GREMLIN Database
CYOE - Protoheme IX farnesyltransferase
UniProt: P0AEA5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10182
Length: 296 (274)
Sequences: 6778 (4582)
Seq/√Len: 276.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_R83_P4.4761.00
59_Y83_P4.3041.00
6_Y10_T4.2371.00
59_Y87_L3.5661.00
52_S94_G3.1601.00
5_Q80_L3.1341.00
69_E72_K3.0691.00
82_S85_V2.9321.00
106_N109_A2.7381.00
64_I193_I2.6141.00
55_V93_L2.4951.00
203_S207_N2.4421.00
109_A152_C2.4021.00
107_P111_W2.3371.00
236_V278_M2.3151.00
186_K189_Q2.2931.00
41_Y104_G2.2331.00
66_R77_V2.1851.00
15_I47_S2.1301.00
84_A88_V2.0581.00
185_F189_Q2.0551.00
49_V97_G2.0521.00
230_G282_D2.0321.00
23_I43_L1.9831.00
5_Q10_T1.9801.00
41_Y100_L1.9321.00
7_L10_T1.8911.00
6_Y85_V1.7861.00
60_I127_Y1.7631.00
103_F110_C1.7581.00
260_W264_L1.7571.00
243_W246_G1.7481.00
159_D162_A1.7481.00
59_Y86_S1.7131.00
94_G117_F1.6991.00
55_V89_Y1.6501.00
182_I204_V1.6481.00
189_Q198_V1.6431.00
239_A243_W1.6141.00
141_L166_L1.6061.00
35_D38_L1.5791.00
119_V142_S1.5731.00
108_L152_C1.5481.00
118_V122_G1.5321.00
250_R253_K1.5211.00
48_L96_A1.5201.00
128_M131_H1.5191.00
8_Q80_L1.5181.00
76_L86_S1.5121.00
67_K191_A1.5111.00
214_I218_V1.5101.00
62_R66_R1.5081.00
123_V138_I1.5061.00
185_F202_I1.4931.00
81_I86_S1.4911.00
128_M138_I1.4641.00
55_V90_A1.4561.00
223_L233_Y1.4541.00
135_G195_V1.4511.00
246_G250_R1.4511.00
88_V92_L1.4491.00
61_D130_R1.4271.00
26_F39_F1.4231.00
243_W247_M1.4051.00
111_W115_M1.3991.00
51_A93_L1.3881.00
91_T95_I1.3601.00
249_L252_Y1.3561.00
163_A167_A1.3521.00
55_V81_I1.3521.00
244_W247_M1.3501.00
242_V246_G1.3491.00
158_F162_A1.3371.00
185_F198_V1.3331.00
68_M187_D1.3241.00
10_T93_L1.3171.00
204_V208_H1.3161.00
29_A151_Y1.3161.00
22_V46_V1.3101.00
207_N211_L1.3051.00
171_L214_I1.3031.00
240_V275_L1.2951.00
158_F163_A1.2941.00
224_S234_L1.2871.00
49_V113_G1.2681.00
40_I44_V1.2641.00
19_L23_I1.2531.00
48_L97_G1.2441.00
61_D64_I1.2381.00
37_P41_Y1.2111.00
270_I274_A1.2071.00
181_A197_P1.1921.00
101_L113_G1.1911.00
204_V207_N1.1881.00
81_I89_Y1.1861.00
256_D259_I1.1841.00
175_P212_Y1.1701.00
259_I263_K1.1701.00
229_A279_M1.1691.00
240_V271_A1.1671.00
22_V42_T1.1661.00
119_V141_L1.1621.00
83_P87_L1.1601.00
60_I125_S1.1511.00
48_L93_L1.1491.00
45_G101_L1.1451.00
59_Y76_L1.1451.00
6_Y9_V1.1421.00
168_I219_A1.1421.00
114_V118_V1.1411.00
99_M104_G1.1311.00
89_Y93_L1.1251.00
10_T51_A1.1241.00
19_L43_L1.1241.00
196_L200_K1.1221.00
247_M267_F1.1211.00
87_L91_T1.1211.00
59_Y90_A1.1191.00
64_I130_R1.1191.00
76_L81_I1.1181.00
62_R76_L1.1041.00
81_I85_V1.1011.00
200_K204_V1.1001.00
258_R261_A1.0881.00
262_R266_G1.0851.00
144_A170_S1.0821.00
269_I273_T1.0821.00
98_F114_V1.0821.00
144_A173_Q1.0791.00
216_F220_T1.0781.00
29_A154_V1.0741.00
229_A282_D1.0641.00
148_V166_L1.0591.00
243_W267_F1.0571.00
224_S227_G1.0491.00
26_F42_T1.0491.00
244_W248_A1.0391.00
211_L215_A1.0321.00
56_F90_A1.0261.00
144_A169_F1.0251.00
108_L112_L1.0201.00
232_K236_V1.0191.00
183_F262_R1.0111.00
55_V86_S1.0101.00
184_R188_Y1.0081.00
101_L105_A1.0071.00
263_K266_G1.0001.00
109_A149_I0.9991.00
119_V123_V0.9971.00
221_L225_L0.9941.00
63_D67_K0.9891.00
186_K190_A0.9841.00
160_S163_A0.9831.00
116_G145_A0.9801.00
35_D154_V0.9801.00
128_M132_S0.9751.00
108_L111_W0.9701.00
98_F110_C0.9691.00
61_D125_S0.9681.00
266_G269_I0.9671.00
77_V86_S0.9641.00
16_F269_I0.9631.00
41_Y105_A0.9601.00
169_F173_Q0.9581.00
95_I99_M0.9541.00
220_T224_S0.9511.00
246_G249_L0.9401.00
234_L238_A0.9341.00
107_P110_C0.9331.00
182_I202_I0.9301.00
248_A252_Y0.9291.00
103_F107_P0.9231.00
245_L248_A0.9221.00
27_L280_S0.9181.00
56_F60_I0.9171.00
167_A171_L0.9161.00
104_G107_P0.9161.00
278_M282_D0.9151.00
133_V194_P0.9131.00
7_L12_P0.9131.00
171_L212_Y0.9071.00
251_G254_V0.9061.00
24_G280_S0.9041.00
118_V123_V0.8991.00
177_S180_I0.8951.00
148_V162_A0.8941.00
34_I39_F0.8941.00
143_G173_Q0.8891.00
157_E161_G0.8881.00
210_T214_I0.8881.00
106_N112_L0.8851.00
213_I248_A0.8851.00
145_A149_I0.8831.00
144_A150_G0.8801.00
194_P199_V0.8761.00
108_L156_G0.8741.00
231_Y235_V0.8641.00
69_E186_K0.8621.00
256_D260_W0.8611.00
217_A241_S0.8591.00
37_P40_I0.8551.00
236_V240_V0.8481.00
22_V146_P0.8471.00
115_M118_V0.8461.00
58_N61_D0.8431.00
209_I213_I0.8411.00
207_N210_T0.8371.00
187_D190_A0.8361.00
239_A242_V0.8311.00
136_T177_S0.8261.00
268_S272_I0.8210.99
116_G149_I0.8200.99
75_V79_G0.8180.99
113_G149_I0.8150.99
233_Y237_A0.8130.99
244_W251_G0.8120.99
6_Y89_Y0.8120.99
270_I273_T0.8100.99
252_Y255_A0.8080.99
61_D193_I0.8080.99
245_L249_L0.8050.99
176_H180_I0.8010.99
63_D66_R0.7950.99
261_A265_F0.7880.99
99_M103_F0.7860.99
260_W263_K0.7840.99
56_F91_T0.7830.99
164_I226_G0.7830.99
253_K256_D0.7820.99
101_L110_C0.7770.99
132_S138_I0.7770.99
203_S206_K0.7760.99
10_T89_Y0.7750.99
98_F101_L0.7740.99
136_T178_Y0.7720.99
25_G150_G0.7720.99
28_L151_Y0.7710.99
85_V89_Y0.7660.99
236_V241_S0.7650.99
243_W250_R0.7630.99
98_F103_F0.7620.99
85_V88_V0.7620.99
252_Y256_D0.7590.99
56_F122_G0.7550.99
50_V54_C0.7470.99
123_V128_M0.7430.99
100_L104_G0.7420.99
8_Q75_V0.7420.99
267_F271_A0.7400.99
44_V100_L0.7270.99
147_P153_A0.7270.99
139_G176_H0.7250.99
220_T237_A0.7190.99
140_S174_M0.7180.99
59_Y62_R0.7150.99
206_K209_I0.7150.99
151_Y155_T0.7100.98
261_A264_L0.7100.98
230_G233_Y0.7090.98
64_I191_A0.7040.98
277_V281_V0.7020.98
109_A113_G0.7020.98
90_A94_G0.6990.98
160_S164_I0.6960.98
33_S37_P0.6920.98
178_Y196_L0.6900.98
202_I206_K0.6890.98
25_G29_A0.6860.98
54_C58_N0.6850.98
143_G146_P0.6850.98
132_S196_L0.6840.98
27_L276_S0.6840.98
188_Y195_V0.6820.98
51_A89_Y0.6820.98
68_M188_Y0.6790.98
92_L99_M0.6790.98
220_T241_S0.6790.98
136_T173_Q0.6770.98
76_L79_G0.6770.98
105_A109_A0.6710.98
145_A148_V0.6690.98
37_P44_V0.6660.98
215_A219_A0.6650.98
248_A251_G0.6640.98
26_F154_V0.6630.98
48_L100_L0.6580.98
147_P150_G0.6570.98
237_A241_S0.6540.97
232_K281_V0.6500.97
105_A110_C0.6500.97
75_V80_L0.6470.97
265_F269_I0.6460.97
151_Y162_A0.6450.97
275_L278_M0.6410.97
64_I67_K0.6410.97
240_V243_W0.6390.97
217_A220_T0.6360.97
214_I249_L0.6360.97
14_I54_C0.6320.97
237_A278_M0.6290.97
180_I183_F0.6280.97
134_Y137_L0.6260.97
147_P169_F0.6260.97
5_Q8_Q0.6240.97
14_I17_G0.6230.97
51_A55_V0.6230.97
27_L283_F0.6210.97
160_S225_L0.6210.97
139_G177_S0.6210.97
238_A242_V0.6190.96
38_L154_V0.6190.96
147_P151_Y0.6180.96
123_V127_Y0.6170.96
52_S122_G0.6160.96
218_V221_L0.6150.96
213_I216_F0.6140.96
232_K282_D0.6140.96
172_W176_H0.6140.96
235_V239_A0.6140.96
141_L170_S0.6140.96
14_I177_S0.6120.96
45_G100_L0.6100.96
186_K258_R0.6090.96
236_V282_D0.6090.96
182_I185_F0.6050.96
276_S280_S0.6040.96
44_V48_L0.6030.96
112_L152_C0.6010.96
216_F241_S0.6010.96
18_N116_G0.5990.96
210_T249_L0.5990.96
36_Y40_I0.5980.96
181_A187_D0.5940.96
84_A87_L0.5940.96
106_N153_A0.5940.96
23_I39_F0.5930.95
17_G21_S0.5910.95
230_G234_L0.5890.95
151_Y159_D0.5880.95
133_V199_V0.5870.95
230_G240_V0.5850.95
28_L229_A0.5840.95
143_G147_P0.5820.95
159_D163_A0.5810.95
136_T174_M0.5800.95
223_L234_L0.5770.95
87_L90_A0.5730.95
266_G270_I0.5680.94
186_K259_I0.5670.94
134_Y200_K0.5650.94
236_V274_A0.5620.94
219_A223_L0.5620.94
249_L253_K0.5600.94
272_I276_S0.5590.94
14_I61_D0.5580.94
240_V244_W0.5560.94
254_V260_W0.5550.94
15_I43_L0.5540.94
177_S181_A0.5530.93
69_E73_N0.5530.93
139_G173_Q0.5520.93
143_G176_H0.5510.93
242_V245_L0.5500.93
50_V180_I0.5460.93
241_S245_L0.5460.93
247_M251_G0.5450.93
139_G180_I0.5430.93
68_M176_H0.5430.93
135_G139_G0.5410.93
132_S199_V0.5410.93
49_V117_F0.5400.93
221_L224_S0.5400.93
32_G35_D0.5400.93
38_L42_T0.5390.93
43_L47_S0.5340.92
101_L104_G0.5320.92
205_A248_A0.5320.92
279_M283_F0.5310.92
205_A209_I0.5270.92
9_V86_S0.5250.92
137_L174_M0.5240.92
37_P104_G0.5230.91
220_T234_L0.5220.91
60_I121_V0.5200.91
30_S33_S0.5180.91
224_S233_Y0.5180.91
128_M135_G0.5160.91
209_I264_L0.5150.91
210_T213_I0.5150.91
262_R265_F0.5140.91
139_G143_G0.5120.91
108_L155_T0.5110.91
148_V158_F0.5100.90
231_Y242_V0.5100.90
150_G154_V0.5100.90
274_A278_M0.5090.90
58_N75_V0.5070.90
44_V96_A0.5070.90
220_T223_L0.5060.90
18_N22_V0.5060.90
156_G159_D0.5060.90
19_L22_V0.5050.90
7_L89_Y0.5050.90
201_G205_A0.5050.90
38_L41_Y0.5040.90
94_G98_F0.5030.90
233_Y240_V0.5020.90
280_S283_F0.5010.90
238_A241_S0.5010.90
42_T46_V0.5010.90
97_G113_G0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4od4A 1 0.8986 100 0.231 Contact Map
4tq3A 1 0.9358 100 0.303 Contact Map
2xq2A 2 0.7669 16.2 0.952 Contact Map
4wk5A 2 0.3514 3.7 0.964 Contact Map
3ixzA 1 0.6419 3.2 0.965 Contact Map
3ze3A 4 0.3311 2.5 0.967 Contact Map
4llsA 2 0.3818 2.4 0.968 Contact Map
2ls2A 1 0.0845 2.1 0.968 Contact Map
2zxeA 1 0.6385 2.1 0.969 Contact Map
4lfgA 2 0.4155 2.1 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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