GREMLIN Database
ACRA - Multidrug efflux pump subunit AcrA
UniProt: P0AE06 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11703
Length: 397 (349)
Sequences: 21936 (17449)
Seq/√Len: 934.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
78_K95_Q3.1151.00
92_S175_K2.9471.00
338_V351_E2.7761.00
44_T358_R2.7091.00
327_G333_E2.6721.00
322_T334_T2.5851.00
88_E181_S2.5571.00
335_R357_D2.4301.00
325_V335_R2.3671.00
61_S215_D2.3541.00
123_Q127_N2.3101.00
310_Q347_W2.2821.00
261_E279_I2.2151.00
47_T355_A2.2131.00
258_G278_A2.1741.00
307_L346_K2.1661.00
95_Q175_K2.1581.00
109_K168_R2.1471.00
129_Y138_I2.0951.00
48_E346_K2.0881.00
130_Q134_G2.0831.00
80_N95_Q2.0751.00
147_L151_Q2.0741.00
241_K257_D2.0681.00
47_T304_N2.0411.00
71_Q173_Y2.0341.00
98_P102_Q2.0331.00
88_E91_V2.0311.00
92_S177_T1.9761.00
129_Y146_A1.9201.00
354_K357_D1.9111.00
48_E307_L1.9021.00
340_S348_L1.8901.00
130_Q147_L1.8881.00
80_N92_S1.8761.00
252_I286_T1.8561.00
243_K257_D1.8471.00
86_D183_R1.8281.00
216_V295_A1.8241.00
243_K253_K1.8011.00
140_K144_D1.7871.00
133_L143_Y1.7821.00
60_T214_V1.7461.00
333_E369_P1.7371.00
113_A116_Q1.7351.00
185_G207_Q1.7351.00
215_D275_T1.7161.00
331_K372_Q1.7161.00
22_L25_C1.6871.00
339_A347_W1.6861.00
53_T296_R1.6861.00
89_A181_S1.6831.00
150_A154_N1.6731.00
121_I125_T1.6671.00
338_V350_T1.6631.00
213_Y277_R1.6561.00
116_Q161_K1.6351.00
332_V360_V1.6311.00
340_S350_T1.6291.00
123_Q154_N1.6281.00
133_L140_K1.6191.00
242_A278_A1.6151.00
158_T161_K1.6111.00
106_D109_K1.5971.00
76_I189_V1.5931.00
119_A150_A1.5871.00
216_V278_A1.5771.00
241_K259_T1.5571.00
326_V373_V1.5551.00
126_V130_Q1.5451.00
319_G336_P1.5331.00
67_E202_A1.5191.00
151_Q154_N1.5001.00
341_Q348_L1.5001.00
64_R208_Q1.4921.00
76_I94_Y1.4871.00
21_A25_C1.4781.00
114_K156_A1.4761.00
316_T334_T1.4751.00
45_V306_I1.4731.00
315_R321_A1.4691.00
325_V357_D1.4671.00
142_E145_Q1.4591.00
82_K85_S1.4551.00
323_V337_I1.4541.00
120_N123_Q1.4501.00
123_Q150_A1.4481.00
60_T212_I1.4431.00
214_V293_V1.4421.00
45_V356_G1.4251.00
65_I205_T1.4161.00
55_E296_R1.4071.00
208_Q211_P1.4041.00
49_P303_P1.3941.00
246_L293_V1.3881.00
217_T275_T1.3861.00
310_Q345_D1.3841.00
126_V143_Y1.3841.00
55_E294_R1.3781.00
119_A123_Q1.3761.00
165_E168_R1.3711.00
112_L116_Q1.3701.00
41_G362_S1.3681.00
126_V150_A1.3641.00
267_V274_I1.3591.00
105_Y164_V1.3541.00
145_Q149_D1.3491.00
112_L164_V1.3471.00
302_N348_L1.3401.00
77_L97_D1.3371.00
42_V375_A1.3361.00
143_Y147_L1.3271.00
93_L204_A1.3241.00
308_V359_V1.3221.00
74_G96_I1.3181.00
39_A374_K1.3151.00
219_S222_D1.3131.00
120_N124_L1.2961.00
114_K118_A1.2961.00
42_V326_V1.2941.00
102_Q171_L1.2911.00
327_G331_K1.2901.00
42_V358_R1.2881.00
243_K298_E1.2851.00
154_N158_T1.2701.00
127_N130_Q1.2701.00
43_V361_I1.2651.00
102_Q106_D1.2621.00
184_I204_A1.2621.00
22_L26_D1.2591.00
305_A348_L1.2561.00
49_P304_N1.2561.00
243_K296_R1.2481.00
116_Q120_N1.2411.00
161_K165_E1.2371.00
178_S206_V1.2241.00
196_Q199_Q1.2191.00
259_T279_I1.2161.00
245_S296_R1.2111.00
211_P279_I1.2081.00
126_V147_L1.2061.00
166_T170_N1.1991.00
101_Y174_T1.1931.00
306_I355_A1.1881.00
73_S197_N1.1871.00
67_E205_T1.1861.00
245_S253_K1.1861.00
186_K205_T1.1801.00
92_S95_Q1.1671.00
112_L157_V1.1641.00
168_R172_A1.1581.00
262_F277_R1.1551.00
337_I349_V1.1511.00
111_D114_K1.1481.00
120_N151_Q1.1441.00
94_Y204_A1.1411.00
105_Y109_K1.1411.00
214_V295_A1.1321.00
78_K191_E1.1281.00
81_F91_V1.1261.00
187_S204_A1.1151.00
187_S190_T1.1121.00
131_K135_T1.1121.00
215_D277_R1.1041.00
244_V280_F1.0981.00
125_T129_Y1.0971.00
127_N131_K1.0911.00
223_F274_I1.0891.00
321_A339_A1.0841.00
119_A154_N1.0801.00
264_D275_T1.0711.00
326_V358_R1.0681.00
82_K187_S1.0671.00
63_Y211_P1.0651.00
343_I346_K1.0631.00
164_V168_R1.0621.00
157_V161_K1.0611.00
122_A153_A1.0611.00
310_Q342_A1.0591.00
141_Q145_Q1.0581.00
260_L278_A1.0541.00
128_R144_D1.0521.00
131_K134_G1.0521.00
94_Y176_V1.0511.00
325_V333_E1.0511.00
71_Q75_I1.0451.00
83_E186_K1.0431.00
313_V347_W1.0411.00
59_R272_G1.0381.00
130_Q143_Y1.0351.00
222_D225_R1.0281.00
105_Y168_R1.0241.00
76_I195_V1.0211.00
104_T107_S1.0201.00
214_V244_V1.0181.00
98_P174_T1.0161.00
125_T145_Q1.0151.00
149_D153_A1.0131.00
60_T287_L1.0071.00
147_L150_A1.0051.00
107_S163_A1.0031.00
44_T356_G1.0001.00
342_A347_W0.9951.00
109_K113_A0.9931.00
313_V321_A0.9931.00
70_P176_V0.9921.00
60_T293_V0.9891.00
213_Y279_I0.9881.00
79_R191_E0.9811.00
282_N285_H0.9771.00
325_V328_A0.9721.00
328_A333_E0.9721.00
51_Q298_E0.9671.00
77_L95_Q0.9671.00
249_S254_F0.9651.00
195_V203_L0.9611.00
25_C28_K0.9451.00
259_T281_P0.9441.00
330_D372_Q0.9361.00
136_Q140_K0.9301.00
63_Y213_Y0.9291.00
211_P281_P0.9251.00
178_S181_S0.9241.00
66_A180_I0.9141.00
324_L369_P0.9101.00
144_D147_L0.9061.00
116_Q157_V0.9051.00
268_D271_T0.9021.00
51_Q301_L0.9021.00
19_S23_T0.8981.00
119_A157_V0.8981.00
149_D152_Q0.8961.00
129_Y142_E0.8941.00
118_A152_Q0.8931.00
81_F204_A0.8911.00
115_A118_A0.8881.00
308_V323_V0.8831.00
107_S111_D0.8821.00
81_F187_S0.8811.00
188_N202_A0.8811.00
86_D285_H0.8801.00
334_T369_P0.8761.00
326_V330_D0.8751.00
245_S294_R0.8741.00
73_S196_Q0.8691.00
53_T298_E0.8691.00
156_A160_A0.8681.00
86_D181_S0.8641.00
326_V332_V0.8621.00
94_Y187_S0.8601.00
111_D163_A0.8581.00
180_I206_V0.8581.00
20_L24_G0.8561.00
118_A121_I0.8561.00
62_A289_P0.8551.00
49_P301_L0.8541.00
94_Y203_L0.8541.00
260_L276_L0.8501.00
52_I225_R0.8501.00
85_S91_V0.8481.00
47_T306_I0.8451.00
108_A160_A0.8401.00
72_V101_Y0.8401.00
182_G206_V0.8401.00
340_S347_W0.8381.00
298_E301_L0.8381.00
360_V367_V0.8371.00
121_I148_A0.8361.00
115_A160_A0.8341.00
38_P371_V0.8331.00
316_T322_T0.8301.00
104_T170_N0.8251.00
124_L127_N0.8211.00
167_A170_N0.8191.00
218_Q276_L0.8121.00
81_F184_I0.8101.00
118_A156_A0.8091.00
109_K164_V0.8071.00
99_A169_I0.8071.00
106_D165_E0.8061.00
95_Q98_P0.8041.00
169_I172_A0.8041.00
77_L98_P0.8041.00
188_N205_T0.8031.00
160_A163_A0.8001.00
43_V309_P0.8001.00
314_T322_T0.7991.00
18_G22_L0.7991.00
46_K355_A0.7901.00
212_I289_P0.7881.00
124_L144_D0.7881.00
125_T141_Q0.7871.00
302_N305_A0.7861.00
50_L343_I0.7861.00
332_V373_V0.7861.00
118_A122_A0.7841.00
121_I145_Q0.7831.00
169_I173_Y0.7831.00
121_I124_L0.7811.00
20_L25_C0.7811.00
146_A149_D0.7801.00
228_Q240_G0.7761.00
43_V46_K0.7691.00
115_A153_A0.7691.00
335_R354_K0.7691.00
112_L161_K0.7651.00
218_Q226_L0.7651.00
98_P175_K0.7641.00
118_A149_D0.7631.00
113_A158_T0.7611.00
86_D209_L0.7601.00
70_P195_V0.7571.00
40_V360_V0.7571.00
148_A152_Q0.7541.00
228_Q263_S0.7541.00
23_T26_D0.7541.00
332_V367_V0.7541.00
83_E187_S0.7541.00
70_P94_Y0.7531.00
37_M372_Q0.7521.00
63_Y279_I0.7511.00
61_S213_Y0.7471.00
246_L249_S0.7471.00
349_V353_L0.7471.00
65_I207_Q0.7461.00
227_K240_G0.7441.00
216_V297_L0.7401.00
79_R94_Y0.7401.00
110_G162_A0.7401.00
368_R371_V0.7391.00
21_A24_G0.7391.00
324_L334_T0.7381.00
17_S20_L0.7361.00
167_A171_L0.7321.00
326_V360_V0.7311.00
323_V359_V0.7271.00
322_T336_P0.7261.00
328_A357_D0.7261.00
54_T222_D0.7251.00
104_T166_T0.7231.00
244_V258_G0.7221.00
75_I194_L0.7211.00
52_I300_G0.7181.00
247_I294_R0.7171.00
311_Q362_S0.7171.00
340_S352_G0.7161.00
324_L332_V0.7161.00
328_A335_R0.7151.00
327_G330_D0.7151.00
64_R190_T0.7051.00
63_Y208_Q0.7041.00
20_L23_T0.7021.00
68_V179_P0.7021.00
335_R352_G0.7001.00
69_R199_Q0.6991.00
56_L216_V0.6961.00
244_V295_A0.6951.00
324_L367_V0.6951.00
183_R209_L0.6931.00
76_I203_L0.6921.00
339_A349_V0.6921.00
71_Q100_T0.6891.00
105_Y171_L0.6891.00
64_R191_E0.6881.00
58_G293_V0.6851.00
37_M374_K0.6851.00
358_R375_A0.6801.00
162_A165_E0.6761.00
159_A163_A0.6751.00
312_G361_I0.6741.00
45_V353_L0.6741.00
328_A331_K0.6731.00
111_D115_A0.6731.00
246_L287_L0.6711.00
14_L18_G0.6691.00
104_T108_A0.6691.00
263_S276_L0.6681.00
308_V312_G0.6661.00
13_V20_L0.6591.00
156_A159_A0.6551.00
138_I142_E0.6551.00
45_V357_D0.6541.00
77_L80_N0.6521.00
245_S251_G0.6471.00
69_R202_A0.6401.00
346_K350_T0.6381.00
133_L138_I0.6381.00
43_V308_V0.6361.00
108_A111_D0.6361.00
12_V19_S0.6321.00
54_T299_E0.6321.00
81_F85_S0.6321.00
56_L218_Q0.6311.00
42_V361_I0.6311.00
309_P312_G0.6291.00
73_S194_L0.6281.00
261_E277_R0.6281.00
199_Q202_A0.6281.00
56_L222_D0.6281.00
253_K296_R0.6271.00
288_L291_M0.6261.00
133_L136_Q0.6251.00
330_D375_A0.6231.00
103_A169_I0.6201.00
56_L297_L0.6201.00
64_R180_I0.6151.00
87_I93_L0.6151.00
119_A126_V0.6141.00
68_V204_A0.6131.00
172_A177_T0.6101.00
46_K346_K0.6101.00
213_Y261_E0.6101.00
306_I352_G0.6071.00
43_V346_K0.6071.00
116_Q119_A0.6031.00
210_D283_P0.6021.00
58_G214_V0.6011.00
11_A25_C0.6001.00
189_V193_A0.5981.00
330_D358_R0.5981.00
125_T149_D0.5981.00
67_E193_A0.5981.00
312_G359_V0.5941.00
210_D285_H0.5941.00
244_V278_A0.5941.00
52_I341_Q0.5941.00
11_A15_M0.5931.00
142_E146_A0.5891.00
220_S292_F0.5881.00
50_L307_L0.5871.00
50_L341_Q0.5871.00
325_V359_V0.5861.00
214_V280_F0.5861.00
140_K147_L0.5841.00
139_S142_E0.5831.00
367_V373_V0.5811.00
125_T146_A0.5781.00
274_I291_M0.5761.00
100_T104_T0.5741.00
308_V313_V0.5701.00
61_S65_I0.5701.00
56_L295_A0.5701.00
62_A207_Q0.5691.00
207_Q289_P0.5681.00
100_T170_N0.5681.00
328_A358_R0.5671.00
252_I284_D0.5661.00
241_K298_E0.5661.00
207_Q265_V0.5661.00
104_T167_A0.5641.00
163_A167_A0.5641.00
323_V352_G0.5621.00
108_A167_A0.5611.00
122_A149_D0.5611.00
23_T27_D0.5591.00
59_R290_G0.5591.00
90_G177_T0.5581.00
50_L348_L0.5581.00
314_T324_L0.5581.00
113_A117_A0.5551.00
43_V47_T0.5541.00
44_T47_T0.5541.00
13_V16_L0.5511.00
70_P203_L0.5501.00
18_G21_A0.5491.00
52_I299_E0.5481.00
258_G280_F0.5481.00
212_I282_N0.5481.00
122_A125_T0.5471.00
19_S22_L0.5441.00
153_A157_V0.5441.00
202_A205_T0.5431.00
253_K257_D0.5431.00
115_A119_A0.5421.00
47_T354_K0.5421.00
272_G292_F0.5411.00
36_Q39_A0.5391.00
98_P171_L0.5391.00
244_V248_T0.5381.00
140_K143_Y0.5341.00
46_K307_L0.5341.00
353_L357_D0.5331.00
108_A112_L0.5321.00
163_A166_T0.5321.00
226_L260_L0.5291.00
217_T268_D0.5291.00
209_L289_P0.5281.00
118_A153_A0.5271.00
60_T246_L0.5271.00
307_L348_L0.5251.00
129_Y132_L0.5251.00
117_A121_I0.5241.00
278_A295_A0.5241.00
189_V195_V0.5241.00
101_Y167_A0.5241.00
176_V203_L0.5231.00
123_Q126_V0.5221.00
313_V337_I0.5221.00
110_G155_A0.5211.00
302_N350_T0.5211.00
124_L148_A0.5191.00
316_T319_G0.5191.00
220_S248_T0.5181.00
187_S191_E0.5181.00
153_A156_A0.5161.00
138_I143_Y0.5161.00
122_A146_A0.5151.00
79_R187_S0.5131.00
216_V276_L0.5121.00
109_K112_L0.5111.00
68_V180_I0.5111.00
152_Q156_A0.5101.00
217_T273_S0.5081.00
66_A206_V0.5071.00
11_A18_G0.5061.00
249_S252_I0.5051.00
54_T297_L0.5051.00
128_R132_L0.5051.00
326_V329_D0.5051.00
128_R141_Q0.5041.00
148_A151_Q0.5041.00
228_Q261_E0.5031.00
75_I97_D0.5011.00
189_V203_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vf7A 5 0.5995 100 0.271 Contact Map
3lnnA 6 0.8287 100 0.28 Contact Map
4dk0A 5 0.7657 100 0.283 Contact Map
3fppA 3 0.6247 100 0.309 Contact Map
4l8jA 2 0.7909 100 0.311 Contact Map
3ne5B 3 0.7935 100 0.313 Contact Map
4kkuA 1 0.6675 100 0.36 Contact Map
2f1mA 2 0.5919 100 0.42 Contact Map
4tkoB 1 0.5869 100 0.501 Contact Map
2k32A 1 0.2897 99.8 0.717 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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