GREMLIN Database
YHBW - Uncharacterized protein YhbW
UniProt: P0ADV5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12792
Length: 335 (294)
Sequences: 16424 (10506)
Seq/√Len: 612.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
232_N290_K5.1271.00
34_R70_N3.2981.00
215_L218_P2.8111.00
35_L324_E2.7941.00
232_N287_D2.7331.00
75_H107_D2.6971.00
35_L38_K2.6011.00
136_P182_Q2.5991.00
294_G297_S2.5201.00
203_H207_S2.4531.00
68_A102_Y2.4471.00
37_E73_T2.4411.00
178_Q208_N2.4291.00
232_N236_E2.3841.00
231_S234_D2.3711.00
287_D290_K2.3001.00
64_I76_L2.2991.00
229_A234_D2.2791.00
177_A204_L2.1511.00
140_A183_L2.1501.00
202_L206_R2.1361.00
207_S211_P2.1091.00
324_E328_D2.0821.00
30_L34_R2.0621.00
27_S103_P2.0401.00
34_R38_K2.0301.00
33_A67_L2.0281.00
199_F203_H1.9921.00
233_R237_F1.9691.00
204_L208_N1.9591.00
202_L220_A1.9581.00
296_Q300_R1.9571.00
199_F301_E1.9541.00
297_S301_E1.9331.00
147_D164_K1.9021.00
39_R327_M1.9011.00
321_H324_E1.8941.00
230_D329_V1.8891.00
31_D34_R1.8851.00
44_Y74_L1.8681.00
99_N104_G1.8331.00
181_A208_N1.8151.00
95_F106_I1.8021.00
284_L291_V1.7821.00
127_H130_G1.7801.00
68_A76_L1.7651.00
30_L70_N1.7651.00
118_Q122_M1.7651.00
45_W77_G1.7581.00
59_A94_Q1.7401.00
240_T244_Q1.6981.00
208_N211_P1.6721.00
143_V164_K1.6331.00
33_A44_Y1.6061.00
200_Q203_H1.5961.00
35_L39_R1.5871.00
204_L207_S1.5841.00
178_Q211_P1.5771.00
95_F108_L1.5671.00
321_H325_L1.5641.00
140_A144_D1.5431.00
67_L76_L1.5371.00
290_K293_H1.5351.00
228_A291_V1.5031.00
143_V183_L1.5011.00
289_A293_H1.4691.00
178_Q182_Q1.4411.00
21_S24_E1.4261.00
30_L66_Y1.4241.00
222_V304_A1.4181.00
292_R296_Q1.4161.00
230_D321_H1.3971.00
209_F218_P1.3881.00
171_G187_F1.3711.00
234_D238_L1.3701.00
37_E71_T1.3701.00
325_L329_V1.3691.00
66_Y69_A1.3561.00
33_A71_T1.3511.00
136_P183_L1.3441.00
144_D148_A1.3401.00
229_A235_A1.3381.00
38_K72_T1.3371.00
143_V167_V1.3291.00
66_Y101_L1.3261.00
290_K294_G1.2991.00
46_L64_I1.2951.00
59_A62_V1.2801.00
86_H94_Q1.2691.00
209_F214_R1.2651.00
293_H297_S1.2631.00
24_E28_H1.2611.00
144_D149_R1.2521.00
27_S31_D1.2511.00
234_D237_F1.2451.00
219_Y305_D1.2271.00
178_Q212_S1.2231.00
168_W221_M1.2091.00
77_G107_D1.2021.00
228_A288_K1.1991.00
288_K325_L1.1971.00
139_V183_L1.1911.00
91_I138_D1.1881.00
58_A97_T1.1871.00
227_I238_L1.1871.00
237_F240_T1.1801.00
136_P140_A1.1711.00
31_D35_L1.1701.00
140_A153_P1.1681.00
37_E72_T1.1661.00
174_L204_L1.1581.00
181_A212_S1.1581.00
239_F243_Q1.1561.00
275_G279_A1.1551.00
168_W186_P1.1521.00
64_I78_S1.1501.00
195_P297_S1.1491.00
178_Q204_L1.1431.00
182_Q212_S1.1321.00
143_V185_L1.1271.00
274_Y277_Q1.1251.00
230_D234_D1.1251.00
33_A74_L1.1241.00
258_P262_Q1.1191.00
161_Y164_K1.1161.00
130_G133_D1.1121.00
175_Y178_Q1.1031.00
208_N212_S1.1031.00
228_A325_L1.0921.00
62_V65_G1.0901.00
98_L106_I1.0891.00
103_P160_G1.0871.00
262_Q265_D1.0861.00
39_R323_F1.0841.00
108_L142_L1.0841.00
237_F241_S1.0741.00
286_G291_V1.0741.00
142_L146_F1.0711.00
61_S94_Q1.0661.00
284_L294_G1.0571.00
157_P161_Y1.0521.00
81_V91_I1.0451.00
80_G170_L1.0441.00
46_L67_L1.0391.00
66_Y70_N1.0341.00
34_R72_T1.0321.00
275_G278_Q1.0241.00
151_P154_H1.0231.00
31_D316_H1.0221.00
90_V94_Q1.0111.00
110_L139_V1.0061.00
199_F302_T1.0051.00
80_G111_G1.0051.00
219_Y306_E1.0051.00
236_E240_T1.0031.00
62_V98_L1.0021.00
309_V326_A0.9991.00
134_N137_R0.9981.00
28_H31_D0.9941.00
194_A197_M0.9901.00
200_Q204_L0.9891.00
137_R141_E0.9881.00
99_N162_G0.9881.00
141_E144_D0.9861.00
99_N163_E0.9841.00
322_S325_L0.9831.00
116_S120_T0.9771.00
197_M200_Q0.9761.00
143_V147_D0.9761.00
296_Q301_E0.9761.00
38_K324_E0.9671.00
274_Y278_Q0.9601.00
264_M269_S0.9601.00
61_S81_V0.9581.00
150_D153_P0.9551.00
226_I309_V0.9501.00
239_F285_V0.9491.00
133_D175_Y0.9461.00
23_R27_S0.9451.00
180_A187_F0.9421.00
188_A221_M0.9411.00
43_R77_G0.9361.00
150_D154_H0.9271.00
229_A238_L0.9191.00
20_S28_H0.9171.00
179_L183_L0.9131.00
224_I284_L0.9101.00
293_H296_Q0.9031.00
28_H316_H0.9021.00
259_P262_Q0.9011.00
136_P179_L0.8971.00
233_R236_E0.8961.00
155_V158_V0.8951.00
177_A208_N0.8871.00
157_P160_G0.8821.00
36_A323_F0.8811.00
26_F101_L0.8811.00
230_D325_L0.8801.00
88_P141_E0.8771.00
141_E153_P0.8761.00
205_Y209_F0.8671.00
134_N138_D0.8631.00
241_S244_Q0.8591.00
236_E280_L0.8581.00
27_S30_L0.8581.00
31_D38_K0.8571.00
65_G69_A0.8561.00
64_I68_A0.8481.00
323_F327_M0.8471.00
41_Y327_M0.8441.00
224_I295_L0.8391.00
209_F216_E0.8361.00
265_D269_S0.8351.00
43_R306_E0.8311.00
117_D120_T0.8301.00
100_T160_G0.8281.00
195_P199_F0.8241.00
177_A181_A0.8201.00
82_M113_A0.8201.00
245_A248_K0.8201.00
83_L138_D0.8191.00
169_L180_A0.8161.00
25_A28_H0.8121.00
209_F212_S0.8111.00
247_V250_R0.8101.00
236_E239_F0.8091.00
144_D153_P0.8081.00
203_H303_D0.8071.00
262_Q269_S0.8021.00
130_G134_N0.8021.00
144_D151_P0.8011.00
196_D199_F0.7951.00
271_S275_G0.7891.00
174_L208_N0.7851.00
206_R220_A0.7841.00
68_A106_I0.7841.00
69_A102_Y0.7841.00
187_F205_Y0.7831.00
83_L91_I0.7761.00
138_D142_L0.7741.00
231_S235_A0.7731.00
238_L325_L0.7731.00
146_F165_I0.7721.00
38_K328_D0.7681.00
261_I264_M0.7661.00
260_P264_M0.7661.00
96_G155_V0.7631.00
244_Q248_K0.7591.00
136_P175_Y0.7581.00
99_N164_K0.7581.00
99_N161_Y0.7531.00
209_F215_L0.7521.00
178_Q207_S0.7511.00
273_Q276_V0.7501.00
177_A187_F0.7501.00
311_G326_A0.7501.00
100_T163_E0.7491.00
129_S175_Y0.7441.00
297_S300_R0.7381.00
238_L241_S0.7371.00
169_L176_S0.7351.00
132_I175_Y0.7341.00
64_I106_I0.7341.00
202_L205_Y0.7331.00
68_A98_L0.7331.00
22_A25_A0.7291.00
155_V159_P0.7251.00
140_A182_Q0.7241.00
107_D168_W0.7231.00
145_W151_P0.7221.00
113_A120_T0.7211.00
30_L67_L0.7191.00
236_E285_V0.7191.00
91_I142_L0.7181.00
88_P138_D0.7151.00
206_R210_K0.7141.00
261_I265_D0.7131.00
64_I98_L0.7121.00
169_L179_L0.7111.00
169_L184_G0.7091.00
119_R122_M0.7041.00
50_H93_E0.7041.00
241_S245_A0.7031.00
43_R308_M0.7021.00
112_R131_D0.7001.00
45_W79_G0.6991.00
243_Q246_F0.6941.00
226_I326_A0.6931.00
75_H166_P0.6931.00
258_P265_D0.6901.00
42_H73_T0.6891.00
174_L178_Q0.6891.00
258_P261_I0.6821.00
32_L323_F0.6801.00
240_T243_Q0.6791.00
28_H32_L0.6781.00
144_D147_D0.6781.00
311_G323_F0.6781.00
126_R134_N0.6741.00
217_K305_D0.6731.00
137_R140_A0.6721.00
118_Q121_M0.6711.00
232_N235_A0.6691.00
182_Q208_N0.6691.00
206_R217_K0.6691.00
112_R135_F0.6661.00
77_G168_W0.6661.00
95_F146_F0.6631.00
212_S215_L0.6621.00
99_N159_P0.6571.00
295_L307_I0.6571.00
156_R159_P0.6551.00
182_Q211_P0.6541.00
78_S106_I0.6541.00
206_R305_D0.6531.00
48_E86_H0.6531.00
189_F201_A0.6511.00
61_S95_F0.6491.00
86_H90_V0.6451.00
76_L102_Y0.6451.00
65_G98_L0.6441.00
46_L63_L0.6441.00
289_A292_R0.6431.00
26_F66_Y0.6381.00
257_L262_Q0.6351.00
220_A304_A0.6331.00
230_D288_K0.6311.00
35_L327_M0.6291.00
96_G157_P0.6291.00
87_S90_V0.6291.00
206_R209_F0.6281.00
272_E276_V0.6281.00
269_S272_E0.6261.00
27_S72_T0.6251.00
260_P265_D0.6251.00
27_S69_A0.6251.00
247_V251_R0.6211.00
171_G176_S0.6211.00
202_L302_T0.6181.00
44_Y67_L0.6171.00
158_V161_Y0.6161.00
30_L69_A0.6151.00
99_N102_Y0.6151.00
63_L97_T0.6121.00
195_P301_E0.6111.00
110_L142_L0.6101.00
71_T105_R0.6101.00
37_E74_L0.6101.00
42_H75_H0.6091.00
271_S279_A0.6081.00
181_A209_F0.6071.00
177_A205_Y0.6061.00
288_K328_D0.6061.00
166_P219_Y0.6011.00
83_L110_L0.5991.00
206_R303_D0.5981.00
36_A74_L0.5981.00
81_V95_F0.5981.00
271_S274_Y0.5971.00
294_G298_I0.5971.00
140_A143_V0.5971.00
30_L33_A0.5961.00
26_F30_L0.5961.00
139_V169_L0.5921.00
221_M306_E0.5911.00
156_R161_Y0.5891.00
223_C308_M0.5861.00
24_E27_S0.5841.00
110_L167_V0.5831.00
299_L304_A0.5821.00
245_A249_L0.5801.00
296_Q299_L0.5751.00
141_E145_W0.5721.00
258_P269_S0.5711.00
248_K251_R0.5691.00
52_M55_I0.5671.00
65_G102_Y0.5671.00
257_L260_P0.5671.00
229_A232_N0.5671.00
226_I284_L0.5671.00
89_L145_W0.5661.00
86_H91_I0.5651.00
155_V160_G0.5631.00
60_T78_S0.5601.00
175_Y179_L0.5601.00
246_F250_R0.5601.00
203_H206_R0.5591.00
172_S201_A0.5571.00
174_L200_Q0.5561.00
71_T74_L0.5561.00
258_P264_M0.5551.00
201_A204_L0.5551.00
288_K292_R0.5511.00
295_L309_V0.5480.99
20_S24_E0.5460.99
96_G100_T0.5460.99
172_S191_S0.5450.99
276_V279_A0.5430.99
210_K213_A0.5430.99
109_G170_L0.5410.99
210_K215_L0.5390.99
66_Y102_Y0.5350.99
107_D166_P0.5340.99
195_P302_T0.5320.99
259_P265_D0.5300.99
43_R75_H0.5300.99
228_A326_A0.5290.99
288_K329_V0.5240.99
96_G146_F0.5240.99
121_M125_R0.5220.99
62_V94_Q0.5220.99
225_N312_Q0.5210.99
235_A239_F0.5210.99
190_A193_F0.5200.99
107_D306_E0.5190.99
273_Q277_Q0.5180.99
259_P264_M0.5180.99
227_I239_F0.5170.99
135_F169_L0.5170.99
231_S237_F0.5150.99
141_E151_P0.5140.99
29_S32_L0.5140.99
282_M294_G0.5130.99
246_F249_L0.5130.99
198_L201_A0.5110.99
79_G188_A0.5110.99
228_A287_D0.5100.99
289_A329_V0.5100.99
149_R153_P0.5100.99
222_V298_I0.5090.99
224_I307_I0.5070.99
225_N310_N0.5070.99
179_L182_Q0.5060.99
197_M201_A0.5060.99
92_A146_F0.5050.99
65_G68_A0.5050.99
207_S210_K0.5040.99
39_R324_E0.5040.99
62_V66_Y0.5040.99
62_V101_L0.5010.99
191_S198_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1lucA 1 0.9284 100 0.208 Contact Map
1lucB 1 0.9194 100 0.219 Contact Map
2wgkA 2 0.9731 100 0.222 Contact Map
4us5A 3 0.9672 100 0.231 Contact Map
2i7gA 2 0.9493 100 0.236 Contact Map
3raoA 2 0.9582 100 0.259 Contact Map
3sdoA 2 0.9701 100 0.27 Contact Map
3b9oA 2 0.9582 100 0.273 Contact Map
1z69A 4 0.9164 100 0.273 Contact Map
1ezwA 3 0.9313 100 0.274 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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