GREMLIN Database
CREA - Protein CreA
UniProt: P0AE91 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11217
Length: 157 (140)
Sequences: 608 (306)
Seq/√Len: 25.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_D102_E3.9351.00
51_K89_E3.6171.00
56_Y149_A3.4781.00
130_A147_I3.4031.00
27_V132_L3.3031.00
36_P68_G3.2441.00
36_P39_K3.0561.00
46_D126_R2.8461.00
119_V134_Y2.5600.99
79_A83_Q2.5470.99
28_D37_D2.4950.99
28_D38_H2.4250.99
54_T85_V2.1970.97
23_E41_V2.0150.96
15_L18_L1.9930.95
112_V116_L1.9680.95
30_V38_H1.9620.95
26_S41_V1.7500.91
77_D144_K1.7330.90
51_K91_S1.6960.89
67_G72_A1.6830.89
84_Q88_I1.6100.87
116_L133_A1.5930.86
30_V138_V1.5920.86
101_G121_F1.5640.85
137_K140_E1.5600.85
58_S125_K1.5450.84
128_A149_A1.5410.84
10_L20_H1.4920.82
76_S146_A1.4680.81
65_I69_L1.4580.81
30_V140_E1.4170.79
95_K124_A1.4130.78
9_S12_L1.3670.76
59_R116_L1.3420.75
109_T116_L1.3350.74
22_E125_K1.3300.74
53_V129_L1.2980.72
39_K61_K1.2970.72
45_F57_V1.2950.72
38_H117_Q1.2850.71
16_G19_A1.2660.70
70_G143_P1.2610.70
14_M57_V1.2130.67
44_A126_R1.2100.67
81_S128_A1.2100.67
100_Q106_K1.1940.66
14_M20_H1.1650.64
42_V121_F1.1520.63
62_T72_A1.1180.60
40_I75_T1.1100.60
24_I147_I1.1090.60
79_A85_V1.1090.60
35_G38_H1.1010.59
119_V135_S1.0900.58
56_Y148_S1.0860.58
100_Q122_Y1.0840.58
71_L111_L1.0760.57
27_V43_E1.0730.57
56_Y102_E1.0490.55
15_L130_A1.0490.55
10_L13_I1.0440.55
78_A116_L1.0410.55
11_S49_D1.0340.54
78_A134_Y1.0340.54
13_I17_P1.0210.53
59_R109_T1.0180.53
58_S78_A1.0150.53
79_A102_E1.0140.53
46_D125_K1.0060.52
11_S14_M0.9960.52
29_T134_Y0.9940.51
117_Q138_V0.9850.51
25_G121_F0.9640.49
34_I63_G0.9620.49
55_C141_G0.9520.48
9_S50_V0.9510.48
70_G73_E0.9410.48
68_G140_E0.9390.47
106_K132_L0.9350.47
11_S17_P0.9270.47
44_A118_V0.9090.45
9_S14_M0.9030.45
85_V127_N0.8910.44
28_D36_P0.8890.44
75_T78_A0.8880.44
11_S124_A0.8740.43
57_V109_T0.8680.42
39_K86_G0.8660.42
42_V106_K0.8630.42
43_E59_R0.8490.41
10_L51_K0.8400.40
53_V133_A0.8380.40
56_Y86_G0.8330.40
140_E146_A0.8300.40
50_V91_S0.8280.39
23_E80_I0.8270.39
132_L138_V0.8260.39
7_I13_I0.8250.39
14_M17_P0.8080.38
58_S135_S0.8050.38
8_L102_E0.8010.37
108_R115_S0.7980.37
45_F80_I0.7950.37
60_A74_D0.7880.37
75_T144_K0.7830.36
59_R78_A0.7820.36
69_L93_R0.7740.36
77_D142_S0.7720.36
113_F139_V0.7640.35
40_I107_K0.7580.35
36_P71_L0.7550.34
34_I139_V0.7490.34
63_G145_N0.7430.34
127_N151_P0.7270.33
12_L15_L0.7260.32
83_Q111_L0.7190.32
67_G70_G0.7190.32
23_E26_S0.7140.32
30_V117_Q0.7100.31
30_V112_V0.7060.31
29_T37_D0.7000.31
117_Q121_F0.7000.31
76_S89_E0.6990.31
108_R111_L0.6910.30
53_V116_L0.6880.30
36_P86_G0.6820.30
36_P67_G0.6820.30
64_G145_N0.6820.30
29_T145_N0.6800.30
66_K69_L0.6790.30
7_I16_G0.6780.29
51_K93_R0.6710.29
53_V150_V0.6710.29
113_F133_A0.6700.29
101_G152_V0.6680.29
29_T67_G0.6670.29
101_G144_K0.6670.29
44_A54_T0.6580.28
30_V33_M0.6570.28
85_V128_A0.6570.28
50_V129_L0.6560.28
24_I128_A0.6550.28
80_I116_L0.6500.28
111_L138_V0.6460.28
23_E103_V0.6460.28
17_P20_H0.6420.27
103_V117_Q0.6390.27
62_T74_D0.6350.27
28_D39_K0.6290.27
12_L24_I0.6280.26
16_G20_H0.6280.26
40_I78_A0.6260.26
30_V71_L0.6250.26
111_L137_K0.6150.26
81_S151_P0.6090.25
57_V128_A0.6070.25
60_A145_N0.6010.25
43_E118_V0.5990.25
90_L122_Y0.5970.25
81_S84_Q0.5970.25
46_D51_K0.5940.25
117_Q136_D0.5880.24
108_R136_D0.5870.24
10_L15_L0.5850.24
23_E88_I0.5780.24
28_D33_M0.5690.23
53_V88_I0.5650.23
55_C63_G0.5630.23
106_K115_S0.5620.23
7_I11_S0.5620.23
7_I104_V0.5610.23
49_D92_D0.5550.23
137_K150_V0.5550.23
94_I130_A0.5540.22
17_P128_A0.5540.22
103_V129_L0.5530.22
64_G72_A0.5530.22
35_G69_L0.5510.22
57_V133_A0.5500.22
63_G140_E0.5500.22
101_G122_Y0.5480.22
57_V94_I0.5480.22
28_D142_S0.5480.22
39_K68_G0.5470.22
60_A69_L0.5450.22
50_V90_L0.5430.22
94_I147_I0.5410.22
77_D107_K0.5400.22
119_V136_D0.5400.22
33_M37_D0.5360.22
62_T66_K0.5340.21
61_K139_V0.5330.21
78_A133_A0.5310.21
22_E85_V0.5280.21
42_V130_A0.5260.21
88_I108_R0.5250.21
88_I128_A0.5250.21
50_V53_V0.5210.21
18_L21_A0.5180.21
122_Y133_A0.5180.21
61_K135_S0.5170.21
34_I38_H0.5160.21
127_N130_A0.5150.21
56_Y83_Q0.5130.20
22_E44_A0.5110.20
8_L54_T0.5070.20
29_T113_F0.5050.20
81_S148_S0.5050.20
26_S148_S0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c75H 2 0.7834 12.3 0.96 Contact Map
4c91A 2 0.828 10.1 0.961 Contact Map
3tdgA 2 0.707 6.4 0.965 Contact Map
4u6dA 2 0.6433 6.3 0.965 Contact Map
4le5A 2 0.8089 6.1 0.965 Contact Map
2m1zA 1 0.6051 5.9 0.965 Contact Map
1twyA 5 0.7134 5.8 0.965 Contact Map
2lw3A 1 0.242 5.8 0.966 Contact Map
4k3bA 1 0.5732 5.6 0.966 Contact Map
4ombA 1 0.6943 3.5 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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