GREMLIN Database
YHEV - Uncharacterized protein YheV
UniProt: P0ADW8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14364
Length: 66 (63)
Sequences: 155 (78)
Seq/√Len: 9.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_R57_E3.6480.98
24_M44_E2.3590.79
34_E40_H2.3550.79
8_I22_M2.2280.75
24_M31_D2.0240.67
25_W62_I1.9520.64
22_M33_V1.9390.64
30_I59_V1.8440.60
31_D64_H1.7080.54
22_M28_N1.7070.54
4_R64_H1.6820.52
29_N41_Q1.6690.52
3_I39_G1.5190.45
18_A46_D1.4990.44
4_R37_K1.4250.41
42_M48_E1.4220.41
32_I43_R1.4050.40
39_G42_M1.3660.38
12_K59_V1.2940.35
22_M40_H1.2870.35
18_A37_K1.2460.33
26_R33_V1.2440.33
40_H58_Q1.2350.33
31_D43_R1.2080.32
44_E51_D1.1950.31
32_I59_V1.1630.30
21_S27_E1.1500.30
23_A26_R1.1280.29
41_Q53_V1.1060.28
51_D56_D1.1030.28
18_A48_E1.0990.28
21_S39_G1.0870.27
42_M59_V1.0720.27
53_V56_D1.0440.26
17_Q64_H1.0170.25
29_N58_Q0.9830.24
25_W34_E0.9780.24
14_P36_V0.9620.23
5_K48_E0.9030.21
26_R58_Q0.8910.21
22_M32_I0.8820.21
47_K50_R0.8670.20
24_M32_I0.8650.20
3_I57_E0.8510.20
8_I12_K0.8490.20
34_E55_K0.8370.19
12_K37_K0.8230.19
12_K33_V0.8220.19
44_E48_E0.8150.19
48_E51_D0.8010.18
23_A59_V0.7870.18
12_K43_R0.7860.18
15_A39_G0.7680.17
43_R59_V0.7460.17
27_E41_Q0.7370.17
18_A59_V0.7360.17
48_E54_R0.7080.16
22_M25_W0.7080.16
49_A57_E0.7060.16
26_R31_D0.7050.16
12_K29_N0.7020.16
37_K51_D0.6990.16
4_R62_I0.6940.15
26_R29_N0.6750.15
8_I27_E0.6710.15
29_N47_K0.6470.14
45_A62_I0.6470.14
23_A44_E0.6320.14
23_A46_D0.6320.14
17_Q45_A0.6320.14
37_K64_H0.6300.14
25_W64_H0.6210.14
18_A28_N0.6120.14
49_A55_K0.5890.13
24_M62_I0.5820.13
3_I51_D0.5820.13
28_N41_Q0.5790.13
52_H55_K0.5760.13
28_N47_K0.5740.13
15_A26_R0.5710.13
32_I57_E0.5680.13
4_R46_D0.5660.13
8_I42_M0.5630.13
15_A29_N0.5630.13
12_K39_G0.5490.12
12_K22_M0.5440.12
5_K8_I0.5430.12
41_Q48_E0.5300.12
4_R33_V0.5290.12
19_Q50_R0.5220.12
28_N57_E0.5160.12
3_I50_R0.5090.12
27_E50_R0.5050.12
36_V47_K0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2k4xA 1 0.6364 81.8 0.865 Contact Map
1neeA 1 0.697 63.4 0.883 Contact Map
2d74B 1 0.6818 63.3 0.883 Contact Map
3cw2K 1 0.697 62.3 0.884 Contact Map
1nuiA 1 0.8182 58.5 0.886 Contact Map
3ga8A 1 0.7727 55.9 0.888 Contact Map
4e2xA 1 0.8485 55.1 0.889 Contact Map
3j21g 1 0.6212 53.8 0.889 Contact Map
3po3S 1 0.6818 48 0.893 Contact Map
1k81A 1 0.5455 45.9 0.894 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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