GREMLIN Database
AROM - Protein AroM
UniProt: P0AE28 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10083
Length: 225 (219)
Sequences: 216 (172)
Seq/√Len: 11.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_G208_P3.0940.96
45_V62_L2.8980.94
21_L213_N2.8590.94
55_E71_S2.8100.93
149_W189_D2.7450.92
15_M38_G2.6830.91
58_I141_M2.6160.90
59_L67_L2.5550.89
35_S38_G2.5000.88
142_L193_F2.4950.88
218_R222_E2.4740.87
80_Q84_E2.4220.86
15_M35_S2.3260.84
13_V21_L2.2870.83
12_I15_M2.2840.83
36_L78_D2.1700.79
58_I102_I2.1640.79
180_A184_D2.1310.78
10_I99_T2.1250.78
94_I215_L2.0970.77
113_L220_A2.0850.76
132_V198_R2.0610.76
102_I141_M2.0420.75
171_I188_L2.0060.73
164_I192_G2.0020.73
70_V193_F1.9170.70
133_G178_L1.8970.69
71_S74_K1.8200.66
33_H213_N1.7970.65
96_L119_L1.7800.64
195_Q198_R1.7650.63
195_Q205_L1.7650.63
140_E193_F1.7030.60
60_T164_I1.6860.60
187_M221_A1.6820.59
61_L164_I1.6200.56
35_S98_S1.6190.56
31_I224_L1.6180.56
95_L216_I1.6130.56
8_L197_H1.6030.56
100_A141_M1.5780.54
116_S148_K1.5590.53
161_G220_A1.5280.52
180_A203_K1.5240.52
12_I35_S1.5170.51
12_I38_G1.5060.51
148_K178_L1.5050.51
12_I141_M1.5020.51
156_P213_N1.4940.50
201_L205_L1.4920.50
41_S143_P1.4890.50
60_T157_V1.4780.49
9_T17_E1.4680.49
63_N184_D1.4520.48
75_V135_I1.4350.47
5_L95_L1.4240.47
59_L102_I1.4090.46
44_E123_V1.4040.46
4_S113_L1.4030.46
102_I137_P1.3960.45
12_I17_E1.3880.45
176_K180_A1.3870.45
96_L134_V1.3720.44
15_M61_L1.3510.43
13_V68_A1.3450.43
6_A103_S1.3310.42
59_L164_I1.3300.42
11_G14_P1.3190.42
163_P190_C1.2900.40
121_P156_P1.2870.40
211_L222_E1.2870.40
4_S30_N1.2850.40
92_D113_L1.2680.39
137_P141_M1.2620.39
17_E35_S1.2620.39
18_V27_D1.2500.38
60_T70_V1.2320.38
87_D105_M1.2200.37
45_V49_Y1.2200.37
67_L165_H1.2090.36
96_L167_S1.1920.36
95_L222_E1.1740.35
67_L138_V1.1680.35
113_L126_I1.1670.35
98_S141_M1.1490.34
100_A187_M1.1490.34
11_G15_M1.1430.34
38_G141_M1.1420.33
17_E38_G1.1410.33
18_V216_I1.1280.33
117_R178_L1.1100.32
44_E66_Q1.1050.32
80_Q94_I1.1040.32
32_S91_Y1.1020.32
17_E164_I1.0980.32
55_E118_I1.0960.31
42_R66_Q1.0930.31
59_L138_V1.0920.31
98_S190_C1.0890.31
96_L169_Q1.0840.31
13_V35_S1.0790.31
217_A223_L1.0780.31
7_I97_M1.0700.30
6_A13_V1.0640.30
122_L127_V1.0630.30
35_S141_M1.0620.30
159_S174_A1.0620.30
36_L49_Y1.0510.30
130_H171_I1.0430.29
95_L218_R1.0410.29
97_M125_S1.0400.29
35_S100_A1.0270.29
164_I191_L1.0160.28
86_L183_A1.0150.28
58_I96_L1.0030.28
23_T214_V1.0020.28
107_A110_T0.9980.27
79_L199_D0.9800.27
84_E88_N0.9800.27
17_E87_D0.9760.27
69_H138_V0.9690.26
22_L198_R0.9660.26
5_L198_R0.9630.26
27_D75_V0.9610.26
26_I206_D0.9580.26
62_L215_L0.9560.26
15_M141_M0.9530.26
13_V19_L0.9490.26
99_T164_I0.9390.25
44_E64_D0.9380.25
86_L89_Q0.9340.25
12_I39_K0.9300.25
99_T148_K0.9300.25
15_M100_A0.9290.25
134_V215_L0.9290.25
50_A135_I0.9270.25
20_P114_E0.9260.25
131_Q182_G0.9250.25
62_L186_I0.9250.25
38_G98_S0.9210.25
175_G198_R0.9150.24
149_W182_G0.9140.24
99_T190_C0.9100.24
40_L45_V0.9000.24
120_P148_K0.8950.24
197_H213_N0.8880.23
95_L123_V0.8770.23
59_L141_M0.8750.23
143_P177_E0.8720.23
72_R144_V0.8680.23
47_A50_A0.8680.23
13_V91_Y0.8640.23
96_L114_E0.8620.22
11_G17_E0.8580.22
79_L188_L0.8550.22
134_V149_W0.8550.22
115_P136_V0.8520.22
75_V80_Q0.8500.22
39_K90_G0.8460.22
17_E61_L0.8460.22
110_T114_E0.8450.22
65_N141_M0.8400.22
170_K177_E0.8300.21
66_Q71_S0.8260.21
83_V94_I0.8250.21
91_Y193_F0.8220.21
102_I116_S0.8140.21
98_S164_I0.8120.21
141_M164_I0.8110.21
178_L208_P0.8050.21
41_S44_E0.8010.20
6_A91_Y0.7980.20
101_N188_L0.7960.20
22_L183_A0.7950.20
90_G211_L0.7950.20
97_M187_M0.7920.20
135_I186_I0.7850.20
187_M191_L0.7790.20
31_I180_A0.7780.20
64_D83_V0.7760.20
38_G61_L0.7750.20
212_S215_L0.7750.20
38_G164_I0.7690.19
174_A206_D0.7660.19
114_E162_N0.7640.19
88_N184_D0.7640.19
96_L222_E0.7630.19
95_L119_L0.7620.19
102_I187_M0.7600.19
102_I115_P0.7600.19
63_N136_V0.7600.19
125_S194_H0.7590.19
77_R224_L0.7570.19
33_H63_N0.7540.19
10_I14_P0.7470.19
43_E81_G0.7470.19
96_L220_A0.7460.19
43_E177_E0.7460.19
80_Q178_L0.7330.18
38_G65_N0.7270.18
44_E74_K0.7270.18
7_I111_I0.7250.18
61_L135_I0.7220.18
20_P192_G0.7190.18
64_D224_L0.7180.18
24_E89_Q0.7170.18
116_S216_I0.7170.18
83_V112_F0.7140.18
214_V224_L0.7070.18
17_E98_S0.7040.17
132_V152_L0.7010.17
87_D189_D0.6980.17
139_E142_L0.6940.17
123_V206_D0.6920.17
100_A164_I0.6880.17
7_I156_P0.6820.17
12_I100_A0.6800.17
93_V216_I0.6780.17
70_V111_I0.6750.17
14_P79_L0.6740.17
177_E181_K0.6730.17
21_L214_V0.6710.17
68_A102_I0.6610.16
119_L198_R0.6590.16
35_S65_N0.6560.16
57_T83_V0.6540.16
50_A172_I0.6530.16
47_A68_A0.6520.16
121_P219_L0.6510.16
105_M219_L0.6490.16
125_S203_K0.6440.16
99_T116_S0.6430.16
85_V215_L0.6420.16
31_I223_L0.6390.16
12_I62_L0.6310.15
35_S164_I0.6300.15
43_E109_N0.6280.15
47_A172_I0.6280.15
186_I217_A0.6280.15
188_L219_L0.6230.15
7_I55_E0.6220.15
58_I65_N0.6190.15
8_L94_I0.6180.15
55_E199_D0.6160.15
49_Y201_L0.6150.15
115_P162_N0.6090.15
5_L122_L0.6080.15
76_E103_S0.6070.15
16_Q22_L0.6060.15
54_G166_D0.6010.15
155_S170_K0.6010.15
6_A132_V0.6000.15
48_E142_L0.6000.15
10_I58_I0.5990.15
182_G186_I0.5990.15
19_L138_V0.5980.15
122_L126_I0.5980.15
170_K186_I0.5930.15
61_L65_N0.5920.15
50_A143_P0.5900.14
160_L166_D0.5880.14
36_L171_I0.5880.14
191_L220_A0.5850.14
13_V17_E0.5840.14
65_N143_P0.5810.14
78_D191_L0.5800.14
96_L149_W0.5780.14
49_Y142_L0.5750.14
163_P189_D0.5690.14
120_P189_D0.5680.14
145_Q197_H0.5680.14
124_S217_A0.5680.14
53_A129_D0.5680.14
117_R120_P0.5670.14
4_S146_A0.5670.14
141_M193_F0.5650.14
40_L86_L0.5620.14
52_E101_N0.5620.14
67_L99_T0.5610.14
188_L201_L0.5610.14
173_D176_K0.5610.14
14_P17_E0.5580.14
88_N193_F0.5580.14
45_V68_A0.5560.14
45_V148_K0.5550.14
167_S170_K0.5520.14
64_D109_N0.5520.14
70_V134_V0.5500.14
48_E155_S0.5500.14
13_V31_I0.5490.13
57_T102_I0.5490.13
40_L73_R0.5480.13
58_I137_P0.5480.13
94_I184_D0.5480.13
138_V157_V0.5460.13
14_P102_I0.5450.13
15_M98_S0.5450.13
93_V210_L0.5410.13
169_Q176_K0.5400.13
47_A88_N0.5380.13
39_K134_V0.5370.13
182_G207_V0.5370.13
201_L210_L0.5370.13
98_S163_P0.5330.13
14_P137_P0.5310.13
115_P148_K0.5300.13
116_S138_V0.5290.13
40_L217_A0.5280.13
35_S191_L0.5280.13
9_T164_I0.5270.13
14_P35_S0.5240.13
40_L223_L0.5220.13
79_L107_A0.5190.13
48_E177_E0.5180.13
9_T163_P0.5170.13
214_V222_E0.5150.13
39_K56_D0.5140.13
118_I187_M0.5130.13
110_T212_S0.5100.13
148_K183_A0.5090.13
134_V184_D0.5090.13
174_A195_Q0.5090.13
213_N218_R0.5090.13
39_K100_A0.5070.13
54_G159_S0.5060.13
74_K203_K0.5030.12
93_V110_T0.5020.12
142_L186_I0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dgdA 4 0.8578 99.5 0.804 Contact Map
3ixlA 1 0.8444 99.5 0.806 Contact Map
2xedA 1 0.8756 99.5 0.812 Contact Map
3s81A 2 0.8978 99.4 0.812 Contact Map
4fq5B 4 0.8889 99.4 0.815 Contact Map
2gzmA 3 0.8444 99.4 0.818 Contact Map
3ojcA 4 0.8844 99.4 0.818 Contact Map
4ix1A 2 0.8444 99.4 0.819 Contact Map
3outA 5 0.8622 99.4 0.821 Contact Map
3uhfA 1 0.84 99.4 0.821 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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