GREMLIN Database
ARTM - Arginine ABC transporter permease protein ArtM
UniProt: P0AE30 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11627
Length: 222 (201)
Sequences: 15458 (8984)
Seq/√Len: 633.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
152_S208_M3.2631.00
25_V99_S3.2291.00
94_A165_A3.2231.00
177_S193_A2.9891.00
125_C135_T2.9731.00
121_Q142_Y2.7711.00
13_H17_T2.7141.00
131_S134_D2.7031.00
36_I48_V2.6771.00
58_T63_Q2.5801.00
33_F107_T2.4141.00
122_W135_T2.2801.00
33_F103_A2.1811.00
43_V47_L2.0961.00
113_A147_S2.0511.00
43_V46_W1.9671.00
206_L210_L1.9431.00
37_L49_R1.9301.00
18_L165_A1.9021.00
126_S135_T1.8721.00
198_L202_G1.8671.00
89_E92_L1.8501.00
122_W126_S1.8351.00
12_L200_V1.8001.00
116_A146_R1.7991.00
14_T17_T1.7641.00
34_T110_F1.7371.00
19_T159_F1.7271.00
131_S135_T1.7141.00
202_G206_L1.7131.00
67_I97_A1.7111.00
21_A95_L1.6651.00
181_Y187_V1.6611.00
177_S189_V1.6591.00
33_F48_V1.6311.00
52_I107_T1.6231.00
17_T91_W1.6011.00
206_L209_R1.5911.00
108_Q111_Y1.5861.00
38_T115_R1.5841.00
106_T151_Y1.5721.00
26_A102_S1.5451.00
42_P46_W1.5231.00
132_K136_L1.5151.00
10_K13_H1.5011.00
207_M210_L1.4851.00
31_L110_F1.4821.00
63_Q101_N1.4661.00
29_L103_A1.4581.00
14_T170_L1.4581.00
210_L213_R1.4551.00
9_M13_H1.4431.00
41_T46_W1.4221.00
42_P45_V1.4101.00
38_T114_I1.4011.00
58_T101_N1.3761.00
91_W95_L1.3331.00
32_I36_I1.3311.00
122_W139_L1.3161.00
130_M134_D1.3101.00
37_L108_Q1.3041.00
181_Y190_F1.2881.00
55_F100_L1.2771.00
126_S132_K1.2431.00
175_G179_L1.2371.00
114_I139_L1.2321.00
36_I39_L1.2111.00
64_I97_A1.2001.00
90_P169_T1.1941.00
19_T162_T1.1911.00
23_L155_V1.1871.00
21_A99_S1.1811.00
176_Y179_L1.1771.00
46_W50_G1.1491.00
47_L50_G1.1421.00
7_E176_Y1.1281.00
109_L154_E1.1251.00
25_V95_L1.1231.00
175_G178_Q1.1181.00
12_L196_I1.1141.00
171_M175_G1.1131.00
7_E10_K1.1121.00
63_Q67_I1.1091.00
134_D137_A1.1091.00
159_F200_V1.1081.00
67_I93_C1.1061.00
30_A106_T1.0981.00
27_L151_Y1.0941.00
47_L51_Y1.0851.00
53_T202_G1.0811.00
17_T21_A1.0621.00
22_S99_S1.0611.00
207_M211_I1.0591.00
165_A172_E1.0551.00
110_F147_S1.0541.00
53_T198_L1.0531.00
111_Y115_R1.0531.00
159_F204_L1.0531.00
125_C138_I1.0511.00
64_I164_L1.0451.00
180_L189_V1.0421.00
48_V107_T1.0411.00
163_S197_Y1.0381.00
36_I44_L1.0361.00
19_T155_V1.0311.00
136_L140_L1.0211.00
106_T154_E1.0211.00
50_G53_T1.0121.00
117_I146_R1.0021.00
95_L99_S1.0011.00
15_S159_F0.9981.00
157_L161_S0.9951.00
203_L207_M0.9841.00
209_R212_E0.9781.00
60_L101_N0.9721.00
55_F104_A0.9641.00
210_L214_K0.9621.00
41_T44_L0.9551.00
37_L52_I0.9551.00
184_T187_V0.9471.00
209_R213_R0.9461.00
64_I165_A0.9421.00
94_A168_I0.9411.00
66_L70_G0.9311.00
65_F69_Y0.9281.00
39_L48_V0.9251.00
106_T110_F0.9241.00
120_G124_S0.9151.00
136_L139_L0.9151.00
15_S197_Y0.9141.00
45_V49_R0.9131.00
29_L99_S0.9041.00
133_K137_A0.8971.00
40_K45_V0.8901.00
132_K135_T0.8901.00
37_L45_V0.8851.00
92_L96_I0.8771.00
159_F201_N0.8681.00
146_R150_S0.8651.00
102_S154_E0.8601.00
60_L161_S0.8591.00
91_W170_L0.8571.00
117_I143_A0.8511.00
178_Q181_Y0.8511.00
34_T38_T0.8501.00
92_L95_L0.8471.00
51_Y104_A0.8421.00
51_Y103_A0.8411.00
24_I28_I0.8411.00
21_A25_V0.8381.00
174_M197_Y0.8371.00
85_H88_S0.8361.00
20_V24_I0.8331.00
68_Y93_C0.8311.00
179_L183_R0.8301.00
10_K14_T0.8271.00
21_A91_W0.8261.00
28_I32_I0.8151.00
63_Q97_A0.8131.00
51_Y55_F0.8061.00
68_Y168_I0.7981.00
90_P170_L0.7961.00
34_T114_I0.7881.00
119_E123_Q0.7871.00
18_L162_T0.7801.00
199_V203_L0.7791.00
174_M190_F0.7781.00
120_G123_Q0.7741.00
181_Y189_V0.7731.00
23_L158_V0.7731.00
122_W132_K0.7661.00
189_V193_A0.7641.00
41_T47_L0.7611.00
46_W49_R0.7611.00
102_S161_S0.7601.00
114_I143_A0.7591.00
165_A170_L0.7551.00
16_L20_V0.7471.00
12_L173_V0.7451.00
49_R53_T0.7421.00
167_T171_M0.7421.00
18_L94_A0.7311.00
171_M176_Y0.7301.00
90_P168_I0.7291.00
14_T172_E0.7241.00
66_L191_G0.7241.00
98_L162_T0.7231.00
41_T45_V0.7201.00
6_P10_K0.7161.00
156_V204_L0.7131.00
177_S181_Y0.7101.00
109_L150_S0.7081.00
29_L33_F0.7071.00
98_L158_V0.7061.00
57_G160_K0.7041.00
166_Y169_T0.7031.00
174_M193_A0.7031.00
195_I199_V0.6991.00
154_E157_L0.6971.00
163_S166_Y0.6961.00
18_L170_L0.6931.00
163_S174_M0.6851.00
166_Y175_G0.6811.00
101_N154_E0.6811.00
15_S19_T0.6791.00
25_V28_I0.6791.00
191_G195_I0.6781.00
117_I139_L0.6771.00
26_A106_T0.6761.00
22_S158_V0.6711.00
173_V196_I0.6701.00
119_E122_W0.6651.00
98_L165_A0.6571.00
88_S93_C0.6571.00
68_Y90_P0.6571.00
31_L144_F0.6551.00
88_S92_L0.6541.00
31_L140_L0.6531.00
61_L167_T0.6501.00
44_L47_L0.6461.00
198_L201_N0.6451.00
37_L107_T0.6451.00
102_S106_T0.6441.00
35_I136_L0.6441.00
33_F36_I0.6411.00
40_K43_V0.6391.00
6_P9_M0.6391.00
28_I99_S0.6391.00
36_I47_L0.6381.00
55_F63_Q0.6341.00
36_I41_T0.6311.00
39_L132_K0.6301.00
192_A196_I0.6211.00
99_S103_A0.6161.00
101_N161_S0.6121.00
193_A196_I0.6121.00
135_T139_L0.6091.00
114_I136_L0.6051.00
8_L177_S0.6041.00
139_L142_Y0.5941.00
203_L210_L0.5931.00
180_L184_T0.5911.00
50_G54_L0.5891.00
27_L110_F0.5891.00
39_L42_P0.5821.00
67_I70_G0.5811.00
33_F51_Y0.5771.00
102_S158_V0.5751.00
183_R186_D0.5741.00
49_R52_I0.5731.00
61_L65_F0.5731.00
112_G150_S0.5721.00
211_I215_A0.5721.00
203_L206_L0.5671.00
150_S153_N0.5661.00
14_T91_W0.5651.00
56_T108_Q0.5621.00
61_L164_L0.5581.00
122_W136_L0.5551.00
148_L211_I0.5541.00
196_I200_V0.5531.00
44_L48_V0.5501.00
64_I98_L0.5481.00
19_T23_L0.5481.00
10_K176_Y0.5461.00
188_M191_G0.5451.00
118_P146_R0.5400.99
13_H16_L0.5400.99
204_L208_M0.5390.99
190_F193_A0.5390.99
16_L200_V0.5370.99
18_L22_S0.5370.99
130_M135_T0.5350.99
40_K132_K0.5340.99
122_W125_C0.5330.99
8_L192_A0.5320.99
35_I39_L0.5320.99
33_F37_L0.5300.99
25_V29_L0.5270.99
21_A24_I0.5260.99
8_L196_I0.5240.99
17_T95_L0.5230.99
54_L58_T0.5230.99
155_V204_L0.5230.99
8_L180_L0.5220.99
30_A110_F0.5220.99
10_K17_T0.5190.99
143_A147_S0.5190.99
173_V197_Y0.5170.99
28_I31_L0.5170.99
64_I94_A0.5170.99
9_M196_I0.5150.99
11_G176_Y0.5140.99
205_T209_R0.5140.99
8_L176_Y0.5130.99
64_I168_I0.5110.99
177_S190_F0.5100.99
145_K215_A0.5080.99
60_L63_Q0.5050.99
65_F190_F0.5040.99
125_C128_L0.5010.99
7_E180_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ymuD 2 0.9279 100 0.591 Contact Map
3tuiA 2 0.9324 99.9 0.645 Contact Map
2onkC 2 0.9459 99.9 0.665 Contact Map
3rlfF 1 0.9279 99.9 0.669 Contact Map
3d31C 2 0.9324 99.8 0.674 Contact Map
4tquM 1 0.973 99.8 0.691 Contact Map
3rlfG 1 0.973 99.8 0.708 Contact Map
4tquN 1 0.9054 99.7 0.735 Contact Map
4cbcA 3 0.4144 14 0.957 Contact Map
4ltoA 3 0.4685 13.3 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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