GREMLIN Database
CSGE - Curli production assembly/transport component CsgE
UniProt: P0AE95 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13411
Length: 129 (112)
Sequences: 131 (80)
Seq/√Len: 7.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_Y47_F4.2650.98
79_Q118_L2.9250.84
89_P101_A2.8160.82
18_G35_T2.3320.68
45_R59_L2.1520.61
75_I102_L2.1370.60
66_S69_W1.9540.53
68_R118_L1.9440.53
31_L92_R1.9230.52
57_G86_F1.7830.47
47_F105_T1.7820.46
121_T125_A1.7710.46
27_V74_T1.7590.46
46_A109_L1.7250.44
61_I116_Q1.7210.44
75_I117_A1.6750.42
26_E119_L1.6450.41
73_I109_L1.6040.40
33_D48_S1.5240.37
32_T47_F1.5130.36
41_H45_R1.5070.36
36_V94_F1.5030.36
89_P128_E1.4880.35
64_R101_A1.4610.34
30_L49_D1.4310.33
50_K105_T1.4220.33
25_V61_I1.3970.32
83_F89_P1.3930.32
73_I126_H1.3680.31
71_S116_Q1.3630.31
22_A32_T1.3570.31
37_S81_V1.3560.31
17_A32_T1.3190.29
106_E113_Q1.3010.29
61_I78_N1.2810.28
35_T87_L1.2770.28
123_D128_E1.2730.28
44_Y57_G1.2530.27
22_A53_S1.2490.27
107_E111_R1.2450.27
42_D90_L1.2420.27
75_I115_N1.1970.25
38_S122_G1.1880.25
114_I118_L1.1710.25
83_F101_A1.1660.25
83_F120_S1.1580.24
45_R69_W1.1460.24
36_V65_P1.1420.24
25_V52_E1.1380.24
26_E86_F1.1350.24
79_Q127_D1.1200.23
84_Q98_V1.1150.23
23_V105_T1.0690.22
73_I99_V1.0680.22
48_S106_E1.0560.21
102_L111_R1.0510.21
44_Y58_N1.0460.21
27_V78_N1.0410.21
51_W120_S1.0090.20
72_W94_F0.9970.20
101_A128_E0.9930.20
42_D79_Q0.9830.20
80_D124_L0.9740.19
44_Y87_L0.9670.19
17_A20_L0.9650.19
52_E118_L0.9640.19
53_S105_T0.9580.19
32_T51_W0.9560.19
41_H127_D0.9490.19
58_N120_S0.9470.19
43_F63_E0.9450.19
43_F70_G0.9450.19
40_G70_G0.9450.19
40_G63_E0.9450.19
63_E70_G0.9450.19
40_G43_F0.9450.19
61_I115_N0.9410.19
77_V109_L0.9180.18
33_D60_T0.9180.18
36_V84_Q0.9110.18
74_T92_R0.9080.18
79_Q121_T0.8960.17
57_G105_T0.8900.17
32_T114_I0.8780.17
51_W84_Q0.8720.17
122_G125_A0.8650.17
108_A113_Q0.8540.17
64_R74_T0.8510.16
45_R68_R0.8430.16
60_T118_L0.8400.16
59_L102_L0.8380.16
42_D119_L0.8360.16
75_I95_E0.8280.16
34_H37_S0.8270.16
27_V38_S0.8050.15
97_T100_F0.8000.15
28_P32_T0.7970.15
109_L124_L0.7900.15
61_I87_L0.7770.15
26_E58_N0.7750.15
30_L95_E0.7670.15
66_S118_L0.7630.15
76_T83_F0.7570.15
42_D86_F0.7570.15
17_A21_H0.7490.14
72_W86_F0.7400.14
75_I96_K0.7360.14
64_R128_E0.7280.14
89_P105_T0.7230.14
38_S52_E0.7080.14
34_H60_T0.7030.13
92_R124_L0.7020.13
48_S92_R0.6950.13
82_I103_I0.6940.13
44_Y105_T0.6890.13
41_H94_F0.6870.13
54_D96_K0.6830.13
113_Q120_S0.6720.13
29_G43_F0.6700.13
29_G63_E0.6700.13
29_G40_G0.6700.13
29_G70_G0.6700.13
27_V105_T0.6630.13
26_E46_A0.6500.13
85_T124_L0.6420.12
32_T125_A0.6400.12
48_S91_K0.6370.12
37_S104_Q0.6370.12
32_T44_Y0.6300.12
111_R127_D0.6220.12
46_A99_V0.6140.12
50_K99_V0.6130.12
59_L98_V0.6120.12
90_L105_T0.6040.12
72_W84_Q0.5990.12
24_E48_S0.5990.12
27_V58_N0.5990.12
31_L109_L0.5890.11
25_V72_W0.5830.11
39_I68_R0.5820.11
88_F110_N0.5770.11
106_E126_H0.5750.11
18_G21_H0.5730.11
53_S111_R0.5680.11
36_V51_W0.5640.11
61_I103_I0.5640.11
61_I122_G0.5620.11
104_Q107_E0.5590.11
28_P80_D0.5550.11
57_G111_R0.5530.11
49_D94_F0.5530.11
34_H85_T0.5480.11
37_S126_H0.5480.11
23_V26_E0.5350.11
46_A65_P0.5330.11
108_A120_S0.5240.10
37_S50_K0.5230.10
35_T67_A0.5230.10
55_Y62_N0.5230.10
39_I94_F0.5170.10
20_L110_N0.5120.10
59_L69_W0.5090.10
51_W55_Y0.5070.10
83_F124_L0.5060.10
68_R78_N0.5030.10
32_T110_N0.5030.10
103_I117_A0.5020.10
98_V117_A0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4nq8A 2 0.7907 25.3 0.94 Contact Map
4n91A 2 0.8062 20.6 0.942 Contact Map
4nf0A 2 0.7829 20.3 0.942 Contact Map
4k3bA 1 0.8217 18.4 0.943 Contact Map
3vmtA 1 0.8837 16.9 0.944 Contact Map
4nn3A 1 0.8062 16.8 0.944 Contact Map
4mx6A 1 0.814 16.4 0.945 Contact Map
4xfeA 1 0.7674 15.9 0.945 Contact Map
4nhbA 2 0.7907 15.6 0.945 Contact Map
4p47A 1 0.8295 13.5 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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