GREMLIN Database
CSGF - Curli production assembly/transport component CsgF
UniProt: P0AE98 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13412
Length: 138 (121)
Sequences: 251 (186)
Seq/√Len: 16.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_S69_D4.8671.00
25_Q34_N3.4961.00
71_F80_L3.4431.00
53_D56_Y3.3800.99
28_N41_L2.4730.95
38_G44_S2.3830.94
40_F44_S2.3370.93
35_P38_G2.2630.92
98_N129_S2.1630.90
72_T124_S1.8840.83
63_E128_V1.8370.81
101_I125_T1.8080.80
20_G36_N1.7250.77
23_T49_N1.7040.76
107_R127_Q1.6940.76
83_L93_G1.5660.70
115_V126_I1.5550.69
101_I124_S1.5350.68
11_M56_Y1.5180.67
20_G38_G1.5140.67
90_G97_T1.5060.66
44_S80_L1.4670.64
65_P73_Q1.4260.62
7_V12_L1.4110.61
66_S88_N1.4070.61
88_N123_T1.3720.59
15_P102_V1.3720.59
23_T66_S1.3390.57
97_T100_Y1.3380.57
24_F75_I1.2970.55
26_F75_I1.2950.54
93_G97_T1.2930.54
88_N91_K1.2860.54
34_N39_A1.2570.52
100_Y116_T1.2520.52
48_Q102_V1.2480.52
79_I86_N1.2420.51
25_Q76_Q1.2300.51
30_N43_N1.2140.50
8_V63_E1.1960.49
15_P18_W1.1950.49
42_L80_L1.1920.48
40_F78_Q1.1800.48
6_A15_P1.1620.47
44_S78_Q1.1550.46
13_I17_S1.1520.46
20_G76_Q1.1490.46
16_L55_S1.1400.45
8_V13_I1.1390.45
34_N87_I1.1370.45
28_N45_A1.1110.44
17_S120_T1.1090.43
71_F103_D1.1050.43
82_G106_N1.0940.43
95_M98_N1.0930.42
74_A99_D1.0890.42
71_F86_N1.0780.42
38_G42_L1.0680.41
39_A43_N1.0620.41
40_F82_G1.0470.40
25_Q36_N1.0390.39
46_Q102_V1.0290.39
43_N78_Q1.0230.38
42_L48_Q1.0220.38
63_E73_Q1.0180.38
48_Q71_F1.0170.38
30_N40_F1.0130.38
25_Q123_T1.0120.38
7_V15_P0.9920.37
22_M79_I0.9800.36
10_L13_I0.9580.35
107_R112_Q0.9580.35
47_A128_V0.9460.34
6_A18_W0.9410.34
17_S22_M0.9150.33
11_M16_L0.9130.32
67_A81_G0.9080.32
38_G120_T0.9070.32
6_A23_T0.9050.32
110_Q113_L0.8900.31
72_T96_V0.8810.31
19_A64_T0.8750.31
20_G110_Q0.8740.30
81_G89_T0.8710.30
44_S98_N0.8700.30
24_F41_L0.8640.30
8_V56_Y0.8600.30
66_S109_G0.8570.30
115_V129_S0.8560.30
7_V10_L0.8520.29
62_I104_I0.8510.29
41_L45_A0.8340.28
71_F118_R0.8330.28
55_S83_L0.8330.28
12_L104_I0.8290.28
61_G87_I0.8200.28
72_T115_V0.8180.28
68_L84_L0.7990.27
90_G109_G0.7920.26
20_G97_T0.7910.26
52_K109_G0.7830.26
110_Q127_Q0.7790.26
46_Q94_R0.7650.25
84_L98_N0.7600.25
36_N110_Q0.7470.24
54_P112_Q0.7470.24
88_N111_L0.7460.24
76_Q116_T0.7370.24
80_L94_R0.7280.24
94_R126_I0.7160.23
69_D79_I0.7140.23
42_L46_Q0.7100.23
7_V16_L0.7030.23
12_L62_I0.6980.22
21_T89_T0.6970.22
36_N39_A0.6940.22
24_F28_N0.6910.22
36_N97_T0.6900.22
7_V53_D0.6890.22
79_I93_G0.6860.22
30_N41_L0.6860.22
79_I122_Q0.6850.22
13_I18_W0.6830.22
102_V114_N0.6820.22
48_Q129_S0.6780.22
13_I19_A0.6720.21
7_V18_W0.6700.21
46_Q100_Y0.6680.21
81_G92_P0.6630.21
100_Y109_G0.6610.21
6_A14_S0.6540.21
87_I100_Y0.6530.21
14_S18_W0.6520.21
47_A126_I0.6470.20
15_P23_T0.6430.20
10_L124_S0.6420.20
22_M117_D0.6410.20
14_S62_I0.6400.20
28_N85_S0.6380.20
20_G44_S0.6360.20
20_G84_L0.6350.20
106_N113_L0.6330.20
57_N108_D0.6310.20
21_T30_N0.6270.20
78_Q82_G0.6270.20
86_N126_I0.6260.20
40_F74_A0.6260.20
48_Q80_L0.6230.19
78_Q88_N0.6100.19
20_G100_Y0.6050.19
111_L128_V0.6040.19
99_D127_Q0.6030.19
116_T123_T0.6020.19
10_L14_S0.6020.19
76_Q100_Y0.5980.18
95_M124_S0.5970.18
86_N99_D0.5950.18
20_G35_P0.5950.18
38_G116_T0.5920.18
64_T102_V0.5920.18
108_D114_N0.5890.18
17_S66_S0.5870.18
71_F84_L0.5850.18
67_A77_S0.5760.18
50_S70_N0.5620.17
20_G73_Q0.5580.17
81_G128_V0.5500.17
43_N115_V0.5460.17
97_T109_G0.5410.17
46_Q64_T0.5370.16
26_F92_P0.5350.16
24_F37_N0.5240.16
83_L120_T0.5230.16
11_M39_A0.5220.16
68_L111_L0.5190.16
22_M27_R0.5140.16
71_F102_V0.5140.16
49_N102_V0.5110.16
9_L12_L0.5070.15
42_L116_T0.5050.15
6_A16_L0.5050.15
62_I89_T0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k3bA 1 0.6304 56.5 0.927 Contact Map
3kyqA 1 0.7246 23.1 0.941 Contact Map
3bw6A 1 0.7246 22.2 0.941 Contact Map
4c91A 2 0.7609 12.3 0.948 Contact Map
3ixsB 1 0.2246 8.5 0.951 Contact Map
2vx8A 2 0.6232 6.1 0.954 Contact Map
4a2lA 4 0.7029 5.5 0.956 Contact Map
3fsoA 1 0.3406 4.6 0.957 Contact Map
2a2uA 3 0.7681 4.5 0.957 Contact Map
4y04A 2 0.5362 4.5 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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