GREMLIN Database
CPXR - Transcriptional regulatory protein CpxR
UniProt: P0AE88 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10020
Length: 232 (200)
Sequences: 77101 (55248)
Seq/√Len: 3906.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_T30_V3.8051.00
14_T32_H3.3351.00
18_K30_V3.2891.00
38_L65_A2.7801.00
7_V37_A2.7651.00
35_E56_K2.5561.00
29_I45_I2.4641.00
34_G57_K2.4091.00
57_K65_A2.3951.00
33_D56_K2.3041.00
42_D69_T2.2781.00
24_E108_V2.1541.00
20_L104_D2.1381.00
3_K29_I2.1321.00
31_A40_L2.0761.00
18_K22_E2.0401.00
53_M80_R1.9451.00
3_K27_N1.9401.00
32_H36_Q1.8671.00
86_R106_E1.8271.00
50_L62_T1.8101.00
195_R198_D1.8081.00
29_I40_L1.8051.00
33_D36_Q1.7751.00
76_M89_G1.7451.00
67_R95_D1.7271.00
160_T163_T1.7251.00
65_A69_T1.7241.00
64_K92_L1.7171.00
63_L74_V1.7101.00
5_L31_A1.6861.00
178_R198_D1.6781.00
83_E103_N1.6111.00
96_D110_R1.6111.00
34_G62_T1.5971.00
76_M94_A1.5871.00
57_K61_D1.5861.00
166_Y170_Q1.5721.00
167_L184_E1.5201.00
21_L111_I1.5151.00
176_V184_E1.4781.00
135_E140_V1.4741.00
41_L66_L1.4701.00
58_N61_D1.4681.00
80_R85_D1.4531.00
48_L72_T1.4501.00
65_A68_Q1.4351.00
177_S180_H1.4281.00
35_E57_K1.4281.00
200_H203_N1.4261.00
11_R32_H1.3801.00
40_L45_I1.3771.00
63_L76_M1.3651.00
138_A151_D1.3591.00
47_L111_I1.3271.00
75_I114_I1.3211.00
40_L43_D1.3151.00
61_D64_K1.3131.00
38_L62_T1.3031.00
60_I89_G1.2951.00
52_V60_I1.2831.00
95_D117_R1.2801.00
95_D114_I1.2691.00
161_E207_K1.2691.00
171_H174_Q1.2631.00
26_F112_R1.2541.00
180_H184_E1.2431.00
162_F166_Y1.2331.00
38_L57_K1.2231.00
133_T140_V1.2191.00
5_L45_I1.2181.00
167_L171_H1.2151.00
108_V112_R1.2131.00
7_V54_M1.2071.00
88_L92_L1.2071.00
8_D14_T1.1961.00
140_V149_S1.1871.00
211_R215_H1.1861.00
9_D51_D1.1721.00
36_Q40_L1.1691.00
31_A37_A1.1671.00
36_Q39_D1.1601.00
82_S85_D1.1591.00
60_I88_L1.1561.00
50_L63_L1.1441.00
24_E112_R1.1201.00
142_N145_R1.1161.00
5_L37_A1.1051.00
83_E87_V1.1051.00
179_E194_D1.0951.00
35_E39_D1.0891.00
52_V76_M1.0781.00
47_L115_L1.0771.00
25_G112_R1.0761.00
39_D43_D1.0731.00
5_L40_L1.0661.00
199_M202_S1.0521.00
109_A113_A1.0471.00
167_L176_V1.0451.00
31_A36_Q1.0381.00
195_R199_M1.0311.00
4_I26_F1.0271.00
106_E109_A1.0251.00
87_V91_E1.0211.00
84_L88_L1.0161.00
91_E112_R1.0151.00
18_K28_V1.0041.00
38_L42_D0.9971.00
6_L17_L0.9961.00
37_A41_L0.9931.00
147_E154_T0.9901.00
159_G163_T0.9861.00
86_R99_P0.9811.00
15_S30_V0.9811.00
143_P166_Y0.9771.00
11_R15_S0.9651.00
163_T166_Y0.9651.00
141_L169_A0.9651.00
37_A62_T0.9641.00
64_K88_L0.9581.00
52_V58_N0.9501.00
48_L66_L0.9491.00
17_L77_L0.9361.00
7_V31_A0.9331.00
60_I92_L0.9301.00
50_L74_V0.9271.00
5_L41_L0.9221.00
164_L168_L0.9181.00
141_L162_F0.9101.00
176_V180_H0.9091.00
12_E16_L0.9051.00
196_A200_H0.9001.00
63_L92_L0.8941.00
50_L76_M0.8911.00
114_I117_R0.8871.00
149_S154_T0.8851.00
81_G99_P0.8741.00
49_L107_L0.8701.00
63_L94_A0.8581.00
83_E86_R0.8561.00
7_V48_L0.8551.00
167_L181_L0.8431.00
39_D42_D0.8381.00
15_S18_K0.8371.00
144_G174_Q0.8361.00
73_P95_D0.8341.00
61_D65_A0.8331.00
13_L102_F0.8291.00
19_E23_M0.8271.00
135_E138_A0.8221.00
75_I110_R0.8211.00
11_R14_T0.8211.00
26_F108_V0.8161.00
52_V85_D0.8161.00
62_T66_L0.8151.00
174_Q180_H0.8121.00
201_I205_R0.8101.00
132_P144_G0.8071.00
104_D108_V0.8071.00
48_L74_V0.8031.00
194_D198_D0.8031.00
210_D216_P0.8031.00
88_L91_E0.8021.00
41_L72_T0.8021.00
178_R194_D0.7961.00
195_R202_S0.7961.00
6_L28_V0.7961.00
199_M203_N0.7941.00
180_H183_Q0.7861.00
203_N206_R0.7781.00
106_E110_R0.7771.00
202_S206_R0.7761.00
167_L170_Q0.7741.00
85_D88_L0.7741.00
57_K62_T0.7611.00
52_V80_R0.7601.00
179_E183_Q0.7541.00
64_K68_Q0.7501.00
15_S19_E0.7481.00
49_L111_I0.7471.00
209_P215_H0.7451.00
54_M62_T0.7451.00
49_L77_L0.7451.00
146_Q163_T0.7451.00
34_G38_L0.7441.00
103_N106_E0.7441.00
77_L102_F0.7421.00
113_A118_S0.7391.00
41_L45_I0.7391.00
133_T142_N0.7391.00
158_T207_K0.7381.00
3_K46_D0.7361.00
87_V105_R0.7341.00
66_L70_H0.7301.00
113_A116_R0.7301.00
115_L118_S0.7231.00
20_L108_V0.7201.00
7_V62_T0.7131.00
84_L105_R0.7131.00
210_D219_K0.7081.00
17_L107_L0.7021.00
3_K45_I0.6951.00
118_S122_E0.6891.00
139_L150_F0.6871.00
34_G56_K0.6871.00
163_T167_L0.6841.00
53_M79_A0.6761.00
90_L110_R0.6751.00
38_L41_L0.6681.00
38_L69_T0.6651.00
89_G94_A0.6641.00
209_P216_P0.6641.00
67_R73_P0.6581.00
205_R210_D0.6551.00
192_P197_I0.6541.00
66_L74_V0.6521.00
22_E28_V0.6491.00
198_D201_I0.6471.00
16_L20_L0.6431.00
6_L30_V0.6421.00
102_F107_L0.6381.00
86_R103_N0.6371.00
41_L48_L0.6341.00
34_G54_M0.6321.00
91_E109_A0.6291.00
14_T18_K0.6281.00
105_R109_A0.6261.00
149_S152_G0.6261.00
60_I85_D0.6261.00
42_D65_A0.6231.00
71_Q121_S0.6221.00
71_Q120_W0.6201.00
168_L201_I0.6191.00
10_D79_A0.6191.00
73_P115_L0.6161.00
4_I47_L0.6131.00
110_R114_I0.6061.00
146_Q162_F0.6051.00
4_I21_L0.6041.00
21_L26_F0.6021.00
75_I96_D0.6021.00
6_L18_K0.6021.00
83_E105_R0.6001.00
141_L166_Y0.5971.00
73_P117_R0.5971.00
143_P170_Q0.5961.00
170_Q176_V0.5961.00
174_Q184_E0.5921.00
170_Q184_E0.5901.00
49_L75_I0.5881.00
102_F106_E0.5871.00
73_P118_S0.5861.00
138_A150_F0.5861.00
193_F196_A0.5851.00
150_F153_Q0.5811.00
150_F211_R0.5811.00
109_A112_R0.5801.00
67_R72_T0.5761.00
96_D113_A0.5761.00
160_T200_H0.5751.00
150_F209_P0.5711.00
51_D100_K0.5681.00
8_D54_M0.5661.00
171_H184_E0.5651.00
215_H218_F0.5631.00
174_Q181_L0.5621.00
112_R116_R0.5591.00
9_D78_T0.5591.00
141_L148_A0.5581.00
52_V89_G0.5571.00
63_L67_R0.5551.00
50_L66_L0.5551.00
165_L216_P0.5531.00
142_N147_E0.5481.00
36_Q56_K0.5481.00
158_T161_E0.5441.00
20_L24_E0.5441.00
50_L54_M0.5431.00
150_F210_D0.5421.00
87_V90_L0.5411.00
84_L87_V0.5371.00
81_G101_P0.5371.00
41_L69_T0.5311.00
22_E27_N0.5281.00
138_A142_N0.5221.00
66_L72_T0.5221.00
9_D54_M0.5201.00
16_L19_E0.5191.00
13_L16_L0.5171.00
211_R217_W0.5131.00
26_F115_L0.5101.00
73_P121_S0.5101.00
10_D13_L0.5091.00
111_I115_L0.5081.00
105_R108_V0.5071.00
19_E22_E0.5061.00
134_L143_P0.5021.00
78_T86_R0.5011.00
178_R201_I0.5001.00
44_S70_H0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gwrA 1 0.9526 100 0.229 Contact Map
4b09A 2 0.9052 100 0.231 Contact Map
4kfcA 2 0.9612 100 0.231 Contact Map
2oqrA 2 0.9698 100 0.235 Contact Map
3r0jA 2 0.9397 100 0.245 Contact Map
1ys7A 2 0.9655 100 0.249 Contact Map
1p2fA 1 0.9267 100 0.254 Contact Map
1kgsA 1 0.9353 100 0.269 Contact Map
3q9sA 1 0.9009 100 0.287 Contact Map
2hqrA 2 0.9267 100 0.298 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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