GREMLIN Database
CSGG - Curli production assembly/transport component CsgG
UniProt: P0AEA2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13413
Length: 277 (252)
Sequences: 256 (169)
Seq/√Len: 10.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
159_F213_R6.8111.00
29_L192_T3.3790.97
79_A138_V3.2630.96
57_Q63_F3.1390.95
76_P142_I2.9240.93
56_I141_S2.5660.87
79_A84_V2.4920.85
79_A142_I2.4670.85
254_L257_K2.3760.82
14_S143_I2.3070.80
17_L76_P2.2800.80
27_P76_P2.1960.77
96_L233_S2.1420.75
172_I223_S2.1090.74
138_V178_V2.0790.73
109_K204_G1.9800.69
205_V254_L1.9780.69
191_N232_M1.9720.69
155_G224_N1.9520.68
250_G258_A1.9120.66
146_E230_C1.9080.66
82_M228_M1.9040.66
76_P210_D1.8620.64
137_M229_L1.8610.64
76_P79_A1.8450.63
30_M181_V1.8290.62
33_A36_Y1.8060.61
47_G113_A1.8050.61
185_E249_R1.7670.60
10_V217_G1.7520.59
82_M133_A1.7510.59
200_E208_F1.7470.59
205_V236_E1.7040.57
27_P210_D1.6840.56
148_N235_I1.6760.55
86_A225_E1.6510.54
109_K240_I1.6410.54
223_S228_M1.6270.53
10_V15_G1.6190.53
48_K236_E1.6140.53
76_P231_L1.6040.52
14_S253_D1.5900.51
135_N180_N1.5880.51
65_P147_S1.5860.51
88_K188_S1.5610.50
27_P89_D1.5430.49
36_Y233_S1.5400.49
102_Q106_N1.5390.49
186_I190_V1.5340.49
71_F106_N1.5290.49
131_L136_I1.5290.49
150_K245_D1.5230.48
71_F102_Q1.5070.47
99_Q168_Q1.5070.47
247_I256_N1.5030.47
147_S201_V1.4920.47
228_M236_E1.4840.46
29_L208_F1.4800.46
178_V217_G1.4690.46
181_V190_V1.4630.45
153_G220_G1.4540.45
52_S96_L1.4530.45
39_L228_M1.4250.44
83_L224_N1.4220.43
47_G185_E1.4180.43
59_E99_Q1.4130.43
5_F10_V1.4080.43
112_R212_Q1.3910.42
96_L133_A1.3880.42
32_R96_L1.3690.41
82_M233_S1.3660.41
154_V208_F1.3440.40
10_V136_I1.3380.40
200_E204_G1.3340.39
171_Q191_N1.3120.38
9_A26_R1.3120.38
210_D230_C1.3120.38
73_T90_S1.3100.38
109_K200_E1.2800.37
143_I175_N1.2630.36
135_N233_S1.2600.36
12_L258_A1.2480.36
85_T89_D1.2460.36
118_G245_D1.2440.35
8_V11_M1.2410.35
171_Q237_T1.2350.35
29_L67_P1.2240.35
12_L26_R1.2160.34
6_L9_A1.1930.33
7_L26_R1.1930.33
159_F191_N1.1880.33
9_A12_L1.1810.33
183_T206_F1.1730.32
255_Q258_A1.1730.32
5_F9_A1.1680.32
111_I134_A1.1650.32
95_P200_E1.1640.32
10_V48_K1.1620.32
51_V87_L1.1560.32
8_V14_S1.1510.32
133_A245_D1.1460.31
51_V255_Q1.1400.31
47_G182_S1.1330.31
70_N109_K1.1270.31
30_M113_A1.1250.30
67_P241_F1.1150.30
87_L239_V1.1090.30
41_H258_A1.1070.30
152_G158_Y1.1070.30
111_I251_L1.1060.30
46_T253_D1.1050.30
146_E171_Q1.0980.29
173_A234_A1.0950.29
94_I185_E1.0910.29
57_Q70_N1.0910.29
42_L86_A1.0880.29
137_M253_D1.0860.29
79_A174_V1.0770.29
135_N245_D1.0690.28
52_S102_Q1.0650.28
82_M175_N1.0640.28
97_E177_R1.0630.28
39_L44_A1.0520.28
161_I243_I1.0390.27
55_N219_V1.0300.27
8_V253_D1.0150.26
133_A174_V1.0100.26
194_K225_E1.0040.26
131_L178_V1.0040.26
71_F113_A1.0000.26
149_V185_E0.9950.26
50_F96_L0.9870.25
138_V242_L0.9850.25
78_S141_S0.9840.25
175_N237_T0.9830.25
83_L178_V0.9790.25
25_A149_V0.9670.25
13_L136_I0.9600.24
145_Y170_D0.9580.24
188_S191_N0.9580.24
68_A230_C0.9470.24
160_G224_N0.9450.24
27_P164_D0.9420.24
114_A117_N0.9340.23
55_N79_A0.9330.23
45_P92_W0.9330.23
111_I224_N0.9320.23
33_A68_A0.9280.23
79_A193_S0.9280.23
17_L52_S0.9270.23
247_I250_G0.9240.23
56_I173_A0.9230.23
101_L128_L0.9220.23
44_A255_Q0.9190.23
91_R125_R0.9190.23
132_T196_I0.9180.23
42_L192_T0.9170.23
69_S106_N0.9150.23
71_F149_V0.9100.23
7_L11_M0.9070.23
117_N183_T0.9010.22
36_Y210_D0.8930.22
144_G175_N0.8850.22
67_P175_N0.8850.22
183_T258_A0.8790.22
134_A187_L0.8780.22
17_L192_T0.8740.21
25_A117_N0.8690.21
68_A181_V0.8590.21
115_Q251_L0.8580.21
38_D67_P0.8580.21
118_G180_N0.8570.21
105_L151_S0.8530.21
170_D218_E0.8510.21
11_M14_S0.8500.21
191_N213_R0.8490.21
189_S206_F0.8490.21
30_M191_N0.8480.21
115_Q130_S0.8450.21
96_L135_N0.8430.20
146_E187_L0.8400.20
62_Q83_L0.8360.20
91_R176_L0.8350.20
57_Q73_T0.8340.20
45_P155_G0.8320.20
90_S254_L0.8290.20
141_S194_K0.8270.20
181_V237_T0.8250.20
80_T197_L0.8200.20
173_A228_M0.8200.20
119_T126_I0.8200.20
11_M258_A0.8190.20
205_V213_R0.8150.20
100_G171_Q0.8130.20
109_K223_S0.8130.20
6_L122_I0.8060.19
5_F217_G0.8060.19
33_A174_V0.8050.19
8_V248_D0.8040.19
91_R200_E0.8030.19
55_N81_A0.8020.19
6_L163_A0.8010.19
112_R182_S0.8000.19
55_N253_D0.7980.19
52_S256_N0.7950.19
221_Y238_G0.7940.19
83_L155_G0.7940.19
18_T196_I0.7930.19
25_A196_I0.7890.19
90_S171_Q0.7880.19
36_Y85_T0.7870.19
44_A186_I0.7840.19
44_A201_V0.7830.19
248_D255_Q0.7830.19
123_N196_I0.7790.19
8_V48_K0.7790.19
21_P196_I0.7720.18
124_N207_R0.7720.18
194_K226_P0.7720.18
190_V215_L0.7720.18
82_M135_N0.7720.18
89_D156_A0.7710.18
66_Y208_F0.7650.18
159_F207_R0.7620.18
216_E224_N0.7600.18
8_V122_I0.7580.18
136_I187_L0.7550.18
110_I178_V0.7550.18
135_N251_L0.7510.18
97_E226_P0.7470.18
7_L229_L0.7460.18
108_R198_S0.7440.18
239_V251_L0.7380.17
185_E248_D0.7330.17
17_L247_I0.7320.17
169_L237_T0.7300.17
157_R216_E0.7300.17
85_T100_G0.7280.17
56_I138_V0.7260.17
8_V17_L0.7250.17
45_P160_G0.7230.17
59_E82_M0.7220.17
63_F112_R0.7190.17
54_Y145_Y0.7150.17
88_K191_N0.7120.17
43_P54_Y0.7070.17
197_L213_R0.7020.16
195_T208_F0.6950.16
118_G135_N0.6940.16
133_A180_N0.6940.16
125_R154_V0.6940.16
88_K189_S0.6930.16
126_I257_K0.6920.16
93_F246_G0.6890.16
212_Q215_L0.6880.16
108_R224_N0.6880.16
50_F132_T0.6880.16
82_M191_N0.6850.16
159_F197_L0.6850.16
21_P24_A0.6850.16
149_V248_D0.6850.16
102_Q181_V0.6800.16
47_G212_Q0.6800.16
11_M127_P0.6790.16
133_A251_L0.6770.16
7_L12_L0.6750.16
35_S161_I0.6740.16
108_R155_G0.6690.16
126_I255_Q0.6690.16
189_S211_Y0.6690.16
8_V111_I0.6670.16
10_V119_T0.6670.16
9_A13_L0.6670.16
172_I241_F0.6660.16
6_L19_A0.6650.16
111_I196_I0.6650.16
127_P164_D0.6630.15
89_D147_S0.6570.15
80_T175_N0.6560.15
11_M20_P0.6560.15
141_S231_L0.6540.15
170_D252_W0.6490.15
19_A186_I0.6480.15
101_L184_G0.6460.15
13_L183_T0.6450.15
96_L232_M0.6430.15
169_L175_N0.6410.15
73_T79_A0.6390.15
86_A236_E0.6290.15
34_Q229_L0.6290.15
155_G218_E0.6280.15
8_V258_A0.6280.15
56_I168_Q0.6250.15
51_V145_Y0.6240.15
52_S118_G0.6230.15
8_V15_G0.6220.14
12_L17_L0.6200.14
175_N205_V0.6200.14
149_V258_A0.6190.14
96_L191_N0.6170.14
161_I219_V0.6150.14
46_T255_Q0.6140.14
63_F90_S0.6130.14
60_T153_G0.6120.14
104_L190_V0.6110.14
155_G170_D0.6080.14
251_L256_N0.6030.14
9_A46_T0.6030.14
104_L234_A0.6020.14
181_V250_G0.6020.14
213_R236_E0.6010.14
65_P181_V0.6010.14
132_T245_D0.5990.14
70_N76_P0.5970.14
11_M126_I0.5930.14
148_N226_P0.5930.14
59_E103_N0.5910.14
17_L172_I0.5910.14
181_V251_L0.5890.14
38_D80_T0.5890.14
183_T248_D0.5870.14
45_P105_L0.5870.14
217_G221_Y0.5800.14
143_I146_E0.5780.13
36_Y232_M0.5780.13
95_P189_S0.5760.13
40_T52_S0.5750.13
253_D256_N0.5740.13
130_S187_L0.5710.13
13_L138_V0.5690.13
54_Y155_G0.5680.13
114_A135_N0.5680.13
138_V247_I0.5660.13
116_E147_S0.5650.13
59_E63_F0.5650.13
59_E216_E0.5650.13
218_E224_N0.5630.13
69_S254_L0.5620.13
9_A201_V0.5610.13
27_P202_Q0.5590.13
116_E173_A0.5590.13
248_D257_K0.5580.13
103_N216_E0.5580.13
8_V94_I0.5560.13
54_Y184_G0.5550.13
172_I197_L0.5540.13
52_S247_I0.5530.13
150_K211_Y0.5530.13
134_A139_E0.5520.13
70_N227_V0.5480.13
119_T125_R0.5480.13
30_M227_V0.5480.13
69_S95_P0.5460.13
111_I128_L0.5450.13
230_C236_E0.5430.13
9_A248_D0.5410.13
31_P195_T0.5410.13
136_I227_V0.5400.13
146_E254_L0.5350.13
6_L44_A0.5330.13
106_N113_A0.5320.13
64_K70_N0.5320.13
45_P224_N0.5310.12
51_V64_K0.5300.12
145_Y208_F0.5270.12
190_V203_A0.5250.12
12_L44_A0.5250.12
26_R201_V0.5240.12
118_G130_S0.5230.12
7_L66_Y0.5220.12
8_V256_N0.5210.12
139_E168_Q0.5200.12
147_S248_D0.5160.12
218_E234_A0.5110.12
89_D227_V0.5080.12
169_L204_G0.5040.12
59_E208_F0.5010.12
5_F138_V0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uv2A 3 0.8773 100 0.429 Contact Map
2miiA 1 0.5271 99.5 0.856 Contact Map
4q6vA 1 0.4765 99.4 0.864 Contact Map
3w1eA 1 0.8267 98.8 0.894 Contact Map
4hrvA 2 0.5271 98 0.917 Contact Map
3zbiC 1 0.0939 79.9 0.957 Contact Map
2ylnA 1 0.6859 64.8 0.962 Contact Map
3ly7A 2 0.6245 55.6 0.964 Contact Map
4n4rB 1 0.5451 46.7 0.966 Contact Map
2iqiA 1 0.5848 27 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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