GREMLIN Database
YTFP - Gamma-glutamylcyclotransferase family protein YtfP
UniProt: P0AE48 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12516
Length: 113 (107)
Sequences: 413 (314)
Seq/√Len: 30.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_R107_D4.9691.00
4_F53_G4.8731.00
72_R77_A3.1351.00
15_N69_L3.0311.00
3_I66_L2.9691.00
67_D78_R2.8271.00
55_V88_A2.7321.00
10_R109_L2.6741.00
59_D62_T2.6241.00
23_Q57_R2.2720.99
46_P79_Q1.9750.97
67_D91_Y1.8680.96
34_Q102_L1.8030.95
13_Q109_L1.7290.93
30_I44_A1.6250.91
83_T86_G1.5180.88
35_L44_A1.4630.86
59_D63_L1.4630.86
28_F31_D1.4540.86
43_G93_Y1.4460.85
28_F83_T1.4280.85
63_L78_R1.4250.84
41_Y71_T1.3460.81
55_V85_Y1.3460.81
42_P54_E1.3230.80
69_L89_W1.3230.80
5_V9_L1.3140.79
43_G94_Q1.3100.79
9_L54_E1.2980.78
3_I8_S1.2800.77
78_R91_Y1.2620.76
19_M22_A1.2390.75
9_L15_N1.2310.74
83_T88_A1.2260.74
9_L42_P1.2060.73
12_K16_S1.2050.73
76_Y103_I1.1730.71
80_L87_S1.1710.71
29_S52_H1.1570.70
78_R89_W1.1320.68
72_R75_E1.1260.68
103_I106_G1.1150.67
44_A90_M1.1140.67
3_I63_L1.1090.66
55_V83_T1.1080.66
3_I69_L1.1070.66
5_V15_N1.0910.65
58_I63_L1.0370.61
55_V76_Y1.0190.60
30_I33_Y1.0090.59
5_V42_P0.9980.58
13_Q108_W0.9800.57
26_G56_Y0.9670.56
21_N33_Y0.9650.56
5_V54_E0.9620.55
97_V100_L0.9040.51
3_I78_R0.8980.50
19_M68_A0.8970.50
102_L105_S0.8810.49
54_E91_Y0.8810.49
26_G85_Y0.8720.48
33_Y92_V0.8660.48
53_G70_R0.8650.48
32_N49_G0.8640.48
44_A51_V0.8530.47
29_S50_T0.8520.47
34_Q37_S0.8430.46
61_A97_V0.8350.45
33_Y90_M0.8250.44
41_Y75_E0.8150.44
32_N46_P0.8050.43
38_L43_G0.7980.42
55_V84_P0.7950.42
30_I81_I0.7870.41
48_N51_V0.7820.41
27_D79_Q0.7790.41
96_P105_S0.7750.41
71_T76_Y0.7640.40
35_L82_Q0.7550.39
76_Y101_K0.7500.39
45_V80_L0.7490.39
51_V90_M0.7480.38
8_S103_I0.7410.38
64_A71_T0.7370.38
28_F33_Y0.7360.38
71_T75_E0.7300.37
9_L69_L0.7270.37
44_A92_V0.7240.37
81_I90_M0.7200.36
61_A65_E0.7180.36
96_P101_K0.7110.36
8_S69_L0.7090.36
51_V95_R0.7090.36
83_T90_M0.7010.35
28_F108_W0.7010.35
24_L27_D0.7000.35
8_S12_K0.6950.35
42_P78_R0.6950.35
31_D34_Q0.6890.34
3_I76_Y0.6880.34
8_S37_S0.6770.33
42_P69_L0.6740.33
82_Q87_S0.6660.32
16_S54_E0.6660.32
23_Q29_S0.6660.32
5_V69_L0.6590.32
9_L91_Y0.6580.32
39_G69_L0.6560.32
8_S15_N0.6470.31
22_A59_D0.6400.31
21_N62_T0.6390.31
6_Y9_L0.6380.31
11_H46_P0.6370.30
9_L67_D0.6360.30
32_N50_T0.6350.30
16_S42_P0.6320.30
47_G55_V0.6310.30
58_I62_T0.6290.30
71_T89_W0.6240.30
33_Y77_A0.6220.29
78_R84_P0.6200.29
13_Q44_A0.6190.29
22_A88_A0.6170.29
15_N108_W0.6130.29
65_E76_Y0.6130.29
80_L86_G0.6120.29
3_I88_A0.6090.29
20_T49_G0.6090.29
60_N95_R0.6000.28
3_I42_P0.5970.28
83_T93_Y0.5870.27
74_G77_A0.5850.27
3_I90_M0.5840.27
21_N29_S0.5770.27
5_V16_S0.5760.27
75_E95_R0.5760.27
87_S95_R0.5710.26
30_I109_L0.5680.26
11_H87_S0.5580.25
73_G94_Q0.5580.25
28_F88_A0.5570.25
56_Y83_T0.5570.25
33_Y40_H0.5530.25
56_Y86_G0.5490.25
11_H64_A0.5440.25
19_M56_Y0.5400.24
4_F70_R0.5380.24
36_Y42_P0.5370.24
37_S106_G0.5330.24
20_T96_P0.5330.24
17_H85_Y0.5310.24
36_Y90_M0.5300.24
5_V11_H0.5260.24
17_H90_M0.5250.23
27_D35_L0.5220.23
7_G42_P0.5160.23
28_F107_D0.5050.22
47_G106_G0.5010.22
84_P90_M0.5010.22
18_W69_L0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xhsA 1 1 100 0.261 Contact Map
1v30A 1 0.9735 100 0.28 Contact Map
2qikA 1 0.9027 99.9 0.35 Contact Map
1vkbA 1 0.9823 99.9 0.356 Contact Map
4issA 2 0.9735 99.9 0.364 Contact Map
4gysA 2 0 99.9 0.409 Contact Map
2g0qA 1 0.9558 99.8 0.464 Contact Map
2jqvA 1 0.9558 99.8 0.481 Contact Map
3judA 1 0.9735 99.8 0.496 Contact Map
3cryA 2 0.9735 99.7 0.551 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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