GREMLIN Database
CYSG - Siroheme synthase
UniProt: P0AEA8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10188
Length: 457 (447)
Sequences: 965 (657)
Seq/√Len: 31.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_G69_L6.4211.00
336_C411_G5.0861.00
17_I28_A4.9471.00
71_D96_R4.3341.00
65_F92_A3.8631.00
45_F60_L3.8491.00
218_V317_L3.7211.00
195_N200_I3.7031.00
16_L73_C3.7011.00
409_E417_R3.4681.00
33_D257_N3.4401.00
221_V297_V3.4251.00
147_L151_L3.3961.00
410_N415_T3.0601.00
194_N200_I3.0531.00
17_I38_L2.9721.00
219_V238_Q2.8941.00
28_A49_F2.8011.00
246_V289_E2.7561.00
288_R292_K2.7011.00
138_L184_V2.6641.00
194_N199_A2.6511.00
4_L113_M2.6381.00
245_V259_V2.5981.00
284_Q288_R2.5501.00
287_L316_T2.5331.00
13_R74_W2.5291.00
289_E292_K2.4740.99
249_R271_R2.4460.99
399_M403_M2.4050.99
405_V426_L2.4040.99
407_I437_S2.3900.99
393_K396_E2.3670.99
192_L199_A2.3460.99
410_N413_A2.3390.99
335_G412_T2.3030.99
196_D200_I2.2730.99
105_A108_A2.2720.99
421_G429_L2.2510.99
305_F310_G2.2480.99
124_V147_L2.2170.99
408_V440_I2.2150.99
191_S194_N2.2100.99
14_D39_T2.2080.99
8_C99_F2.1920.99
25_E46_I2.1720.98
380_F441_I2.1530.98
316_T320_A2.1030.98
339_Y416_Q2.0590.98
117_I126_V2.0460.98
131_T159_G2.0170.98
196_D199_A1.9950.97
239_I259_V1.9450.97
229_G233_L1.8880.96
191_S195_N1.8760.96
188_L194_N1.8650.96
65_F89_V1.8530.96
152_G155_A1.8490.96
217_E325_S1.8470.96
195_N199_A1.8320.96
103_V262_D1.8120.95
80_T86_N1.7810.95
77_I113_M1.7780.95
227_D234_K1.7580.94
122_L139_L1.7490.94
367_D370_N1.7180.94
239_I297_V1.7160.94
39_T73_C1.7110.94
358_G390_I1.7030.93
306_I334_S1.6970.93
217_E323_P1.6800.93
53_A60_L1.6750.93
253_D257_N1.6670.93
128_S136_A1.6590.92
163_G167_Q1.6570.92
37_R59_T1.6400.92
291_Q320_A1.6350.92
391_Q395_I1.6310.92
3_H9_Q1.6080.91
50_T62_E1.5980.91
405_V427_G1.5930.91
349_Y446_G1.5930.91
217_E295_R1.5820.91
122_L128_S1.5810.91
41_N69_L1.5800.90
28_A58_L1.5770.90
90_S94_E1.5710.90
3_H112_I1.5710.90
189_A194_N1.5590.90
88_R92_A1.5460.89
46_I49_F1.5440.89
287_L320_A1.5320.89
376_Q411_G1.5270.89
53_A58_L1.5250.89
264_D294_K1.5240.89
266_V289_E1.5220.89
30_L116_I1.5140.88
158_A183_F1.5010.88
391_Q427_G1.4970.88
426_L429_L1.4930.88
421_G425_Q1.4850.87
25_E48_Q1.4800.87
387_A426_L1.4800.87
191_S200_I1.4760.87
428_E432_Q1.4680.87
17_I31_L1.4660.87
229_G234_K1.4580.86
74_W97_R1.4470.86
6_I111_F1.4390.86
392_Q396_E1.4360.86
104_D109_A1.4340.86
188_L195_N1.4270.85
18_V89_V1.4240.85
289_E294_K1.4230.85
52_W57_M1.3960.84
221_V239_I1.3870.84
126_V139_L1.3850.83
195_N198_K1.3770.83
190_Q200_I1.3700.83
28_A38_L1.3660.83
10_L15_C1.3660.83
120_S123_M1.3570.82
409_E434_N1.3530.82
337_S440_I1.3460.82
132_S258_L1.3440.82
94_E110_S1.3280.81
70_L96_R1.3260.81
378_L394_L1.3240.81
272_A385_N1.3240.81
197_Q200_I1.3230.81
92_A96_R1.2980.79
349_Y443_R1.2930.79
192_L195_N1.2880.79
189_A192_L1.2870.79
30_L261_R1.2750.78
66_D69_L1.2700.78
176_R260_R1.2690.78
379_V440_I1.2600.77
43_L64_P1.2490.77
85_L88_R1.2460.76
204_T207_L1.2430.76
132_S158_A1.2390.76
143_L147_L1.2360.76
15_C113_M1.2260.75
332_A381_Y1.2230.75
348_D361_K1.2200.75
190_Q195_N1.2180.75
188_L200_I1.2160.75
249_R267_F1.2160.75
160_Q200_I1.2150.74
150_H153_Q1.2140.74
244_V266_V1.2110.74
81_D86_N1.2090.74
70_L98_I1.2060.74
67_E88_R1.2010.74
189_A200_I1.1990.73
252_S255_I1.1930.73
188_L191_S1.1930.73
189_A195_N1.1880.73
409_E433_M1.1860.73
234_K325_S1.1770.72
4_L103_V1.1740.72
219_V297_V1.1710.72
114_P125_A1.1700.72
244_V289_E1.1680.71
122_L155_A1.1670.71
116_I261_R1.1630.71
306_I353_V1.1600.71
192_L200_I1.1550.71
87_Q91_E1.1530.70
395_I402_E1.1510.70
331_T334_S1.1480.70
389_T392_Q1.1480.70
51_A55_A1.1400.70
251_V255_I1.1390.70
290_A322_I1.1340.69
45_F62_E1.1250.69
160_Q201_T1.1180.68
384_L437_S1.1170.68
301_G310_G1.1110.68
191_S199_A1.1100.68
354_R370_N1.1080.67
247_Y268_V1.1080.67
188_L192_L1.1060.67
132_S183_F1.1020.67
90_S102_V1.1010.67
23_V86_N1.0970.67
124_V355_L1.0900.66
54_D61_V1.0900.66
63_G66_D1.0800.65
4_L159_G1.0800.65
76_A98_I1.0790.65
314_L326_V1.0770.65
402_E424_T1.0650.64
48_Q52_W1.0600.64
85_L89_V1.0560.64
401_G424_T1.0530.63
119_R144_E1.0480.63
29_R265_R1.0470.63
20_G49_F1.0440.63
246_V286_L1.0440.63
79_A86_N1.0350.62
179_W358_G1.0350.62
210_E319_N1.0320.62
28_A63_G1.0300.62
18_V76_A1.0240.61
90_S109_A1.0210.61
39_T59_T1.0170.61
121_P331_T1.0080.60
32_L57_M1.0080.60
386_Q437_S1.0060.60
50_T54_D1.0060.60
38_L58_L1.0010.59
354_R380_F0.9980.59
428_E431_Q0.9920.59
128_S131_T0.9900.59
23_V80_T0.9800.58
219_V295_R0.9760.57
200_I203_T0.9760.57
384_L433_M0.9740.57
90_S110_S0.9680.57
197_Q201_T0.9640.56
388_A392_Q0.9630.56
353_V380_F0.9620.56
354_R376_Q0.9610.56
228_A235_G0.9610.56
7_F125_A0.9560.56
78_A89_V0.9550.56
20_G45_F0.9470.55
2_D11_R0.9400.55
196_D206_Q0.9390.54
324_F339_Y0.9340.54
342_I406_A0.9260.53
69_L92_A0.9190.53
215_R291_Q0.9150.53
138_L142_K0.9100.52
354_R378_L0.9080.52
17_I24_A0.9070.52
231_L235_G0.9070.52
102_V185_N0.9060.52
25_E52_W0.9030.52
112_I245_V0.9020.51
249_R336_C0.9000.51
443_R446_G0.8970.51
121_P152_G0.8910.51
3_H439_I0.8910.51
87_Q427_G0.8900.51
99_F111_F0.8900.51
43_L85_L0.8890.50
135_L358_G0.8880.50
192_L196_D0.8850.50
403_M443_R0.8850.50
387_A405_V0.8810.50
116_I123_M0.8760.49
235_G330_I0.8740.49
34_A38_L0.8740.49
16_L41_N0.8720.49
399_M443_R0.8720.49
425_Q429_L0.8710.49
271_R274_Y0.8670.49
238_Q325_S0.8670.49
409_E435_S0.8670.49
165_V365_E0.8660.49
188_L196_D0.8640.48
176_R261_R0.8630.48
78_A86_N0.8610.48
79_A103_V0.8590.48
360_L379_V0.8570.48
8_C125_A0.8570.48
187_R191_S0.8540.48
9_Q18_V0.8520.47
229_G297_V0.8500.47
14_D37_R0.8490.47
91_E95_A0.8480.47
25_E29_R0.8480.47
387_A407_I0.8370.46
360_L364_G0.8370.46
109_A246_V0.8360.46
66_D91_E0.8330.46
72_T97_R0.8320.46
151_L233_L0.8320.46
408_V411_G0.8290.46
221_V231_L0.8270.45
17_I234_K0.8250.45
43_L63_G0.8250.45
277_V348_D0.8220.45
40_V352_S0.8210.45
169_F174_E0.8170.45
134_V144_E0.8140.44
276_C297_V0.8080.44
395_I401_G0.8070.44
23_V26_R0.8070.44
86_N105_A0.8050.44
255_I389_T0.8040.44
154_V336_C0.8040.44
32_L58_L0.8040.44
37_R210_E0.8040.44
28_A35_G0.8030.44
335_G348_D0.8030.44
351_Q361_K0.8030.44
7_F367_D0.8020.43
379_V413_A0.8000.43
156_K160_Q0.8000.43
286_L317_L0.7980.43
103_V261_R0.7970.43
340_S440_I0.7950.43
348_D351_Q0.7870.42
359_H368_W0.7850.42
33_D139_L0.7820.42
223_A255_I0.7800.42
182_L187_R0.7790.42
125_A152_G0.7780.42
343_P445_V0.7760.41
21_G80_T0.7740.41
91_E427_G0.7720.41
273_G276_C0.7720.41
2_D120_S0.7720.41
311_G346_H0.7710.41
65_F70_L0.7700.41
2_D9_Q0.7650.41
118_D123_M0.7630.40
287_L291_Q0.7600.40
12_D131_T0.7600.40
15_C36_A0.7580.40
406_A411_G0.7560.40
104_D230_L0.7560.40
74_W99_F0.7530.40
247_Y252_S0.7510.39
360_L386_Q0.7510.39
370_N373_A0.7510.39
124_V143_L0.7490.39
134_V262_D0.7490.39
283_N286_L0.7480.39
128_S274_Y0.7450.39
360_L437_S0.7440.39
177_R259_V0.7430.39
49_F52_W0.7430.39
147_L407_I0.7420.39
367_D373_A0.7410.39
94_E99_F0.7410.39
249_R378_L0.7380.38
83_D105_A0.7370.38
118_D121_P0.7360.38
102_V261_R0.7330.38
380_F390_I0.7330.38
125_A136_A0.7330.38
187_R200_I0.7310.38
90_S108_A0.7310.38
156_K291_Q0.7310.38
310_G343_P0.7310.38
249_R354_R0.7310.38
40_V164_R0.7300.38
50_T60_L0.7300.38
330_I340_S0.7290.38
417_R433_M0.7280.38
57_M396_E0.7280.38
187_R195_N0.7260.38
387_A421_G0.7260.38
278_P412_T0.7250.37
39_T58_L0.7180.37
134_V180_E0.7170.37
272_A386_Q0.7160.37
150_H390_I0.7140.37
113_M276_C0.7130.37
113_M375_K0.7120.36
7_F101_N0.7100.36
236_L240_Q0.7090.36
83_D107_K0.7090.36
45_F53_A0.7080.36
17_I365_E0.7060.36
43_L441_I0.7040.36
356_I441_I0.7020.36
310_G346_H0.6980.35
91_E170_A0.6970.35
407_I413_A0.6960.35
346_H351_Q0.6920.35
21_G79_A0.6920.35
288_R291_Q0.6910.35
34_A77_I0.6910.35
22_D30_L0.6900.35
238_Q327_V0.6900.35
305_F341_G0.6900.35
81_D418_V0.6890.35
52_W55_A0.6880.35
413_A437_S0.6870.35
301_G412_T0.6860.35
55_A402_E0.6850.34
22_D395_I0.6830.34
156_K198_K0.6820.34
249_R437_S0.6820.34
30_L179_W0.6810.34
300_K382_M0.6810.34
4_L94_E0.6800.34
137_R381_Y0.6790.34
190_Q194_N0.6770.34
191_S196_D0.6760.34
45_F58_L0.6760.34
188_L193_A0.6760.34
82_D88_R0.6750.34
23_V81_D0.6740.34
190_Q199_A0.6730.34
247_Y335_G0.6720.34
372_A399_M0.6710.33
267_F441_I0.6710.33
14_D73_C0.6710.33
384_L445_V0.6690.33
387_A429_L0.6690.33
336_C409_E0.6690.33
13_R297_V0.6670.33
237_Q337_S0.6670.33
391_Q426_L0.6660.33
210_E291_Q0.6650.33
253_D256_M0.6650.33
236_L421_G0.6620.33
49_F53_A0.6610.33
339_Y411_G0.6590.33
27_K103_V0.6590.33
53_A284_Q0.6580.33
228_A234_K0.6580.33
111_F367_D0.6570.32
144_E261_R0.6550.32
311_G377_T0.6550.32
128_S183_F0.6530.32
87_Q107_K0.6530.32
113_M409_E0.6520.32
12_D37_R0.6520.32
312_E382_M0.6510.32
346_H447_L0.6500.32
182_L185_N0.6500.32
231_L239_I0.6480.32
297_V318_C0.6450.32
189_A193_A0.6450.32
306_I425_Q0.6450.32
343_P406_A0.6450.32
27_K381_Y0.6440.32
128_S155_A0.6440.32
10_L34_A0.6440.32
407_I430_A0.6440.32
336_C380_F0.6430.31
40_V49_F0.6430.31
406_A416_Q0.6430.31
259_V335_G0.6410.31
282_I316_T0.6400.31
417_R434_N0.6380.31
309_R312_E0.6380.31
124_V254_D0.6370.31
41_N71_D0.6370.31
351_Q366_L0.6360.31
256_M297_V0.6350.31
229_G237_Q0.6340.31
34_A92_A0.6340.31
194_N234_K0.6330.31
110_S223_A0.6320.31
41_N288_R0.6320.31
212_L291_Q0.6270.30
67_E92_A0.6270.30
138_L141_E0.6270.30
309_R313_E0.6260.30
3_H129_G0.6250.30
144_E381_Y0.6230.30
6_I113_M0.6210.30
238_Q413_A0.6210.30
336_C433_M0.6190.30
387_A391_Q0.6190.30
34_A255_I0.6190.30
107_K415_T0.6130.29
4_L30_L0.6130.29
284_Q340_S0.6110.29
235_G239_I0.6110.29
340_S343_P0.6110.29
144_E180_E0.6080.29
102_V109_A0.6080.29
128_S275_H0.6070.29
308_G311_G0.6060.29
45_F49_F0.6060.29
82_D85_L0.6060.29
85_L246_V0.6060.29
294_K426_L0.6040.29
154_V188_L0.6040.29
17_I150_H0.6040.29
22_D294_K0.6040.29
272_A275_H0.6030.29
17_I115_S0.6010.29
313_E382_M0.6000.29
309_R382_M0.6000.29
260_R381_Y0.5990.28
48_Q158_A0.5990.28
44_A50_T0.5980.28
80_T416_Q0.5980.28
337_S381_Y0.5970.28
24_A103_V0.5970.28
119_R381_Y0.5960.28
41_N65_F0.5950.28
97_R122_L0.5950.28
147_L183_F0.5950.28
279_Q382_M0.5940.28
259_V441_I0.5940.28
125_A353_V0.5940.28
111_F415_T0.5940.28
55_A91_E0.5930.28
234_K321_G0.5920.28
233_L338_A0.5910.28
219_V325_S0.5900.28
316_T439_I0.5900.28
379_V412_T0.5890.28
106_P109_A0.5880.28
138_L159_G0.5870.28
142_K164_R0.5870.28
217_E297_V0.5870.28
305_F311_G0.5870.28
187_R190_Q0.5860.28
285_I289_E0.5860.28
211_P424_T0.5850.28
21_G86_N0.5840.28
3_H16_L0.5840.28
12_D35_G0.5830.27
50_T319_N0.5830.27
387_A425_Q0.5830.27
48_Q218_V0.5830.27
105_A109_A0.5820.27
90_S131_T0.5820.27
176_R262_D0.5820.27
396_E408_V0.5820.27
80_T89_V0.5810.27
161_L239_I0.5810.27
118_D137_R0.5790.27
102_V108_A0.5790.27
51_A291_Q0.5770.27
365_E391_Q0.5770.27
238_Q297_V0.5760.27
217_E332_A0.5760.27
344_L355_L0.5760.27
2_D138_L0.5760.27
188_L199_A0.5750.27
323_P331_T0.5750.27
137_R144_E0.5740.27
205_E209_N0.5730.27
90_S122_L0.5730.27
106_P177_R0.5730.27
190_Q203_T0.5720.27
330_I362_T0.5720.27
201_T206_Q0.5720.27
7_F176_R0.5710.27
84_A414_V0.5700.27
430_A433_M0.5690.27
343_P440_I0.5690.27
281_E373_A0.5690.27
190_Q193_A0.5680.26
388_A407_I0.5680.26
38_L92_A0.5680.26
350_A377_T0.5670.26
44_A210_E0.5670.26
298_R347_R0.5670.26
193_A200_I0.5650.26
34_A126_V0.5650.26
7_F17_I0.5640.26
61_V210_E0.5640.26
177_R430_A0.5630.26
300_K309_R0.5620.26
429_L432_Q0.5620.26
419_I433_M0.5620.26
248_D347_R0.5610.26
385_N390_I0.5610.26
132_S255_I0.5600.26
144_E260_R0.5590.26
283_N439_I0.5590.26
342_I416_Q0.5580.26
198_K201_T0.5570.26
179_W344_L0.5570.26
260_R344_L0.5570.26
257_N261_R0.5570.26
125_A331_T0.5570.26
300_K312_E0.5550.26
159_G166_K0.5550.26
248_D298_R0.5540.26
408_V418_V0.5530.26
151_L219_V0.5520.26
122_L211_P0.5510.25
190_Q196_D0.5490.25
68_S87_Q0.5480.25
291_Q405_V0.5480.25
47_P50_T0.5470.25
114_P118_D0.5470.25
114_P445_V0.5470.25
32_L52_W0.5460.25
267_F276_C0.5460.25
344_L381_Y0.5460.25
16_L98_I0.5450.25
39_T255_I0.5450.25
318_C324_F0.5440.25
349_Y447_L0.5440.25
279_Q357_T0.5440.25
424_T428_E0.5430.25
203_T206_Q0.5420.25
34_A326_V0.5410.25
387_A430_A0.5400.25
29_R52_W0.5400.25
6_I352_S0.5390.25
409_E437_S0.5380.25
215_R323_P0.5370.25
41_N73_C0.5370.25
380_F385_N0.5370.25
9_Q285_I0.5350.24
114_P152_G0.5350.24
54_D167_Q0.5340.24
101_N251_V0.5340.24
83_D425_Q0.5330.24
361_K366_L0.5330.24
157_Y161_L0.5330.24
186_D337_S0.5330.24
279_Q300_K0.5320.24
343_P377_T0.5290.24
300_K313_E0.5290.24
277_V282_I0.5290.24
167_Q330_I0.5290.24
101_N178_F0.5280.24
354_R407_I0.5280.24
346_H350_A0.5280.24
337_S344_L0.5280.24
137_R240_Q0.5270.24
16_L65_F0.5250.24
129_G418_V0.5250.24
228_A301_G0.5250.24
109_A435_S0.5250.24
198_K389_T0.5250.24
327_V331_T0.5240.24
37_R53_A0.5240.24
273_G297_V0.5230.24
109_A180_E0.5220.24
335_G368_W0.5220.24
17_I292_K0.5210.24
3_H334_S0.5210.24
246_V361_K0.5210.24
185_N194_N0.5190.24
399_M408_V0.5180.23
25_E45_F0.5170.23
352_S390_I0.5140.23
33_D118_D0.5130.23
212_L428_E0.5130.23
182_L191_S0.5130.23
354_R390_I0.5120.23
417_R432_Q0.5120.23
55_A61_V0.5110.23
171_T388_A0.5110.23
76_A79_A0.5100.23
384_L435_S0.5100.23
386_Q407_I0.5100.23
248_D313_E0.5090.23
352_S383_G0.5090.23
89_V92_A0.5080.23
167_Q441_I0.5080.23
15_C132_S0.5080.23
160_Q164_R0.5080.23
189_A199_A0.5080.23
281_E304_P0.5070.23
115_S259_V0.5070.23
40_V61_V0.5060.23
13_R110_S0.5050.23
301_G351_Q0.5050.23
29_R46_I0.5040.23
248_D309_R0.5040.23
405_V431_Q0.5040.23
300_K345_T0.5040.23
189_A196_D0.5030.23
44_A143_L0.5030.23
291_Q318_C0.5020.23
26_R80_T0.5020.23
353_V427_G0.5010.22
238_Q241_Q0.5000.22
246_V354_R0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pjqA 2 0.9934 100 0.302 Contact Map
2yboA 2 0.523 100 0.64 Contact Map
1s4dA 4 0.5536 100 0.644 Contact Map
1ve2A 2 0.4967 100 0.668 Contact Map
1va0A 2 0.488 100 0.681 Contact Map
1cbfA 2 0.512 100 0.682 Contact Map
4e16A 2 0.4902 100 0.682 Contact Map
3ndcA 2 0.5098 100 0.686 Contact Map
3i4tA 2 0.4967 100 0.705 Contact Map
1wyzA 2 0.4705 100 0.711 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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