GREMLIN Database
CPXP - Periplasmic protein CpxP
UniProt: P0AE85 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11872
Length: 166 (146)
Sequences: 389 (288)
Seq/√Len: 23.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_M120_M6.4911.00
99_A103_A4.2031.00
92_E115_K3.7761.00
48_G135_K3.2631.00
92_E96_R3.0731.00
62_L116_V3.0601.00
95_V114_A2.8861.00
118_N122_R2.8220.99
62_L123_L2.8140.99
134_E137_Q2.4130.98
109_R113_M2.2220.97
20_H26_S2.1490.96
91_D127_E2.1420.96
77_E101_K2.0660.95
53_E56_R2.0320.95
50_S131_V1.8890.92
15_V22_A1.8700.92
99_A106_Q1.8210.91
57_Q60_R1.8100.90
95_V111_V1.7750.90
87_A91_D1.7150.88
90_F114_A1.6390.85
99_A111_V1.6330.85
33_G36_L1.6190.85
57_Q61_D1.6000.84
94_A119_Q1.5970.84
17_S21_A1.5170.81
65_Q119_Q1.4530.78
119_Q123_L1.4240.76
59_M62_L1.4180.76
131_V135_K1.3990.75
121_Y129_Q1.3790.74
90_F95_V1.3170.70
99_A122_R1.3130.70
66_A116_V1.3070.70
93_N125_T1.2670.67
3_I14_A1.2600.67
124_L128_Q1.2570.66
55_Q124_L1.2570.66
55_Q128_Q1.2570.66
96_R100_E1.2490.66
109_R112_E1.2440.66
85_V90_F1.2180.64
40_S144_R1.2040.63
106_Q109_R1.1850.62
131_V140_M1.1780.61
122_R129_Q1.1690.61
82_H118_N1.1600.60
145_D148_Q1.1560.60
96_R99_A1.1500.59
66_A127_E1.1390.59
129_Q141_E1.1160.57
52_T85_V1.1030.56
9_M99_A1.0950.56
13_L134_E1.0850.55
91_D94_A1.0680.54
10_A13_L1.0520.53
89_N126_P1.0460.52
78_L130_A1.0390.52
11_S106_Q1.0260.51
47_D50_S1.0240.51
132_L136_H1.0220.50
58_Q61_D1.0200.50
10_A22_A1.0110.50
51_L55_Q1.0010.49
51_L124_L1.0010.49
51_L128_Q1.0010.49
20_H24_V1.0000.49
102_M111_V0.9900.48
52_T142_Q0.9860.48
42_Q63_M0.9840.48
38_Q41_T0.9610.46
48_G136_H0.9570.46
103_A107_I0.9540.46
53_E71_P0.9510.45
52_T107_I0.9470.45
10_A126_P0.9430.45
107_I110_Q0.9410.45
92_E112_E0.9350.44
47_D92_E0.9350.44
33_G39_R0.9280.44
114_A117_R0.9260.44
79_E87_A0.9240.44
81_M106_Q0.9100.43
130_A141_E0.9010.42
8_V12_T0.9000.42
58_Q90_F0.8980.42
41_T46_F0.8900.41
144_R147_T0.8900.41
85_V107_I0.8830.41
34_E37_T0.8800.40
27_G100_E0.8740.40
85_V114_A0.8700.40
62_L130_A0.8680.40
29_N34_E0.8650.39
75_V78_L0.8630.39
16_S19_S0.8620.39
57_Q64_Q0.8590.39
89_N117_R0.8460.38
46_F59_M0.8440.38
7_A65_Q0.8430.38
112_E115_K0.8410.38
102_M122_R0.8340.37
102_M118_N0.8140.36
8_V109_R0.8080.36
83_R91_D0.8070.36
47_D138_Q0.8030.35
82_H136_H0.8010.35
75_V108_A0.7990.35
27_G108_A0.7870.34
99_A107_I0.7840.34
21_A25_G0.7780.34
12_T65_Q0.7740.33
7_A35_E0.7670.33
104_N108_A0.7560.32
14_A17_S0.7560.32
10_A52_T0.7550.32
99_A113_M0.7470.32
113_M117_R0.7400.31
54_H57_Q0.7390.31
100_E107_I0.7370.31
107_I111_V0.7310.31
6_A20_H0.7300.31
58_Q91_D0.7280.31
23_E139_R0.7270.31
59_M113_M0.7260.31
64_Q68_H0.7240.30
131_V134_E0.7220.30
133_N136_H0.7030.29
39_R84_L0.7010.29
94_A98_Q0.6960.29
60_R131_V0.6950.29
86_T118_N0.6910.28
102_M109_R0.6870.28
80_T109_R0.6840.28
100_E134_E0.6820.28
41_T93_N0.6760.28
62_L120_M0.6760.28
3_I69_E0.6730.27
10_A14_A0.6710.27
8_V11_S0.6710.27
54_H123_L0.6680.27
20_H139_R0.6680.27
11_S118_N0.6610.27
8_V44_H0.6580.27
57_Q63_M0.6570.27
109_R123_L0.6530.26
95_V136_H0.6480.26
16_S129_Q0.6470.26
77_E112_E0.6470.26
17_S87_A0.6460.26
103_A115_K0.6410.26
83_R95_V0.6300.25
63_M74_N0.6290.25
13_L122_R0.6220.25
35_E47_D0.6220.25
112_E142_Q0.6220.25
24_V97_A0.6200.25
86_T121_Y0.6170.24
48_G56_R0.6170.24
71_P74_N0.6160.24
80_T93_N0.6160.24
9_M121_Y0.6140.24
18_L139_R0.6120.24
23_E26_S0.6110.24
73_V99_A0.6050.24
134_E148_Q0.6050.24
53_E70_Q0.6010.24
95_V117_R0.5990.23
65_Q68_H0.5980.23
86_T122_R0.5980.23
132_L135_K0.5980.23
9_M73_V0.5970.23
81_M94_A0.5970.23
39_R78_L0.5930.23
74_N77_E0.5920.23
7_A34_E0.5920.23
10_A95_V0.5910.23
6_A105_E0.5890.23
42_Q138_Q0.5880.23
85_V132_L0.5880.23
43_S56_R0.5870.23
72_P76_S0.5870.23
115_K119_Q0.5840.23
70_Q104_N0.5840.23
65_Q108_A0.5820.23
31_H35_E0.5760.22
29_N36_L0.5750.22
50_S125_T0.5740.22
6_A9_M0.5710.22
33_G53_E0.5670.22
56_R116_V0.5650.22
79_E136_H0.5610.22
29_N83_R0.5590.21
50_S82_H0.5560.21
6_A11_S0.5540.21
11_S121_Y0.5510.21
33_G37_T0.5490.21
62_L95_V0.5470.21
18_L115_K0.5400.21
87_A90_F0.5380.21
59_M97_A0.5380.21
11_S58_Q0.5370.20
144_R148_Q0.5350.20
49_I135_K0.5340.20
34_E138_Q0.5310.20
85_V110_Q0.5220.20
5_T126_P0.5220.20
113_M116_V0.5200.20
66_A120_M0.5160.20
48_G82_H0.5160.20
11_S15_V0.5130.19
60_R63_M0.5120.19
137_Q141_E0.5080.19
37_T142_Q0.5080.19
64_Q109_R0.5050.19
36_L138_Q0.5050.19
5_T9_M0.5010.19
54_H58_Q0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3o39A 2 0.5783 99.9 0.429 Contact Map
3itfA 2 0.6687 99.9 0.435 Contact Map
3oeoA 3 0.5482 99.9 0.455 Contact Map
3zg1A 2 0.6325 99.9 0.467 Contact Map
4wwfA 2 0.6506 99.7 0.562 Contact Map
3layA 5 0.4699 99.6 0.619 Contact Map
2qguA 1 0.6024 46.3 0.915 Contact Map
2zzsA 4 0.4458 26.7 0.925 Contact Map
4xxlA 1 0.4759 22.1 0.928 Contact Map
4fczB 1 0.6386 21.6 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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