GREMLIN Database
YHCB - Inner membrane protein YhcB
UniProt: P0ADW3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12614
Length: 132 (121)
Sequences: 262 (176)
Seq/√Len: 16.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_Y76_H3.3330.99
56_F81_S2.7710.97
37_E42_K2.4630.94
120_G123_G2.3340.92
59_S67_A2.2640.91
8_I12_V2.2450.91
59_S63_L2.2150.90
118_S122_S2.1770.89
47_E54_S2.1380.88
105_S108_Q2.0850.87
35_Q39_E2.0470.86
60_A78_A1.9420.83
15_I34_L1.8800.81
10_L16_I1.8550.80
40_K46_D1.8450.80
34_L44_E1.7870.77
15_I19_V1.7140.74
8_I34_L1.6700.72
63_L77_M1.6610.72
42_K79_K1.6410.71
43_A115_R1.6340.71
16_I101_E1.5980.69
52_L73_L1.5910.68
3_W52_L1.5860.68
18_A21_M1.5800.68
62_L84_L1.5750.68
48_Y52_L1.5720.67
41_N104_A1.5690.67
56_F60_A1.5500.66
67_A73_L1.5430.66
119_E122_S1.5140.64
11_V15_I1.5120.64
59_S70_Y1.5090.64
59_S81_S1.5020.64
19_V106_N1.4290.60
66_M72_Q1.4040.58
75_Q118_S1.3880.57
47_E50_E1.3070.53
36_Y44_E1.2850.52
8_I78_A1.2430.49
57_A74_Y1.2130.47
10_L13_G1.2060.47
3_W86_P1.2010.47
6_A10_L1.2000.47
74_Y81_S1.1910.46
84_L94_P1.1860.46
56_F78_A1.1760.45
77_M80_S1.1760.45
12_V20_A1.1670.45
114_P117_Y1.1570.44
67_A74_Y1.1560.44
33_A83_S1.1550.44
22_R31_Q1.1470.44
55_H116_D1.1290.43
106_N109_A1.1260.42
73_L119_E1.1030.41
19_V96_R1.1020.41
4_E15_I1.1000.41
78_A81_S1.0970.41
5_Y15_I1.0930.41
42_K72_Q1.0790.40
13_G17_G1.0380.38
70_Y120_G0.9980.35
24_G31_Q0.9960.35
62_L70_Y0.9920.35
49_R89_S0.9910.35
9_G15_I0.9730.34
80_S118_S0.9700.34
39_E60_A0.9660.34
52_L86_P0.9630.34
73_L120_G0.9610.33
7_L75_Q0.9600.33
47_E51_E0.9590.33
28_L52_L0.9520.33
66_M82_S0.9420.32
33_A49_R0.9410.32
52_L69_D0.9390.32
61_E64_D0.9380.32
99_L102_S0.9360.32
34_L57_A0.9250.32
35_Q68_H0.9210.31
41_N45_L0.9190.31
89_S92_A0.9100.31
103_E110_P0.9040.31
5_Y96_R0.8780.29
65_T78_A0.8760.29
104_A108_Q0.8750.29
22_R38_L0.8740.29
96_R99_L0.8720.29
18_A62_L0.8710.29
37_E83_S0.8690.29
62_L68_H0.8490.28
34_L105_S0.8470.28
63_L81_S0.8460.28
22_R64_D0.8430.28
46_D87_E0.8340.27
38_L78_A0.8320.27
48_Y115_R0.8270.27
21_M35_Q0.8210.27
63_L75_Q0.8070.26
43_A46_D0.7880.25
81_S85_L0.7780.25
14_I41_N0.7780.25
18_A90_A0.7620.24
78_A102_S0.7610.24
11_V113_M0.7580.24
5_Y9_G0.7410.23
47_E71_R0.7390.23
77_M95_F0.7290.23
77_M94_P0.7200.22
9_G26_R0.7070.22
5_Y35_Q0.6960.21
7_L97_N0.6930.21
41_N49_R0.6890.21
27_K71_R0.6870.21
11_V104_A0.6840.21
103_E107_D0.6800.21
24_G107_D0.6780.21
15_I100_A0.6740.21
17_G117_Y0.6730.21
74_Y78_A0.6670.20
97_N101_E0.6660.20
18_A45_L0.6530.20
27_K75_Q0.6520.20
7_L107_D0.6490.20
37_E57_A0.6430.19
7_L14_I0.6400.19
67_A120_G0.6400.19
59_S119_E0.6390.19
36_Y47_E0.6380.19
67_A81_S0.6340.19
101_E105_S0.6310.19
20_A111_V0.6290.19
12_V110_P0.6280.19
22_R115_R0.6270.19
63_L67_A0.6260.19
100_A105_S0.6210.19
51_E58_R0.6200.19
49_R113_M0.6190.19
38_L74_Y0.6190.19
91_E95_F0.6150.18
25_N87_E0.6100.18
52_L120_G0.6060.18
19_V112_Q0.6010.18
13_G56_F0.6000.18
100_A107_D0.6000.18
19_V57_A0.5910.18
13_G115_R0.5910.18
3_W17_G0.5770.17
99_L104_A0.5750.17
10_L34_L0.5740.17
59_S77_M0.5730.17
32_Q87_E0.5720.17
39_E68_H0.5690.17
52_L59_S0.5620.17
28_L48_Y0.5620.17
20_A66_M0.5590.17
27_K39_E0.5560.16
19_V108_Q0.5550.16
43_A61_E0.5520.16
106_N110_P0.5510.16
37_E97_N0.5470.16
16_I66_M0.5440.16
80_S119_E0.5400.16
103_E108_Q0.5380.16
11_V121_A0.5320.16
97_N104_A0.5310.16
64_D73_L0.5310.16
63_L74_Y0.5270.16
65_T69_D0.5260.16
60_A84_L0.5240.15
116_D123_G0.5240.15
9_G64_D0.5200.15
8_I65_T0.5180.15
21_M25_N0.5140.15
13_G21_M0.5130.15
21_M44_E0.5120.15
11_V48_Y0.5100.15
7_L20_A0.5060.15
26_R37_E0.5030.15
13_G118_S0.5020.15
19_V94_P0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2f95B 2 0.1288 79.3 0.898 Contact Map
4cq4A 4 0.5833 68.6 0.906 Contact Map
3rvyA 3 0.1742 68.2 0.906 Contact Map
3zg1A 2 0.6894 51.7 0.916 Contact Map
1scfA 4 0 48.8 0.917 Contact Map
4um9B 2 0 48 0.917 Contact Map
4gycB 2 0.1591 46.4 0.918 Contact Map
3qnqA 2 0.3258 45.5 0.919 Contact Map
4ltoA 3 0.3939 44.4 0.919 Contact Map
3effK 4 0.5152 40.7 0.921 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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