GREMLIN Database
MAP1 - Methionine aminopeptidase
UniProt: P0AE18 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10570
Length: 264 (218)
Sequences: 16380 (9565)
Seq/√Len: 647.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_R246_E3.9351.00
197_P242_D3.5081.00
135_L156_F2.7671.00
31_Y44_I2.6591.00
27_M48_Y2.4261.00
128_I160_E2.4001.00
140_V240_V2.3731.00
122_G230_L2.3661.00
23_E53_Q2.3421.00
114_I118_P2.3371.00
47_D52_E2.3331.00
135_L138_R2.1671.00
123_E127_R2.1001.00
13_K103_D2.0951.00
147_R192_N2.0411.00
119_T122_G2.0201.00
37_S87_L2.0131.00
48_Y53_Q2.0031.00
127_R131_E2.0021.00
156_F160_E1.9461.00
14_M200_T1.9271.00
154_Q158_E1.8801.00
44_I47_D1.8731.00
157_V207_V1.8541.00
16_V19_R1.8451.00
130_Q134_Y1.8411.00
139_M152_A1.8331.00
48_Y52_E1.8211.00
11_I239_V1.7951.00
120_I124_R1.7561.00
131_E135_L1.7501.00
24_V48_Y1.7221.00
43_R47_D1.7131.00
73_I86_K1.7121.00
27_M30_P1.6661.00
145_N148_E1.6381.00
150_G154_Q1.6231.00
151_A155_K1.6121.00
39_G84_D1.6111.00
121_M229_S1.5781.00
121_M124_R1.5641.00
101_I106_H1.5621.00
173_I237_T1.5611.00
29_E113_F1.5591.00
21_A109_T1.5481.00
136_A153_I1.5421.00
89_K92_D1.5351.00
141_K144_I1.5151.00
134_Y138_R1.5121.00
155_K159_A1.4981.00
16_V102_K1.4951.00
44_I48_Y1.4871.00
241_T246_E1.4541.00
208_N231_S1.4531.00
131_E156_F1.4471.00
132_S156_F1.4471.00
124_R160_E1.4141.00
120_I123_E1.4041.00
131_E160_E1.3891.00
129_T232_A1.3871.00
27_M44_I1.3851.00
114_I126_C1.3741.00
15_R19_R1.3741.00
39_G43_R1.3731.00
137_L238_I1.3691.00
34_P90_D1.3661.00
142_P197_P1.3611.00
139_M144_I1.3581.00
132_S157_V1.3481.00
33_K36_V1.3461.00
90_D117_K1.3421.00
37_S40_E1.3381.00
145_N194_V1.3111.00
86_K92_D1.3031.00
88_L115_V1.2701.00
239_V248_L1.2571.00
42_D46_N1.2261.00
7_T10_D1.2241.00
27_M31_Y1.2101.00
144_I148_E1.2091.00
133_L137_L1.2081.00
93_I122_G1.1831.00
19_R23_E1.1811.00
21_A107_G1.1741.00
9_E13_K1.1721.00
20_L55_A1.1621.00
105_F175_R1.1611.00
126_C234_Y1.1601.00
169_C182_Q1.1581.00
9_E12_E1.1411.00
28_I45_C1.1401.00
124_R128_I1.1381.00
196_K199_M1.1381.00
64_G106_H1.1141.00
12_E16_V1.1111.00
241_T244_G1.1071.00
23_E48_Y1.0851.00
97_D108_D1.0831.00
135_L152_A1.0791.00
200_T239_V1.0771.00
13_K16_V1.0751.00
121_M209_A1.0741.00
8_P12_E1.0691.00
136_A152_A1.0681.00
148_E151_A1.0681.00
195_L201_F1.0571.00
147_R190_E1.0511.00
20_L102_K1.0441.00
136_A149_I1.0411.00
135_L139_M1.0391.00
25_L113_F1.0381.00
209_A229_S1.0311.00
16_V103_D1.0131.00
195_L240_V1.0081.00
128_I156_F0.9991.00
6_K179_E0.9961.00
134_Y247_I0.9861.00
69_V94_V0.9851.00
147_R151_A0.9831.00
18_G237_T0.9791.00
36_V40_E0.9681.00
124_R127_R0.9681.00
127_R130_Q0.9671.00
140_V245_C0.9651.00
133_L236_H0.9501.00
137_L247_I0.9491.00
140_V203_I0.9461.00
238_I245_C0.9411.00
125_L209_A0.9381.00
108_D235_E0.9361.00
45_C49_I0.9301.00
27_M53_Q0.9261.00
49_I100_V0.9241.00
36_V44_I0.9241.00
5_I199_M0.9161.00
10_D175_R0.9141.00
20_L104_G0.9121.00
71_I88_L0.9111.00
18_G22_A0.9101.00
83_D86_K0.9071.00
25_L109_T0.9051.00
26_E30_P0.9031.00
118_P123_E0.8911.00
125_L232_A0.8891.00
46_N67_K0.8891.00
17_A107_G0.8741.00
40_E43_R0.8741.00
22_A251_R0.8721.00
165_V208_N0.8681.00
71_I94_V0.8671.00
20_L100_V0.8651.00
140_V195_L0.8601.00
21_A100_V0.8601.00
149_I195_L0.8591.00
202_T237_T0.8541.00
86_K89_K0.8461.00
90_D116_G0.8371.00
152_A155_K0.8371.00
12_E15_R0.8371.00
76_V86_K0.8351.00
56_V101_I0.8331.00
156_F159_A0.8281.00
14_M18_G0.8201.00
55_A100_V0.8201.00
111_K236_H0.8191.00
32_V115_V0.8191.00
146_L195_L0.8181.00
140_V238_I0.8161.00
18_G249_T0.8081.00
93_I114_I0.8041.00
41_L88_L0.8031.00
146_L193_V0.8021.00
238_I247_I0.7971.00
144_I152_A0.7961.00
22_A250_L0.7931.00
97_D235_E0.7921.00
45_C69_V0.7891.00
140_V149_I0.7861.00
23_E27_M0.7851.00
153_I169_C0.7841.00
198_G239_V0.7821.00
32_V41_L0.7791.00
152_A156_F0.7731.00
118_P122_G0.7721.00
95_N110_S0.7691.00
142_P242_D0.7681.00
70_C80_G0.7661.00
44_I52_E0.7651.00
203_I238_I0.7621.00
53_Q56_V0.7601.00
239_V246_E0.7561.00
96_I113_F0.7551.00
19_R22_A0.7521.00
131_E159_A0.7511.00
29_E111_K0.7501.00
72_S92_D0.7441.00
10_D105_F0.7431.00
241_T245_C0.7421.00
141_K245_C0.7401.00
172_G181_P0.7381.00
34_P115_V0.7361.00
137_L245_C0.7341.00
26_E251_R0.7331.00
106_H177_F0.7321.00
197_P241_T0.7281.00
66_P81_I0.7271.00
158_E163_S0.7261.00
163_S208_N0.7241.00
150_G169_C0.7211.00
67_K81_I0.7191.00
137_L203_I0.7151.00
71_I86_K0.7041.00
74_N77_V0.7011.00
130_Q234_Y0.6981.00
173_I200_T0.6971.00
39_G67_K0.6961.00
22_A26_E0.6951.00
31_Y36_V0.6941.00
119_T230_L0.6931.00
20_L53_Q0.6931.00
145_N192_N0.6921.00
128_I131_E0.6921.00
16_V20_L0.6891.00
125_L162_F0.6841.00
136_A139_M0.6801.00
128_I157_V0.6771.00
49_I55_A0.6761.00
35_G87_L0.6761.00
91_G115_V0.6721.00
193_V199_M0.6711.00
139_M142_P0.6701.00
79_H178_H0.6691.00
5_I196_K0.6681.00
24_V45_C0.6611.00
18_G107_G0.6591.00
135_L155_K0.6561.00
191_T194_V0.6561.00
144_I149_I0.6551.00
17_A102_K0.6551.00
125_L230_L0.6551.00
23_E26_E0.6531.00
32_V113_F0.6491.00
25_L98_V0.6481.00
74_N80_G0.6431.00
131_E134_Y0.6411.00
37_S84_D0.6411.00
77_V80_G0.6391.00
27_M52_E0.6391.00
63_H67_K0.6361.00
46_N57_S0.6331.00
31_Y48_Y0.6321.00
209_A230_L0.6311.00
24_V100_V0.6301.00
142_P240_V0.6271.00
142_P196_K0.6251.00
121_M125_L0.6181.00
147_R191_T0.6181.00
45_C98_V0.6181.00
46_N68_S0.6121.00
21_A98_V0.6101.00
46_N63_H0.6091.00
71_I115_V0.6051.00
173_I202_T0.6001.00
114_I122_G0.5991.00
28_I44_I0.5991.00
153_I165_V0.5961.00
14_M175_R0.5931.00
143_G194_V0.5901.00
157_V162_F0.5861.00
6_K10_D0.5821.00
136_A203_I0.5821.00
28_I41_L0.5821.00
128_I162_F0.5811.00
142_P244_G0.5801.00
151_A192_N0.5801.00
39_G42_D0.5771.00
39_G83_D0.5721.00
24_V27_M0.5721.00
32_V94_V0.5711.00
132_S136_A0.5711.00
18_G109_T0.5711.00
184_L190_E0.5701.00
99_T107_G0.5651.00
30_P34_P0.5641.00
117_K123_E0.5621.00
41_L94_V0.5621.00
71_I92_D0.5591.00
8_P197_P0.5581.00
26_E111_K0.5581.00
204_E235_E0.5571.00
148_E152_A0.5551.00
133_L234_Y0.5541.00
142_P241_T0.5521.00
41_L69_V0.5501.00
246_E250_L0.5491.00
126_C130_Q0.5481.00
18_G248_L0.5461.00
97_D171_H0.5461.00
201_F240_V0.5461.00
21_A24_V0.5461.00
24_V49_I0.5461.00
8_P241_T0.5451.00
169_C184_L0.5451.00
240_V245_C0.5421.00
25_L29_E0.5401.00
40_E52_E0.5381.00
97_D204_E0.5350.99
95_N233_Q0.5350.99
74_N92_D0.5340.99
247_I250_L0.5310.99
132_S153_I0.5300.99
75_E95_N0.5290.99
28_I31_Y0.5290.99
146_L183_V0.5270.99
125_L207_V0.5250.99
118_P126_C0.5230.99
139_M149_I0.5210.99
93_I118_P0.5180.99
10_D13_K0.5140.99
171_H235_E0.5130.99
49_I98_V0.5120.99
74_N86_K0.5070.99
26_E29_E0.5050.99
114_I117_K0.5050.99
155_K158_E0.5040.99
141_K244_G0.5040.99
149_I152_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fukA 2 0.9924 100 0.121 Contact Map
3s6bA 1 0.9924 100 0.138 Contact Map
4fo7A 3 0.9697 100 0.143 Contact Map
2gg2A 1 0.9924 100 0.144 Contact Map
4iu6A 1 0.9811 100 0.146 Contact Map
3tb5A 1 0.9621 100 0.148 Contact Map
2b3hA 1 0.9811 100 0.148 Contact Map
1qxyA 1 0.9356 100 0.148 Contact Map
3tavA 2 0.9432 100 0.154 Contact Map
3mx6A 1 0.9735 100 0.16 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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