GREMLIN Database
ARAH - L-arabinose transport system permease protein AraH
UniProt: P0AE26 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10059
Length: 328 (268)
Sequences: 31338 (19715)
Seq/√Len: 1204.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
110_L230_L3.9411.00
114_V226_V3.6001.00
114_V230_L3.0991.00
91_T112_L3.0011.00
118_L226_V2.9621.00
207_E221_K2.8571.00
95_V108_A2.7561.00
200_T224_I2.5551.00
69_L279_V2.5541.00
216_P219_R2.5151.00
62_G180_T2.5091.00
126_K218_V2.4621.00
219_R223_I2.3591.00
117_G229_G2.3471.00
188_G192_N2.3451.00
190_L196_F2.3151.00
113_G233_A2.3021.00
189_L193_K2.2681.00
118_L222_I2.2611.00
120_N138_T2.2171.00
257_I290_E2.2001.00
199_N220_T2.1781.00
122_F126_K2.1521.00
196_F223_I2.1221.00
186_I190_L2.0901.00
101_S104_I2.0691.00
64_V258_V1.9991.00
86_A146_A1.9681.00
92_T109_G1.9651.00
110_L234_I1.9601.00
103_W107_A1.8951.00
113_G229_G1.8311.00
92_T237_I1.8191.00
203_I220_T1.7841.00
58_I287_G1.7731.00
106_V237_I1.7661.00
185_I189_L1.7561.00
65_A279_V1.7421.00
71_C228_S1.7091.00
70_F187_F1.6961.00
121_G222_I1.6891.00
202_A210_A1.6831.00
140_Q143_R1.6721.00
58_I284_L1.6471.00
195_T199_N1.6301.00
73_A201_L1.5541.00
116_C142_V1.5491.00
62_G283_I1.5291.00
110_L237_I1.5211.00
196_F200_T1.5191.00
257_I307_R1.5181.00
87_C116_C1.4931.00
223_I226_V1.4781.00
126_K222_I1.4661.00
208_E211_R1.4621.00
138_T142_V1.4551.00
83_S143_R1.4521.00
100_E104_I1.4501.00
207_E211_R1.4391.00
94_V149_I1.4341.00
85_I239_L1.4291.00
64_V85_I1.4121.00
199_N215_V1.4061.00
104_I107_A1.3871.00
275_K278_Y1.3821.00
184_L280_V1.3791.00
265_G278_Y1.3751.00
94_V97_N1.3701.00
74_S224_I1.3531.00
199_N210_A1.3351.00
63_M235_A1.3281.00
95_V100_E1.3091.00
122_F222_I1.2971.00
67_G231_V1.2911.00
109_G113_G1.2901.00
265_G282_G1.2881.00
70_F224_I1.2851.00
210_A215_V1.2811.00
203_I217_V1.2771.00
95_V98_L1.2751.00
164_A167_Y1.2691.00
62_G280_V1.2601.00
81_V232_S1.2481.00
125_A218_V1.2391.00
168_A171_F1.2381.00
222_I226_V1.2341.00
68_M262_C1.2311.00
76_D131_A1.2291.00
107_A111_L1.2291.00
76_D221_K1.2261.00
54_L288_T1.2261.00
50_N291_N1.2251.00
192_N201_L1.2221.00
215_V220_T1.2181.00
105_G109_G1.2161.00
63_M238_I1.2131.00
66_C187_F1.2101.00
54_L287_G1.1941.00
203_I210_A1.1931.00
167_Y170_W1.1671.00
111_L114_V1.1631.00
68_M258_V1.1611.00
91_T95_V1.1511.00
76_D225_F1.1501.00
188_G193_K1.1501.00
183_C231_V1.1461.00
161_S164_A1.1411.00
65_A261_A1.1391.00
226_V230_L1.1391.00
166_G169_N1.1301.00
100_E108_A1.1141.00
84_V116_C1.1121.00
83_S142_V1.1101.00
92_T241_S1.1071.00
291_N294_N1.0891.00
90_V146_A1.0871.00
58_I283_I1.0841.00
67_G81_V1.0831.00
211_R217_V1.0821.00
223_I227_L1.0761.00
302_A305_V1.0741.00
211_R218_V1.0731.00
254_Y257_I1.0711.00
187_F227_L1.0681.00
220_T223_I1.0561.00
290_E307_R1.0561.00
109_G237_I1.0551.00
163_F166_G1.0551.00
143_R147_Y1.0521.00
59_S177_I1.0511.00
123_V134_T1.0421.00
94_V150_S1.0381.00
115_L118_L1.0371.00
229_G233_A1.0371.00
90_V248_P1.0371.00
52_K56_L1.0361.00
184_L231_V1.0361.00
185_I188_G1.0311.00
65_A262_C1.0281.00
73_A274_G1.0241.00
200_T220_T1.0241.00
178_W182_A1.0231.00
139_M143_R1.0201.00
69_L262_C1.0191.00
304_Y307_R1.0181.00
182_A186_I1.0151.00
114_V233_A1.0091.00
261_A282_G0.9971.00
125_A135_T0.9911.00
122_F127_L0.9911.00
227_L231_V0.9881.00
107_A110_L0.9801.00
261_A283_I0.9721.00
87_C91_T0.9671.00
120_N134_T0.9591.00
196_F220_T0.9581.00
292_A296_L0.9541.00
83_S139_M0.9491.00
188_G277_S0.9371.00
277_S281_A0.9361.00
64_V235_A0.9331.00
72_L262_C0.9321.00
236_G240_A0.9281.00
175_A178_W0.9281.00
123_V127_L0.9261.00
128_K207_E0.9261.00
124_I134_T0.9221.00
90_V150_S0.9211.00
219_R222_I0.9181.00
228_S232_S0.9181.00
65_A283_I0.9121.00
82_A255_E0.9101.00
198_R201_L0.9031.00
57_A61_S0.9001.00
160_E163_F0.8971.00
49_I52_K0.8971.00
74_S200_T0.8961.00
69_L274_G0.8951.00
148_I302_A0.8901.00
73_A192_N0.8901.00
180_T184_L0.8881.00
78_D81_V0.8831.00
209_A213_A0.8801.00
60_M235_A0.8771.00
88_A113_G0.8761.00
95_V105_G0.8741.00
88_A109_G0.8721.00
293_M306_V0.8721.00
286_L307_R0.8721.00
218_V221_K0.8661.00
181_V185_I0.8651.00
191_L200_T0.8641.00
111_L115_L0.8631.00
68_M81_V0.8631.00
51_M292_A0.8591.00
89_G240_A0.8591.00
85_I251_S0.8551.00
203_I224_I0.8531.00
62_G184_L0.8501.00
85_I254_Y0.8481.00
63_M180_T0.8481.00
104_I108_A0.8461.00
89_G246_G0.8441.00
119_V123_V0.8411.00
70_F227_L0.8391.00
94_V98_L0.8371.00
171_F178_W0.8361.00
66_C183_C0.8351.00
84_V232_S0.8321.00
91_T94_V0.8301.00
177_I181_V0.8291.00
206_N209_A0.8291.00
71_C78_D0.8241.00
70_F191_L0.8221.00
232_S236_G0.8171.00
93_A246_G0.8071.00
110_L233_A0.8051.00
84_V113_G0.8041.00
156_G159_D0.8031.00
275_K279_V0.8011.00
273_I277_S0.7981.00
98_L101_S0.7981.00
118_L122_F0.7971.00
88_A236_G0.7971.00
115_L119_V0.7941.00
66_C279_V0.7921.00
152_G155_V0.7921.00
217_V221_K0.7911.00
291_N295_L0.7871.00
313_A317_F0.7861.00
279_V283_I0.7821.00
164_A168_A0.7811.00
92_T105_G0.7791.00
64_V81_V0.7771.00
89_G250_T0.7771.00
203_I221_K0.7741.00
96_I105_G0.7701.00
121_G125_A0.7631.00
53_G57_A0.7621.00
144_G147_Y0.7591.00
218_V222_I0.7591.00
207_E217_V0.7571.00
190_L193_K0.7501.00
167_Y171_F0.7491.00
100_E103_W0.7481.00
162_F165_L0.7421.00
230_L233_A0.7381.00
110_L114_V0.7361.00
64_V67_G0.7311.00
88_A112_L0.7281.00
169_N172_G0.7271.00
67_G232_S0.7241.00
121_G126_K0.7241.00
230_L234_I0.7171.00
186_I189_L0.7171.00
71_C225_F0.7131.00
50_N295_L0.7111.00
63_M183_C0.7061.00
309_L313_A0.7021.00
176_P238_I0.7011.00
199_N216_P0.6931.00
141_I145_L0.6921.00
283_I287_G0.6921.00
106_V110_L0.6891.00
284_L288_T0.6851.00
85_I235_A0.6851.00
79_L259_I0.6831.00
160_E164_A0.6781.00
260_S311_L0.6781.00
87_C113_G0.6771.00
58_I62_G0.6771.00
131_A225_F0.6751.00
125_A222_I0.6721.00
61_S257_I0.6711.00
61_S261_A0.6701.00
249_M252_I0.6691.00
72_L259_I0.6671.00
189_L192_N0.6621.00
84_V88_A0.6621.00
301_F304_Y0.6611.00
59_S180_T0.6591.00
87_C142_V0.6581.00
54_L291_N0.6561.00
55_G59_S0.6521.00
113_G117_G0.6501.00
143_R255_E0.6461.00
170_W178_W0.6451.00
184_L188_G0.6421.00
84_V229_G0.6361.00
217_V220_T0.6361.00
187_F231_V0.6361.00
102_L241_S0.6351.00
173_L176_P0.6351.00
233_A237_I0.6351.00
307_R311_L0.6331.00
187_F191_L0.6281.00
117_G226_V0.6281.00
300_P303_Q0.6281.00
74_S203_I0.6271.00
175_A179_L0.6261.00
69_L276_I0.6251.00
150_S153_K0.6231.00
164_A169_N0.6231.00
190_L223_I0.6191.00
53_G291_N0.6191.00
239_L254_Y0.6191.00
227_L230_L0.6171.00
76_D207_E0.6171.00
69_L73_A0.6151.00
264_L282_G0.6141.00
67_G71_C0.6141.00
54_L58_I0.6141.00
84_V142_V0.6111.00
93_A155_V0.6101.00
290_E303_Q0.6081.00
91_T108_A0.6071.00
84_V120_N0.6061.00
124_I131_A0.6061.00
196_F227_L0.6061.00
61_S283_I0.6041.00
48_F51_M0.5991.00
88_A232_S0.5991.00
163_F167_Y0.5921.00
128_K218_V0.5901.00
56_L177_I0.5881.00
140_Q144_G0.5871.00
183_C234_I0.5851.00
293_M298_I0.5841.00
252_I255_E0.5831.00
303_Q307_R0.5831.00
95_V112_L0.5801.00
70_F190_L0.5791.00
84_V117_G0.5751.00
56_L242_R0.5711.00
60_M239_L0.5711.00
66_C184_L0.5671.00
143_R252_I0.5671.00
221_K224_I0.5641.00
257_I304_Y0.5631.00
182_A185_I0.5631.00
61_S254_Y0.5611.00
158_E161_S0.5611.00
261_A279_V0.5611.00
262_C279_V0.5591.00
136_L140_Q0.5561.00
124_I225_F0.5561.00
74_S221_K0.5551.00
49_I53_G0.5541.00
165_L168_A0.5521.00
208_E212_L0.5511.00
110_L113_G0.5501.00
66_C188_G0.5491.00
250_T253_G0.5481.00
80_S120_N0.5481.00
91_T109_G0.5451.00
190_L194_T0.5441.00
229_G232_S0.5421.00
173_L178_W0.5421.00
261_A286_L0.5411.00
149_I152_G0.5411.00
264_L314_A0.5391.00
57_A291_N0.5391.00
306_V309_L0.5361.00
92_T95_V0.5361.00
92_T236_G0.5351.00
183_C187_F0.5351.00
55_G58_I0.5351.00
114_V117_G0.5321.00
66_C185_I0.5321.00
170_W175_A0.5311.00
173_L241_S0.5281.00
188_G275_K0.5281.00
102_L106_V0.5271.00
210_A217_V0.5251.00
139_M255_E0.5251.00
179_L182_A0.5251.00
82_A253_G0.5231.00
239_L243_M0.5221.00
48_F52_K0.5201.00
71_C76_D0.5191.00
265_G279_V0.5191.00
179_L183_C0.5181.00
86_A250_T0.5181.00
192_N195_T0.5161.00
81_V228_S0.5161.00
62_G66_C0.5161.00
153_K157_I0.5151.00
166_G170_W0.5151.00
226_V229_G0.5111.00
164_A175_A0.5081.00
242_R246_G0.5081.00
50_N53_G0.5051.00
75_G207_E0.5051.00
278_Y282_G0.5041.00
135_T139_M0.5041.00
87_C112_L0.5031.00
201_L204_G0.5031.00
100_E105_G0.5031.00
253_G257_I0.5031.00
78_D228_S0.5021.00
61_S65_A0.5011.00
53_G56_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g1uA 2 0.814 97.5 0.873 Contact Map
2nq2A 2 0.8384 97.1 0.881 Contact Map
2qi9A 2 0.8811 97 0.882 Contact Map
2onkC 2 0.7226 39.8 0.944 Contact Map
3d31C 2 0.7317 37.4 0.945 Contact Map
1u7gA 3 0.5732 22.4 0.951 Contact Map
4cylA 1 0 10.8 0.957 Contact Map
2gfpA 2 0.5549 10.6 0.958 Contact Map
2m8rA 1 0.1372 8.2 0.96 Contact Map
3p5nA 2 0.3079 8.1 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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