GREMLIN Database
LPTC - Lipopolysaccharide export system protein LptC
UniProt: P0ADV9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12806
Length: 191 (178)
Sequences: 1121 (914)
Seq/√Len: 68.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
99_D114_H9.2931.00
65_Q80_Q4.4911.00
160_G174_L3.2841.00
145_S162_K3.1421.00
133_N147_D3.0001.00
41_T69_Y2.9491.00
132_D147_D2.8951.00
50_L58_L2.8761.00
166_N169_S2.7821.00
153_G156_F2.6151.00
164_R173_E2.5891.00
161_L176_E2.5001.00
162_K176_E2.3511.00
66_H79_T2.3141.00
99_D113_G2.3051.00
53_N57_A2.2681.00
47_T64_A2.2421.00
68_E79_T2.1971.00
98_A111_L2.1151.00
64_A78_F2.0501.00
45_E66_H2.0361.00
158_S180_T2.0191.00
166_N171_N2.0171.00
115_V131_T1.8531.00
131_T145_S1.8481.00
103_L109_L1.8011.00
131_T134_A1.7261.00
137_N140_T1.6881.00
94_W167_L1.6881.00
149_V163_M1.6460.99
151_L158_S1.6420.99
20_I23_N1.6060.99
116_E128_R1.5960.99
75_V102_K1.5860.99
130_T150_T1.5740.99
116_E130_T1.5190.99
144_T164_R1.5010.99
101_A111_L1.4750.99
161_L177_K1.4740.99
145_S163_M1.4680.99
80_Q99_D1.4500.98
162_K175_I1.4370.98
142_D166_N1.4210.98
18_V22_I1.4100.98
143_V165_G1.4070.98
150_T157_N1.3990.98
100_K112_Y1.3480.98
112_Y133_N1.3250.97
110_Y135_Q1.3060.97
118_N128_R1.2900.97
38_N72_D1.2760.97
13_S55_E1.2360.96
145_S176_E1.2340.96
18_V21_G1.2330.96
47_T67_V1.2250.96
52_Y70_Y1.2160.95
17_L21_G1.2060.95
69_Y76_S1.1850.95
94_W117_V1.1770.95
137_N166_N1.1570.94
150_T159_S1.1470.94
8_V12_L1.1210.93
81_P94_W1.1180.93
81_P101_A1.1100.93
120_L126_L1.1050.93
87_D90_K1.0820.92
15_A25_A1.0750.91
98_A148_L1.0740.91
40_P70_Y1.0510.91
161_L175_I1.0460.90
113_G157_N1.0360.90
110_Y133_N1.0320.90
148_L159_S1.0310.90
164_R175_I1.0240.89
52_Y94_W1.0150.89
158_S178_V1.0120.89
141_Q168_R1.0080.89
131_T162_K0.9990.88
74_A106_D0.9850.87
74_A105_N0.9770.87
52_Y58_L0.9750.87
19_M22_I0.9640.86
108_M135_Q0.9630.86
67_V116_E0.9610.86
43_K180_T0.9600.86
19_M101_A0.9580.86
19_M23_N0.9450.85
60_Y83_L0.9440.85
149_V174_L0.9390.85
7_W10_I0.9390.85
137_N142_D0.9220.84
174_L180_T0.9210.84
63_I82_V0.9200.84
137_N144_T0.9170.83
107_R139_V0.9120.83
94_W182_Y0.9120.83
97_K118_N0.9090.83
68_E77_W0.9050.83
8_V14_L0.9030.82
108_M137_N0.9020.82
96_V115_V0.8960.82
114_H132_D0.8930.82
82_V160_G0.8890.81
165_G172_A0.8880.81
33_V37_N0.8840.81
9_I14_L0.8710.80
111_L136_I0.8700.80
12_L15_A0.8560.79
156_F160_G0.8560.79
56_G111_L0.8460.78
179_R182_Y0.8420.78
82_V95_S0.8420.78
17_L22_I0.8410.78
44_S78_F0.8350.77
43_K101_A0.8310.77
117_V129_I0.8300.77
102_K112_Y0.8240.76
7_W15_A0.8100.75
174_L178_V0.8020.74
78_F103_L0.8010.74
61_R84_T0.7880.73
30_T33_V0.7840.73
118_N126_L0.7840.73
16_V30_T0.7770.72
10_I14_L0.7770.72
26_E64_A0.7750.72
144_T163_M0.7730.72
154_T182_Y0.7720.71
114_H150_T0.7710.71
55_E98_A0.7650.71
52_Y158_S0.7610.70
160_G163_M0.7610.70
104_T108_M0.7530.70
16_V24_M0.7460.69
92_P119_A0.7450.69
131_T169_S0.7440.69
77_W102_K0.7410.68
60_Y69_Y0.7400.68
18_V24_M0.7380.68
84_T95_S0.7350.68
165_G182_Y0.7330.67
90_K129_I0.7300.67
46_H65_Q0.7270.67
58_L86_F0.7220.66
70_Y123_D0.7160.66
14_L25_A0.7110.65
6_R12_L0.7100.65
46_H80_Q0.7070.65
17_L20_I0.6990.64
40_P43_K0.6980.64
76_S101_A0.6980.64
98_A163_M0.6950.63
53_N59_S0.6860.62
13_S77_W0.6840.62
83_L96_V0.6840.62
139_V159_S0.6830.62
36_N39_D0.6830.62
15_A29_D0.6780.61
115_V149_V0.6760.61
117_V143_V0.6740.61
45_E55_E0.6740.61
11_V29_D0.6690.60
108_M165_G0.6640.60
64_A88_K0.6630.60
60_Y136_I0.6600.59
24_M28_D0.6590.59
100_K113_G0.6580.59
151_L172_A0.6530.59
74_A177_K0.6530.59
20_I24_M0.6430.57
108_M160_G0.6420.57
11_V20_I0.6410.57
60_Y103_L0.6400.57
109_L166_N0.6400.57
64_A81_P0.6390.57
6_R14_L0.6390.57
134_A176_E0.6340.56
152_Y157_N0.6300.56
45_E140_T0.6290.56
63_I84_T0.6280.56
109_L140_T0.6270.55
48_D63_I0.6230.55
134_A145_S0.6230.55
51_V168_R0.6230.55
50_L61_R0.6220.55
44_S47_T0.6200.55
49_T76_S0.6190.55
131_T143_V0.6160.54
134_A162_K0.6150.54
105_N139_V0.6080.53
17_L25_A0.6010.52
36_N154_T0.5970.52
20_I26_E0.5970.52
84_T92_P0.5960.52
103_L141_Q0.5950.52
121_V124_S0.5930.51
96_V184_I0.5920.51
145_S148_L0.5920.51
40_P71_S0.5910.51
141_Q157_N0.5880.51
38_N68_E0.5870.51
129_I180_T0.5810.50
69_Y117_V0.5780.50
9_I24_M0.5770.49
65_Q81_P0.5770.49
62_L170_K0.5760.49
131_T148_L0.5720.49
117_V151_L0.5700.49
131_T146_E0.5690.49
103_L138_L0.5670.48
51_V138_L0.5670.48
160_G172_A0.5660.48
145_S161_L0.5630.48
62_L119_A0.5620.48
6_R20_I0.5610.48
18_V55_E0.5600.47
130_T152_Y0.5580.47
10_I181_S0.5560.47
16_V37_N0.5550.47
39_D66_H0.5540.47
42_Y143_V0.5540.47
62_L83_L0.5530.47
105_N109_L0.5510.46
25_A28_D0.5480.46
96_V117_V0.5430.45
94_W165_G0.5430.45
45_E102_K0.5420.45
52_Y174_L0.5410.45
163_M174_L0.5400.45
35_V160_G0.5400.45
125_Q154_T0.5400.45
42_Y69_Y0.5380.45
97_K114_H0.5370.45
125_Q153_G0.5360.45
147_D177_K0.5360.45
107_R137_N0.5340.44
12_L23_N0.5330.44
57_A121_V0.5310.44
106_D129_I0.5300.44
123_D126_L0.5300.44
98_A133_N0.5300.44
116_E140_T0.5240.43
76_S170_K0.5230.43
91_I128_R0.5230.43
158_S172_A0.5220.43
151_L179_R0.5220.43
165_G176_E0.5220.43
127_R153_G0.5200.43
41_T145_S0.5180.42
114_H128_R0.5170.42
19_M96_V0.5160.42
101_A104_T0.5160.42
10_I21_G0.5130.42
57_A95_S0.5120.42
149_V162_K0.5110.42
46_H98_A0.5090.41
15_A19_M0.5080.41
100_K159_S0.5070.41
153_G167_L0.5060.41
18_V27_K0.5060.41
163_M172_A0.5060.41
121_V178_V0.5050.41
60_Y67_V0.5040.41
82_V97_K0.5020.41
10_I15_A0.5020.41
17_L27_K0.5020.41
149_V166_N0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3my2A 2 0.6545 100 0.32 Contact Map
4uu4A 1 0.6649 99.3 0.666 Contact Map
2r19A 3 0.7016 99.1 0.695 Contact Map
4q35A 1 0.6283 98.6 0.74 Contact Map
1v54G 1 0.377 7.3 0.94 Contact Map
2y69G 1 0.377 6.9 0.94 Contact Map
4um9B 2 0 5.1 0.944 Contact Map
3ne5B 3 0.5183 4.9 0.944 Contact Map
3wvfA 1 0.6073 4.9 0.944 Contact Map
1y0gA 2 0.7801 4.7 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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