GREMLIN Database
BCP - Putative peroxiredoxin bcp
UniProt: P0AE52 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10108
Length: 156 (142)
Sequences: 11607 (7152)
Seq/√Len: 600.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_R128_A3.2601.00
14_S22_Q2.9061.00
31_Q66_D2.7921.00
41_A78_L2.6931.00
54_R88_N2.6801.00
10_A103_F2.5161.00
14_S24_N2.4791.00
127_D133_E2.4261.00
57_M61_K2.3711.00
16_P22_Q2.3011.00
17_D21_E2.1941.00
9_I131_K2.1761.00
107_G120_H2.1091.00
56_N59_E2.0241.00
12_K26_T1.9981.00
5_K8_D1.9311.00
18_Q82_A1.8761.00
24_N27_D1.8671.00
127_D131_K1.8471.00
57_M88_N1.7931.00
12_K24_N1.7761.00
72_T97_H1.7501.00
15_L92_L1.6781.00
134_H151_W1.6661.00
98_Q102_Q1.6411.00
72_T100_C1.6381.00
23_V28_F1.6251.00
50_A87_L1.6131.00
15_L99_V1.5981.00
56_N145_H1.4961.00
42_M85_E1.4941.00
17_D23_V1.4811.00
61_K66_D1.4341.00
42_M80_R1.3811.00
79_S83_E1.3581.00
65_V152_L1.3321.00
17_D90_T1.3321.00
34_L125_L1.3121.00
54_R89_F1.3071.00
28_F68_L1.3021.00
100_C119_I1.2971.00
28_F33_V1.2841.00
33_V66_D1.2781.00
126_I132_I1.2701.00
58_D61_K1.2401.00
97_H101_E1.2301.00
72_T119_I1.2081.00
146_D150_N1.2021.00
32_R65_V1.1851.00
33_V68_L1.1851.00
16_P75_P1.1741.00
56_N146_D1.1631.00
6_A134_H1.1621.00
37_F70_I1.1611.00
99_V103_F1.1551.00
51_C55_D1.1441.00
136_F151_W1.1401.00
59_E62_K1.1391.00
69_G91_L1.1391.00
32_R133_E1.1391.00
147_V150_N1.1051.00
52_G56_N1.0951.00
10_A126_I1.0871.00
36_Y50_A1.0851.00
48_V142_S1.0751.00
105_V122_I1.0661.00
76_E80_R1.0641.00
42_M84_K1.0531.00
51_C54_R1.0391.00
105_V124_F0.9961.00
97_H106_W0.9931.00
59_E149_L0.9921.00
58_D62_K0.9921.00
53_L67_V0.9861.00
33_V130_G0.9721.00
34_L123_S0.9681.00
80_R83_E0.9681.00
42_M77_K0.9591.00
13_F103_F0.9581.00
30_G128_A0.9531.00
10_A132_I0.9431.00
25_L33_V0.9411.00
36_Y89_F0.9301.00
52_G55_D0.9241.00
12_K25_L0.9201.00
143_N146_D0.9191.00
101_E106_W0.9141.00
79_S82_A0.9131.00
19_D79_S0.9061.00
125_L134_H0.9041.00
125_L151_W0.9041.00
66_D90_T0.9021.00
13_F99_V0.8901.00
75_P93_S0.8881.00
17_D92_L0.8871.00
23_V68_L0.8761.00
74_K77_K0.8741.00
97_H100_C0.8731.00
68_L92_L0.8681.00
35_V126_I0.8621.00
17_D20_G0.8601.00
98_Q101_E0.8591.00
47_T85_E0.8451.00
124_F132_I0.8371.00
34_L65_V0.8281.00
33_V126_I0.8261.00
29_Q130_G0.8261.00
63_A152_L0.8161.00
100_C106_W0.8151.00
6_A132_I0.8081.00
108_E111_F0.8051.00
140_K143_N0.7961.00
81_F85_E0.7901.00
32_R64_G0.7881.00
64_G128_A0.7871.00
48_V51_C0.7871.00
6_A135_V0.7841.00
70_I99_V0.7831.00
133_E138_D0.7781.00
107_G110_S0.7761.00
143_N147_V0.7711.00
51_C85_E0.7691.00
10_A25_L0.7681.00
49_Q123_S0.7671.00
125_L136_F0.7651.00
54_R57_M0.7611.00
134_H147_V0.7581.00
35_V103_F0.7551.00
16_P95_E0.7551.00
26_T29_Q0.7521.00
5_K135_V0.7491.00
109_K118_G0.7471.00
19_D82_A0.7441.00
18_Q90_T0.7431.00
136_F148_V0.7421.00
60_L149_L0.7371.00
120_H138_D0.7291.00
25_L28_F0.7241.00
58_D88_N0.7191.00
122_I135_V0.7121.00
76_E79_S0.6961.00
40_K73_D0.6961.00
37_F105_V0.6921.00
53_L148_V0.6871.00
34_L53_L0.6811.00
43_T121_R0.6801.00
120_H137_D0.6711.00
78_L81_F0.6671.00
40_K118_G0.6641.00
110_S118_G0.6601.00
59_E63_A0.6581.00
39_P43_T0.6511.00
75_P79_S0.6501.00
49_Q53_L0.6491.00
32_R125_L0.6491.00
38_Y41_A0.6481.00
63_A149_L0.6431.00
18_Q79_S0.6401.00
82_A91_L0.6381.00
50_A69_G0.6361.00
123_S148_V0.6351.00
11_P102_Q0.6351.00
52_G145_H0.6351.00
28_F66_D0.6321.00
36_Y49_Q0.6321.00
41_A77_K0.6291.00
74_K95_E0.6281.00
10_A99_V0.6241.00
54_R58_D0.6231.00
9_I29_Q0.6201.00
99_V102_Q0.6181.00
8_D135_V0.6141.00
38_Y69_G0.5961.00
37_F103_F0.5941.00
34_L148_V0.5941.00
73_D77_K0.5931.00
56_N60_L0.5911.00
44_P47_T0.5881.00
57_M66_D0.5841.00
40_K43_T0.5831.00
124_F135_V0.5771.00
137_D141_T0.5721.00
32_R152_L0.5701.00
107_G118_G0.5671.00
138_D142_S0.5651.00
94_D97_H0.5591.00
53_L145_H0.5560.99
77_K80_R0.5560.99
68_L90_T0.5540.99
126_I130_G0.5520.99
60_L65_V0.5460.99
57_M67_V0.5440.99
125_L148_V0.5350.99
78_L93_S0.5310.99
36_Y69_G0.5310.99
100_C105_V0.5300.99
34_L152_L0.5290.99
23_V27_D0.5220.99
29_Q129_D0.5210.99
36_Y53_L0.5190.99
105_V120_H0.5180.99
31_Q64_G0.5170.99
13_F25_L0.5120.99
20_G75_P0.5110.99
107_G111_F0.5090.99
38_Y81_F0.5090.99
16_P20_G0.5080.99
35_V68_L0.5070.99
12_K29_Q0.5060.99
36_Y123_S0.5040.99
67_V89_F0.5010.99
40_K74_K0.5000.99
39_P121_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1prxA 2 0.9936 100 0.258 Contact Map
2v2gA 2 0.9808 100 0.265 Contact Map
1xccA 2 0.9808 100 0.273 Contact Map
3a2vA 5 0.9615 100 0.29 Contact Map
1xiyA 1 0.9615 100 0.294 Contact Map
3w6gA 6 0.9359 100 0.295 Contact Map
2xhfA 2 0.9295 100 0.314 Contact Map
3ixrA 1 0.9872 100 0.318 Contact Map
1xvwA 3 0.9615 100 0.32 Contact Map
3tjjA 3 0.9615 100 0.328 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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