GREMLIN Database
CHAB - Cation transport regulator ChaB
UniProt: P0AE63 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12402
Length: 76 (69)
Sequences: 178 (113)
Seq/√Len: 13.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_Y53_H7.2001.00
67_G73_H4.3071.00
6_K23_D3.6360.99
6_K26_K2.9670.97
36_Y55_V2.3910.90
47_S50_E2.0140.80
63_E74_K1.6250.64
65_A73_H1.6100.63
50_E61_K1.4130.53
33_W50_E1.4120.52
16_V73_H1.3910.51
17_L21_A1.3810.51
6_K19_S1.3680.50
45_D50_E1.3670.50
46_A55_V1.3360.48
21_A29_F1.2360.43
27_E35_Q1.2210.42
33_W48_R1.2100.42
32_A36_Y1.1940.41
4_K29_F1.1600.39
4_K75_K1.1490.39
16_V71_K1.1340.38
62_H74_K1.0830.35
22_Q35_Q1.0630.34
67_G70_D1.0570.34
65_A75_K1.0560.34
45_D61_K1.0540.34
19_S23_D1.0440.33
9_L13_V1.0030.31
34_D61_K1.0010.31
23_D26_K0.9930.31
29_F62_H0.9910.31
12_S15_H0.9780.30
58_A75_K0.9550.29
46_A50_E0.9390.29
8_D17_L0.9370.28
53_H66_K0.9280.28
7_S47_S0.9250.28
35_Q38_D0.9220.28
58_A62_H0.9210.28
1_M10_P0.9070.27
35_Q55_V0.9030.27
70_D74_K0.8920.27
48_R51_T0.8830.26
37_K51_T0.8540.25
19_S45_D0.8370.24
25_Y33_W0.8370.24
12_S73_H0.8290.24
4_K11_E0.8170.24
7_S50_E0.8120.23
46_A54_K0.8000.23
7_S29_F0.7940.23
23_D33_W0.7860.22
2_P10_P0.7850.22
22_Q59_A0.7700.22
27_E63_E0.7560.21
19_S71_K0.7540.21
49_E61_K0.7540.21
26_K44_D0.7410.21
31_S71_K0.7390.21
3_Y10_P0.7370.21
5_T70_D0.7320.20
11_E14_K0.7250.20
3_Y27_E0.7150.20
26_K54_K0.7080.20
44_D63_E0.6660.18
37_K71_K0.6660.18
4_K68_D0.6640.18
64_Y72_W0.6640.18
22_Q72_W0.6380.17
31_S66_K0.6380.17
27_E31_S0.6350.17
34_D55_V0.6210.17
8_D71_K0.6210.17
14_K54_K0.6180.17
36_Y46_A0.6160.17
23_D31_S0.6130.17
20_H66_K0.6110.17
34_D48_R0.6040.16
54_K62_H0.6000.16
23_D63_E0.5950.16
21_A31_S0.5920.16
33_W53_H0.5810.16
45_D65_A0.5740.15
2_P59_A0.5710.15
12_S67_G0.5660.15
11_E70_D0.5530.15
23_D51_T0.5530.15
38_D55_V0.5510.15
13_V22_Q0.5480.15
14_K75_K0.5470.15
51_T54_K0.5450.15
38_D62_H0.5420.15
16_V26_K0.5360.14
16_V67_G0.5350.14
20_H23_D0.5350.14
22_Q58_A0.5330.14
25_Y48_R0.5320.14
7_S12_S0.5310.14
58_A63_E0.5250.14
5_T37_K0.5210.14
16_V23_D0.5150.14
46_A52_A0.5050.14
4_K19_S0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sg7A 1 0.9868 100 0.166 Contact Map
1zy7A 1 0.7632 12.1 0.929 Contact Map
3aa0A 1 0.9737 10.5 0.931 Contact Map
2xocA 1 0.3947 8.5 0.934 Contact Map
1fc6A 1 0.6053 6.2 0.938 Contact Map
4ayoA 1 0.6053 5.5 0.94 Contact Map
1wx0A 6 0.25 4.4 0.942 Contact Map
1uvqC 1 0.2632 4.3 0.942 Contact Map
1dl2A 1 0.5789 4.2 0.943 Contact Map
4ld6A 1 0.6579 4 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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