GREMLIN Database
RL23 - 50S ribosomal protein L23
UniProt: P0ADZ0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10883
Length: 100 (91)
Sequences: 2477 (1304)
Seq/√Len: 136.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_I60_T3.4801.00
13_A33_K3.2131.00
65_G79_D2.6031.00
36_K62_V2.5151.00
61_L84_Y2.3811.00
56_E88_K2.3361.00
63_V80_W2.2781.00
33_K80_W2.1421.00
60_T81_K2.0751.00
54_E91_Q2.0691.00
67_V76_R1.8811.00
54_E88_K1.8631.00
29_T84_Y1.8591.00
12_R35_A1.7751.00
20_A31_V1.7191.00
67_V74_I1.6751.00
63_V82_K1.6361.00
56_E86_T1.6231.00
15_H33_K1.5191.00
7_L49_K1.4941.00
70_H73_R1.4661.00
59_N86_T1.4551.00
34_V43_I1.4211.00
45_A49_K1.4211.00
11_L50_L1.4051.00
36_K79_D1.3791.00
41_A45_A1.3781.00
39_T42_E1.3351.00
12_R33_K1.2851.00
42_E45_A1.2561.00
8_L50_L1.2291.00
65_G76_R1.2211.00
28_N91_Q1.1941.00
30_I93_L1.1830.99
15_H31_V1.1720.99
28_N92_N1.1460.99
28_N90_G1.1360.99
76_R79_D1.1090.99
31_V84_Y1.1080.99
87_L91_Q1.0890.99
48_Q54_E1.0870.99
16_V21_S1.0770.99
33_K78_S1.0740.99
62_V79_D1.0700.99
41_A44_K1.0550.99
29_T86_T1.0340.99
52_E91_Q1.0040.98
23_A31_V0.9970.98
69_R74_I0.9810.98
11_L47_V0.9640.98
94_D97_G0.9610.98
56_E89_E0.9390.97
6_R42_E0.9380.97
17_S21_S0.9350.97
29_T59_N0.9230.97
47_V55_V0.9050.97
21_S24_M0.8990.97
48_Q55_V0.8980.97
88_K91_Q0.8970.97
64_K80_W0.8860.96
56_E59_N0.8680.96
6_R37_D0.8660.96
32_L47_V0.8470.95
7_L10_V0.8350.95
29_T57_V0.8320.95
22_T25_E0.8300.95
14_P53_V0.8130.94
32_L93_L0.8120.94
61_L82_K0.8040.94
36_K78_S0.8000.94
49_K52_E0.7840.93
33_K82_K0.7830.93
55_V58_V0.7680.92
47_V85_V0.7590.92
23_A27_S0.7580.92
70_H75_G0.7540.92
19_K22_T0.7460.91
39_T58_V0.7380.91
42_E46_A0.7350.90
66_K77_R0.7200.90
15_H20_A0.6990.88
33_K36_K0.6980.88
64_K78_S0.6950.88
23_A29_T0.6940.88
22_T27_S0.6910.88
20_A69_R0.6860.87
47_V50_L0.6810.87
71_G75_G0.6790.87
40_K69_R0.6730.86
21_S96_V0.6720.86
67_V70_H0.6650.86
56_E87_L0.6610.85
23_A84_Y0.6610.85
68_K75_G0.6600.85
64_K79_D0.6600.85
9_K12_R0.6590.85
30_I92_N0.6530.84
46_A83_A0.6520.84
63_V77_R0.6470.84
47_V58_V0.6360.83
18_E38_A0.6260.82
44_K48_Q0.6110.80
6_R9_K0.6030.80
28_N56_E0.5930.78
10_V47_V0.5930.78
65_G77_R0.5930.78
52_E90_G0.5770.76
10_V46_A0.5690.75
20_A50_L0.5680.75
24_M95_F0.5660.75
6_R16_V0.5630.75
38_A46_A0.5570.74
70_H74_I0.5550.74
47_V93_L0.5500.73
56_E91_Q0.5480.73
22_T94_D0.5460.73
7_L45_A0.5420.72
60_T83_A0.5410.72
28_N88_K0.5410.72
58_V85_V0.5400.72
12_R16_V0.5390.72
7_L42_E0.5370.71
14_P93_L0.5360.71
62_V81_K0.5350.71
39_T45_A0.5280.70
8_L12_R0.5280.70
47_V53_V0.5170.68
21_S32_L0.5160.68
27_S86_T0.5160.68
91_Q94_D0.5140.68
20_A36_K0.5140.68
35_A42_E0.5070.67
14_P71_G0.5030.66
19_K80_W0.5020.66
21_S95_F0.5020.66
53_V85_V0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zjrQ 1 0.93 100 0.147 Contact Map
4btdX 1 0.92 100 0.147 Contact Map
4tp9T 1 0.93 100 0.15 Contact Map
3j3wT 1 0.94 100 0.169 Contact Map
3j39X 1 0.87 100 0.292 Contact Map
1vx7Y 1 0.87 100 0.302 Contact Map
2go54 1 0.8 99.9 0.312 Contact Map
4w20X 1 0.87 99.9 0.314 Contact Map
3zf7X 1 0.87 99.9 0.314 Contact Map
3bboV 1 0.82 99.9 0.314 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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