GREMLIN Database
CORC - Magnesium and cobalt efflux protein CorC
UniProt: P0AE78 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13654
Length: 292 (256)
Sequences: 7752 (5128)
Seq/√Len: 320.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
249_H255_E3.6491.00
214_V279_V3.3791.00
258_D263_Q3.2831.00
79_M178_L3.2271.00
256_T263_Q3.0671.00
81_T106_I2.7291.00
256_T265_K2.6961.00
107_S112_H2.6871.00
87_T90_E2.6571.00
243_V277_V2.6351.00
213_T267_A2.5281.00
84_R107_S2.4591.00
213_T276_Q2.3571.00
208_S211_T2.3521.00
265_K280_K2.3461.00
86_Q90_E2.3081.00
134_S137_K2.3041.00
263_Q282_P2.3011.00
211_T278_H2.2901.00
263_Q280_K2.2841.00
145_V154_M2.2621.00
121_D140_R2.2311.00
107_S136_D2.2181.00
149_K157_E2.1681.00
267_A278_H2.1541.00
79_M175_V2.0381.00
84_R136_D1.9961.00
242_L259_I1.9441.00
105_V139_L1.9241.00
69_V154_M1.9221.00
167_I175_V1.9111.00
207_L211_T1.9021.00
57_M61_V1.8901.00
223_F227_F1.8841.00
72_I151_V1.8271.00
265_K278_H1.8241.00
81_T110_K1.7971.00
268_M275_I1.7321.00
268_M276_Q1.7261.00
84_R114_E1.7051.00
239_I277_V1.7001.00
211_T280_K1.6731.00
167_I178_L1.6721.00
86_Q91_C1.6541.00
207_L213_T1.6511.00
83_K86_Q1.6491.00
223_F279_V1.6111.00
82_L91_C1.5921.00
147_E176_S1.5831.00
262_Y281_I1.5761.00
218_A223_F1.5721.00
270_D275_I1.5481.00
116_I142_A1.5451.00
213_T278_H1.5391.00
206_Q212_W1.5301.00
82_L105_V1.5301.00
224_N229_T1.5271.00
80_I94_V1.5181.00
204_F218_A1.4981.00
111_D174_G1.4781.00
165_M178_L1.4661.00
93_D97_E1.4631.00
85_N107_S1.4591.00
258_D282_P1.4411.00
223_F239_I1.4211.00
107_S114_E1.4211.00
154_M179_V1.4111.00
218_A239_I1.3981.00
101_S118_M1.3851.00
236_V245_Q1.3751.00
80_I98_S1.3721.00
67_Q71_D1.3611.00
41_I58_L1.3581.00
246_A259_I1.3571.00
185_L189_V1.3531.00
243_V266_V1.3521.00
106_I113_I1.3171.00
57_M188_I1.3081.00
214_V223_F1.3061.00
156_K159_R1.3051.00
95_I103_F1.2861.00
80_I100_H1.2771.00
210_H281_I1.2701.00
264_F279_V1.2621.00
182_E186_E1.2581.00
262_Y279_V1.2481.00
78_Q217_L1.2411.00
264_F277_V1.2391.00
261_G281_I1.2371.00
261_G282_P1.2231.00
214_V239_I1.2141.00
151_V184_I1.2121.00
149_K154_M1.2091.00
203_D215_R1.2071.00
267_A276_Q1.2031.00
157_E161_Q1.2031.00
207_L210_H1.1911.00
224_N230_H1.1861.00
86_Q94_V1.1821.00
243_V257_I1.1771.00
207_L278_H1.1731.00
80_I103_F1.1621.00
244_M274_I1.1621.00
204_F226_A1.1611.00
72_I179_V1.1571.00
44_S48_D1.1501.00
142_A167_I1.1481.00
109_D112_H1.1461.00
215_R276_Q1.1431.00
206_Q209_R1.1351.00
98_S103_F1.1301.00
69_V168_V1.1291.00
45_G55_R1.1261.00
76_R174_G1.1251.00
243_V264_F1.1031.00
61_V188_I1.0991.00
113_I167_I1.0971.00
102_R164_H1.0891.00
37_L44_S1.0861.00
259_I264_F1.0861.00
216_A240_G1.0841.00
194_D197_D1.0711.00
247_F257_I1.0711.00
243_V247_F1.0631.00
90_E93_D1.0531.00
133_F137_K1.0531.00
33_N36_E1.0511.00
205_R213_T1.0411.00
182_E192_I1.0111.00
240_G244_M1.0051.00
220_I224_N1.0051.00
158_F166_A1.0001.00
116_I165_M0.9841.00
81_T175_V0.9751.00
165_M180_T0.9701.00
37_L50_I0.9661.00
135_M139_L0.9661.00
224_N231_F0.9651.00
76_R111_D0.9601.00
108_E112_H0.9561.00
83_K106_I0.9551.00
93_D127_R0.9501.00
204_F212_W0.9491.00
219_S222_D0.9471.00
69_V145_V0.9441.00
83_K108_E0.9421.00
136_D139_L0.9421.00
257_I264_F0.9381.00
84_R139_L0.9301.00
114_E139_L0.9271.00
216_A274_I0.9241.00
149_K153_R0.9221.00
146_P149_K0.9221.00
96_I124_P0.9201.00
125_F138_V0.9171.00
246_A257_I0.9141.00
92_L96_I0.9141.00
247_F251_P0.9051.00
143_V166_A0.9021.00
82_L103_F0.9021.00
79_M110_K0.8991.00
204_F214_V0.8981.00
69_V179_V0.8951.00
72_I184_I0.8941.00
143_V161_Q0.8941.00
244_M250_L0.8921.00
77_S174_G0.8921.00
253_R268_M0.8911.00
70_R147_E0.8881.00
227_F262_Y0.8861.00
111_D175_V0.8831.00
143_V157_E0.8781.00
88_L91_C0.8751.00
170_D176_S0.8681.00
232_S236_V0.8661.00
95_I122_L0.8641.00
89_D131_E0.8641.00
231_F242_L0.8601.00
145_V168_V0.8591.00
85_N136_D0.8491.00
32_K40_L0.8481.00
157_E160_S0.8361.00
95_I119_A0.8331.00
220_I236_V0.8311.00
93_D96_I0.8291.00
102_R182_E0.8241.00
117_L138_V0.8221.00
164_H185_L0.8151.00
104_P116_I0.8121.00
38_L59_E0.7891.00
70_R176_S0.7871.00
220_I231_F0.7831.00
78_Q273_R0.7801.00
193_E200_D0.7791.00
192_I197_D0.7781.00
121_D196_Y0.7771.00
258_D261_G0.7731.00
215_R218_A0.7731.00
229_T262_Y0.7731.00
210_H283_D0.7630.99
82_L94_V0.7600.99
101_S120_K0.7590.99
64_I184_I0.7580.99
181_I192_I0.7560.99
88_L133_F0.7540.99
212_W227_F0.7530.99
94_V97_E0.7520.99
104_P167_I0.7500.99
269_A272_R0.7490.99
182_E197_D0.7470.99
118_M121_D0.7450.99
69_V149_K0.7440.99
68_R71_D0.7370.99
64_I155_L0.7370.99
64_I152_D0.7360.99
131_E134_S0.7360.99
89_D93_D0.7270.99
186_E191_E0.7260.99
254_G265_K0.7250.99
242_L246_A0.7220.99
253_R269_A0.7200.99
34_R66_D0.7190.99
34_R38_L0.7180.99
91_C134_S0.7110.99
154_M158_F0.7100.99
182_E195_E0.7010.99
41_I45_G0.7010.99
96_I128_S0.7010.99
84_R87_T0.7000.99
170_D173_G0.7000.99
189_V192_I0.6960.99
206_Q281_I0.6960.99
106_I109_D0.6960.99
171_E241_G0.6910.99
145_V166_A0.6880.99
203_D218_A0.6860.99
187_L191_E0.6860.99
89_D132_A0.6830.99
242_L257_I0.6790.99
102_R118_M0.6780.99
33_N37_L0.6760.99
250_L269_A0.6730.99
133_F138_V0.6730.99
186_E197_D0.6720.99
39_A43_D0.6720.99
55_R59_E0.6710.99
224_N234_E0.6700.99
224_N232_S0.6670.99
44_S49_L0.6660.99
240_G273_R0.6640.99
255_E274_I0.6640.99
45_G57_M0.6610.99
83_K107_S0.6600.99
274_I277_V0.6590.98
34_R65_A0.6570.98
205_R276_Q0.6550.98
206_Q226_A0.6530.98
125_F133_F0.6490.98
84_R91_C0.6450.98
193_E199_E0.6440.98
247_F255_E0.6410.98
94_V98_S0.6380.98
82_L86_Q0.6380.98
242_L264_F0.6380.98
247_F256_T0.6360.98
129_D132_A0.6340.98
60_G188_I0.6340.98
32_K44_S0.6320.98
252_A255_E0.6310.98
102_R165_M0.6290.98
155_L184_I0.6280.98
43_D47_N0.6280.98
90_E94_V0.6270.98
57_M60_G0.6270.98
33_N48_D0.6260.98
164_H182_E0.6240.98
39_A44_S0.6200.98
34_R62_M0.6200.98
206_Q211_T0.6180.98
204_F223_F0.6170.98
156_K160_S0.6170.98
222_D226_A0.6170.98
129_D133_F0.6160.98
182_E191_E0.6160.98
76_R170_D0.6150.98
206_Q210_H0.6140.98
230_H260_D0.6140.98
106_I110_K0.6130.98
162_R193_E0.6130.98
58_L62_M0.6120.98
214_V227_F0.6100.98
102_R195_E0.6090.97
154_M184_I0.6080.97
220_I239_I0.6080.97
153_R156_K0.6070.97
35_D38_L0.6040.97
216_A239_I0.6030.97
42_R59_E0.6030.97
246_A260_D0.6030.97
97_E198_E0.5980.97
155_L181_I0.5950.97
128_S131_E0.5940.97
105_V135_M0.5900.97
41_I59_E0.5890.97
74_I100_H0.5870.97
125_F129_D0.5870.97
106_I112_H0.5860.97
143_V163_Y0.5830.97
57_M64_I0.5830.97
91_C135_M0.5830.97
210_H280_K0.5820.97
186_E194_D0.5810.97
232_S246_A0.5810.97
207_L275_I0.5800.97
220_I242_L0.5780.97
89_D92_L0.5760.97
101_S195_E0.5740.96
119_A123_L0.5710.96
202_I205_R0.5710.96
151_V187_L0.5700.96
186_E195_E0.5700.96
192_I195_E0.5690.96
114_E136_D0.5690.96
168_V179_V0.5670.96
239_I264_F0.5650.96
65_A152_D0.5630.96
142_A165_M0.5630.96
106_I114_E0.5630.96
146_P169_I0.5590.96
56_D60_G0.5590.96
182_E196_Y0.5590.96
88_L132_A0.5560.96
54_T64_I0.5540.96
142_A175_V0.5530.96
227_F279_V0.5520.96
109_D174_G0.5520.96
147_E188_I0.5520.96
212_W226_A0.5470.95
235_E245_Q0.5470.95
224_N227_F0.5450.95
207_L268_M0.5440.95
181_I189_V0.5430.95
193_E197_D0.5400.95
146_P171_E0.5400.95
28_H31_P0.5390.95
170_D174_G0.5390.95
38_L41_I0.5380.95
70_R237_D0.5340.95
104_P113_I0.5320.95
220_I233_D0.5310.95
132_A137_K0.5310.95
221_E225_E0.5300.94
149_K168_V0.5300.94
147_E168_V0.5290.94
224_N233_D0.5290.94
68_R148_S0.5280.94
102_R194_D0.5260.94
62_M65_A0.5260.94
223_F226_A0.5260.94
182_E194_D0.5250.94
238_T241_G0.5230.94
71_D244_M0.5220.94
148_S238_T0.5200.94
185_L192_I0.5190.94
125_F128_S0.5180.94
38_L62_M0.5170.94
36_E44_S0.5170.94
64_I154_M0.5170.94
218_A222_D0.5150.94
82_L135_M0.5130.93
33_N44_S0.5110.93
275_I278_H0.5100.93
203_D217_L0.5090.93
64_I151_V0.5090.93
122_L125_F0.5070.93
57_M189_V0.5070.93
226_A229_T0.5050.93
207_L267_A0.5050.93
73_M178_L0.5040.93
89_D127_R0.5020.93
91_C95_I0.5010.93
60_G64_I0.5010.93
48_D55_R0.5000.93
135_M138_V0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hg0A 2 0.7945 100 0.27 Contact Map
3lhhA 1 0.4281 100 0.663 Contact Map
3oi8A 2 0.5342 99.9 0.688 Contact Map
3ocoA 2 0.4623 99.9 0.691 Contact Map
3ocmA 5 0.5103 99.9 0.695 Contact Map
2v8qE 1 0.7979 99.9 0.709 Contact Map
3kxrA 3 0.5514 99.9 0.709 Contact Map
3lv9A 2 0.4452 99.9 0.71 Contact Map
4iysA 2 0.4863 99.9 0.72 Contact Map
3dedA 2 0.2945 99.9 0.733 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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