GREMLIN Database
MAZE - Antitoxin MazE
UniProt: P0AE72 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10571
Length: 82 (76)
Sequences: 221 (188)
Seq/√Len: 21.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_P22_M4.3431.00
17_I22_M3.6431.00
33_V44_I3.2331.00
41_K45_E2.5410.98
62_I67_L2.3990.97
63_T66_N2.2720.96
7_K29_I2.0010.92
62_I66_N1.9400.91
19_A23_Q1.8040.88
20_T23_Q1.7260.85
27_L42_L1.7030.85
4_S14_A1.6200.81
72_D81_V1.5900.80
25_L31_D1.5410.78
5_S62_I1.5400.78
27_L33_V1.5030.76
62_I68_H1.4750.75
13_P19_A1.4460.73
8_R25_L1.3880.70
55_L59_V1.3690.69
21_L37_L1.3170.66
19_A34_K1.2940.65
7_K22_M1.2840.64
17_I42_L1.2370.61
34_K60_N1.2340.61
56_A65_E1.2180.60
26_N45_E1.2160.60
59_V62_I1.1390.55
4_S49_K1.0780.50
56_A79_K1.0390.48
8_R33_V1.0100.46
60_N64_P0.9990.45
54_T71_I0.9940.45
13_P37_L0.9820.44
17_I45_E0.9770.44
11_N16_R0.9740.43
32_E52_V0.9730.43
21_L32_E0.9700.43
22_M29_I0.9520.42
7_K30_D0.9470.42
6_V33_V0.9410.41
35_I48_R0.9290.41
14_A30_D0.9160.40
13_P31_D0.8990.39
13_P30_D0.8980.39
24_A39_D0.8960.38
20_T56_A0.8860.38
9_W12_S0.8790.37
57_E75_E0.8630.36
38_V41_K0.8620.36
11_N80_E0.8560.36
29_I64_P0.8560.36
8_R34_K0.8520.36
73_W76_P0.8440.35
23_Q70_N0.8400.35
6_V66_N0.8350.35
7_K19_A0.8170.33
14_A79_K0.8160.33
7_K13_P0.7990.32
43_I81_V0.7760.31
26_N79_K0.7750.31
46_P79_K0.7700.31
56_A61_D0.7650.30
15_V24_A0.7610.30
16_R80_E0.7580.30
13_P29_I0.7490.30
23_Q72_D0.7480.29
27_L32_E0.7410.29
37_L56_A0.7240.28
14_A29_I0.7110.27
6_V28_N0.7080.27
24_A59_V0.7020.27
28_N45_E0.7000.27
5_S57_E0.6840.26
39_D70_N0.6840.26
7_K34_K0.6830.26
4_S23_Q0.6790.26
6_V60_N0.6770.26
63_T68_H0.6680.25
27_L30_D0.6680.25
48_R71_I0.6560.25
44_I73_W0.6550.25
13_P66_N0.6540.24
28_N36_D0.6280.23
30_D40_G0.6190.23
47_V57_E0.6170.23
58_L61_D0.6140.23
22_M59_V0.6120.22
6_V21_L0.6120.22
15_V40_G0.6120.22
26_N44_I0.6070.22
14_A69_E0.5990.22
15_V30_D0.5890.21
70_N76_P0.5890.21
26_N49_K0.5850.21
36_D70_N0.5840.21
18_P63_T0.5770.21
35_I61_D0.5710.21
5_S20_T0.5680.20
40_G46_P0.5630.20
43_I75_E0.5510.20
14_A17_I0.5480.20
48_R79_K0.5430.19
20_T60_N0.5400.19
38_V69_E0.5380.19
25_L40_G0.5380.19
32_E77_K0.5370.19
22_M25_L0.5230.19
25_L56_A0.5140.18
52_V57_E0.5120.18
6_V23_Q0.5100.18
24_A34_K0.5080.18
5_S26_N0.5030.18
42_L81_V0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1mvfD 1 0.5366 99.9 0.336 Contact Map
3zvkE 2 0.6585 99.4 0.583 Contact Map
2mrnA 2 0.6098 99.4 0.589 Contact Map
3tndB 3 0.8171 99.2 0.625 Contact Map
3o27A 2 0.6098 98.9 0.67 Contact Map
1yfbA 2 0.6098 98.2 0.735 Contact Map
2l66A 2 0.622 97.8 0.759 Contact Map
2w1tA 2 0.9634 94.5 0.831 Contact Map
3d31A 2 0.5488 32.6 0.906 Contact Map
1gutA 5 0.561 31.7 0.907 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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