GREMLIN Database
YTFL - UPF0053 inner membrane protein YtfL
UniProt: P0AE45 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12512
Length: 447 (410)
Sequences: 7402 (4935)
Seq/√Len: 243.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
222_V322_I4.1361.00
392_K398_D3.9451.00
355_I422_V3.8061.00
401_K406_K3.4801.00
399_S406_K3.4261.00
399_S408_E3.3111.00
250_N255_H3.2171.00
386_M420_L3.0101.00
289_V298_A2.9841.00
230_D233_S2.9751.00
354_L410_V2.9161.00
229_E233_S2.8971.00
250_N280_G2.8471.00
224_W249_C2.8271.00
264_D284_R2.8071.00
349_D352_S2.7721.00
406_K423_T2.7221.00
408_E423_T2.6951.00
128_A131_A2.6391.00
248_V283_I2.5821.00
354_L419_Q2.5811.00
141_R145_Y2.5101.00
406_K425_I2.4861.00
311_V322_I2.4641.00
227_L250_N2.4211.00
111_G157_L2.4041.00
212_V298_A2.3851.00
293_L301_S2.3741.00
152_W156_G2.3661.00
364_V368_L2.3051.00
222_V319_V2.2651.00
33_L47_V2.2431.00
385_F402_F2.2041.00
410_V421_L2.1761.00
311_V319_V2.1361.00
278_N281_V2.1051.00
382_I420_L2.0931.00
348_R352_S2.0771.00
17_F139_P2.0761.00
224_W253_I2.0621.00
352_S421_L2.0241.00
46_R141_R2.0181.00
411_D419_Q2.0081.00
15_S69_A1.9821.00
46_R138_N1.9761.00
225_F234_L1.9621.00
298_A323_I1.9521.00
227_L280_G1.9471.00
56_M148_T1.9391.00
364_V422_V1.8981.00
359_T364_V1.8901.00
259_Y286_T1.8821.00
215_S295_L1.8731.00
227_L257_I1.8641.00
37_A48_L1.8521.00
160_I164_I1.8501.00
135_R139_P1.8371.00
413_D418_D1.8221.00
352_S423_T1.8161.00
36_L134_L1.8111.00
32_K130_E1.7811.00
225_F248_V1.7781.00
249_C256_I1.7671.00
41_N134_L1.7661.00
184_V201_I1.7491.00
236_N240_E1.7391.00
411_D418_D1.7351.00
49_N141_R1.7231.00
345_I359_T1.7141.00
229_E234_L1.6971.00
354_L421_L1.6471.00
228_H250_N1.6271.00
359_T382_I1.6261.00
215_S323_I1.6221.00
309_F322_I1.6141.00
347_A350_E1.6121.00
210_R214_S1.6031.00
365_M370_I1.5971.00
326_N330_T1.5941.00
408_E421_L1.5871.00
347_A353_W1.5821.00
21_S136_I1.5731.00
364_V382_I1.5651.00
244_S261_D1.5641.00
355_I382_I1.5531.00
15_S65_L1.5471.00
223_I237_K1.5311.00
407_F420_L1.5301.00
156_G160_I1.5261.00
386_M407_F1.5251.00
204_V332_L1.5231.00
46_R137_I1.5001.00
200_L204_V1.4941.00
291_D320_V1.4901.00
404_G425_I1.4861.00
200_L332_L1.4811.00
7_V75_V1.4701.00
348_R351_N1.4631.00
252_D255_H1.4501.00
226_D229_E1.4341.00
387_M417_I1.4321.00
293_L298_A1.4201.00
295_L328_V1.4201.00
43_N134_L1.4111.00
300_E303_K1.4071.00
254_D318_L1.4061.00
401_K425_I1.4031.00
223_I243_H1.4011.00
329_M333_M1.3961.00
386_M409_V1.3861.00
131_A135_R1.3801.00
402_F407_F1.3771.00
348_R421_L1.3711.00
34_K38_D1.3691.00
386_M400_V1.3611.00
250_N257_I1.3601.00
355_I364_V1.3591.00
405_Y424_R1.3481.00
379_Y388_F1.3461.00
47_V137_I1.3421.00
60_V143_C1.3351.00
120_T161_I1.3341.00
34_K48_L1.3321.00
410_V419_Q1.3321.00
389_M402_F1.3311.00
20_M132_V1.3291.00
103_I107_S1.3251.00
36_L41_N1.3251.00
245_K308_D1.3231.00
233_S236_N1.3161.00
45_Q49_N1.3151.00
220_E318_L1.3111.00
259_Y309_F1.3081.00
404_G424_R1.2941.00
136_I139_P1.2891.00
47_V133_A1.2861.00
6_L10_C1.2861.00
219_R254_D1.2811.00
348_R354_L1.2761.00
43_N138_N1.2751.00
40_G44_A1.2711.00
5_I9_L1.2671.00
70_I73_G1.2641.00
223_I241_H1.2611.00
156_G159_N1.2531.00
405_Y422_V1.2441.00
139_P142_F1.2431.00
386_M390_L1.2331.00
17_F136_I1.2301.00
345_I367_V1.2241.00
145_Y148_T1.2231.00
48_L52_E1.2161.00
148_T152_W1.2091.00
361_I365_M1.2061.00
309_F324_T1.2051.00
99_Q103_I1.2001.00
76_G109_V1.1991.00
138_N142_F1.1951.00
60_V151_V1.1921.00
41_N44_A1.1811.00
18_F64_G1.1791.00
229_E237_K1.1731.00
124_I167_L1.1681.00
10_C14_V1.1581.00
338_G341_L1.1481.00
14_V68_V1.1471.00
223_I246_F1.1411.00
37_A45_Q1.1411.00
226_D251_E1.1371.00
256_I311_V1.1271.00
23_I26_A1.1251.00
219_R318_L1.1241.00
301_S305_A1.1221.00
326_N336_L1.1121.00
18_F143_C1.1071.00
241_H246_F1.1051.00
286_T311_V1.1041.00
351_N424_R1.1001.00
276_A279_S1.0991.00
33_L48_L1.0971.00
290_P293_L1.0831.00
212_V312_I1.0791.00
268_R282_Q1.0791.00
400_V407_F1.0711.00
365_M373_F1.0701.00
260_V282_Q1.0701.00
336_L341_L1.0641.00
245_K326_N1.0631.00
162_F167_L1.0571.00
212_V289_V1.0561.00
62_Q65_L1.0531.00
43_N47_V1.0531.00
254_D319_V1.0471.00
368_L405_Y1.0441.00
15_S19_S1.0431.00
387_M393_I1.0401.00
383_G387_M1.0381.00
69_A113_F1.0341.00
65_L69_A1.0331.00
346_V354_L1.0261.00
221_N416_R1.0211.00
224_W319_V1.0171.00
28_S33_L1.0161.00
50_M57_F1.0151.00
257_I283_I0.9971.00
385_F407_F0.9881.00
117_A122_K0.9831.00
407_F422_V0.9821.00
232_Q236_N0.9791.00
101_S105_S0.9771.00
225_F279_S0.9771.00
8_I72_G0.9751.00
42_I45_Q0.9721.00
163_R168_P0.9671.00
49_N53_N0.9641.00
19_S23_I0.9631.00
180_I187_G0.9601.00
153_F156_G0.9561.00
160_I163_R0.9551.00
175_I183_V0.9541.00
53_N56_M0.9521.00
28_S129_P0.9501.00
235_K239_A0.9501.00
97_S101_S0.9491.00
227_L283_I0.9491.00
142_F145_Y0.9481.00
226_D249_C0.9451.00
302_F310_A0.9411.00
356_D419_Q0.9401.00
289_V310_A0.9381.00
33_L51_Q0.9381.00
401_K404_G0.9371.00
365_M371_D0.9341.00
238_V246_F0.9331.00
8_I109_V0.9321.00
251_E255_H0.9211.00
215_S328_V0.9191.00
357_G382_I0.9161.00
188_A198_H0.9141.00
389_M400_V0.9131.00
390_L400_V0.9111.00
287_L301_S0.9101.00
22_E122_K0.9071.00
21_S140_M0.9051.00
236_N239_A0.9041.00
373_F385_F0.9021.00
293_L297_E0.9001.00
44_A134_L0.8951.00
213_P291_D0.8941.00
345_I353_W0.8901.00
396_R411_D0.8901.00
76_G80_F0.8871.00
231_E234_L0.8841.00
8_I79_A0.8821.00
289_V312_I0.8700.99
74_I106_F0.8690.99
35_L39_E0.8680.99
221_N358_G0.8670.99
187_G191_G0.8650.99
135_R138_N0.8640.99
280_G283_I0.8620.99
20_M125_G0.8620.99
345_I355_I0.8620.99
100_L104_L0.8590.99
326_N341_L0.8560.99
337_V344_Q0.8530.99
308_D329_M0.8500.99
107_S111_G0.8490.99
118_D122_K0.8480.99
74_I77_D0.8430.99
12_I117_A0.8410.99
180_I193_L0.8410.99
212_V323_I0.8380.99
360_P363_D0.8380.99
357_G383_G0.8380.99
207_L299_L0.8380.99
149_P153_F0.8350.99
236_N270_L0.8350.99
144_L148_T0.8330.99
287_L310_A0.8330.99
390_L394_P0.8310.99
77_D105_S0.8270.99
238_V265_L0.8230.99
72_G109_V0.8210.99
314_N320_V0.8200.99
159_N169_M0.8180.99
207_L328_V0.8180.99
133_A137_I0.8170.99
37_A41_N0.8150.99
159_N163_R0.8150.99
383_G416_R0.8120.99
227_L234_L0.8100.99
385_F389_M0.8030.99
70_I106_F0.7980.99
337_V343_E0.7910.99
50_M137_I0.7910.99
46_R49_N0.7900.99
228_H280_G0.7860.99
32_K36_L0.7860.99
314_N317_A0.7850.99
177_S209_S0.7840.99
17_F64_G0.7820.99
264_D340_G0.7820.99
326_N335_D0.7800.99
60_V144_L0.7730.99
335_D338_G0.7720.99
222_V253_I0.7720.99
7_V11_L0.7700.99
7_V10_C0.7690.99
65_L118_D0.7680.99
20_M24_S0.7680.99
330_T335_D0.7670.99
66_N110_T0.7670.99
207_L296_S0.7660.99
81_S85_H0.7650.99
16_A20_M0.7600.99
256_I319_V0.7570.98
247_L311_V0.7560.98
315_E384_G0.7500.98
257_I280_G0.7500.98
61_V140_M0.7470.98
65_L113_F0.7450.98
200_L207_L0.7440.98
12_I112_M0.7430.98
374_P379_Y0.7410.98
314_N318_L0.7400.98
70_I110_T0.7400.98
326_N339_Q0.7400.98
15_S113_F0.7390.98
225_F246_F0.7390.98
55_G123_R0.7380.98
138_N141_R0.7380.98
348_R411_D0.7380.98
119_L154_F0.7370.98
326_N331_T0.7360.98
73_G77_D0.7350.98
36_L39_E0.7340.98
81_S101_S0.7310.98
238_V262_S0.7310.98
177_S181_Y0.7290.98
247_L256_I0.7280.98
357_G417_I0.7280.98
290_P315_E0.7280.98
62_Q69_A0.7270.98
261_D264_D0.7260.98
73_G76_G0.7250.98
245_K261_D0.7220.98
12_I72_G0.7220.98
28_S47_V0.7220.98
356_D359_T0.7210.98
330_T338_G0.7210.98
65_L119_L0.7200.98
65_L68_V0.7190.98
219_R314_N0.7180.98
213_P320_V0.7170.98
379_Y385_F0.7160.98
308_D326_N0.7160.98
30_K52_E0.7130.98
70_I77_D0.7120.98
32_K35_L0.7110.98
287_L305_A0.7080.98
23_I125_G0.7040.98
269_V272_N0.7040.98
15_S66_N0.7030.98
244_S263_K0.7010.97
15_S68_V0.7000.97
217_T337_V0.7000.97
11_L71_L0.6980.97
66_N122_K0.6940.97
212_V293_L0.6930.97
132_V136_I0.6930.97
371_D403_A0.6920.97
336_L339_Q0.6920.97
301_S304_T0.6910.97
247_L259_Y0.6860.97
231_E277_L0.6850.97
281_V285_N0.6840.97
249_C252_D0.6830.97
71_L102_F0.6830.97
24_S133_A0.6780.97
62_Q66_N0.6750.97
211_T214_S0.6740.97
326_N338_G0.6730.97
177_S205_F0.6720.97
43_N46_R0.6700.97
361_I379_Y0.6690.97
181_Y202_E0.6690.97
393_I412_I0.6680.97
13_A16_A0.6680.97
370_I405_Y0.6670.97
234_L238_V0.6650.97
223_I240_E0.6650.97
198_H202_E0.6640.97
177_S208_E0.6630.97
389_M403_A0.6620.96
351_N426_D0.6620.96
390_L398_D0.6570.96
62_Q73_G0.6570.96
54_P57_F0.6560.96
68_V72_G0.6560.96
77_D81_S0.6550.96
378_N388_F0.6540.96
325_L336_L0.6520.96
150_L154_F0.6520.96
43_N137_I0.6510.96
239_A271_A0.6510.96
66_N113_F0.6500.96
74_I102_F0.6490.96
239_A267_N0.6470.96
43_N135_R0.6470.96
15_S62_Q0.6450.96
245_K309_F0.6440.96
19_S113_F0.6430.96
203_N332_L0.6430.96
37_A40_G0.6420.96
72_G113_F0.6380.96
12_I15_S0.6380.96
55_G159_N0.6380.96
331_T335_D0.6370.96
142_F146_V0.6370.96
116_F161_I0.6360.96
273_Q276_A0.6360.96
219_R315_E0.6350.96
225_F237_K0.6350.96
347_A352_S0.6330.95
286_T309_F0.6320.95
364_V367_V0.6310.95
65_L117_A0.6300.95
19_S118_D0.6280.95
225_F238_V0.6270.95
396_R412_I0.6250.95
14_V18_F0.6230.95
227_L230_D0.6230.95
345_I364_V0.6230.95
110_T114_I0.6230.95
361_I373_F0.6190.95
299_L333_M0.6190.95
80_F105_S0.6180.95
49_N145_Y0.6180.95
22_E118_D0.6170.95
102_F106_F0.6170.95
68_V110_T0.6170.95
298_A328_V0.6160.95
249_C253_I0.6140.95
351_N423_T0.6140.95
300_E304_T0.6130.95
168_P171_R0.6130.95
365_M377_G0.6100.94
85_H98_E0.6090.94
63_I150_L0.6080.94
96_L99_Q0.6080.94
237_K240_E0.6070.94
143_C147_C0.6060.94
36_L44_A0.6050.94
23_I63_I0.6030.94
50_M144_L0.6030.94
199_E203_N0.6020.94
256_I288_I0.6010.94
244_S338_G0.5990.94
33_L44_A0.5980.94
277_L281_V0.5980.94
154_F158_A0.5970.94
184_V188_A0.5950.94
347_A351_N0.5950.94
313_M319_V0.5940.94
346_V350_E0.5940.94
287_L307_E0.5930.94
58_F62_Q0.5920.94
299_L325_L0.5910.93
261_D284_R0.5900.93
19_S65_L0.5890.93
367_V370_I0.5890.93
361_I364_V0.5890.93
383_G417_I0.5890.93
127_I167_L0.5880.93
28_S130_E0.5870.93
201_I205_F0.5870.93
95_E99_Q0.5850.93
330_T341_L0.5850.93
66_N106_F0.5850.93
335_D339_Q0.5840.93
58_F117_A0.5830.93
70_I105_S0.5830.93
37_A43_N0.5820.93
412_I415_Y0.5820.93
244_S339_Q0.5810.93
106_F109_V0.5800.93
206_E209_S0.5770.93
238_V266_L0.5770.93
346_V419_Q0.5770.93
299_L328_V0.5770.93
395_K398_D0.5770.93
233_S237_K0.5750.93
308_D336_L0.5740.92
62_Q119_L0.5730.92
73_G110_T0.5720.92
66_N69_A0.5720.92
329_M336_L0.5710.92
53_N144_L0.5710.92
85_H101_S0.5700.92
51_Q54_P0.5690.92
225_F229_E0.5690.92
131_A134_L0.5690.92
147_C150_L0.5680.92
146_V149_P0.5670.92
212_V294_T0.5660.92
28_S57_F0.5660.92
326_N340_G0.5660.92
401_K423_T0.5660.92
214_S380_E0.5650.92
283_I286_T0.5650.92
259_Y283_I0.5650.92
49_N52_E0.5600.92
245_K339_Q0.5600.92
163_R169_M0.5600.92
161_I165_F0.5580.91
16_A117_A0.5580.91
66_N70_I0.5570.91
247_L380_E0.5550.91
74_I78_A0.5550.91
123_R126_M0.5540.91
4_S8_I0.5530.91
129_P132_V0.5530.91
359_T363_D0.5530.91
71_L75_V0.5530.91
234_L279_S0.5530.91
63_I110_T0.5520.91
208_E296_S0.5520.91
298_A302_F0.5500.91
23_I62_Q0.5500.91
45_Q48_L0.5490.91
213_P380_E0.5480.91
365_M376_S0.5480.91
361_I382_I0.5470.91
19_S69_A0.5470.91
81_S98_E0.5460.91
219_R316_Y0.5460.91
56_M144_L0.5450.90
30_K48_L0.5430.90
365_M374_P0.5430.90
5_I79_A0.5420.90
19_S77_D0.5410.90
26_A59_T0.5400.90
406_K410_V0.5390.90
29_R179_D0.5390.90
22_E66_N0.5380.90
74_I109_V0.5380.90
168_P172_K0.5380.90
288_I313_M0.5380.90
31_I182_A0.5360.90
330_T336_L0.5360.90
85_H97_S0.5350.90
162_F166_K0.5350.90
155_N158_A0.5320.89
417_I420_L0.5320.89
329_M338_G0.5320.89
179_D187_G0.5320.89
47_V51_Q0.5310.89
61_V68_V0.5310.89
62_Q113_F0.5300.89
129_P133_A0.5300.89
181_Y206_E0.5290.89
57_F63_I0.5290.89
374_P377_G0.5280.89
11_L68_V0.5270.89
21_S25_L0.5270.89
254_D315_E0.5270.89
348_R418_D0.5260.89
68_V106_F0.5260.89
73_G78_A0.5260.89
58_F122_K0.5250.89
297_E300_E0.5250.89
59_T66_N0.5240.89
385_F400_V0.5230.89
27_A126_M0.5210.88
187_G192_V0.5200.88
69_A119_L0.5190.88
326_N333_M0.5190.88
418_D421_L0.5180.88
325_L333_M0.5180.88
245_K259_Y0.5170.88
19_S66_N0.5160.88
185_E202_E0.5160.88
353_W367_V0.5150.88
77_D114_I0.5140.88
19_S61_V0.5140.88
387_M398_D0.5120.88
330_T339_Q0.5120.88
226_D250_N0.5120.88
73_G106_F0.5110.87
77_D102_F0.5110.87
268_R272_N0.5110.87
207_L294_T0.5100.87
219_R320_V0.5100.87
214_S387_M0.5100.87
244_S308_D0.5100.87
124_I128_A0.5090.87
290_P313_M0.5080.87
261_D308_D0.5080.87
205_F208_E0.5070.87
215_S331_T0.5060.87
253_I319_V0.5060.87
308_D325_L0.5060.87
28_S36_L0.5060.87
272_N276_A0.5050.87
355_I367_V0.5050.87
248_V279_S0.5050.87
272_N277_L0.5030.87
385_F403_A0.5020.87
368_L422_V0.5010.86
23_I54_P0.5010.86
289_V293_L0.5010.86
227_L278_N0.5010.86
25_L133_A0.5000.86
213_P217_T0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hg0A 2 0.5123 100 0.51 Contact Map
3lhhA 1 0.2796 100 0.77 Contact Map
3ocoA 2 0.302 99.9 0.787 Contact Map
3oi8A 2 0.349 99.9 0.788 Contact Map
3ocmA 5 0.3333 99.9 0.788 Contact Map
2v8qE 1 0.5347 99.9 0.795 Contact Map
3kxrA 3 0.3602 99.9 0.802 Contact Map
3lv9A 2 0.2908 99.9 0.803 Contact Map
4iysA 2 0.3177 99.9 0.81 Contact Map
3t4nC 1 0.566 99.9 0.816 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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