GREMLIN Database
ASTA - Arginine N-succinyltransferase
UniProt: P0AE37 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13998
Length: 344 (334)
Sequences: 690 (413)
Seq/√Len: 22.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
178_S218_S4.2721.00
236_R259_L4.2571.00
277_V326_C3.7921.00
60_F147_F3.6711.00
177_Q181_K3.6591.00
272_S333_R3.5321.00
326_C332_V3.4261.00
279_E321_L3.4191.00
268_A335_V3.3851.00
219_Q223_D3.2281.00
16_M33_E3.1661.00
318_A322_D3.1611.00
303_V320_Q2.9300.99
292_V316_L2.8560.99
307_T314_L2.7880.99
49_G56_Q2.7620.99
76_I148_M2.7450.99
148_M159_V2.6970.99
21_K128_D2.6660.99
292_V305_V2.6290.99
187_D190_R2.5850.99
150_A295_E2.5170.98
201_A205_E2.4590.98
236_R240_E2.3750.98
152_R264_D2.3120.97
13_S33_E2.2830.97
250_I255_G2.2790.97
317_T320_Q2.2690.97
172_Y177_Q2.2090.96
193_F197_T2.1350.95
149_A333_R2.1350.95
103_V186_M2.1090.95
237_A240_E2.0860.95
53_K56_Q2.0860.95
148_M263_I2.0840.95
43_A47_W2.0470.94
88_N258_T2.0340.94
164_R235_A1.9960.93
296_N299_H1.9810.93
25_G164_R1.9670.93
137_G164_R1.9630.93
12_V33_E1.9520.92
88_N113_S1.9250.92
12_V36_L1.9010.91
163_M232_T1.8890.91
87_Y204_A1.8680.91
30_P196_G1.8220.89
115_D249_Y1.8170.89
121_E137_G1.7730.88
278_A328_A1.7700.88
149_A272_S1.7640.88
56_Q154_K1.7570.88
122_L145_F1.7320.87
9_R44_I1.7090.86
74_C143_S1.6960.86
92_G109_T1.6870.85
7_V40_I1.6690.85
18_L39_R1.6640.85
143_S293_A1.6230.83
146_M293_A1.6150.83
245_R265_R1.5980.82
55_E83_N1.5940.82
145_F232_T1.5920.82
275_V334_L1.5800.81
150_A274_L1.5670.81
249_Y258_T1.5170.79
87_Y207_M1.4990.78
250_I332_V1.4950.78
141_S145_F1.4900.77
120_S156_N1.4800.77
127_L140_L1.4610.76
148_M152_R1.4410.75
204_A252_I1.4400.75
84_D205_E1.4300.74
41_E44_I1.4200.74
184_F207_M1.4050.73
295_E300_F1.4030.73
125_L137_G1.3990.73
95_V204_A1.3910.72
121_E192_D1.3860.72
299_H325_K1.3720.71
59_V75_A1.3700.71
6_P47_W1.3670.71
75_A124_T1.3640.71
42_R55_E1.3630.71
132_R137_G1.3570.70
321_L326_C1.3560.70
137_G235_A1.3540.70
113_S205_E1.3400.69
43_A300_F1.3310.69
280_G315_I1.3250.68
242_E268_A1.3190.68
17_Q128_D1.3120.68
7_V15_L1.3000.67
327_H330_D1.2990.67
46_T78_V1.2890.66
228_V236_R1.2720.65
141_S200_K1.2710.65
262_D265_R1.2600.64
164_R229_H1.2540.64
166_V223_D1.2510.64
322_D325_K1.2510.64
157_D262_D1.2410.63
179_L212_I1.2240.62
152_R263_I1.2160.62
109_T112_L1.2140.61
120_S261_C1.2130.61
109_T205_E1.2120.61
229_H235_A1.2090.61
60_F76_I1.1960.60
139_L291_L1.1930.60
79_A122_L1.1820.59
316_L321_L1.1780.59
64_D131_W1.1750.59
100_E204_A1.1740.59
86_W252_I1.1710.59
191_A206_L1.1680.58
105_N185_S1.1630.58
125_L132_R1.1610.58
91_V246_Y1.1540.57
80_V121_E1.1510.57
2_M136_N1.1440.57
123_C200_K1.1430.57
296_N325_K1.1350.56
137_G192_D1.1320.56
314_L334_L1.1290.56
123_C145_F1.1260.55
142_K242_E1.1190.55
42_R46_T1.1170.55
141_S232_T1.1080.54
96_H187_D1.1050.54
71_A131_W1.1020.54
192_D195_C1.0980.54
9_R41_E1.0920.53
42_R57_G1.0860.53
162_E191_A1.0700.52
29_L36_L1.0670.51
55_E78_V1.0670.51
59_V160_V1.0660.51
276_E331_R1.0640.51
150_A333_R1.0640.51
58_Y108_P1.0620.51
18_L88_N1.0500.50
125_L164_R1.0480.50
121_E125_L1.0450.50
89_Y252_I1.0450.50
121_E164_R1.0400.50
164_R188_F1.0390.50
113_S179_L1.0350.49
168_D172_Y1.0320.49
188_F192_D1.0320.49
277_V316_L1.0320.49
25_G229_H1.0310.49
147_F151_F1.0260.49
38_A220_E1.0110.48
316_L320_Q1.0080.47
4_I148_M1.0040.47
32_N197_T1.0000.47
69_T128_D0.9990.47
93_T106_A0.9950.46
61_V76_I0.9940.46
43_A216_F0.9940.46
143_S329_G0.9930.46
16_M31_A0.9910.46
7_V47_W0.9900.46
125_L235_A0.9840.46
27_T164_R0.9820.46
84_D200_K0.9810.46
25_G235_A0.9780.45
8_E44_I0.9760.45
43_A244_F0.9660.45
151_F233_A0.9640.44
305_V334_L0.9600.44
23_G27_T0.9550.44
165_G229_H0.9520.44
154_K297_Y0.9480.43
204_A249_Y0.9460.43
148_M151_F0.9440.43
242_E267_R0.9390.43
107_L215_H0.9390.43
95_V117_T0.9350.42
62_L143_S0.9310.42
244_F266_V0.9290.42
79_A117_T0.9210.41
28_S124_T0.9210.41
58_Y78_V0.9200.41
204_A207_M0.9200.41
142_K268_A0.9180.41
77_E123_C0.9180.41
96_H200_K0.9030.40
60_F141_S0.9020.40
145_F266_V0.9020.40
277_V321_L0.8950.40
207_M252_I0.8940.40
14_A70_V0.8930.40
65_S323_A0.8920.40
14_A69_T0.8870.39
67_T281_Q0.8870.39
267_R301_R0.8860.39
4_I143_S0.8860.39
113_S116_H0.8850.39
23_G164_R0.8820.39
278_A283_A0.8790.39
121_E161_A0.8750.38
166_V227_Q0.8660.38
69_T130_D0.8650.38
120_S124_T0.8630.38
96_H205_E0.8600.37
176_W180_G0.8590.37
295_E333_R0.8580.37
112_L252_I0.8580.37
80_V192_D0.8550.37
4_I169_E0.8530.37
23_G121_E0.8530.37
230_P233_A0.8510.37
225_I229_H0.8490.37
169_E317_T0.8400.36
122_L201_A0.8330.36
62_L85_P0.8290.35
4_I74_C0.8290.35
103_V141_S0.8270.35
183_F213_Y0.8250.35
99_K210_H0.8230.35
188_F242_E0.8230.35
163_M228_V0.8210.35
18_L180_G0.8200.35
200_K232_T0.8200.35
226_G250_I0.8180.35
25_G137_G0.8170.35
108_P158_K0.8140.35
114_N203_I0.8130.34
147_F261_C0.8130.34
114_N209_K0.8110.34
143_S302_V0.8110.34
47_W236_R0.8060.34
2_M62_L0.8060.34
3_V323_A0.8050.34
193_F302_V0.8030.34
120_S263_I0.7980.34
220_E281_Q0.7980.34
39_R73_I0.7940.33
142_K204_A0.7940.33
54_S314_L0.7940.33
273_R308_D0.7910.33
127_L137_G0.7890.33
41_E45_K0.7880.33
125_L192_D0.7850.33
62_L222_Q0.7810.33
121_E163_M0.7770.32
121_E235_A0.7740.32
191_A212_I0.7730.32
49_G154_K0.7700.32
96_H300_F0.7670.32
5_R11_D0.7660.32
64_D78_V0.7660.32
224_V266_V0.7650.32
12_V159_V0.7640.31
177_Q186_M0.7610.31
103_V200_K0.7570.31
26_L39_R0.7510.31
100_E179_L0.7510.31
123_C232_T0.7480.31
158_K260_E0.7470.30
90_R277_V0.7460.30
91_V275_V0.7450.30
67_T250_I0.7440.30
18_L113_S0.7410.30
277_V331_R0.7400.30
186_M206_L0.7390.30
96_H232_T0.7390.30
167_I189_S0.7390.30
137_G161_A0.7390.30
52_P306_R0.7360.30
90_R201_A0.7320.30
123_C163_M0.7300.29
31_A138_Y0.7300.29
184_F206_L0.7290.29
63_E68_G0.7280.29
233_A326_C0.7260.29
195_C252_I0.7250.29
100_E106_A0.7240.29
165_G211_P0.7240.29
270_R314_L0.7210.29
35_T238_V0.7200.29
82_L117_T0.7200.29
179_L214_T0.7180.29
129_P284_Q0.7160.29
101_L184_F0.7150.29
27_T235_A0.7130.29
149_A269_I0.7120.28
12_V180_G0.7120.28
137_G234_P0.7100.28
143_S325_K0.7100.28
121_E132_R0.7090.28
307_T320_Q0.7070.28
319_A322_D0.7050.28
87_Y249_Y0.7050.28
93_T247_R0.7040.28
206_L213_Y0.7030.28
214_T222_Q0.7020.28
177_Q180_G0.7010.28
114_N179_L0.7000.28
315_I318_A0.6970.28
60_F261_C0.6950.28
164_R192_D0.6910.27
285_G292_V0.6910.27
267_R271_K0.6860.27
221_A224_V0.6860.27
77_E124_T0.6840.27
113_S147_F0.6840.27
303_V312_E0.6800.27
25_G126_F0.6800.27
255_G300_F0.6790.27
228_V232_T0.6750.26
218_S223_D0.6750.26
181_K218_S0.6740.26
46_T51_L0.6730.26
247_R260_E0.6720.26
24_G115_D0.6720.26
186_M252_I0.6700.26
308_D311_T0.6670.26
131_W186_M0.6660.26
138_Y238_V0.6660.26
23_G137_G0.6660.26
79_A82_L0.6660.26
238_V259_L0.6640.26
48_Q212_I0.6620.26
46_T255_G0.6620.26
23_G28_S0.6620.26
146_M279_E0.6580.26
86_W204_A0.6580.26
16_M35_T0.6570.25
28_S31_A0.6550.25
60_F74_C0.6550.25
56_Q142_K0.6540.25
139_L317_T0.6540.25
273_R309_P0.6530.25
87_Y252_I0.6520.25
165_G242_E0.6520.25
112_L186_M0.6520.25
94_L193_F0.6510.25
288_P328_A0.6450.25
13_S69_T0.6430.25
86_W89_Y0.6430.25
179_L248_N0.6420.25
292_V314_L0.6390.25
276_E303_V0.6390.25
53_K58_Y0.6370.24
92_G205_E0.6350.24
15_L307_T0.6330.24
88_N297_Y0.6330.24
23_G161_A0.6310.24
92_G122_L0.6310.24
193_F196_G0.6290.24
28_S75_A0.6280.24
161_A164_R0.6280.24
47_W179_L0.6240.24
69_T153_D0.6240.24
91_V214_T0.6230.24
97_A142_K0.6220.24
273_R312_E0.6220.24
22_T288_P0.6220.24
198_G228_V0.6210.24
43_A76_I0.6180.24
281_Q287_F0.6180.24
238_V250_I0.6180.24
42_R78_V0.6180.24
51_L58_Y0.6170.23
238_V292_V0.6150.23
76_I318_A0.6140.23
104_Y107_L0.6130.23
116_H244_F0.6120.23
3_V223_D0.6120.23
20_S31_A0.6110.23
104_Y205_E0.6090.23
41_E285_G0.6090.23
94_L203_I0.6090.23
145_F294_N0.6080.23
276_E306_R0.6060.23
71_A128_D0.6060.23
75_A150_A0.6030.23
41_E255_G0.6020.23
74_C92_G0.6010.23
43_A145_F0.6010.23
78_V233_A0.5980.23
138_Y316_L0.5980.23
168_D321_L0.5970.22
46_T154_K0.5940.22
17_Q44_I0.5930.22
26_L302_V0.5920.22
39_R229_H0.5920.22
28_S103_V0.5890.22
230_P315_I0.5890.22
85_P205_E0.5880.22
273_R283_A0.5880.22
43_A109_T0.5870.22
196_G199_Q0.5870.22
318_A328_A0.5860.22
305_V320_Q0.5860.22
210_H246_Y0.5860.22
241_K267_R0.5830.22
159_V266_V0.5820.22
61_V268_A0.5820.22
146_M272_S0.5810.22
274_L331_R0.5800.22
19_A29_L0.5790.22
98_S205_E0.5730.21
22_T135_G0.5730.21
101_L213_Y0.5720.21
4_I93_T0.5710.21
47_W58_Y0.5710.21
306_R332_V0.5710.21
95_V122_L0.5710.21
166_V218_S0.5710.21
22_T26_L0.5700.21
23_G26_L0.5670.21
2_M86_W0.5670.21
315_I332_V0.5660.21
293_A332_V0.5650.21
115_D246_Y0.5640.21
136_N195_C0.5640.21
87_Y221_A0.5640.21
273_R307_T0.5630.21
233_A313_R0.5620.21
220_E223_D0.5620.21
95_V104_Y0.5610.21
66_E169_E0.5600.21
61_V149_A0.5600.21
285_G326_C0.5600.21
168_D279_E0.5600.21
107_L187_D0.5590.21
123_C135_G0.5580.21
4_I15_L0.5570.21
166_V224_V0.5560.21
4_I62_L0.5550.21
26_L259_L0.5540.20
49_G53_K0.5530.20
227_Q233_A0.5520.20
74_C238_V0.5510.20
84_D180_G0.5510.20
57_G302_V0.5490.20
114_N224_V0.5480.20
32_N48_Q0.5470.20
13_S54_S0.5450.20
117_T205_E0.5450.20
76_I310_A0.5430.20
291_L310_A0.5420.20
312_E316_L0.5400.20
88_N249_Y0.5390.20
24_G35_T0.5390.20
60_F145_F0.5380.20
192_D200_K0.5370.20
288_P306_R0.5360.20
60_F186_M0.5360.20
39_R235_A0.5360.20
82_L140_L0.5350.20
57_G77_E0.5350.20
62_L261_C0.5340.20
220_E330_D0.5340.20
125_L240_E0.5340.20
76_I271_K0.5340.20
51_L56_Q0.5310.19
190_R201_A0.5310.19
89_Y143_S0.5310.19
51_L78_V0.5290.19
261_C266_V0.5290.19
192_D225_I0.5280.19
157_D220_E0.5280.19
26_L178_S0.5280.19
282_P308_D0.5280.19
282_P322_D0.5260.19
86_W291_L0.5240.19
12_V37_S0.5220.19
316_L332_V0.5210.19
224_V255_G0.5210.19
266_V269_I0.5210.19
159_V244_F0.5210.19
247_R261_C0.5180.19
187_D269_I0.5160.19
150_A320_Q0.5160.19
101_L210_H0.5160.19
212_I217_L0.5140.19
117_T198_G0.5140.19
121_E209_K0.5140.19
15_L238_V0.5130.19
21_K26_L0.5130.19
91_V108_P0.5110.19
104_Y122_L0.5110.19
121_E225_I0.5100.19
40_I57_G0.5090.19
123_C137_G0.5090.19
73_I79_A0.5090.19
315_I327_H0.5080.18
178_S212_I0.5060.18
114_N215_H0.5060.18
326_C331_R0.5040.18
205_E232_T0.5030.18
113_S129_P0.5030.18
106_A152_R0.5020.18
183_F253_F0.5010.18
27_T137_G0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yleA 1 0.9477 100 0.302 Contact Map
3blnA 2 0.407 98.6 0.925 Contact Map
3juwA 2 0.4651 98.4 0.929 Contact Map
1tiqA 1 0.5058 98.4 0.929 Contact Map
2kcwA 1 0.4186 98.4 0.93 Contact Map
2atrA 2 0.3837 98.3 0.93 Contact Map
1u6mA 1 0.5407 98.3 0.93 Contact Map
3fncA 2 0.4506 98.2 0.932 Contact Map
3dsbA 2 0.439 98.2 0.932 Contact Map
2bueA 1 0.5145 98.2 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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