contacts

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CYSW - Sulfate transport system permease protein CysW

UniProt:	P0AEB0	Sequences: MAEVTQLKRYDARPINWGKWFLIGIGMLVSAFILLVPMIYIFVQAFSKGLMPVLQNLADPDMLHAIWLTVMIALIAVPVNLVFGILLAWLVTRFNFPGRQLLLTLLDIPFAVSPVVAGLVYLLFYGSNGPLGGWLDEHNLQIMFSWPGMVLVTIFVTCPFVVRELVPVMLSQGSQEDEAAILLGASGWQMFRRVTLPNIRWALLYGVVLTNARAIGEFGAVSVVSGSIRGETLSLPLQIELLEQDYNTVGSFTAAALLTLMAIITLFLKSMLQWRLENQEKRAQQEEHHEH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10198
Length:	291 (243)
Sequences:	75706 (48840)
Seq/√Len:	3133.1

ECOLI - CYSW CYST POTH PSTC THIP YCJO POTI UGPA YDCU PSTA POTB YNJC POTC MALG YCJP MODB MALF YDCV UGPE TAUC SSUC YEHY PROW YEHW PHNE METI YECS
BACSU - AMYD YESP GANP ARAP YTEP YQGH MDXF LPLB YURN YESQ YQGI YURM GANQ YVGM MDXG SSUC AMYC YTLD LPLC OPUAB ARAQ YTCP OPUBD OPUCD OPUCB METP TCYL OPUBB TCYB YXEN ARTQ
HALSA - Q9HP01 Q9HR05 Q9HMT4 Q9HML6 Q9HPK3 Q9HHQ7 Q9HS11 Q9HP02 Q9HHQ6 Q9HNI9 Q9HS12
SULSO - Q97YY2 Q97YY3 Q97UZ0 Q97VC0 Q97UF3 Q97Z98 Q97ZC2 Q97UF4 Q97UY9 Q97ZC1 Q97ZT7 Q97ZT6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
189_Q	193_R	3.807	1.00
67_W	71_M	3.221	1.00
181_I	190_M	3.146	1.00
166_V	170_L	2.918	1.00
186_S	189_Q	2.557	1.00
64_H	67_W	2.507	1.00
180_A	190_M	2.497	1.00
93_R	177_D	2.457	1.00
79_V	154_I	2.444	1.00
65_A	238_Q	2.425	1.00
75_I	150_V	2.407	1.00
168_V	202_A	2.366	1.00
177_D	195_T	2.306	1.00
187_G	190_M	2.302	1.00
233_L	241_L	2.298	1.00
45_A	53_V	2.291	1.00
54_L	58_A	2.291	1.00
63_L	67_W	2.282	1.00
51_M	54_L	2.256	1.00
188_W	192_R	2.246	1.00
77_V	207_V	2.179	1.00
51_M	55_Q	2.084	1.00
96_F	99_R	2.065	1.00
165_L	203_L	2.060	1.00
247_N	250_G	2.051	1.00
185_A	189_Q	1.976	1.00
189_Q	192_R	1.938	1.00
92_T	170_L	1.888	1.00
39_I	43_V	1.877	1.00
267_F	271_M	1.866	1.00
176_E	198_N	1.849	1.00
169_M	199_I	1.845	1.00
43_V	47_S	1.843	1.00
71_M	146_W	1.823	1.00
161_V	206_G	1.823	1.00
85_I	191_F	1.801	1.00
64_H	68_L	1.795	1.00
177_D	190_M	1.791	1.00
180_A	185_A	1.782	1.00
85_I	199_I	1.734	1.00
181_I	187_G	1.700	1.00
103_L	166_V	1.685	1.00
177_D	181_I	1.674	1.00
238_Q	242_L	1.662	1.00
73_A	211_N	1.647	1.00
71_M	75_I	1.645	1.00
85_I	165_L	1.643	1.00
76_A	214_A	1.590	1.00
87_L	162_V	1.588	1.00
84_G	161_V	1.582	1.00
81_L	207_V	1.529	1.00
91_V	162_V	1.521	1.00
55_Q	250_G	1.518	1.00
174_S	177_D	1.474	1.00
36_V	40_Y	1.473	1.00
55_Q	58_A	1.470	1.00
230_G	233_L	1.430	1.00
82_V	86_L	1.408	1.00
88_A	165_L	1.400	1.00
98_G	101_L	1.399	1.00
24_G	28_L	1.399	1.00
40_Y	44_Q	1.398	1.00
95_N	99_R	1.378	1.00
161_V	210_T	1.374	1.00
218_F	222_S	1.374	1.00
49_G	52_P	1.372	1.00
92_T	166_V	1.336	1.00
146_W	232_T	1.327	1.00
80_N	210_T	1.306	1.00
174_S	178_E	1.302	1.00
50_L	54_L	1.300	1.00
169_M	195_T	1.288	1.00
205_Y	209_L	1.283	1.00
233_L	238_Q	1.267	1.00
42_F	256_A	1.257	1.00
196_L	203_L	1.255	1.00
165_L	206_G	1.254	1.00
144_F	147_P	1.254	1.00
93_R	174_S	1.239	1.00
180_A	194_V	1.238	1.00
186_S	190_M	1.235	1.00
175_Q	178_E	1.220	1.00
220_A	224_V	1.213	1.00
142_I	145_S	1.213	1.00
68_L	71_M	1.210	1.00
28_L	32_F	1.210	1.00
149_M	221_V	1.199	1.00
89_W	169_M	1.182	1.00
234_S	237_L	1.158	1.00
242_L	247_N	1.155	1.00
101_L	104_T	1.150	1.00
61_D	64_H	1.143	1.00
242_L	245_D	1.138	1.00
55_Q	59_D	1.135	1.00
142_I	147_P	1.131	1.00
92_T	169_M	1.130	1.00
85_I	203_L	1.130	1.00
17_W	21_F	1.125	1.00
75_I	78_P	1.124	1.00
152_V	224_V	1.122	1.00
78_P	82_V	1.112	1.00
172_Q	198_N	1.107	1.00
229_R	232_T	1.100	1.00
225_S	232_T	1.093	1.00
40_Y	43_V	1.091	1.00
19_K	23_I	1.091	1.00
218_F	240_E	1.079	1.00
200_R	204_L	1.074	1.00
240_E	244_Q	1.073	1.00
158_C	162_V	1.072	1.00
18_G	22_L	1.069	1.00
101_L	105_L	1.066	1.00
177_D	187_G	1.061	1.00
79_V	150_V	1.058	1.00
69_T	235_L	1.047	1.00
21_F	25_I	1.046	1.00
72_I	234_S	1.045	1.00
125_Y	148_G	1.038	1.00
81_L	203_L	1.036	1.00
123_L	127_S	1.034	1.00
238_Q	241_L	1.027	1.00
18_G	21_F	1.023	1.00
41_I	256_A	1.023	1.00
76_A	153_T	1.019	1.00
21_F	24_G	1.014	1.00
86_L	90_L	1.011	1.00
75_I	79_V	1.005	1.00
76_A	80_N	0.996	1.00
53_V	256_A	0.995	1.00
185_A	190_M	0.984	1.00
150_V	154_I	0.981	1.00
70_V	74_L	0.976	1.00
89_W	191_F	0.976	1.00
217_E	220_A	0.974	1.00
198_N	201_W	0.973	1.00
233_L	237_L	0.962	1.00
165_L	202_A	0.951	1.00
164_E	206_G	0.949	1.00
145_S	232_T	0.938	1.00
57_L	63_L	0.936	1.00
99_R	170_L	0.932	1.00
268_L	271_M	0.931	1.00
66_I	235_L	0.930	1.00
143_M	147_P	0.929	1.00
238_Q	254_A	0.927	1.00
268_L	272_L	0.926	1.00
89_W	187_G	0.924	1.00
20_W	24_G	0.916	1.00
71_M	74_L	0.910	1.00
88_A	92_T	0.909	1.00
44_Q	47_S	0.906	1.00
74_L	78_P	0.899	1.00
143_M	146_W	0.898	1.00
31_A	35_L	0.897	1.00
190_M	193_R	0.897	1.00
88_A	169_M	0.893	1.00
153_T	214_A	0.891	1.00
97_P	100_Q	0.888	1.00
84_G	162_V	0.885	1.00
146_W	150_V	0.880	1.00
52_P	55_Q	0.879	1.00
33_I	37_P	0.876	1.00
78_P	207_V	0.874	1.00
121_Y	224_V	0.871	1.00
187_G	191_F	0.867	1.00
72_I	146_W	0.866	1.00
261_M	264_I	0.864	1.00
185_A	193_R	0.863	1.00
147_P	151_L	0.863	1.00
221_V	234_S	0.858	1.00
107_D	163_R	0.858	1.00
79_V	82_V	0.857	1.00
76_A	150_V	0.850	1.00
66_I	70_V	0.849	1.00
23_I	27_M	0.847	1.00
44_Q	252_F	0.846	1.00
217_E	221_V	0.845	1.00
121_Y	152_V	0.841	1.00
263_I	267_F	0.839	1.00
161_V	165_L	0.836	1.00
199_I	202_A	0.835	1.00
165_L	199_I	0.834	1.00
67_W	70_V	0.832	1.00
243_E	251_S	0.832	1.00
168_V	199_I	0.832	1.00
87_L	158_C	0.828	1.00
190_M	195_T	0.824	1.00
264_I	268_L	0.822	1.00
118_G	219_G	0.819	1.00
210_T	214_A	0.817	1.00
192_R	196_L	0.817	1.00
50_L	53_V	0.812	1.00
62_M	254_A	0.811	1.00
152_V	220_A	0.810	1.00
191_F	196_L	0.810	1.00
52_P	249_V	0.802	1.00
222_S	237_L	0.802	1.00
91_V	103_L	0.801	1.00
200_R	203_L	0.793	1.00
100_Q	103_L	0.791	1.00
80_N	84_G	0.789	1.00
114_P	156_V	0.783	1.00
267_F	270_S	0.781	1.00
145_S	148_G	0.780	1.00
71_M	147_P	0.775	1.00
225_S	229_R	0.775	1.00
191_F	195_T	0.774	1.00
41_I	252_F	0.771	1.00
75_I	154_I	0.767	1.00
44_Q	48_K	0.761	1.00
80_N	161_V	0.758	1.00
202_A	206_G	0.757	1.00
122_L	126_G	0.756	1.00
22_L	25_I	0.755	1.00
72_I	153_T	0.751	1.00
147_P	150_V	0.751	1.00
84_G	165_L	0.748	1.00
144_F	148_G	0.743	1.00
195_T	198_N	0.742	1.00
242_L	250_G	0.735	1.00
237_L	241_L	0.733	1.00
174_S	181_I	0.730	1.00
68_L	146_W	0.728	1.00
88_A	162_V	0.726	1.00
73_A	77_V	0.724	1.00
250_G	254_A	0.718	1.00
91_V	166_V	0.717	1.00
56_N	257_L	0.716	1.00
57_L	60_P	0.714	1.00
242_L	254_A	0.714	1.00
90_L	96_F	0.712	1.00
36_V	39_I	0.710	1.00
91_V	102_L	0.704	1.00
126_G	143_M	0.701	1.00
80_N	157_T	0.690	1.00
110_F	159_P	0.689	1.00
55_Q	247_N	0.687	1.00
65_A	68_L	0.686	1.00
77_V	211_N	0.685	1.00
172_Q	199_I	0.685	1.00
54_L	57_L	0.684	1.00
266_L	270_S	0.684	1.00
107_D	110_F	0.681	1.00
176_E	194_V	0.681	1.00
83_F	154_I	0.680	1.00
81_L	165_L	0.678	1.00
262_A	266_L	0.676	1.00
72_I	149_M	0.676	1.00
97_P	101_L	0.674	1.00
46_F	49_G	0.667	1.00
225_S	233_L	0.660	1.00
179_A	183_L	0.660	1.00
22_L	26_G	0.657	1.00
63_L	66_I	0.656	1.00
269_K	272_L	0.654	1.00
80_N	214_A	0.653	1.00
27_M	31_A	0.652	1.00
156_V	159_P	0.651	1.00
69_T	215_I	0.649	1.00
264_I	267_F	0.649	1.00
41_I	255_A	0.649	1.00
165_L	169_M	0.648	1.00
157_T	210_T	0.646	1.00
117_A	155_F	0.645	1.00
148_G	152_V	0.642	1.00
149_M	153_T	0.640	1.00
31_A	34_L	0.638	1.00
43_V	46_F	0.634	1.00
83_F	158_C	0.633	1.00
203_L	206_G	0.633	1.00
25_I	28_L	0.632	1.00
30_S	34_L	0.631	1.00
95_N	100_Q	0.631	1.00
72_I	150_V	0.629	1.00
118_G	223_V	0.624	1.00
144_F	229_R	0.621	1.00
217_E	234_S	0.619	1.00
17_W	20_W	0.612	1.00
236_P	258_L	0.611	1.00
252_F	255_A	0.609	1.00
248_T	252_F	0.608	1.00
123_L	126_G	0.608	1.00
203_L	207_V	0.607	1.00
94_F	187_G	0.602	1.00
121_Y	124_F	0.602	1.00
100_Q	104_T	0.602	1.00
248_T	251_S	0.600	1.00
114_P	219_G	0.599	1.00
58_A	61_D	0.598	1.00
112_V	117_A	0.595	1.00
69_T	236_P	0.594	1.00
190_M	194_V	0.592	1.00
77_V	81_L	0.591	1.00
80_N	154_I	0.591	1.00
73_A	215_I	0.591	1.00
239_I	254_A	0.585	1.00
20_W	23_I	0.583	1.00
164_E	202_A	0.583	1.00
77_V	214_A	0.579	1.00
179_A	182_L	0.578	1.00
60_P	63_L	0.574	1.00
219_G	222_S	0.573	1.00
89_W	195_T	0.570	1.00
56_N	250_G	0.569	1.00
65_A	235_L	0.569	1.00
82_V	85_I	0.569	1.00
103_L	163_R	0.567	1.00
213_R	216_G	0.567	1.00
192_R	195_T	0.566	1.00
35_L	39_I	0.565	1.00
270_S	273_Q	0.564	1.00
157_T	213_R	0.564	1.00
88_A	166_V	0.564	1.00
76_A	154_I	0.563	1.00
98_G	102_L	0.562	1.00
207_V	210_T	0.561	1.00
87_L	106_L	0.556	1.00
110_F	160_F	0.556	1.00
59_D	63_L	0.555	1.00
72_I	76_A	0.555	1.00
149_M	225_S	0.554	1.00
204_L	207_V	0.553	1.00
90_L	94_F	0.552	1.00
112_V	116_V	0.549	1.00
148_G	224_V	0.547	1.00
64_H	71_M	0.547	1.00
99_R	103_L	0.547	1.00
212_A	216_G	0.546	1.00
241_L	244_Q	0.541	1.00
261_M	265_T	0.541	1.00
32_F	36_V	0.536	1.00
153_T	217_E	0.535	1.00
178_E	181_I	0.535	1.00
96_F	100_Q	0.534	1.00
115_V	223_V	0.534	1.00
60_P	64_H	0.533	1.00
26_G	30_S	0.531	1.00
19_K	22_L	0.531	1.00
186_S	192_R	0.527	1.00
96_F	102_L	0.525	1.00
24_G	27_M	0.524	1.00
95_N	174_S	0.521	1.00
258_L	262_A	0.521	1.00
122_L	143_M	0.520	1.00
105_L	109_P	0.520	1.00
153_T	221_V	0.516	1.00
29_V	33_I	0.514	1.00
269_K	273_Q	0.514	1.00
255_A	258_L	0.514	1.00
250_G	253_T	0.512	1.00
252_F	256_A	0.511	1.00
206_G	210_T	0.510	1.00
117_A	121_Y	0.510	1.00
87_L	90_L	0.510	1.00
73_A	214_A	0.508	1.00
103_L	170_L	0.507	1.00
219_G	223_V	0.507	1.00
77_V	82_V	0.506	1.00
89_W	93_R	0.505	1.00
240_E	243_E	0.503	1.00
68_L	232_T	0.502	1.00
237_L	240_E	0.502	1.00
104_T	108_I	0.500	1.00
210_T	213_R	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2onkC	2	0.8625	100	0.295	Contact Map
3d31C	2	0.8522	100	0.301	Contact Map
4tquM	1	0.9244	100	0.359	Contact Map
4tquN	1	0.8591	100	0.391	Contact Map
3rlfG	1	0.8832	100	0.4	Contact Map
3rlfF	1	0.9141	100	0.401	Contact Map
4ymuD	2	0.7354	100	0.499	Contact Map
3tuiA	2	0.7148	99.9	0.535	Contact Map
4pypA	1	0.6976	38.1	0.935	Contact Map
2mfrA	1	0.189	37.3	0.935	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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