GREMLIN Database
AMN - AMP nucleosidase
UniProt: P0AE12 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10039
Length: 484 (469)
Sequences: 435 (176)
Seq/√Len: 8.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
210_V275_L7.7351.00
16_K19_A5.9361.00
101_L112_I4.6520.99
11_A98_N4.2810.98
20_L24_S4.2420.98
17_L87_I4.1070.98
18_D94_R4.0880.98
160_D414_Y3.9380.97
56_S84_T3.9080.97
15_D94_R3.6730.96
276_V292_L3.5890.95
17_L101_L3.5420.95
57_L87_I3.2600.92
160_D334_V3.1170.90
347_V377_T3.0150.88
230_A266_I2.9690.87
24_S116_P2.9620.87
10_P105_Y2.6590.81
184_A416_F2.6550.80
23_Q116_P2.4080.73
273_I457_I2.3480.71
223_D226_S2.2710.69
229_I268_A2.2200.67
97_L179_V2.2190.67
77_F104_L2.2150.67
154_I449_I2.1990.66
177_R323_A2.1630.65
267_T464_R2.1610.65
227_P267_T2.1570.64
323_A343_S2.1350.64
87_I97_L2.1330.63
16_K94_R2.1330.63
481_P484_R2.0490.60
31_A52_F2.0290.59
217_G435_I2.0270.59
207_T257_K2.0160.59
334_V435_I1.9070.54
10_P14_L1.9020.54
377_T386_R1.8990.54
442_N467_G1.8780.53
191_G392_L1.8170.51
75_G203_F1.8140.51
56_S217_G1.8010.50
14_L333_A1.8000.50
155_G234_A1.7950.50
11_A14_L1.7730.49
57_L356_K1.7590.48
191_G378_T1.7380.47
352_Y356_K1.7370.47
160_D315_I1.7090.46
14_L18_D1.6960.46
31_A34_N1.6850.45
249_A330_V1.6820.45
18_D22_E1.6760.45
16_K115_Q1.6730.45
231_L359_S1.6720.45
299_V440_Q1.6700.45
343_S400_V1.6600.44
39_G42_P1.6540.44
200_F271_Q1.6530.44
87_I101_L1.6520.44
105_Y112_I1.6400.43
8_L12_Q1.6280.43
32_I191_G1.6120.42
234_A237_N1.6080.42
76_R177_R1.6080.42
17_L112_I1.6030.42
267_T271_Q1.5920.42
74_F323_A1.5880.41
333_A358_V1.5730.41
76_R154_I1.5640.40
378_T394_F1.5610.40
220_Q223_D1.5400.39
355_T370_L1.5380.39
193_P232_S1.5360.39
208_R369_R1.5320.39
435_I459_A1.5290.39
98_N105_Y1.5210.39
148_T394_F1.5170.39
442_N481_P1.5140.38
159_A191_G1.5090.38
202_L276_V1.5070.38
9_T12_Q1.5060.38
318_Y360_G1.5060.38
12_Q30_N1.5060.38
23_Q224_P1.5050.38
401_A460_I1.4770.37
57_L114_V1.4760.37
184_A299_V1.4740.37
256_K299_V1.4680.37
195_E203_F1.4670.37
235_G238_W1.4620.36
231_L376_V1.4580.36
92_L212_E1.4510.36
307_G402_I1.4370.35
14_L17_L1.4330.35
172_S359_S1.4210.35
142_L275_L1.4190.35
115_Q464_R1.4180.35
288_I360_G1.4180.35
23_Q362_P1.4180.35
208_R344_I1.4160.35
76_R481_P1.4140.35
435_I448_A1.4010.34
149_T412_Q1.4000.34
266_I270_G1.3990.34
203_F323_A1.3970.34
138_M217_G1.3660.33
241_A465_A1.3650.33
84_T239_I1.3630.33
26_V358_V1.3620.33
203_F212_E1.3600.33
334_V414_Y1.3590.33
334_V440_Q1.3540.32
142_L454_Q1.3510.32
80_A112_I1.3460.32
98_N102_T1.3430.32
202_L457_I1.3420.32
398_R456_G1.3330.32
39_G97_L1.3280.31
29_R217_G1.3280.31
219_S268_A1.3170.31
199_P484_R1.3120.31
14_L112_I1.3080.31
370_L394_F1.3050.31
20_L116_P1.3010.31
231_L311_E1.3000.30
336_P350_A1.2900.30
24_S224_P1.2810.30
314_A461_D1.2760.30
127_I256_K1.2730.30
217_G266_I1.2720.29
159_A389_A1.2720.29
109_G167_E1.2700.29
85_T236_G1.2650.29
169_S392_L1.2610.29
292_L484_R1.2590.29
438_P461_D1.2580.29
283_S287_T1.2540.29
313_Q322_H1.2500.29
209_Y313_Q1.2500.29
209_Y322_H1.2500.29
201_V455_I1.2500.29
208_R481_P1.2490.29
37_T114_V1.2480.29
11_A15_D1.2480.29
142_L449_I1.2430.29
58_T84_T1.2400.28
429_K434_E1.2360.28
458_R461_D1.2300.28
22_E109_G1.2260.28
394_F467_G1.2120.27
79_H231_L1.2100.27
221_I234_A1.2090.27
134_L467_G1.2040.27
154_I481_P1.1980.27
271_Q370_L1.1940.27
184_A216_W1.1930.27
83_Y280_V1.1920.27
230_A239_I1.1800.26
154_I191_G1.1770.26
69_P370_L1.1710.26
68_P159_A1.1670.26
135_D242_E1.1670.26
209_Y291_H1.1650.26
291_H322_H1.1650.26
291_H313_Q1.1650.26
244_E414_Y1.1620.26
301_L347_V1.1600.26
108_Y125_Y1.1530.26
299_V311_E1.1490.25
147_P208_R1.1470.25
16_K222_L1.1420.25
187_R394_F1.1410.25
22_E26_V1.1380.25
58_T113_S1.1350.25
30_N353_D1.1320.25
231_L298_D1.1310.25
339_I377_T1.1290.25
53_V116_P1.1270.25
322_H398_R1.1260.25
313_Q398_R1.1260.25
209_Y398_R1.1260.25
182_S385_L1.1210.25
313_Q456_G1.1200.25
322_H456_G1.1200.25
209_Y456_G1.1200.25
160_D435_I1.1180.24
10_P102_T1.1090.24
17_L438_P1.1040.24
84_T168_F1.1020.24
10_P104_L1.1000.24
416_F440_Q1.0990.24
159_A314_A1.0980.24
17_L466_E1.0950.24
467_G481_P1.0950.24
124_P208_R1.0920.24
344_I391_A1.0890.24
310_R322_H1.0880.24
310_R313_Q1.0880.24
209_Y310_R1.0880.24
378_T481_P1.0840.23
10_P362_P1.0740.23
292_L360_G1.0730.23
106_Q358_V1.0700.23
359_S477_T1.0680.23
251_S303_I1.0680.23
67_N231_L1.0630.23
17_L454_Q1.0590.23
56_S97_L1.0560.23
214_V303_I1.0480.22
101_L105_Y1.0420.22
149_T460_I1.0390.22
75_G412_Q1.0370.22
197_F201_V1.0340.22
291_H398_R1.0340.22
398_R425_C1.0330.22
97_L467_G1.0330.22
173_H366_V1.0320.22
73_A460_I1.0320.22
20_L26_V1.0300.22
291_H425_C1.0300.22
286_K438_P1.0290.22
203_F256_K1.0290.22
291_H456_G1.0280.22
155_G412_Q1.0260.22
425_C456_G1.0260.22
155_G184_A1.0190.22
457_I466_E1.0140.21
208_R484_R1.0120.21
289_C412_Q1.0090.21
22_E217_G1.0080.21
196_H377_T1.0070.21
196_H435_I1.0050.21
25_V126_V1.0050.21
10_P34_N1.0010.21
59_V110_A0.9970.21
18_D87_I0.9960.21
125_Y315_I0.9940.21
303_I451_E0.9900.21
195_E266_I0.9890.21
352_Y355_T0.9870.21
243_T360_G0.9850.21
39_G114_V0.9850.21
291_H310_R0.9840.21
230_A268_A0.9810.21
447_G451_E0.9790.20
181_F431_L0.9790.20
195_E212_E0.9740.20
214_V318_Y0.9730.20
310_R398_R0.9710.20
299_V395_N0.9690.20
253_L377_T0.9670.20
44_E94_R0.9660.20
235_G325_L0.9660.20
310_R456_G0.9650.20
153_Q157_E0.9640.20
344_I484_R0.9640.20
18_D91_T0.9630.20
147_P292_L0.9620.20
234_A303_I0.9590.20
318_Y451_E0.9570.20
75_G370_L0.9560.20
210_V291_H0.9540.20
225_D377_T0.9530.20
292_L380_D0.9530.20
95_S270_G0.9510.20
94_R358_V0.9510.20
11_A112_I0.9480.20
193_P225_D0.9470.20
20_L23_Q0.9470.20
184_A440_Q0.9450.20
212_E323_A0.9420.20
398_R433_G0.9420.20
357_L458_R0.9360.19
433_G456_G0.9340.19
116_P173_H0.9340.19
369_R481_P0.9340.19
230_A238_W0.9330.19
20_L177_R0.9320.19
162_I396_L0.9310.19
299_V416_F0.9290.19
61_W79_H0.9270.19
199_P298_D0.9230.19
187_R438_P0.9220.19
191_G466_E0.9190.19
325_L414_Y0.9180.19
119_H460_I0.9170.19
58_T368_Q0.9160.19
208_R292_L0.9150.19
15_D98_N0.9150.19
256_K335_L0.9130.19
229_I269_D0.9110.19
323_A464_R0.9110.19
380_D484_R0.9080.19
69_P75_G0.9060.19
36_I58_T0.9010.18
177_R327_D0.9000.18
166_T195_E0.8980.18
52_F108_Y0.8970.18
276_V394_F0.8960.18
217_G442_N0.8940.18
173_H481_P0.8940.18
275_L479_N0.8930.18
211_D234_A0.8900.18
155_G216_W0.8900.18
299_V394_F0.8890.18
448_A481_P0.8850.18
184_A220_Q0.8820.18
73_A447_G0.8820.18
466_E481_P0.8800.18
23_Q99_E0.8800.18
192_T197_F0.8780.18
149_T440_Q0.8780.18
175_D307_G0.8730.18
211_D318_Y0.8730.18
385_L456_G0.8700.18
157_E323_A0.8670.18
396_L401_A0.8670.18
177_R389_A0.8660.18
345_A472_S0.8640.18
254_A359_S0.8610.17
344_I369_R0.8610.17
239_I401_A0.8600.17
137_S347_V0.8600.17
76_R184_A0.8580.17
231_L477_T0.8570.17
375_V401_A0.8530.17
116_P224_P0.8490.17
12_Q118_Q0.8490.17
12_Q400_V0.8480.17
93_F321_A0.8470.17
93_F103_L0.8460.17
303_I484_R0.8450.17
15_D23_Q0.8440.17
86_T117_S0.8420.17
385_L398_R0.8420.17
19_A37_T0.8360.17
333_A356_K0.8350.17
315_I334_V0.8330.17
105_Y159_A0.8320.17
16_K25_V0.8320.17
323_A446_E0.8310.17
343_S396_L0.8300.17
123_Y451_E0.8290.17
214_V217_G0.8290.17
135_D238_W0.8240.17
77_F217_G0.8240.17
313_Q425_C0.8220.17
193_P221_I0.8220.17
322_H425_C0.8220.17
209_Y425_C0.8220.17
126_V369_R0.8200.17
341_I377_T0.8200.17
216_W220_Q0.8200.17
454_Q465_A0.8190.17
12_Q114_V0.8190.17
15_D18_D0.8180.16
115_Q333_A0.8170.16
315_I440_Q0.8160.16
154_I380_D0.8060.16
17_L20_L0.8050.16
56_S148_T0.8030.16
239_I243_T0.8020.16
119_H467_G0.8010.16
369_R484_R0.8000.16
201_V357_L0.7990.16
8_L22_E0.7940.16
43_D362_P0.7940.16
336_P407_A0.7940.16
157_E386_R0.7940.16
138_M173_H0.7920.16
339_I467_G0.7910.16
70_K349_R0.7900.16
119_H177_R0.7890.16
329_H379_D0.7880.16
319_V425_C0.7840.16
370_L395_N0.7840.16
14_L101_L0.7840.16
69_P77_F0.7830.16
56_S467_G0.7800.16
11_A19_A0.7790.16
212_E438_P0.7770.16
169_S301_L0.7760.16
94_R98_N0.7750.16
187_R323_A0.7730.15
79_H115_Q0.7720.15
155_G325_L0.7710.15
25_V32_I0.7680.15
263_W269_D0.7680.15
24_S74_F0.7670.15
214_V288_I0.7670.15
192_T335_L0.7670.15
364_E389_A0.7670.15
127_I221_I0.7660.15
203_F287_T0.7640.15
212_E407_A0.7640.15
236_G256_K0.7600.15
217_G240_T0.7590.15
124_P143_T0.7580.15
177_R343_S0.7570.15
191_G391_A0.7560.15
358_V365_E0.7540.15
134_L358_V0.7510.15
155_G388_S0.7480.15
10_P26_V0.7470.15
28_L66_T0.7460.15
98_N268_A0.7440.15
155_G315_I0.7440.15
157_E360_G0.7440.15
391_A448_A0.7430.15
299_V469_R0.7400.15
193_P239_I0.7400.15
159_A352_Y0.7400.15
100_Q408_T0.7400.15
395_N479_N0.7380.15
112_I227_P0.7370.15
378_T442_N0.7370.15
209_Y319_V0.7330.15
319_V322_H0.7330.15
313_Q319_V0.7330.15
177_R438_P0.7330.15
94_R139_S0.7320.15
36_I104_L0.7310.15
141_G224_P0.7250.14
113_S177_R0.7230.14
76_R79_H0.7220.14
14_L447_G0.7200.14
75_G107_D0.7200.14
36_I337_P0.7190.14
314_A457_I0.7190.14
219_S288_I0.7190.14
182_S322_H0.7170.14
182_S313_Q0.7170.14
182_S209_Y0.7170.14
299_V327_D0.7170.14
20_L463_L0.7130.14
217_G448_A0.7120.14
147_P484_R0.7120.14
318_Y325_L0.7120.14
15_D62_D0.7090.14
16_K20_L0.7070.14
299_V400_V0.7070.14
74_F162_I0.7070.14
162_I347_V0.7070.14
191_G387_Y0.7060.14
408_T438_P0.7060.14
87_I217_G0.7020.14
30_N358_V0.7010.14
118_Q341_I0.7010.14
126_V283_S0.7010.14
313_Q385_L0.7000.14
322_H385_L0.7000.14
209_Y385_L0.7000.14
125_Y482_P0.6990.14
113_S225_D0.6990.14
155_G175_D0.6960.14
398_R434_E0.6950.14
12_Q26_V0.6940.14
162_I219_S0.6930.14
176_A449_I0.6910.14
438_P458_R0.6890.14
313_Q433_G0.6870.14
322_H433_G0.6870.14
209_Y433_G0.6870.14
215_R343_S0.6870.14
434_E456_G0.6860.14
20_L34_N0.6850.14
191_G201_V0.6850.14
210_V221_I0.6840.14
13_A77_F0.6800.14
32_I238_W0.6790.14
364_E378_T0.6790.14
214_V481_P0.6780.14
119_H299_V0.6760.14
385_L439_G0.6740.13
32_I77_F0.6730.13
391_A481_P0.6710.13
256_K484_R0.6700.13
87_I365_E0.6690.13
30_N400_V0.6690.13
66_T84_T0.6690.13
155_G160_D0.6680.13
133_T223_D0.6660.13
119_H230_A0.6650.13
370_L451_E0.6650.13
159_A173_H0.6640.13
136_R343_S0.6640.13
208_R307_G0.6630.13
59_V239_I0.6620.13
153_Q323_A0.6610.13
56_S115_Q0.6610.13
241_A270_G0.6610.13
315_I380_D0.6600.13
243_T248_E0.6590.13
10_P98_N0.6570.13
386_R408_T0.6510.13
301_L377_T0.6510.13
194_V407_A0.6500.13
333_A389_A0.6490.13
336_P367_K0.6470.13
235_G243_T0.6470.13
291_H433_G0.6470.13
378_T391_A0.6470.13
58_T464_R0.6450.13
161_G438_P0.6440.13
22_E94_R0.6440.13
73_A366_V0.6420.13
275_L464_R0.6420.13
212_E394_F0.6420.13
173_H191_G0.6390.13
221_I224_P0.6390.13
219_S241_A0.6380.13
126_V191_G0.6380.13
398_R449_I0.6370.13
147_P380_D0.6350.13
310_R425_C0.6330.13
104_L142_L0.6320.13
291_H319_V0.6320.13
239_I468_D0.6310.13
311_E477_T0.6310.13
449_I456_G0.6310.13
221_I225_D0.6290.13
45_N468_D0.6290.13
210_V319_V0.6280.13
221_I231_L0.6280.13
17_L56_S0.6270.13
288_I408_T0.6270.13
355_T361_R0.6260.13
412_Q440_Q0.6250.13
71_T172_S0.6240.13
225_D238_W0.6230.13
125_Y258_H0.6220.13
355_T412_Q0.6200.12
425_C433_G0.6200.12
403_D422_T0.6200.12
110_A195_E0.6200.12
140_A239_I0.6190.12
182_S291_H0.6180.12
120_E440_Q0.6170.12
200_F470_L0.6160.12
319_V398_R0.6160.12
10_P301_L0.6120.12
349_R409_I0.6120.12
173_H467_G0.6120.12
319_V456_G0.6100.12
91_T97_L0.6100.12
132_L138_M0.6090.12
448_A467_G0.6080.12
192_T434_E0.6080.12
35_Y113_S0.6080.12
89_R400_V0.6070.12
183_L345_A0.6070.12
108_Y179_V0.6060.12
30_N268_A0.6050.12
11_A89_R0.6050.12
235_G251_S0.6030.12
275_L484_R0.6030.12
135_D234_A0.6010.12
217_G227_P0.6000.12
7_G12_Q0.6000.12
181_F186_L0.5990.12
268_A377_T0.5980.12
135_D360_G0.5980.12
24_S353_D0.5980.12
12_Q229_I0.5970.12
273_I469_R0.5960.12
14_L163_Y0.5950.12
98_N365_E0.5950.12
17_L97_L0.5950.12
216_W303_I0.5950.12
70_K80_A0.5940.12
256_K368_Q0.5940.12
182_S398_R0.5930.12
344_I378_T0.5920.12
119_H408_T0.5920.12
85_T360_G0.5910.12
120_E338_D0.5900.12
61_W66_T0.5890.12
217_G451_E0.5870.12
24_S303_I0.5860.12
22_E358_V0.5860.12
182_S456_G0.5860.12
203_F461_D0.5840.12
301_L321_A0.5840.12
385_L478_F0.5830.12
292_L344_I0.5820.12
199_P402_I0.5820.12
10_P60_T0.5820.12
479_N484_R0.5810.12
59_V268_A0.5810.12
11_A26_V0.5800.12
12_Q34_N0.5780.12
291_H367_K0.5780.12
329_H462_L0.5770.12
10_P13_A0.5770.12
183_L186_L0.5760.12
118_Q465_A0.5750.12
416_F464_R0.5730.12
12_Q99_E0.5730.12
323_A470_L0.5730.12
160_D227_P0.5720.12
270_G463_L0.5720.12
236_G251_S0.5720.12
61_W77_F0.5710.12
344_I402_I0.5710.12
425_C449_I0.5700.12
219_S462_L0.5700.12
161_G477_T0.5700.12
202_L338_D0.5700.12
82_S91_T0.5690.12
29_R59_V0.5690.12
380_D446_E0.5690.12
353_D356_K0.5650.12
169_S368_Q0.5650.12
72_R292_L0.5650.12
118_Q138_M0.5640.11
14_L98_N0.5640.11
82_S400_V0.5630.11
107_D307_G0.5630.11
61_W207_T0.5620.11
258_H315_I0.5620.11
147_P344_I0.5620.11
292_L369_R0.5610.11
347_V409_I0.5610.11
59_V460_I0.5600.11
34_N38_S0.5590.11
74_F270_G0.5590.11
336_P347_V0.5590.11
74_F288_I0.5560.11
442_N449_I0.5560.11
288_I318_Y0.5550.11
35_Y136_R0.5550.11
14_L458_R0.5550.11
158_T349_R0.5550.11
231_L460_I0.5540.11
291_H385_L0.5540.11
86_T365_E0.5520.11
166_T357_L0.5510.11
398_R478_F0.5500.11
226_S349_R0.5490.11
310_R319_V0.5460.11
87_I269_D0.5460.11
127_I288_I0.5420.11
456_G478_F0.5410.11
183_L434_E0.5410.11
203_F458_R0.5400.11
218_C482_P0.5380.11
307_G481_P0.5380.11
280_V286_K0.5360.11
159_A337_P0.5340.11
322_H449_I0.5330.11
313_Q449_I0.5330.11
209_Y449_I0.5330.11
56_S87_I0.5320.11
211_D451_E0.5300.11
315_I446_E0.5300.11
102_T217_G0.5290.11
9_T29_R0.5290.11
13_A85_T0.5290.11
97_L448_A0.5280.11
16_K217_G0.5280.11
288_I447_G0.5280.11
325_L425_C0.5270.11
182_S310_R0.5260.11
236_G329_H0.5260.11
147_P482_P0.5240.11
244_E248_E0.5230.11
315_I412_Q0.5230.11
35_Y479_N0.5230.11
94_R341_I0.5220.11
157_E173_H0.5220.11
151_L277_N0.5210.11
29_R74_F0.5210.11
211_D262_A0.5200.11
148_T181_F0.5190.11
71_T339_I0.5190.11
335_L411_A0.5180.11
8_L112_I0.5170.11
73_A271_Q0.5160.11
310_R385_L0.5160.11
221_I262_A0.5150.11
72_R107_D0.5120.11
68_P225_D0.5120.11
136_R237_N0.5120.11
25_V443_R0.5120.11
135_D148_T0.5110.11
292_L303_I0.5090.11
310_R433_G0.5090.11
82_S102_T0.5080.11
26_V459_A0.5070.11
177_R184_A0.5070.11
132_L177_R0.5070.11
69_P361_R0.5060.11
15_D99_E0.5050.11
237_N477_T0.5040.11
33_G106_Q0.5030.11
398_R435_I0.5030.11
14_L172_S0.5030.11
203_F283_S0.5030.11
221_I235_G0.5030.11
172_S229_I0.5020.10
412_Q461_D0.5010.10
107_D481_P0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1t8sA 3 0.9132 100 0.506 Contact Map
1ybfA 3 0.4979 100 0.893 Contact Map
3mb8A 4 0.5062 99.9 0.907 Contact Map
3phcA 5 0.5 99.9 0.911 Contact Map
2b94A 4 0.4979 99.8 0.925 Contact Map
3bjeA 2 0.5186 99.7 0.927 Contact Map
4mchA 3 0.4917 99.7 0.929 Contact Map
3u40A 4 0.4525 99.7 0.929 Contact Map
3qpbA 6 0.4917 99.7 0.931 Contact Map
4ldnA 3 0.4959 99.7 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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