GREMLIN Database
CITT - Citrate carrier
UniProt: P0AE74 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13538
Length: 487 (407)
Sequences: 9028 (6035)
Seq/√Len: 299.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_A94_W4.5621.00
137_R140_T4.4161.00
362_D366_G4.3041.00
119_V331_D4.2181.00
297_S317_A3.7281.00
129_F133_F3.1401.00
94_W357_R3.0441.00
328_P331_D2.9081.00
210_V220_L2.8361.00
458_K462_R2.8331.00
276_E279_T2.7981.00
149_D167_V2.7371.00
44_M62_A2.7301.00
129_F132_K2.6991.00
456_K459_D2.6761.00
232_S235_Q2.6511.00
293_L317_A2.5841.00
376_S379_A2.5651.00
38_F360_F2.5411.00
35_W39_A2.4531.00
108_F342_L2.4281.00
288_W292_G2.2771.00
195_M449_I2.2711.00
459_D462_R2.2451.00
293_L320_L2.2151.00
150_I244_G2.2141.00
116_G321_M2.2081.00
291_I295_L2.1971.00
112_I318_V2.1841.00
139_L256_Y2.1831.00
46_V50_L2.1801.00
283_L287_E2.1721.00
303_F307_V2.1701.00
363_W367_T2.1481.00
113_F297_S2.1481.00
238_L242_P2.0821.00
285_R289_T2.0281.00
299_G303_F2.0241.00
388_F405_M2.0221.00
389_Y468_G2.0091.00
353_N357_R1.9951.00
283_L286_R1.9741.00
196_W200_I1.9461.00
330_K333_T1.9151.00
145_I171_I1.8981.00
469_V473_S1.8721.00
171_I198_M1.8701.00
109_G318_V1.8691.00
125_R129_F1.8471.00
43_A47_G1.8371.00
40_V65_I1.8331.00
296_L300_L1.8181.00
116_G290_L1.8151.00
234_L238_L1.8101.00
47_G58_I1.7901.00
63_V96_L1.7791.00
47_G50_L1.7681.00
40_V62_A1.7481.00
427_L479_G1.7481.00
385_V431_S1.7461.00
375_F379_A1.7461.00
109_G314_G1.7151.00
367_T371_H1.6951.00
237_F241_L1.6921.00
386_L472_I1.6871.00
204_L247_L1.6861.00
235_Q238_L1.6781.00
382_I476_L1.6701.00
253_W257_V1.6661.00
208_M244_G1.6641.00
292_G296_L1.6461.00
293_L321_M1.6451.00
151_L155_F1.6441.00
149_D202_T1.6301.00
125_R287_E1.6161.00
477_L481_P1.6111.00
282_A285_R1.6021.00
40_V66_C1.5991.00
257_V260_K1.5921.00
250_I470_I1.5901.00
36_H69_G1.5831.00
296_L320_L1.5741.00
366_G370_T1.5641.00
247_L471_Y1.5561.00
303_F306_E1.5551.00
284_T287_E1.5551.00
146_V201_S1.5491.00
94_W97_A1.5381.00
378_N480_W1.5251.00
211_T233_W1.5141.00
40_V69_G1.5131.00
34_A360_F1.5001.00
108_F112_I1.4981.00
115_L118_E1.4971.00
66_C354_G1.4901.00
143_Y252_P1.4871.00
304_G307_V1.4831.00
99_F346_A1.4761.00
64_T319_S1.4691.00
39_A43_A1.4621.00
134_M144_A1.4531.00
253_W256_Y1.4451.00
245_V249_I1.4411.00
277_L280_M1.4141.00
65_I69_G1.3931.00
104_V342_L1.3901.00
478_V482_I1.3861.00
53_I58_I1.3841.00
275_D278_K1.3811.00
37_Y354_G1.3791.00
475_L479_G1.3561.00
53_I57_A1.3551.00
40_V44_M1.3361.00
440_P450_Y1.3311.00
461_W465_A1.3271.00
235_Q422_E1.3211.00
201_S205_S1.3211.00
275_D279_T1.3161.00
300_L307_V1.3071.00
56_T340_N1.3051.00
38_F42_V1.3021.00
355_L361_I1.2991.00
409_I428_L1.2901.00
36_H71_N1.2901.00
254_L257_V1.2841.00
44_M58_I1.2811.00
205_S248_L1.2801.00
438_L468_G1.2731.00
356_T362_D1.2631.00
279_T283_L1.2571.00
34_A363_W1.2521.00
146_V197_M1.2461.00
355_L360_F1.2401.00
118_E336_N1.2381.00
295_L299_G1.2381.00
63_V347_T1.2371.00
153_A205_S1.2351.00
136_K140_T1.2321.00
199_V449_I1.2321.00
278_K281_G1.2291.00
115_L337_S1.2261.00
168_F448_I1.2251.00
282_A287_E1.2241.00
279_T282_A1.2241.00
242_P478_V1.2211.00
411_A414_K1.2031.00
419_V424_L1.2031.00
393_Y398_L1.1941.00
135_G140_T1.1931.00
286_R289_T1.1921.00
43_A65_I1.1891.00
282_A286_R1.1881.00
158_S161_A1.1751.00
41_F355_L1.1741.00
416_I419_V1.1741.00
390_F395_F1.1691.00
293_L300_L1.1571.00
241_L245_V1.1561.00
132_K274_G1.1551.00
145_I174_L1.1541.00
394_L468_G1.1461.00
208_M241_L1.1361.00
281_G287_E1.1341.00
283_L288_W1.1251.00
48_M59_S1.1161.00
458_K461_W1.1161.00
54_P58_I1.1131.00
146_V251_A1.1081.00
385_V427_L1.1061.00
477_L480_W1.1051.00
124_R128_L1.1021.00
465_A469_V1.0981.00
277_L283_L1.0941.00
410_L414_K1.0831.00
138_T193_Y1.0821.00
243_V474_M1.0801.00
196_W463_L1.0781.00
102_T311_T1.0741.00
353_N356_T1.0731.00
97_A353_N1.0691.00
254_L258_L1.0661.00
37_Y66_C1.0591.00
386_L390_F1.0571.00
115_L336_N1.0551.00
67_V95_G1.0541.00
250_I474_M1.0541.00
150_I248_L1.0531.00
60_F343_V1.0501.00
402_T433_G1.0491.00
277_L281_G1.0471.00
254_L470_I1.0401.00
154_P208_M1.0321.00
246_I474_M1.0311.00
259_Y463_L1.0291.00
289_T293_L1.0281.00
439_T442_A1.0211.00
386_L476_L1.0181.00
223_V425_C1.0151.00
195_M455_V1.0151.00
427_L431_S1.0151.00
300_L313_V1.0141.00
159_N206_S1.0071.00
472_I476_L1.0061.00
61_I319_S1.0031.00
406_L425_C1.0021.00
163_T202_T0.9981.00
98_G350_V0.9981.00
411_A415_G0.9971.00
173_N177_L0.9961.00
146_V248_L0.9951.00
42_V46_V0.9901.00
95_G350_V0.9871.00
281_G284_T0.9861.00
109_G315_L0.9821.00
345_L399_S0.9791.00
276_E282_A0.9791.00
102_T309_N0.9731.00
59_S347_T0.9691.00
414_K421_M0.9601.00
280_M284_T0.9561.00
430_L475_L0.9561.00
125_R128_L0.9551.00
204_L251_A0.9531.00
44_M351_M0.9451.00
205_S212_G0.9431.00
300_L316_L0.9371.00
393_Y436_G0.9321.00
384_L428_L0.9311.00
309_N312_A0.9301.00
169_P173_N0.9241.00
175_P194_L0.9241.00
107_V399_S0.9221.00
117_Y122_L0.9211.00
47_G61_I0.9161.00
206_S213_A0.9141.00
325_H328_P0.9141.00
451_G454_Y0.9071.00
372_L383_V0.9041.00
464_G467_F0.9011.00
281_G285_R0.8991.00
440_P447_V0.8961.00
363_W366_G0.8961.00
279_T285_R0.8961.00
388_F431_S0.8901.00
329_W333_T0.8901.00
61_I64_T0.8901.00
473_S477_L0.8891.00
101_S221_E0.8881.00
290_L294_V0.8801.00
394_L442_A0.8801.00
333_T343_V0.8791.00
292_G295_L0.8761.00
195_M198_M0.8741.00
280_M283_L0.8731.00
397_S400_A0.8731.00
48_M58_I0.8731.00
240_F430_L0.8691.00
91_A95_G0.8681.00
290_L293_L0.8651.00
438_L465_A0.8651.00
213_A216_N0.8631.00
208_M237_F0.8621.00
370_T373_E0.8551.00
301_W314_G0.8541.00
328_P332_I0.8541.00
391_A401_H0.8541.00
59_S63_V0.8491.00
438_L461_W0.8481.00
63_V67_V0.8471.00
308_I313_V0.8451.00
139_L252_P0.8451.00
266_S269_V0.8441.00
466_I469_V0.8431.00
459_D463_L0.8431.00
394_L438_L0.8421.00
390_F468_G0.8411.00
219_G429_V0.8371.00
73_L357_R0.8351.00
61_I65_I0.8351.00
215_P443_T0.8341.00
147_I151_L0.8341.00
255_S259_Y0.8331.00
56_T63_V0.8311.00
280_M285_R0.8301.00
397_S436_G0.8281.00
289_T324_L0.8271.00
180_S194_L0.8231.00
289_T292_G0.8231.00
168_F195_M0.8221.00
164_G448_I0.8221.00
398_L442_A0.8211.00
158_S399_S0.8201.00
284_T288_W0.8191.00
215_P433_G0.8161.00
381_V427_L0.8161.00
389_Y472_I0.8111.00
203_S437_C0.8111.00
142_G194_L0.8111.00
436_G442_A0.8081.00
66_C351_M0.8041.00
214_A399_S0.8011.00
124_R276_E0.7961.00
73_L91_A0.7951.00
218_L406_L0.7930.99
293_L301_W0.7910.99
243_V247_L0.7890.99
257_V261_P0.7840.99
44_M48_M0.7820.99
277_L285_R0.7810.99
55_A58_I0.7790.99
199_V446_G0.7770.99
66_C71_N0.7760.99
233_W237_F0.7710.99
215_P399_S0.7710.99
55_A59_S0.7700.99
71_N354_G0.7700.99
398_L436_G0.7680.99
393_Y442_A0.7680.99
251_A467_F0.7650.99
277_L287_E0.7650.99
281_G286_R0.7630.99
113_F321_M0.7630.99
63_V350_V0.7610.99
407_P410_L0.7600.99
399_S402_T0.7600.99
349_V403_A0.7590.99
276_E281_G0.7580.99
41_F351_M0.7580.99
209_F212_G0.7510.99
105_W346_A0.7500.99
297_S301_W0.7490.99
160_T213_A0.7490.99
251_A255_S0.7480.99
248_L252_P0.7470.99
436_G443_T0.7460.99
218_L403_A0.7440.99
93_K97_A0.7420.99
106_L314_G0.7400.99
255_S463_L0.7380.99
131_V174_L0.7360.99
420_P423_Q0.7360.99
246_I478_V0.7360.99
316_L319_S0.7360.99
215_P402_T0.7360.99
365_A369_S0.7340.99
367_T370_T0.7340.99
216_N236_W0.7330.99
294_V301_W0.7320.99
207_S244_G0.7300.99
62_A66_C0.7300.99
274_G279_T0.7300.99
37_Y358_S0.7270.99
293_L297_S0.7250.99
285_R288_W0.7240.99
223_V230_Q0.7240.99
368_M387_V0.7230.99
104_V346_A0.7220.99
399_S444_G0.7220.99
222_F406_L0.7180.99
249_I253_W0.7180.99
406_L410_L0.7170.99
250_I254_L0.7160.99
210_V237_F0.7150.99
301_W304_G0.7150.99
236_W429_V0.7140.99
92_L312_A0.7130.99
387_V391_A0.7130.99
120_S290_L0.7120.99
327_V332_I0.7110.99
98_G353_N0.7100.99
152_L162_R0.7100.99
148_I167_V0.7100.99
54_P57_A0.7090.99
300_L304_G0.7070.99
171_I194_L0.7070.99
367_T372_L0.7060.99
282_A288_W0.7050.99
41_F44_M0.7020.99
206_S209_F0.7010.99
199_V445_P0.7000.99
153_A159_N0.6990.99
220_L230_Q0.6980.99
95_G98_G0.6970.99
241_L244_G0.6960.99
338_A341_T0.6940.99
399_S443_T0.6940.99
51_E55_A0.6900.99
45_I48_M0.6900.99
215_P345_L0.6890.99
50_L53_I0.6890.99
318_V322_L0.6890.99
388_F428_L0.6880.99
193_Y261_P0.6850.99
242_P245_V0.6790.98
204_L248_L0.6780.98
297_S300_L0.6760.98
382_I386_L0.6740.98
463_L466_I0.6730.98
371_H374_G0.6710.98
210_V217_V0.6700.98
276_E280_M0.6700.98
233_W236_W0.6700.98
197_M201_S0.6680.98
377_P381_V0.6680.98
380_T384_L0.6670.98
254_L466_I0.6660.98
67_V312_A0.6650.98
280_M286_R0.6640.98
163_T449_I0.6640.98
437_C446_G0.6630.98
218_L399_S0.6620.98
426_I430_L0.6620.98
444_G447_V0.6610.98
382_I472_I0.6600.98
115_L119_V0.6600.98
298_L302_V0.6600.98
288_W291_I0.6590.98
237_F242_P0.6540.98
162_R202_T0.6540.98
236_W426_I0.6540.98
219_G425_C0.6520.98
92_L95_G0.6520.98
160_T206_S0.6480.98
203_S445_P0.6470.98
33_Q36_H0.6470.98
54_P340_N0.6470.98
410_L413_G0.6460.98
383_V387_V0.6460.98
242_P246_I0.6450.98
104_V345_L0.6450.98
67_V70_S0.6450.98
326_V329_W0.6440.98
289_T326_V0.6430.98
129_F277_L0.6420.98
380_T416_I0.6390.98
55_A397_S0.6370.98
159_N212_G0.6350.98
274_G277_L0.6350.98
143_Y249_I0.6330.98
153_A206_S0.6330.98
219_G406_L0.6320.98
163_T445_P0.6310.97
206_S434_I0.6300.97
110_A314_G0.6300.97
378_N382_I0.6290.97
279_T287_E0.6290.97
57_A61_I0.6280.97
223_V229_I0.6280.97
280_M287_E0.6280.97
385_V475_L0.6260.97
447_V450_Y0.6260.97
158_S162_R0.6220.97
343_V347_T0.6220.97
108_F337_S0.6220.97
274_G278_K0.6210.97
216_N220_L0.6210.97
37_Y71_N0.6200.97
146_V252_P0.6190.97
110_A297_S0.6170.97
410_L425_C0.6160.97
355_L404_T0.6160.97
205_S209_F0.6150.97
279_T286_R0.6140.97
239_C478_V0.6140.97
359_G362_D0.6110.97
274_G282_A0.6110.97
468_G471_Y0.6110.97
341_T399_S0.6100.97
394_L436_G0.6100.97
443_T446_G0.6100.97
60_F347_T0.6070.97
64_T316_L0.6070.97
208_M212_G0.6070.97
316_L320_L0.6050.97
64_T315_L0.6040.97
73_L350_V0.6040.97
107_V158_S0.6030.97
390_F465_A0.6010.97
91_A357_R0.6010.97
71_N358_S0.6010.97
160_T397_S0.6000.97
378_N477_L0.5980.97
385_V472_I0.5970.97
196_W464_G0.5960.96
379_A383_V0.5960.96
95_G99_F0.5950.96
245_V248_L0.5940.96
434_I437_C0.5940.96
466_I470_I0.5930.96
329_W332_I0.5920.96
207_S435_M0.5920.96
149_D162_R0.5910.96
314_G317_A0.5910.96
393_Y397_S0.5890.96
95_G100_S0.5880.96
242_P482_I0.5870.96
232_S241_L0.5870.96
375_F380_T0.5860.96
151_L154_P0.5860.96
154_P209_F0.5850.96
243_V478_V0.5850.96
124_R177_L0.5840.96
423_Q480_W0.5840.96
97_A100_S0.5830.96
255_S258_L0.5830.96
369_S412_V0.5810.96
56_T59_S0.5810.96
106_L158_S0.5780.96
372_L375_F0.5770.96
380_T424_L0.5770.96
385_V389_Y0.5760.96
145_I149_D0.5760.96
153_A212_G0.5760.96
229_I235_Q0.5730.96
67_V71_N0.5730.96
287_E290_L0.5720.96
413_G424_L0.5720.96
159_N213_A0.5710.96
244_G249_I0.5700.95
103_T107_V0.5690.95
262_E265_H0.5690.95
397_S401_H0.5690.95
142_G252_P0.5690.95
107_V111_F0.5670.95
274_G280_M0.5650.95
251_A463_L0.5650.95
256_Y259_Y0.5650.95
293_L304_G0.5650.95
331_D336_N0.5620.95
354_G358_S0.5620.95
51_E54_P0.5620.95
220_L231_I0.5610.95
51_E450_Y0.5610.95
215_P398_L0.5610.95
92_L96_L0.5580.95
139_L143_Y0.5570.95
159_N202_T0.5550.95
161_A236_W0.5530.95
310_A313_V0.5530.95
56_T333_T0.5520.95
310_A314_G0.5520.95
112_I332_I0.5500.95
213_A443_T0.5490.94
153_A162_R0.5490.94
143_Y256_Y0.5480.94
106_L110_A0.5470.94
277_L282_A0.5470.94
125_R281_G0.5460.94
159_N207_S0.5460.94
198_M201_S0.5440.94
290_L301_W0.5430.94
199_V203_S0.5430.94
391_A395_F0.5420.94
455_V459_D0.5420.94
330_K336_N0.5410.94
441_Y457_S0.5410.94
219_G402_T0.5400.94
127_A174_L0.5400.94
246_I470_I0.5390.94
249_I252_P0.5380.94
142_G193_Y0.5380.94
44_M53_I0.5370.94
144_A221_E0.5370.94
327_V330_K0.5350.94
126_I152_L0.5340.94
326_V333_T0.5340.94
200_I251_A0.5340.94
109_G311_T0.5340.94
300_L308_I0.5330.94
381_V476_L0.5330.94
346_A350_V0.5330.94
36_H40_V0.5320.94
63_V66_C0.5310.93
168_F449_I0.5310.93
304_G309_N0.5260.93
47_G62_A0.5250.93
159_N211_T0.5250.93
207_S240_F0.5240.93
279_T284_T0.5240.93
250_I253_W0.5240.93
321_M325_H0.5230.93
326_V332_I0.5230.93
398_L443_T0.5230.93
47_G53_I0.5230.93
442_A446_G0.5220.93
364_F387_V0.5220.93
70_S73_L0.5220.93
149_D201_S0.5220.93
128_L177_L0.5210.93
381_V419_V0.5200.93
39_A42_V0.5200.93
382_I480_W0.5200.93
48_M348_L0.5180.93
402_T428_L0.5170.93
172_K176_P0.5170.93
93_K362_D0.5160.92
107_V345_L0.5150.92
406_L429_V0.5150.92
143_Y147_I0.5140.92
141_L174_L0.5110.92
333_T340_N0.5100.92
290_L297_S0.5090.92
130_L144_A0.5070.92
445_P449_I0.5060.92
36_H39_A0.5060.92
413_G416_I0.5050.92
285_R290_L0.5030.92
409_I412_V0.5030.92
37_Y360_F0.5020.91
107_V444_G0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f35D 2 0.8789 100 0.393 Contact Map
4r1iA 2 0.9097 100 0.665 Contact Map
4r0cA 3 0.8357 99.9 0.726 Contact Map
4pd6A 3 0.7433 31.7 0.963 Contact Map
2m20A 2 0.1232 22.2 0.966 Contact Map
3w9iA 3 0.3224 8.3 0.972 Contact Map
3giaA 1 0.4682 8 0.972 Contact Map
1ldfA 3 0.4661 6.4 0.973 Contact Map
2ksfA 1 0.2197 6.3 0.974 Contact Map
3qe7A 2 0.4949 6.1 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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