GREMLIN Database
MLAC - Probable phospholipid-binding protein MlaC
UniProt: P0ADV7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12798
Length: 211 (192)
Sequences: 1500 (1156)
Seq/√Len: 83.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_Q191_D5.6221.00
92_A198_K4.1901.00
74_G93_Y3.9891.00
32_D36_Q3.5701.00
165_D172_S3.2271.00
96_A201_S2.6831.00
96_A198_K2.6831.00
88_A92_A2.6521.00
87_P90_R2.5411.00
82_Y90_R2.4991.00
118_Q136_T2.3891.00
78_L93_Y2.3481.00
135_V150_F2.2351.00
86_T89_Q2.1991.00
112_Y115_Q2.1141.00
120_A136_T2.0581.00
151_Q165_D1.9491.00
189_G192_G1.8321.00
37_K63_E1.8291.00
77_V93_Y1.8251.00
155_N160_N1.7761.00
191_D195_A1.7681.00
116_T138_I1.7271.00
81_Y182_G1.6981.00
118_Q138_I1.6841.00
33_E37_K1.6841.00
11_L14_A1.6641.00
185_L189_G1.6571.00
85_A190_I1.6381.00
27_P131_V1.6331.00
68_V172_S1.6281.00
31_M133_I1.5921.00
25_T33_E1.5641.00
72_Y76_L1.5571.00
45_E48_Q1.5401.00
72_Y75_A1.5160.99
92_A95_A1.4950.99
68_V166_M1.4840.99
61_D98_R1.4780.99
92_A96_A1.4780.99
72_Y153_R1.4710.99
91_E95_A1.4470.99
136_T145_P1.4370.99
11_L16_L1.4200.99
69_Q153_R1.4130.99
41_R63_E1.4030.99
74_G104_A1.3980.99
36_Q40_D1.3850.99
191_D194_T1.3730.99
17_S22_A1.3640.99
68_V163_A1.3540.99
30_L67_Y1.3510.99
167_I172_S1.3500.99
135_V148_L1.3460.99
42_L109_L1.3440.99
49_I56_L1.3360.99
34_A67_Y1.3350.99
95_A98_R1.3200.99
26_N29_K1.3160.99
76_L174_I1.3140.99
184_L193_L1.3070.98
28_Y32_D1.3040.98
100_Y177_K1.3030.98
137_I148_L1.2970.98
154_K160_N1.2920.98
60_V161_W1.2770.98
188_K196_Q1.2730.98
155_N158_T1.2670.98
134_R149_D1.2440.98
195_A199_S1.2230.98
19_A23_D1.2180.98
112_Y172_S1.1920.97
89_Q194_T1.1860.97
48_Q51_A1.1810.97
76_L175_T1.1750.97
196_Q199_S1.1690.97
20_T23_D1.1550.97
17_S21_A1.1540.97
104_A173_M1.1490.96
78_L85_A1.1300.96
172_S175_T1.1200.96
169_E172_S1.1030.96
188_K192_G1.1010.96
54_D58_T1.0970.95
177_K180_E1.0940.95
69_Q162_Q1.0920.95
184_L196_Q1.0890.95
150_F161_W1.0860.95
183_T187_T1.0750.95
165_D176_T1.0640.95
151_Q172_S1.0620.95
96_A194_T1.0500.94
124_P131_V1.0420.94
18_A22_A1.0370.94
78_L81_Y1.0330.94
18_A21_A1.0220.93
71_K75_A1.0110.93
93_Y193_L1.0100.93
100_Y119_I1.0090.93
75_A82_Y1.0070.93
74_G192_G0.9990.93
155_N159_G0.9890.92
27_P161_W0.9880.92
38_T150_F0.9840.92
144_P169_E0.9820.92
77_V193_L0.9730.92
6_M18_A0.9640.91
150_F181_W0.9540.91
125_L128_K0.9520.91
8_V11_L0.9350.90
30_L152_W0.9240.89
151_Q167_I0.9240.89
86_T90_R0.9200.89
152_W161_W0.9190.89
15_P19_A0.9180.89
88_A91_E0.8920.88
165_D197_L0.8900.87
119_I135_V0.8880.87
40_D44_N0.8880.87
44_N47_P0.8800.87
7_M14_A0.8740.86
82_Y94_F0.8710.86
164_Y174_I0.8690.86
14_A17_S0.8650.86
41_R62_Q0.8650.86
74_G94_F0.8650.86
144_P197_L0.8630.86
88_A199_S0.8590.86
55_Y58_T0.8570.85
13_I18_A0.8550.85
85_A97_F0.8540.85
174_I177_K0.8520.85
19_A22_A0.8520.85
17_S20_T0.8440.85
74_G77_V0.8360.84
6_M11_L0.8330.84
132_P149_D0.8220.83
8_V14_A0.8200.83
85_A89_Q0.8180.83
182_G185_L0.8170.83
115_Q139_D0.8160.82
42_L105_Y0.8130.82
92_A194_T0.8090.82
92_A191_D0.8090.82
130_I164_Y0.7990.81
181_W193_L0.7970.81
85_A90_R0.7940.81
78_L172_S0.7910.80
112_Y163_A0.7850.80
78_L185_L0.7820.80
16_L19_A0.7760.79
46_Q49_I0.7720.79
81_Y84_S0.7680.79
30_L34_A0.7630.78
108_A180_E0.7630.78
131_V161_W0.7610.78
101_L173_M0.7600.78
80_Q84_S0.7600.78
174_I181_W0.7590.78
184_L188_K0.7470.77
45_E63_E0.7430.76
10_L37_K0.7400.76
9_A199_S0.7370.76
48_Q55_Y0.7250.74
43_K114_G0.7220.74
105_Y150_F0.7190.74
49_I53_P0.7170.74
78_L184_L0.7100.73
168_A177_K0.7080.73
195_A198_K0.7060.72
71_K94_F0.7010.72
176_T179_N0.6980.72
172_S197_L0.6980.72
196_Q200_I0.6970.71
73_A97_F0.6950.71
151_Q173_M0.6950.71
100_Y197_L0.6920.71
58_T61_D0.6910.71
14_A20_T0.6880.71
96_A197_L0.6880.71
96_A103_Q0.6860.70
43_K116_T0.6840.70
8_V19_A0.6770.69
99_E201_S0.6770.69
15_P21_A0.6770.69
75_A83_K0.6750.69
96_A99_E0.6740.69
95_A191_D0.6730.69
97_F170_G0.6700.68
101_L105_Y0.6670.68
58_T62_Q0.6650.68
114_G140_P0.6580.67
11_L15_P0.6570.67
9_A118_Q0.6550.67
103_Q201_S0.6550.67
139_D142_G0.6510.66
192_G196_Q0.6500.66
28_Y122_E0.6490.66
31_M152_W0.6490.66
77_V190_I0.6480.66
37_K62_Q0.6460.66
82_Y176_T0.6430.65
78_L163_A0.6380.65
171_V189_G0.6370.65
180_E183_T0.6190.62
116_T140_P0.6190.62
33_E40_D0.6160.62
109_L173_M0.6150.62
191_D202_Q0.6150.62
100_Y171_V0.6080.61
6_M10_L0.6080.61
71_K91_E0.6060.61
92_A195_A0.6060.61
122_E125_L0.6040.61
167_I175_T0.6030.60
11_L199_S0.6030.60
74_G190_I0.6020.60
118_Q144_P0.6000.60
108_A112_Y0.5980.60
59_I63_E0.5920.59
76_L164_Y0.5850.58
154_K159_G0.5840.58
174_I197_L0.5840.58
42_L135_V0.5840.58
40_D92_A0.5830.58
14_A125_L0.5810.58
74_G78_L0.5770.57
76_L178_Q0.5770.57
55_Y59_I0.5760.57
10_L15_P0.5760.57
130_I153_R0.5750.57
172_S176_T0.5740.57
7_M29_K0.5740.57
59_I165_D0.5730.57
169_E173_M0.5720.56
14_A19_A0.5700.56
109_L180_E0.5640.55
181_W194_T0.5630.55
75_A90_R0.5600.55
40_D43_K0.5600.55
194_T198_K0.5580.55
99_E198_K0.5570.54
139_D144_P0.5560.54
54_D195_A0.5530.54
127_D149_D0.5520.54
60_V108_A0.5520.54
89_Q97_F0.5500.54
100_Y104_A0.5480.53
198_K202_Q0.5480.53
34_A117_Y0.5470.53
100_Y174_I0.5450.53
6_M16_L0.5440.53
145_P171_V0.5440.53
11_L17_S0.5430.53
136_T147_R0.5420.52
56_L73_A0.5420.52
29_K33_E0.5420.52
193_L197_L0.5390.52
9_A16_L0.5380.52
173_M185_L0.5380.52
197_L201_S0.5370.52
32_D70_V0.5360.52
31_M119_I0.5360.52
199_S202_Q0.5350.52
53_P109_L0.5330.51
154_K158_T0.5310.51
36_Q195_A0.5300.51
15_P18_A0.5280.51
70_V150_F0.5270.50
71_K90_R0.5260.50
69_Q194_T0.5260.50
7_M10_L0.5230.50
10_L40_D0.5210.50
102_K106_G0.5200.50
125_L155_N0.5190.49
45_E52_N0.5170.49
109_L174_I0.5170.49
90_R94_F0.5160.49
185_L193_L0.5150.49
146_V173_M0.5150.49
76_L167_I0.5140.49
61_D102_K0.5130.49
35_A108_A0.5120.48
175_T179_N0.5110.48
164_Y177_K0.5090.48
67_Y150_F0.5030.47
40_D154_K0.5010.47
7_M13_I0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qguA 1 0.8436 100 0.101 Contact Map
4fczB 1 0.8531 100 0.122 Contact Map
4hz9B 3 0.564 90.7 0.896 Contact Map
3bb9A 2 0.5261 68.9 0.918 Contact Map
3zg1A 2 0.3744 63.9 0.921 Contact Map
3k7cA 2 0.5071 47.4 0.928 Contact Map
4orlA 1 0.5213 38.8 0.932 Contact Map
4q53A 2 0.5213 38.3 0.932 Contact Map
1hmeA 1 0.3318 32 0.935 Contact Map
2mrcA 1 0.4265 29.5 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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