GREMLIN Database
AHPC - Alkyl hydroperoxide reductase subunit C
UniProt: P0AE08 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11384
Length: 187 (147)
Sequences: 8695 (4848)
Seq/√Len: 399.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_W127_P3.1761.00
12_K23_E3.0721.00
42_D79_H2.9631.00
64_L153_K2.9331.00
32_R67_D2.7741.00
8_I108_F2.5471.00
12_K25_T2.5411.00
58_Y62_Q2.4281.00
126_D132_Q2.2891.00
112_R119_D2.2471.00
55_A93_K2.2021.00
14_Q23_E2.1161.00
7_K130_I2.0601.00
3_L6_T1.9551.00
57_H60_E1.9111.00
10_P27_K1.8651.00
18_N22_I1.8581.00
73_T102_G1.8081.00
73_T105_T1.7951.00
13_N104_L1.7771.00
58_Y93_K1.7651.00
103_A107_N1.7531.00
25_T28_D1.7411.00
57_H145_A1.7361.00
19_G83_H1.6981.00
13_N97_I1.6771.00
133_A151_K1.6491.00
66_V152_I1.6471.00
43_F90_A1.6271.00
62_Q67_D1.6101.00
24_I29_T1.4931.00
126_D130_I1.4901.00
43_F81_A1.4791.00
60_E63_K1.4531.00
14_Q76_H1.4361.00
102_G106_R1.4301.00
10_P25_T1.4281.00
59_E63_K1.4251.00
55_A94_Y1.4111.00
105_T118_A1.3971.00
30_E34_S1.3851.00
80_K84_S1.3601.00
70_A96_M1.3321.00
73_T118_A1.3151.00
51_L92_I1.3151.00
49_T142_G1.2981.00
18_N95_A1.2741.00
34_S69_Y1.2461.00
52_G56_D1.2441.00
35_V124_V1.1971.00
57_H146_S1.1881.00
146_S150_R1.1681.00
29_T34_S1.1651.00
33_W66_V1.1611.00
38_F71_V1.1531.00
59_E62_Q1.1481.00
102_G111_M1.1341.00
147_D150_R1.1311.00
2_S131_I1.1201.00
106_R111_M1.1151.00
43_F85_S1.1061.00
29_T69_Y1.1031.00
132_Q138_A1.0971.00
37_F51_L1.0701.00
110_N123_F1.0681.00
34_S67_D1.0661.00
52_G55_A1.0641.00
125_V131_I1.0641.00
60_E149_L1.0531.00
7_K30_E1.0461.00
110_N121_A1.0431.00
104_L108_F1.0351.00
4_I133_A1.0331.00
33_W132_Q1.0261.00
37_F94_Y1.0121.00
77_F81_A1.0101.00
85_S90_A0.9991.00
35_V122_T0.9891.00
53_D57_H0.9891.00
151_K154_A0.9871.00
61_L149_L0.9761.00
67_D95_A0.9751.00
26_E34_S0.9731.00
143_R146_S0.9691.00
124_V151_K0.9601.00
60_E153_K0.9461.00
75_T78_T0.9421.00
20_E80_K0.9371.00
27_K30_E0.9331.00
81_A84_S0.9271.00
65_G127_P0.9201.00
43_F78_T0.9191.00
35_V66_V0.9181.00
102_G105_T0.9131.00
30_E129_G0.9061.00
80_K83_H0.8941.00
76_H98_G0.8941.00
8_I131_I0.8861.00
150_R153_K0.8851.00
149_L153_K0.8671.00
4_I134_I0.8641.00
71_V104_L0.8631.00
123_F131_I0.8581.00
10_P26_E0.8541.00
8_I125_V0.8481.00
11_F108_F0.8431.00
18_N24_I0.8401.00
8_I26_E0.8321.00
53_D56_D0.8321.00
124_V136_V0.8251.00
50_E54_V0.8191.00
36_F108_F0.8171.00
39_Y42_D0.8041.00
54_V148_L0.8031.00
54_V68_V0.7991.00
24_I69_Y0.7951.00
34_S125_V0.7921.00
103_A106_R0.7901.00
105_T111_M0.7891.00
52_G90_A0.7891.00
34_S129_G0.7881.00
136_V151_K0.7871.00
150_R154_A0.7871.00
55_A58_Y0.7861.00
11_F104_L0.7861.00
49_T52_G0.7841.00
14_Q100_P0.7711.00
133_A147_D0.7661.00
64_L149_L0.7511.00
60_E64_L0.7491.00
57_H61_L0.7461.00
122_T148_L0.7431.00
114_D117_L0.7361.00
36_F125_V0.7341.00
75_T100_P0.7281.00
64_L152_I0.7271.00
140_G143_R0.7251.00
41_A74_D0.7231.00
36_F71_V0.7201.00
143_R147_D0.7201.00
35_V148_L0.7171.00
132_Q155_A0.7061.00
69_Y97_I0.7051.00
119_D137_T0.6941.00
41_A117_L0.6901.00
51_L70_A0.6830.99
121_A136_V0.6820.99
8_I104_L0.6810.99
54_V145_A0.6800.99
59_E93_K0.6780.99
124_V133_A0.6740.99
51_L94_Y0.6720.99
131_I134_I0.6670.99
9_K107_N0.6640.99
37_F70_A0.6600.99
33_W152_I0.6550.99
4_I131_I0.6530.99
33_W65_G0.6490.99
134_I137_T0.6420.99
119_D138_A0.6400.99
40_P44_T0.6390.99
113_E116_G0.6370.99
135_E148_L0.6360.99
42_D78_T0.6310.99
10_P30_E0.6310.99
58_Y68_V0.6140.99
2_S6_T0.6130.99
19_G95_A0.6130.99
29_T67_D0.6080.99
77_F80_K0.6080.99
141_I154_A0.6070.99
38_F110_N0.5990.99
53_D145_A0.5990.99
122_T135_E0.5940.99
8_I34_S0.5880.98
121_A137_T0.5860.98
112_R115_E0.5820.98
66_V148_L0.5810.98
39_Y70_A0.5810.98
31_G127_P0.5790.98
141_I155_A0.5740.98
119_D139_E0.5700.98
121_A134_I0.5690.98
45_F48_P0.5660.98
11_F125_V0.5590.98
62_Q93_K0.5590.98
117_L139_E0.5580.98
69_Y95_A0.5550.98
41_A75_T0.5540.98
112_R117_L0.5540.98
38_F108_F0.5540.98
61_L66_V0.5460.98
57_H149_L0.5450.98
18_N21_F0.5450.98
76_H80_K0.5440.97
32_R62_Q0.5430.97
73_T111_M0.5410.97
37_F79_H0.5400.97
49_T141_I0.5400.97
18_N80_K0.5340.97
68_V94_Y0.5290.97
61_L68_V0.5260.97
124_V152_I0.5260.97
18_N97_I0.5250.97
97_I104_L0.5250.97
58_Y67_D0.5250.97
53_D146_S0.5240.97
44_T120_R0.5230.97
39_Y82_W0.5220.97
32_R65_G0.5210.97
20_E83_H0.5130.96
40_P120_R0.5110.96
124_V148_L0.5090.96
28_D31_G0.5080.96
6_T134_I0.5060.96
39_Y79_H0.5050.96
115_E119_D0.5040.96
26_E29_T0.5040.96
40_P82_W0.5010.96
37_F50_E0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3a2vA 5 0.9733 100 0.285 Contact Map
2v2gA 2 0.9733 100 0.286 Contact Map
3w6gA 6 0.9679 100 0.291 Contact Map
1prxA 2 0.9733 100 0.296 Contact Map
1xccA 2 0.9733 100 0.297 Contact Map
3tjjA 3 0.8663 100 0.396 Contact Map
2c0dA 2 0.8877 100 0.409 Contact Map
2pn8A 4 0.9893 100 0.416 Contact Map
4rqxA 3 0.8663 100 0.418 Contact Map
3sbcA 3 0.9572 100 0.42 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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