GREMLIN Database
CPXA - Sensor protein CpxA
UniProt: P0AE82 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10163
Length: 457 (430)
Sequences: 49697 (43711)
Seq/√Len: 2107.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
386_D390_G4.1121.00
385_D446_R4.0221.00
425_E429_Q3.6371.00
308_I345_G3.4891.00
261_T277_I3.4141.00
436_K448_V3.4131.00
379_G450_W3.1791.00
383_T446_R3.0711.00
365_S387_D3.0121.00
396_R439_D2.9511.00
372_G383_T2.8361.00
381_T450_W2.7931.00
345_G431_H2.7861.00
383_T448_V2.7211.00
440_S443_G2.6061.00
381_T448_V2.5901.00
307_T344_Y2.5891.00
374_A381_T2.5841.00
437_A447_L2.5831.00
392_S395_D2.5661.00
333_T370_E2.5491.00
370_E385_D2.5401.00
424_V435_V2.5221.00
265_R278_E2.5111.00
258_Q282_Q2.4931.00
353_A428_I2.4821.00
335_N372_G2.4561.00
438_E446_R2.4201.00
438_E448_V2.3911.00
372_G385_D2.3901.00
439_D445_L2.3901.00
265_R275_E2.3861.00
400_F435_V2.3851.00
428_I433_G2.3771.00
396_R437_A2.3641.00
374_A383_T2.3491.00
216_Q219_L2.3261.00
391_V399_I2.2961.00
307_T342_P2.1901.00
335_N370_E2.1861.00
309_K312_Q2.1641.00
306_E347_P2.1631.00
316_E351_E2.1571.00
395_D398_Q2.1541.00
214_G219_L2.1231.00
434_W450_W2.1071.00
428_I449_I2.1011.00
258_Q281_A2.0991.00
25_L29_K2.0881.00
353_A427_A1.9881.00
376_D381_T1.9811.00
199_E204_N1.9221.00
345_G350_L1.9221.00
321_A355_E1.9171.00
398_Q401_R1.9061.00
325_A362_L1.8941.00
285_D289_N1.8861.00
427_A431_H1.8601.00
393_P396_R1.8561.00
215_P219_L1.8521.00
241_R245_D1.8511.00
258_Q285_D1.8261.00
228_M232_L1.8021.00
305_S344_Y1.7911.00
353_A424_V1.7811.00
436_K450_W1.7631.00
391_V395_D1.7601.00
395_D404_Y1.7441.00
429_Q434_W1.7201.00
354_L382_I1.7171.00
359_R363_R1.7161.00
391_V445_L1.7011.00
218_F222_G1.6991.00
239_Q243_L1.6761.00
39_L42_E1.6751.00
398_Q404_Y1.6741.00
346_N349_A1.6601.00
262_A278_E1.6281.00
365_S368_K1.6251.00
229_V232_L1.6231.00
261_T278_E1.6181.00
229_V233_E1.6141.00
89_T93_R1.5971.00
382_I449_I1.5701.00
370_E387_D1.5451.00
311_N315_S1.5451.00
265_R271_S1.5451.00
260_G273_E1.5381.00
356_N424_V1.5321.00
237_T241_R1.5301.00
204_N207_Q1.5201.00
365_S369_I1.5191.00
264_L274_L1.5181.00
386_D444_G1.5171.00
349_A352_S1.5041.00
257_L281_A1.4871.00
400_F437_A1.4721.00
364_Y405_R1.4681.00
222_G226_N1.4601.00
214_G222_G1.4561.00
439_D442_L1.4461.00
179_L183_A1.4451.00
214_G218_F1.4431.00
249_E352_S1.4411.00
428_I435_V1.4401.00
395_D406_T1.4371.00
324_E327_Q1.4241.00
396_R400_F1.4131.00
200_V229_V1.4051.00
311_N373_F1.4041.00
316_E347_P1.3951.00
392_S441_P1.3851.00
439_D443_G1.3621.00
194_K220_A1.3541.00
353_A449_I1.3531.00
256_R280_E1.3481.00
256_R260_G1.3471.00
278_E282_Q1.3461.00
401_R404_Y1.3401.00
257_L277_I1.3381.00
236_M239_Q1.3231.00
309_K342_P1.3181.00
347_P351_E1.3171.00
322_A326_E1.3151.00
400_F447_L1.3061.00
368_K387_D1.3041.00
349_A430_Q1.2961.00
261_T281_A1.2961.00
320_N351_E1.2791.00
225_F228_M1.2771.00
426_T429_Q1.2731.00
258_Q278_E1.2721.00
315_S334_V1.2711.00
215_P218_F1.2651.00
218_F221_A1.2571.00
226_N229_V1.2571.00
130_G133_S1.2511.00
242_L246_I1.2451.00
336_F373_F1.2321.00
313_L317_V1.2321.00
433_G451_L1.2311.00
194_K198_D1.2261.00
309_K340_P1.2181.00
399_I437_A1.2161.00
245_D402_P1.2081.00
234_R238_S1.2051.00
197_A201_A1.2041.00
349_A427_A1.1951.00
318_L334_V1.1931.00
142_Q148_P1.1881.00
275_E279_T1.1751.00
311_N336_F1.1741.00
199_E207_Q1.1711.00
261_T265_R1.1701.00
405_R414_S1.1691.00
437_A445_L1.1641.00
379_G434_W1.1551.00
206_R233_E1.1541.00
356_N359_R1.1491.00
260_G276_R1.1481.00
191_R194_K1.1201.00
303_L346_N1.1051.00
286_S348_N1.1041.00
208_H230_T1.1031.00
317_V321_A1.1031.00
400_F425_E1.0981.00
197_A200_V1.0981.00
386_D445_L1.0951.00
142_Q146_I1.0921.00
314_W373_F1.0871.00
261_T274_L1.0841.00
193_L197_A1.0841.00
385_D440_S1.0821.00
361_A369_I1.0801.00
305_S431_H1.0671.00
39_L43_Q1.0601.00
197_A225_F1.0591.00
376_D450_W1.0591.00
259_L263_L1.0581.00
289_N293_V1.0581.00
56_E60_D1.0551.00
341_W380_I1.0511.00
208_H233_E1.0461.00
280_E283_R1.0461.00
196_A209_P1.0421.00
219_L222_G1.0401.00
350_L431_H1.0391.00
68_W71_L1.0351.00
272_K276_R1.0311.00
391_V396_R1.0291.00
162_D166_L1.0291.00
393_P439_D1.0281.00
88_V94_V1.0281.00
35_M38_L1.0261.00
354_L384_V1.0241.00
251_R289_N1.0211.00
233_E237_T1.0171.00
224_S227_Q1.0141.00
46_G49_I1.0131.00
256_R259_L1.0101.00
317_V355_E1.0061.00
40_D43_Q1.0041.00
194_K197_A1.0011.00
57_L61_P1.0001.00
184_W188_K0.9991.00
312_Q316_E0.9981.00
145_L148_P0.9981.00
292_L295_S0.9911.00
183_A187_A0.9891.00
42_E46_G0.9891.00
227_Q231_A0.9881.00
219_L223_A0.9861.00
249_E356_N0.9831.00
241_R402_P0.9811.00
50_E54_E0.9781.00
308_I313_L0.9711.00
271_S275_E0.9701.00
355_E359_R0.9621.00
215_P222_G0.9611.00
391_V437_A0.9601.00
357_I435_V0.9591.00
235_M239_Q0.9571.00
313_L345_G0.9551.00
321_A358_V0.9531.00
84_R97_A0.9531.00
337_P374_A0.9491.00
290_D349_A0.9491.00
208_H226_N0.9481.00
391_V397_E0.9471.00
402_P426_T0.9461.00
399_I447_L0.9411.00
236_M240_Q0.9401.00
286_S290_D0.9351.00
341_W375_V0.9351.00
281_A285_D0.9341.00
354_L358_V0.9341.00
258_Q262_A0.9331.00
31_D34_Q0.9321.00
186_L189_P0.9321.00
189_P193_L0.9311.00
276_R280_E0.9301.00
357_I424_V0.9291.00
317_V358_V0.9291.00
210_E226_N0.9201.00
317_V351_E0.9161.00
45_Q48_M0.9161.00
72_F76_D0.9161.00
8_R216_Q0.9141.00
221_A225_F0.9091.00
357_I447_L0.9071.00
428_I451_L0.9061.00
176_T180_L0.9061.00
419_L423_I0.9051.00
43_Q46_G0.8991.00
158_N162_D0.8991.00
248_H356_N0.8971.00
197_A224_S0.8961.00
390_G445_L0.8881.00
318_L322_A0.8871.00
304_V346_N0.8861.00
252_T256_R0.8861.00
330_K365_S0.8851.00
424_V428_I0.8801.00
324_E359_R0.8801.00
320_N355_E0.8781.00
249_E253_P0.8781.00
255_T259_L0.8741.00
37_E41_S0.8731.00
310_A382_I0.8721.00
353_A431_H0.8701.00
196_A207_Q0.8681.00
364_Y389_P0.8681.00
177_P181_W0.8651.00
376_D379_G0.8651.00
214_G221_A0.8631.00
180_L184_W0.8631.00
16_T20_V0.8601.00
198_D220_A0.8591.00
351_E355_E0.8581.00
317_V320_N0.8541.00
357_I449_I0.8541.00
234_R237_T0.8501.00
311_N340_P0.8481.00
194_K224_S0.8461.00
43_Q47_L0.8421.00
309_K341_W0.8411.00
204_N208_H0.8401.00
198_D202_Q0.8391.00
181_W185_S0.8361.00
243_L246_I0.8351.00
251_R285_D0.8291.00
211_L223_A0.8291.00
222_G225_F0.8241.00
315_S319_D0.8241.00
161_F165_L0.8191.00
225_F229_V0.8191.00
189_P194_K0.8191.00
352_S427_A0.8181.00
277_I281_A0.8151.00
56_E59_N0.8131.00
348_N351_E0.8121.00
41_S44_R0.8101.00
141_Y145_L0.8101.00
38_L42_E0.8091.00
279_T316_E0.8081.00
228_M231_A0.8071.00
263_L267_R0.8071.00
305_S345_G0.8021.00
208_H229_V0.8021.00
305_S432_R0.7981.00
26_M29_K0.7961.00
53_V57_L0.7951.00
71_L75_I0.7931.00
405_R416_G0.7911.00
321_A359_R0.7901.00
358_V371_V0.7901.00
38_L41_S0.7891.00
314_W354_L0.7891.00
200_V228_M0.7861.00
54_E58_A0.7841.00
371_V384_V0.7821.00
221_A224_S0.7791.00
290_D352_S0.7771.00
272_K275_E0.7761.00
389_P414_S0.7751.00
162_D165_L0.7731.00
209_P226_N0.7721.00
58_A61_P0.7711.00
211_L214_G0.7711.00
254_L288_I0.7701.00
94_V97_A0.7701.00
393_P397_E0.7691.00
293_V352_S0.7651.00
275_E278_E0.7641.00
310_A380_I0.7631.00
436_K449_I0.7631.00
250_L284_L0.7631.00
392_S406_T0.7631.00
331_S334_V0.7611.00
319_D322_A0.7611.00
363_R414_S0.7601.00
433_G449_I0.7581.00
36_T39_L0.7571.00
330_K334_V0.7551.00
425_E434_W0.7531.00
391_V439_D0.7531.00
191_R195_N0.7511.00
199_E203_G0.7511.00
426_T430_Q0.7481.00
49_I57_L0.7481.00
323_F327_Q0.7441.00
46_G50_E0.7441.00
154_S158_N0.7421.00
68_W72_F0.7411.00
220_A224_S0.7401.00
133_S142_Q0.7391.00
260_G277_I0.7391.00
238_S241_R0.7371.00
157_I161_F0.7351.00
329_G367_T0.7341.00
386_D389_P0.7341.00
136_D139_D0.7331.00
294_M422_A0.7321.00
282_Q285_D0.7321.00
325_A369_I0.7321.00
396_R438_E0.7311.00
314_W371_V0.7311.00
303_L349_A0.7311.00
215_P221_A0.7291.00
185_S188_K0.7261.00
260_G280_E0.7261.00
122_K125_R0.7241.00
89_T95_I0.7231.00
248_H252_T0.7231.00
265_R274_L0.7221.00
25_L28_P0.7221.00
249_E423_I0.7211.00
153_Q156_F0.7201.00
423_I427_A0.7191.00
49_I53_V0.7191.00
209_P222_G0.7191.00
195_N199_E0.7181.00
69_R72_F0.7181.00
308_I347_P0.7161.00
142_Q145_L0.7161.00
203_G207_Q0.7161.00
284_L288_I0.7151.00
52_H56_E0.7131.00
97_A100_S0.7121.00
255_T258_Q0.7111.00
137_G140_N0.7101.00
59_N62_P0.7071.00
303_L430_Q0.7061.00
325_A332_L0.7061.00
383_T438_E0.7051.00
146_I149_A0.7051.00
243_L247_S0.7041.00
106_R110_G0.7021.00
337_P340_P0.7021.00
433_G452_P0.7001.00
292_L296_R0.6991.00
199_E202_Q0.6981.00
44_R47_L0.6961.00
361_A384_V0.6961.00
316_E320_N0.6951.00
37_E40_D0.6931.00
396_R447_L0.6931.00
293_V349_A0.6931.00
183_A186_L0.6921.00
86_L94_V0.6911.00
41_S45_Q0.6891.00
189_P197_A0.6871.00
321_A362_L0.6871.00
318_L332_L0.6841.00
49_I52_H0.6841.00
373_F380_I0.6841.00
35_M39_L0.6821.00
395_D408_E0.6811.00
42_E45_Q0.6811.00
145_L150_S0.6801.00
201_A227_Q0.6801.00
391_V447_L0.6781.00
381_T436_K0.6761.00
375_V380_I0.6761.00
256_R276_R0.6751.00
242_L249_E0.6741.00
393_P440_S0.6711.00
198_D224_S0.6701.00
311_N338_P0.6701.00
352_S355_E0.6691.00
165_L169_I0.6691.00
349_A431_H0.6681.00
357_I428_I0.6681.00
315_S318_L0.6661.00
260_G264_L0.6651.00
240_Q245_D0.6651.00
276_R279_T0.6651.00
214_G217_E0.6641.00
249_E287_M0.6641.00
240_Q298_Q0.6631.00
57_L60_D0.6631.00
246_I291_L0.6611.00
33_R36_T0.6611.00
197_A221_A0.6611.00
303_L431_H0.6611.00
235_M238_S0.6591.00
220_A223_A0.6581.00
323_F326_E0.6581.00
385_D442_L0.6581.00
325_A330_K0.6571.00
358_V369_I0.6571.00
223_A226_N0.6561.00
201_A204_N0.6541.00
245_D249_E0.6531.00
250_L253_P0.6531.00
337_P341_W0.6521.00
84_R98_E0.6521.00
51_Q55_A0.6521.00
217_E221_A0.6511.00
349_A353_A0.6511.00
320_N324_E0.6501.00
283_R351_E0.6501.00
424_V427_A0.6481.00
221_A226_N0.6471.00
390_G444_G0.6441.00
216_Q220_A0.6441.00
273_E277_I0.6431.00
399_I422_A0.6421.00
98_E101_E0.6421.00
330_K362_L0.6411.00
226_N230_T0.6391.00
325_A328_M0.6371.00
237_T240_Q0.6361.00
324_E328_M0.6351.00
328_M365_S0.6351.00
298_Q402_P0.6311.00
231_A234_R0.6301.00
153_Q157_I0.6291.00
30_L34_Q0.6281.00
249_E252_T0.6281.00
97_A101_E0.6271.00
308_I344_Y0.6271.00
158_N161_F0.6261.00
139_D142_Q0.6261.00
47_L51_Q0.6261.00
373_F382_I0.6261.00
335_N374_A0.6251.00
48_M52_H0.6231.00
69_R73_R0.6221.00
105_I109_I0.6211.00
73_R76_D0.6211.00
47_L50_E0.6191.00
326_E329_G0.6181.00
190_A221_A0.6181.00
310_A343_L0.6171.00
319_D323_F0.6171.00
192_K195_N0.6141.00
136_D141_Y0.6131.00
17_L20_V0.6121.00
330_K387_D0.6101.00
312_Q347_P0.6101.00
175_S179_L0.6101.00
337_P373_F0.6101.00
107_N111_Q0.6091.00
274_L278_E0.6091.00
363_R416_G0.6091.00
146_I150_S0.6061.00
40_D44_R0.6061.00
34_Q37_E0.6011.00
264_L273_E0.6011.00
12_I16_T0.6001.00
315_S336_F0.5971.00
197_A228_M0.5971.00
163_R166_L0.5971.00
311_N341_W0.5961.00
70_R74_A0.5961.00
369_I384_V0.5961.00
244_S247_S0.5951.00
200_V203_G0.5941.00
123_Y127_E0.5931.00
409_A415_G0.5921.00
190_A194_K0.5911.00
55_A59_N0.5901.00
358_V362_L0.5901.00
44_R48_M0.5901.00
20_V24_V0.5891.00
405_R415_G0.5881.00
396_R445_L0.5871.00
284_L292_L0.5861.00
190_A193_L0.5851.00
223_A227_Q0.5851.00
313_L350_L0.5841.00
401_R425_E0.5831.00
294_M426_T0.5831.00
263_L273_E0.5821.00
230_T233_E0.5791.00
267_R273_E0.5791.00
127_E133_S0.5771.00
207_Q210_E0.5761.00
397_E401_R0.5761.00
435_V447_L0.5761.00
268_S271_S0.5761.00
55_A58_A0.5761.00
400_F403_F0.5751.00
278_E281_A0.5751.00
142_Q149_A0.5741.00
325_A329_G0.5741.00
83_Q86_L0.5731.00
73_R77_K0.5731.00
192_K196_A0.5721.00
242_L247_S0.5701.00
163_R167_L0.5701.00
252_T259_L0.5701.00
318_L321_A0.5691.00
422_A426_T0.5681.00
188_K192_K0.5681.00
251_R292_L0.5681.00
341_W373_F0.5661.00
74_A77_K0.5651.00
36_T40_D0.5631.00
312_Q315_S0.5611.00
318_L371_V0.5601.00
94_V98_E0.5601.00
207_Q211_L0.5591.00
280_E320_N0.5591.00
294_M402_P0.5571.00
260_G281_A0.5551.00
366_H387_D0.5551.00
293_V296_R0.5541.00
124_G127_E0.5511.00
343_L380_I0.5511.00
159_L162_D0.5501.00
15_L22_M0.5501.00
313_L351_E0.5501.00
159_L163_R0.5501.00
250_L288_I0.5491.00
51_Q54_E0.5471.00
216_Q222_G0.5461.00
185_S189_P0.5451.00
198_D201_A0.5451.00
147_R150_S0.5441.00
257_L261_T0.5431.00
33_R37_E0.5421.00
241_R426_T0.5421.00
72_F75_I0.5411.00
120_K123_Y0.5401.00
70_R73_R0.5391.00
189_P216_Q0.5391.00
243_L291_L0.5391.00
321_A324_E0.5391.00
242_L245_D0.5381.00
201_A231_A0.5361.00
38_L43_Q0.5361.00
193_L196_A0.5351.00
201_A205_L0.5341.00
192_K210_E0.5341.00
290_D348_N0.5321.00
253_P284_L0.5321.00
399_I404_Y0.5321.00
141_Y147_R0.5321.00
350_L451_L0.5321.00
239_Q247_S0.5311.00
308_I350_L0.5311.00
370_E373_F0.5281.00
193_L225_F0.5261.00
247_S253_P0.5261.00
239_Q245_D0.5261.00
31_D35_M0.5251.00
200_V204_N0.5251.00
291_L403_F0.5241.00
232_L235_M0.5241.00
196_A199_E0.5231.00
89_T92_G0.5211.00
197_A203_G0.5211.00
247_S252_T0.5201.00
79_A82_G0.5201.00
249_E280_E0.5191.00
240_Q243_L0.5191.00
13_F16_T0.5181.00
328_M367_T0.5181.00
122_K127_E0.5181.00
251_R284_L0.5181.00
11_A14_W0.5161.00
127_E130_G0.5151.00
341_W344_Y0.5151.00
328_M362_L0.5131.00
362_L365_S0.5131.00
15_L18_A0.5121.00
259_L281_A0.5111.00
129_V132_F0.5101.00
428_I434_W0.5091.00
224_S228_M0.5091.00
284_L291_L0.5091.00
363_R415_G0.5091.00
392_S396_R0.5081.00
255_T260_G0.5081.00
366_H389_P0.5071.00
262_A266_R0.5051.00
337_P375_V0.5041.00
444_G447_L0.5041.00
264_L277_I0.5021.00
138_E141_Y0.5011.00
71_L74_A0.5011.00
155_D159_L0.5011.00
125_R129_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bixA 2 0.5011 100 0.343 Contact Map
4i5sA 2 0.5842 100 0.356 Contact Map
4ctiA 2 0.5011 100 0.397 Contact Map
4q20A 2 0.4945 100 0.463 Contact Map
4gczA 2 0.7768 100 0.466 Contact Map
4mpcA 2 0.6389 100 0.477 Contact Map
3jz3A 2 0.3435 100 0.478 Contact Map
2c2aA 2 0.4967 100 0.479 Contact Map
2q8gA 2 0.6477 100 0.484 Contact Map
2e0aA 2 0.663 100 0.487 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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