GREMLIN Database
AMPE - Protein AmpE
UniProt: P0AE14 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10042
Length: 284 (270)
Sequences: 2942 (2275)
Seq/√Len: 138.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_L196_L4.8481.00
154_G158_G4.4121.00
40_L187_S3.7901.00
91_Y136_L3.1861.00
47_T192_V3.1061.00
205_G221_W3.0451.00
178_Y183_H2.9441.00
124_D127_E2.8161.00
58_L160_V2.7991.00
102_D105_A2.7861.00
175_L189_I2.6251.00
46_M175_L2.6161.00
183_H187_S2.6041.00
34_R38_F2.5771.00
78_G151_L2.5731.00
47_T51_M2.5711.00
28_L50_A2.5361.00
44_L187_S2.4861.00
103_S128_Y2.3501.00
81_C159_P2.3221.00
102_D106_R2.2321.00
55_F164_G2.2041.00
85_G89_L2.0541.00
99_S257_K2.0331.00
240_A262_M1.9941.00
109_M112_E1.9001.00
8_L75_L1.8831.00
145_L204_A1.8571.00
40_L184_R1.8381.00
44_L188_G1.8361.00
91_Y132_L1.8291.00
146_A165_Y1.8271.00
212_G243_S1.8231.00
147_P165_Y1.7801.00
213_H216_K1.7701.00
123_C127_E1.6861.00
140_N204_A1.6771.00
195_V198_W1.6651.00
36_K181_P1.6641.00
51_M164_G1.6511.00
54_T58_L1.6421.00
133_Q259_A1.6411.00
145_L270_V1.6371.00
88_R260_V1.6251.00
39_S184_R1.6221.00
207_V270_V1.6041.00
165_Y197_D1.5791.00
221_W235_V1.5751.00
47_T189_I1.5641.00
164_G196_L1.5641.00
149_F203_L1.5491.00
179_Q182_H1.5461.00
110_A131_E1.5421.00
166_A173_Y1.5341.00
208_Y240_A1.5271.00
81_C160_V1.5251.00
217_A242_F1.5211.00
211_I269_V1.5121.00
225_L235_V1.5111.00
168_L192_V1.4901.00
216_K219_P1.4791.00
192_V196_L1.4701.00
143_F173_Y1.4591.00
31_F50_A1.4571.00
88_R264_K1.4481.00
187_S191_A1.4441.00
145_L207_V1.4431.00
97_A105_A1.4421.00
137_L240_A1.4291.00
220_A223_A1.4221.00
95_L257_K1.4191.00
13_E18_L1.4191.00
151_L159_P1.4151.00
141_F146_A1.4151.00
62_Q65_L1.4091.00
9_V75_L1.4071.00
36_K182_H1.3821.00
30_A34_R1.3801.00
171_W189_I1.3761.00
50_A53_V1.3571.00
225_L234_Q1.3561.00
51_M192_V1.3541.00
7_L275_A1.3521.00
209_A218_L1.3451.00
150_W158_G1.3171.00
47_T188_G1.3121.00
28_L167_F1.2871.00
10_L267_S1.2871.00
110_A128_Y1.2781.00
208_Y266_T1.2761.00
94_Y128_Y1.2611.00
90_H93_A1.2611.00
115_M177_R1.2611.00
133_Q248_P1.2581.00
62_Q67_N1.2571.00
14_R84_A1.2551.00
105_A108_T1.2511.00
9_V78_G1.2401.00
105_A109_M1.2361.00
184_R187_S1.2311.00
10_L271_V1.2221.00
140_N208_Y1.2211.00
47_T171_W1.2151.00
228_F237_T1.1871.00
5_T9_V1.1861.00
18_L26_H1.1660.99
74_W156_T1.1630.99
220_A224_S1.1600.99
66_F70_T1.1440.99
92_H257_K1.1380.99
12_F79_L1.1370.99
26_H30_A1.1330.99
143_F166_A1.1270.99
70_T74_W1.1190.99
93_A109_M1.1110.99
188_G192_V1.1080.99
140_N145_L1.0990.99
78_G159_P1.0950.99
209_A214_G1.0930.99
221_W225_L1.0920.99
95_L99_S1.0900.99
165_Y169_R1.0850.99
65_L73_V1.0780.99
115_M237_T1.0680.99
220_A242_F1.0530.99
250_V256_P1.0490.99
261_S265_K1.0470.99
35_V46_M1.0450.99
88_R92_H1.0420.99
217_A243_S1.0410.99
108_T112_E1.0380.99
8_L71_L1.0340.99
10_L84_A1.0340.99
39_S42_R1.0250.99
50_A54_T1.0230.99
62_Q66_F1.0190.99
6_T151_L1.0160.99
98_A129_L1.0140.99
209_A217_A1.0120.98
260_V263_A1.0040.98
32_F175_L1.0030.98
5_T75_L0.9960.98
130_R252_K0.9950.98
207_V266_T0.9860.98
90_H109_M0.9790.98
71_L75_L0.9780.98
115_M131_E0.9760.98
164_G168_L0.9690.98
31_F53_V0.9690.98
243_S262_M0.9660.98
240_A259_A0.9630.98
205_G235_V0.9610.98
41_G45_G0.9600.98
92_H95_L0.9590.98
40_L188_G0.9550.98
141_F197_D0.9540.98
114_T118_G0.9530.98
141_F236_L0.9530.98
229_H252_K0.9420.98
22_W27_R0.9370.97
211_I265_K0.9350.97
212_G217_A0.9290.97
152_I274_I0.9170.97
117_H256_P0.9160.97
6_T148_L0.9130.97
252_K256_P0.9040.97
209_A243_S0.9040.97
47_T168_L0.9010.97
90_H135_A0.8940.97
94_Y97_A0.8890.97
127_E252_K0.8830.96
136_L263_A0.8810.96
32_F171_W0.8720.96
111_G118_G0.8700.96
101_N106_R0.8570.96
35_V49_I0.8560.96
129_L133_Q0.8560.96
212_G262_M0.8530.96
207_V269_V0.8510.96
55_F157_W0.8450.95
205_G209_A0.8450.95
63_G67_N0.8430.95
16_F79_L0.8330.95
215_E219_P0.8310.95
98_A125_E0.8250.95
229_H233_Y0.8210.95
169_R173_Y0.8200.95
180_T183_H0.8200.95
104_H119_V0.8160.94
104_H108_T0.8140.94
91_Y260_V0.8130.94
138_W169_R0.8120.94
14_R264_K0.8100.94
90_H112_E0.8100.94
29_E174_W0.8080.94
120_P253_V0.8080.94
204_A236_L0.8070.94
57_L60_A0.8050.94
224_S227_D0.8010.94
84_A267_S0.8000.94
125_E129_L0.7950.94
62_Q70_T0.7940.94
224_S242_F0.7910.94
98_A106_R0.7870.93
275_A278_T0.7840.93
130_R250_V0.7830.93
172_Q190_D0.7830.93
58_L62_Q0.7820.93
11_I15_L0.7800.93
118_G123_C0.7800.93
77_I156_T0.7790.93
49_I53_V0.7770.93
31_F34_R0.7770.93
211_I266_T0.7760.93
40_L44_L0.7750.93
141_F165_Y0.7750.93
76_L80_L0.7720.93
6_T152_I0.7630.92
59_R63_G0.7590.92
133_Q240_A0.7590.92
54_T167_F0.7510.92
260_V264_K0.7510.92
97_A109_M0.7470.91
62_Q74_W0.7410.91
270_V274_I0.7400.91
110_A127_E0.7310.91
140_N266_T0.7290.90
127_E130_R0.7260.90
166_A169_R0.7180.90
150_W154_G0.7180.90
218_L222_F0.7150.90
10_L14_R0.7100.89
203_L207_V0.7100.89
216_K245_A0.7090.89
115_M173_Y0.7070.89
205_G239_L0.7050.89
53_V56_L0.7050.89
26_H29_E0.7020.89
93_A97_A0.7000.89
244_L259_A0.7000.89
50_A167_F0.6970.88
156_T159_P0.6910.88
164_G167_F0.6910.88
41_G44_L0.6890.88
273_V277_L0.6870.88
39_S185_L0.6830.87
192_V195_V0.6830.87
153_V158_G0.6820.87
222_F226_G0.6800.87
32_F46_M0.6760.87
178_Y187_S0.6740.87
20_E26_H0.6670.86
96_T100_R0.6670.86
178_Y229_H0.6630.86
115_M194_H0.6590.85
81_C166_A0.6590.85
53_V57_L0.6580.85
216_K220_A0.6580.85
87_V139_I0.6530.85
208_Y239_L0.6500.85
169_R197_D0.6490.85
133_Q246_R0.6480.84
92_H96_T0.6480.84
85_G88_R0.6450.84
207_V273_V0.6450.84
217_A221_W0.6440.84
81_C156_T0.6420.84
56_L59_R0.6380.84
138_W142_R0.6380.84
221_W238_R0.6350.83
80_L160_V0.6340.83
58_L77_I0.6320.83
84_A264_K0.6320.83
225_L238_R0.6310.83
142_R193_L0.6280.83
204_A267_S0.6280.83
213_H217_A0.6270.82
86_K90_H0.6260.82
127_E249_H0.6250.82
209_A221_W0.6240.82
90_H97_A0.6240.82
144_Y263_A0.6220.82
35_V50_A0.6220.82
172_Q194_H0.6210.82
201_V236_L0.6180.82
137_L237_T0.6180.82
27_R30_A0.6130.81
7_L271_V0.6110.81
159_P166_A0.6100.81
130_R237_T0.6100.81
90_H110_A0.6090.81
172_Q230_T0.6070.80
23_Q29_E0.6070.80
267_S270_V0.6070.80
48_I52_G0.6060.80
138_W193_L0.6030.80
142_R172_Q0.6010.80
262_M266_T0.6010.80
55_F59_R0.5980.79
120_P127_E0.5950.79
27_R31_F0.5940.79
68_V71_L0.5940.79
151_L156_T0.5930.79
10_L268_F0.5920.79
28_L160_V0.5910.79
101_N125_E0.5910.79
213_H245_A0.5890.78
138_W172_Q0.5890.78
263_A267_S0.5870.78
235_V242_F0.5870.78
108_T111_G0.5870.78
139_I142_R0.5850.78
73_V77_I0.5850.78
260_V270_V0.5850.78
129_L185_L0.5830.78
194_H231_S0.5790.77
101_N105_A0.5790.77
123_C131_E0.5790.77
29_E177_R0.5780.77
179_Q255_T0.5780.77
186_Q190_D0.5780.77
23_Q138_W0.5760.77
34_R37_H0.5760.77
234_Q238_R0.5760.77
172_Q176_A0.5750.77
127_E131_E0.5740.77
93_A112_E0.5730.76
51_M167_F0.5730.76
237_T250_V0.5720.76
170_A174_W0.5720.76
60_A64_V0.5710.76
138_W170_A0.5670.76
42_R185_L0.5670.76
141_F204_A0.5660.76
88_R91_Y0.5650.75
185_L189_I0.5650.75
117_H120_P0.5630.75
62_Q73_V0.5610.75
78_G156_T0.5610.75
137_L228_F0.5610.75
228_F250_V0.5600.75
72_L76_L0.5590.75
68_V72_L0.5570.74
264_K268_F0.5570.74
47_T196_L0.5570.74
172_Q193_L0.5560.74
190_D194_H0.5560.74
214_G217_A0.5550.74
29_E138_W0.5540.74
116_I254_E0.5530.74
233_Y238_R0.5530.74
29_E139_I0.5520.74
23_Q114_T0.5520.74
5_T74_W0.5500.74
219_P222_F0.5500.74
17_K85_G0.5500.74
181_P185_L0.5500.74
266_T269_V0.5490.73
139_I177_R0.5490.73
44_L48_I0.5480.73
149_F153_V0.5480.73
144_Y267_S0.5480.73
170_A177_R0.5470.73
127_E251_D0.5440.73
91_Y97_A0.5430.73
83_G166_A0.5410.72
84_A144_Y0.5410.72
29_E172_Q0.5400.72
94_Y110_A0.5400.72
139_I174_W0.5400.72
107_A123_C0.5390.72
110_A123_C0.5390.72
5_T8_L0.5350.71
56_L63_G0.5350.71
176_A186_Q0.5350.71
26_H79_L0.5330.71
88_R263_A0.5310.71
130_R249_H0.5290.71
46_M50_A0.5270.70
218_L221_W0.5270.70
212_G265_K0.5260.70
179_Q185_L0.5260.70
208_Y243_S0.5260.70
43_T50_A0.5250.70
29_E173_Y0.5250.70
206_V210_L0.5240.70
83_G143_F0.5220.70
146_A197_D0.5210.70
62_Q156_T0.5210.70
56_L60_A0.5200.69
58_L159_P0.5200.69
178_Y191_A0.5150.69
206_V218_L0.5130.68
194_H230_T0.5130.68
106_R128_Y0.5110.68
141_F205_G0.5100.68
107_A134_N0.5090.68
249_H252_K0.5090.68
18_L237_T0.5080.68
86_K113_L0.5050.67
23_Q170_A0.5040.67
14_R268_F0.5040.67
210_L214_G0.5040.67
19_G24_L0.5030.67
92_H260_V0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ksdA 1 0.2641 13.6 0.957 Contact Map
3j01B 1 0.2641 4.3 0.966 Contact Map
3j00Z 1 0.3275 4.2 0.966 Contact Map
3dl8C 1 0.1232 2.7 0.97 Contact Map
3dinD 1 0.1761 2.7 0.97 Contact Map
4c7rA 3 0.4401 2.7 0.97 Contact Map
4bqdC 1 0.0704 2 0.972 Contact Map
2zjsE 1 0.1408 1.8 0.972 Contact Map
4mndA 2 0.2923 1.6 0.973 Contact Map
1lamA 5 0.2113 1.2 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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