GREMLIN Database
MAZF - mRNA interferase MazF
UniProt: P0AE70 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11249
Length: 111 (103)
Sequences: 1499 (983)
Seq/√Len: 96.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_V102_I3.3601.00
61_E76_D3.2551.00
17_F31_A3.0521.00
95_A98_E2.9991.00
69_R92_G2.5681.00
53_T70_D2.3551.00
49_V75_A2.3371.00
49_V73_A2.2881.00
14_W91_K2.2201.00
11_D93_T2.2041.00
9_M103_K2.1681.00
73_A102_I2.1321.00
20_T26_A1.9641.00
10_G99_L1.8071.00
34_L49_V1.8051.00
15_V31_A1.7341.00
101_L105_K1.7141.00
98_E101_L1.6801.00
32_V94_V1.6601.00
8_D37_F1.5471.00
48_C81_I1.4581.00
18_D26_A1.4511.00
15_V81_I1.4481.00
25_Q29_R1.4241.00
21_K85_A1.4161.00
25_Q74_L1.4070.99
16_D28_H1.3780.99
11_D90_K1.2650.99
55_S72_V1.2560.99
64_L67_Q1.2540.99
82_A85_A1.2210.99
39_Y45_M1.2130.98
17_F79_K1.2090.98
73_A98_E1.1920.98
90_K93_T1.1900.98
103_K110_I1.1830.98
36_P109_L1.1780.98
28_H89_T1.1730.98
14_W89_T1.1610.98
68_E92_G1.1580.98
35_S39_Y1.1530.98
34_L106_I1.1460.98
13_I87_G1.1230.97
66_G92_G1.1160.97
39_Y109_L1.0820.97
20_T79_K1.0750.97
14_W28_H1.0670.97
31_A81_I1.0630.96
57_G61_E1.0440.96
58_Y61_E1.0430.96
94_V99_L1.0290.96
14_W30_P1.0120.95
18_D28_H0.9730.94
17_F48_C0.9630.94
45_M80_S0.9630.94
16_D87_G0.9440.93
62_V98_E0.9240.93
12_L51_C0.9180.92
24_E86_R0.9160.92
67_Q92_G0.9080.92
61_E72_V0.8980.91
47_L80_S0.8890.91
96_P101_L0.8890.91
37_F40_N0.8800.91
23_S44_G0.8750.90
13_I33_V0.8550.89
65_S93_T0.8550.89
33_V48_C0.8520.89
106_I110_I0.8400.88
107_N110_I0.8330.88
13_I88_A0.8270.88
17_F20_T0.8240.87
63_V72_V0.8230.87
18_D27_G0.8210.87
47_L109_L0.8100.87
56_K63_V0.8050.86
31_A48_C0.7950.86
19_P86_R0.7910.85
67_Q71_G0.7840.85
58_Y76_D0.7820.85
14_W88_A0.7820.85
96_P100_Q0.7820.85
35_S109_L0.7720.84
36_P61_E0.7680.84
10_G60_F0.7610.83
18_D89_T0.7510.82
78_V106_I0.7490.82
100_Q104_A0.7430.81
40_N106_I0.7410.81
53_T69_R0.7410.81
25_Q61_E0.7410.81
94_V98_E0.7400.81
67_Q95_A0.7360.81
21_K37_F0.7270.80
61_E74_L0.7270.80
39_Y76_D0.7190.79
100_Q107_N0.7100.78
12_L69_R0.7070.78
39_Y43_T0.7060.78
12_L64_L0.7030.78
51_C71_G0.6960.77
35_S46_C0.6860.76
50_P53_T0.6750.75
75_A110_I0.6720.75
23_S81_I0.6550.73
37_F41_N0.6520.72
51_C64_L0.6410.71
49_V82_A0.6410.71
36_P76_D0.6390.71
59_P76_D0.6380.71
49_V78_V0.6370.71
93_T96_P0.6310.70
12_L92_G0.6310.70
13_I46_C0.6260.69
75_A106_I0.6240.69
56_K59_P0.6190.68
12_L94_V0.6060.67
60_F76_D0.6040.67
9_M99_L0.6030.66
68_E95_A0.6030.66
52_T77_Q0.6020.66
60_F74_L0.5950.65
54_Q74_L0.5950.65
11_D84_R0.5950.65
40_N99_L0.5880.64
55_S63_V0.5880.64
47_L74_L0.5840.64
7_P90_K0.5830.64
39_Y60_F0.5810.64
103_K107_N0.5810.64
54_Q61_E0.5730.62
34_L110_I0.5730.62
57_G72_V0.5710.62
39_Y47_L0.5610.61
51_C66_G0.5610.61
38_M104_A0.5570.60
20_T74_L0.5530.60
60_F75_A0.5510.60
74_L77_Q0.5510.60
27_G74_L0.5470.59
12_L67_Q0.5440.59
10_G74_L0.5430.58
103_K106_I0.5400.58
99_L102_I0.5390.58
15_V87_G0.5390.58
84_R90_K0.5090.54
49_V102_I0.5080.53
46_C80_S0.5070.53
19_P26_A0.5070.53
63_V89_T0.5070.53
50_P56_K0.5030.53
12_L101_L0.5020.53
21_K41_N0.5010.52
16_D88_A0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ub4A 2 0.9279 100 0.26 Contact Map
4mzmA 2 0.955 100 0.271 Contact Map
1m1fA 2 0.9369 100 0.29 Contact Map
4mdxA 2 0.964 100 0.306 Contact Map
2kmtA 2 0.8829 99.2 0.676 Contact Map
3vubA 2 0.8468 98.8 0.719 Contact Map
3pmiA 4 0.7477 28.2 0.921 Contact Map
4eyzA 1 0.6126 13.7 0.932 Contact Map
4muqA 1 0.6577 12.1 0.933 Contact Map
2faoA 1 0.9189 11.8 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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