CORC - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

CORC - Magnesium and cobalt efflux protein CorC

UniProt:	P0AE78	Sequences: MSDDNSHSSDTISNKKGFFSLLLSQLFHGEPKNRDELLALIRDSGQNDLIDEDTRDMLEGVMDIADQRVRDIMIPRSQMITLKRNQTLDECLDVIIESAHSRFPVISEDKDHIEGILMAKDLLPFMRSDAEAFSMDKVLRQAVVVPESKRVDRMLKEFRSQRYHMAIVIDEFGGVSGLVTIEDILELIVGEIEDEYDEEDDIDFRQLSRHTWTVRALASIEDFNEAFGTHFSDEEVDTIGGLVMQAFGHLPARGETIDIDGYQFKVAMADSRRIIQVHVKIPDDSPQPKLDE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13654
Length:	292 (256)
Sequences:	7752 (5128)
Seq/√Len:	320.5

ECOLI - CORC YEGH YTFL YOAE YFJD
BACSU - YHDP YHDT YUGS YRKA YQHB
HALSA - Q9HN02 Q9HHN9 Q9HRX1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
249_H	255_E	3.649	1.00
214_V	279_V	3.379	1.00
258_D	263_Q	3.283	1.00
79_M	178_L	3.227	1.00
256_T	263_Q	3.067	1.00
81_T	106_I	2.729	1.00
256_T	265_K	2.696	1.00
107_S	112_H	2.687	1.00
87_T	90_E	2.657	1.00
243_V	277_V	2.635	1.00
213_T	267_A	2.528	1.00
84_R	107_S	2.459	1.00
213_T	276_Q	2.357	1.00
208_S	211_T	2.352	1.00
265_K	280_K	2.346	1.00
86_Q	90_E	2.308	1.00
134_S	137_K	2.304	1.00
263_Q	282_P	2.301	1.00
211_T	278_H	2.290	1.00
263_Q	280_K	2.284	1.00
145_V	154_M	2.262	1.00
121_D	140_R	2.231	1.00
107_S	136_D	2.218	1.00
149_K	157_E	2.168	1.00
267_A	278_H	2.154	1.00
79_M	175_V	2.038	1.00
84_R	136_D	1.996	1.00
242_L	259_I	1.944	1.00
105_V	139_L	1.924	1.00
69_V	154_M	1.922	1.00
167_I	175_V	1.911	1.00
207_L	211_T	1.902	1.00
57_M	61_V	1.890	1.00
223_F	227_F	1.884	1.00
72_I	151_V	1.827	1.00
265_K	278_H	1.824	1.00
81_T	110_K	1.797	1.00
268_M	275_I	1.732	1.00
268_M	276_Q	1.726	1.00
84_R	114_E	1.705	1.00
239_I	277_V	1.700	1.00
211_T	280_K	1.673	1.00
167_I	178_L	1.672	1.00
86_Q	91_C	1.654	1.00
207_L	213_T	1.651	1.00
83_K	86_Q	1.649	1.00
223_F	279_V	1.611	1.00
82_L	91_C	1.592	1.00
147_E	176_S	1.583	1.00
262_Y	281_I	1.576	1.00
218_A	223_F	1.572	1.00
270_D	275_I	1.548	1.00
116_I	142_A	1.545	1.00
213_T	278_H	1.539	1.00
206_Q	212_W	1.530	1.00
82_L	105_V	1.530	1.00
224_N	229_T	1.527	1.00
80_I	94_V	1.518	1.00
204_F	218_A	1.498	1.00
111_D	174_G	1.478	1.00
165_M	178_L	1.466	1.00
93_D	97_E	1.463	1.00
85_N	107_S	1.459	1.00
258_D	282_P	1.441	1.00
223_F	239_I	1.421	1.00
107_S	114_E	1.421	1.00
154_M	179_V	1.411	1.00
218_A	239_I	1.398	1.00
101_S	118_M	1.385	1.00
236_V	245_Q	1.375	1.00
80_I	98_S	1.372	1.00
67_Q	71_D	1.361	1.00
41_I	58_L	1.358	1.00
246_A	259_I	1.357	1.00
185_L	189_V	1.353	1.00
243_V	266_V	1.352	1.00
106_I	113_I	1.317	1.00
57_M	188_I	1.308	1.00
214_V	223_F	1.306	1.00
156_K	159_R	1.305	1.00
95_I	103_F	1.286	1.00
80_I	100_H	1.277	1.00
210_H	281_I	1.270	1.00
264_F	279_V	1.262	1.00
182_E	186_E	1.258	1.00
262_Y	279_V	1.248	1.00
78_Q	217_L	1.241	1.00
264_F	277_V	1.239	1.00
261_G	281_I	1.237	1.00
261_G	282_P	1.223	1.00
214_V	239_I	1.214	1.00
151_V	184_I	1.212	1.00
149_K	154_M	1.209	1.00
203_D	215_R	1.207	1.00
267_A	276_Q	1.203	1.00
157_E	161_Q	1.203	1.00
207_L	210_H	1.191	1.00
224_N	230_H	1.186	1.00
86_Q	94_V	1.182	1.00
243_V	257_I	1.177	1.00
207_L	278_H	1.173	1.00
80_I	103_F	1.162	1.00
244_M	274_I	1.162	1.00
204_F	226_A	1.161	1.00
72_I	179_V	1.157	1.00
44_S	48_D	1.150	1.00
142_A	167_I	1.148	1.00
109_D	112_H	1.146	1.00
215_R	276_Q	1.143	1.00
206_Q	209_R	1.135	1.00
98_S	103_F	1.130	1.00
69_V	168_V	1.129	1.00
45_G	55_R	1.126	1.00
76_R	174_G	1.125	1.00
243_V	264_F	1.103	1.00
61_V	188_I	1.099	1.00
113_I	167_I	1.097	1.00
102_R	164_H	1.089	1.00
37_L	44_S	1.086	1.00
259_I	264_F	1.086	1.00
216_A	240_G	1.084	1.00
194_D	197_D	1.071	1.00
247_F	257_I	1.071	1.00
243_V	247_F	1.063	1.00
90_E	93_D	1.053	1.00
133_F	137_K	1.053	1.00
33_N	36_E	1.051	1.00
205_R	213_T	1.041	1.00
182_E	192_I	1.011	1.00
240_G	244_M	1.005	1.00
220_I	224_N	1.005	1.00
158_F	166_A	1.000	1.00
116_I	165_M	0.984	1.00
81_T	175_V	0.975	1.00
165_M	180_T	0.970	1.00
37_L	50_I	0.966	1.00
135_M	139_L	0.966	1.00
224_N	231_F	0.965	1.00
76_R	111_D	0.960	1.00
108_E	112_H	0.956	1.00
83_K	106_I	0.955	1.00
93_D	127_R	0.950	1.00
204_F	212_W	0.949	1.00
219_S	222_D	0.947	1.00
69_V	145_V	0.944	1.00
83_K	108_E	0.942	1.00
136_D	139_L	0.942	1.00
257_I	264_F	0.938	1.00
84_R	139_L	0.930	1.00
114_E	139_L	0.927	1.00
216_A	274_I	0.924	1.00
149_K	153_R	0.922	1.00
146_P	149_K	0.922	1.00
96_I	124_P	0.920	1.00
125_F	138_V	0.917	1.00
246_A	257_I	0.914	1.00
92_L	96_I	0.914	1.00
247_F	251_P	0.905	1.00
143_V	166_A	0.902	1.00
82_L	103_F	0.902	1.00
79_M	110_K	0.899	1.00
204_F	214_V	0.898	1.00
69_V	179_V	0.895	1.00
72_I	184_I	0.894	1.00
143_V	161_Q	0.894	1.00
244_M	250_L	0.892	1.00
77_S	174_G	0.892	1.00
253_R	268_M	0.891	1.00
70_R	147_E	0.888	1.00
227_F	262_Y	0.886	1.00
111_D	175_V	0.883	1.00
143_V	157_E	0.878	1.00
88_L	91_C	0.875	1.00
170_D	176_S	0.868	1.00
232_S	236_V	0.866	1.00
95_I	122_L	0.864	1.00
89_D	131_E	0.864	1.00
231_F	242_L	0.860	1.00
145_V	168_V	0.859	1.00
85_N	136_D	0.849	1.00
32_K	40_L	0.848	1.00
157_E	160_S	0.836	1.00
95_I	119_A	0.833	1.00
220_I	236_V	0.831	1.00
93_D	96_I	0.829	1.00
102_R	182_E	0.824	1.00
117_L	138_V	0.822	1.00
164_H	185_L	0.815	1.00
104_P	116_I	0.812	1.00
38_L	59_E	0.789	1.00
70_R	176_S	0.787	1.00
220_I	231_F	0.783	1.00
78_Q	273_R	0.780	1.00
193_E	200_D	0.779	1.00
192_I	197_D	0.778	1.00
121_D	196_Y	0.777	1.00
258_D	261_G	0.773	1.00
215_R	218_A	0.773	1.00
229_T	262_Y	0.773	1.00
210_H	283_D	0.763	0.99
82_L	94_V	0.760	0.99
101_S	120_K	0.759	0.99
64_I	184_I	0.758	0.99
181_I	192_I	0.756	0.99
88_L	133_F	0.754	0.99
212_W	227_F	0.753	0.99
94_V	97_E	0.752	0.99
104_P	167_I	0.750	0.99
269_A	272_R	0.749	0.99
182_E	197_D	0.747	0.99
118_M	121_D	0.745	0.99
69_V	149_K	0.744	0.99
68_R	71_D	0.737	0.99
64_I	155_L	0.737	0.99
64_I	152_D	0.736	0.99
131_E	134_S	0.736	0.99
89_D	93_D	0.727	0.99
186_E	191_E	0.726	0.99
254_G	265_K	0.725	0.99
242_L	246_A	0.722	0.99
253_R	269_A	0.720	0.99
34_R	66_D	0.719	0.99
34_R	38_L	0.718	0.99
91_C	134_S	0.711	0.99
154_M	158_F	0.710	0.99
182_E	195_E	0.701	0.99
41_I	45_G	0.701	0.99
96_I	128_S	0.701	0.99
84_R	87_T	0.700	0.99
170_D	173_G	0.700	0.99
189_V	192_I	0.696	0.99
206_Q	281_I	0.696	0.99
106_I	109_D	0.696	0.99
171_E	241_G	0.691	0.99
145_V	166_A	0.688	0.99
203_D	218_A	0.686	0.99
187_L	191_E	0.686	0.99
89_D	132_A	0.683	0.99
242_L	257_I	0.679	0.99
102_R	118_M	0.678	0.99
33_N	37_L	0.676	0.99
250_L	269_A	0.673	0.99
133_F	138_V	0.673	0.99
186_E	197_D	0.672	0.99
39_A	43_D	0.672	0.99
55_R	59_E	0.671	0.99
224_N	234_E	0.670	0.99
224_N	232_S	0.667	0.99
44_S	49_L	0.666	0.99
240_G	273_R	0.664	0.99
255_E	274_I	0.664	0.99
45_G	57_M	0.661	0.99
83_K	107_S	0.660	0.99
274_I	277_V	0.659	0.98
34_R	65_A	0.657	0.98
205_R	276_Q	0.655	0.98
206_Q	226_A	0.653	0.98
125_F	133_F	0.649	0.98
84_R	91_C	0.645	0.98
193_E	199_E	0.644	0.98
247_F	255_E	0.641	0.98
94_V	98_S	0.638	0.98
82_L	86_Q	0.638	0.98
242_L	264_F	0.638	0.98
247_F	256_T	0.636	0.98
129_D	132_A	0.634	0.98
60_G	188_I	0.634	0.98
32_K	44_S	0.632	0.98
252_A	255_E	0.631	0.98
102_R	165_M	0.629	0.98
155_L	184_I	0.628	0.98
43_D	47_N	0.628	0.98
90_E	94_V	0.627	0.98
57_M	60_G	0.627	0.98
33_N	48_D	0.626	0.98
164_H	182_E	0.624	0.98
39_A	44_S	0.620	0.98
34_R	62_M	0.620	0.98
206_Q	211_T	0.618	0.98
204_F	223_F	0.617	0.98
156_K	160_S	0.617	0.98
222_D	226_A	0.617	0.98
129_D	133_F	0.616	0.98
182_E	191_E	0.616	0.98
76_R	170_D	0.615	0.98
206_Q	210_H	0.614	0.98
230_H	260_D	0.614	0.98
106_I	110_K	0.613	0.98
162_R	193_E	0.613	0.98
58_L	62_M	0.612	0.98
214_V	227_F	0.610	0.98
102_R	195_E	0.609	0.97
154_M	184_I	0.608	0.97
220_I	239_I	0.608	0.97
153_R	156_K	0.607	0.97
35_D	38_L	0.604	0.97
216_A	239_I	0.603	0.97
42_R	59_E	0.603	0.97
246_A	260_D	0.603	0.97
97_E	198_E	0.598	0.97
155_L	181_I	0.595	0.97
128_S	131_E	0.594	0.97
105_V	135_M	0.590	0.97
41_I	59_E	0.589	0.97
74_I	100_H	0.587	0.97
125_F	129_D	0.587	0.97
106_I	112_H	0.586	0.97
143_V	163_Y	0.583	0.97
57_M	64_I	0.583	0.97
91_C	135_M	0.583	0.97
210_H	280_K	0.582	0.97
186_E	194_D	0.581	0.97
232_S	246_A	0.581	0.97
207_L	275_I	0.580	0.97
220_I	242_L	0.578	0.97
89_D	92_L	0.576	0.97
101_S	195_E	0.574	0.96
119_A	123_L	0.571	0.96
202_I	205_R	0.571	0.96
151_V	187_L	0.570	0.96
186_E	195_E	0.570	0.96
192_I	195_E	0.569	0.96
114_E	136_D	0.569	0.96
168_V	179_V	0.567	0.96
239_I	264_F	0.565	0.96
65_A	152_D	0.563	0.96
142_A	165_M	0.563	0.96
106_I	114_E	0.563	0.96
146_P	169_I	0.559	0.96
56_D	60_G	0.559	0.96
182_E	196_Y	0.559	0.96
88_L	132_A	0.556	0.96
54_T	64_I	0.554	0.96
142_A	175_V	0.553	0.96
227_F	279_V	0.552	0.96
109_D	174_G	0.552	0.96
147_E	188_I	0.552	0.96
212_W	226_A	0.547	0.95
235_E	245_Q	0.547	0.95
224_N	227_F	0.545	0.95
207_L	268_M	0.544	0.95
181_I	189_V	0.543	0.95
193_E	197_D	0.540	0.95
146_P	171_E	0.540	0.95
28_H	31_P	0.539	0.95
170_D	174_G	0.539	0.95
38_L	41_I	0.538	0.95
70_R	237_D	0.534	0.95
104_P	113_I	0.532	0.95
220_I	233_D	0.531	0.95
132_A	137_K	0.531	0.95
221_E	225_E	0.530	0.94
149_K	168_V	0.530	0.94
147_E	168_V	0.529	0.94
224_N	233_D	0.529	0.94
68_R	148_S	0.528	0.94
102_R	194_D	0.526	0.94
62_M	65_A	0.526	0.94
223_F	226_A	0.526	0.94
182_E	194_D	0.525	0.94
238_T	241_G	0.523	0.94
71_D	244_M	0.522	0.94
148_S	238_T	0.520	0.94
185_L	192_I	0.519	0.94
125_F	128_S	0.518	0.94
38_L	62_M	0.517	0.94
36_E	44_S	0.517	0.94
64_I	154_M	0.517	0.94
218_A	222_D	0.515	0.94
82_L	135_M	0.513	0.93
33_N	44_S	0.511	0.93
275_I	278_H	0.510	0.93
203_D	217_L	0.509	0.93
64_I	151_V	0.509	0.93
122_L	125_F	0.507	0.93
57_M	189_V	0.507	0.93
226_A	229_T	0.505	0.93
207_L	267_A	0.505	0.93
73_M	178_L	0.504	0.93
89_D	127_R	0.502	0.93
91_C	95_I	0.501	0.93
60_G	64_I	0.501	0.93
48_D	55_R	0.500	0.93
135_M	138_V	0.500	0.93

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4hg0A	2	0.7945	100	0.27	Contact Map
3lhhA	1	0.4281	100	0.663	Contact Map
3oi8A	2	0.5342	99.9	0.688	Contact Map
3ocoA	2	0.4623	99.9	0.691	Contact Map
3ocmA	5	0.5103	99.9	0.695	Contact Map
2v8qE	1	0.7979	99.9	0.709	Contact Map
3kxrA	3	0.5514	99.9	0.709	Contact Map
3lv9A	2	0.4452	99.9	0.71	Contact Map
4iysA	2	0.4863	99.9	0.72	Contact Map
3dedA	2	0.2945	99.9	0.733	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0097 seconds.