GREMLIN Database
LPTA - Lipopolysaccharide export system protein LptA
UniProt: P0ADV1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12618
Length: 185 (154)
Sequences: 1381 (1043)
Seq/√Len: 84.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_L147_E3.7291.00
110_S126_N3.4951.00
41_D57_N3.4881.00
46_D49_G3.1221.00
70_D91_K3.0001.00
127_A141_I2.9411.00
60_V72_V2.8021.00
69_A88_G2.6171.00
115_E118_K2.5831.00
69_A72_V2.5591.00
119_D146_K2.3661.00
31_D64_T2.2711.00
53_T73_V2.2111.00
54_F74_V2.1791.00
42_Q55_T2.1321.00
110_S125_G2.1001.00
131_Q134_S2.0911.00
109_A123_L2.0751.00
122_V142_T2.0461.00
113_H124_T2.0271.00
75_T85_V2.0071.00
72_V88_G1.9261.00
93_A112_M1.8971.00
138_G152_A1.8771.00
61_T66_K1.8691.00
59_I68_N1.7141.00
38_I54_F1.7141.00
41_D159_R1.6921.00
37_H161_T1.6201.00
39_E161_T1.6001.00
73_V89_Y1.5861.00
45_L76_R1.5851.00
106_E130_Q1.5701.00
36_I62_Q1.5541.00
71_K89_Y1.5351.00
95_F107_G1.4890.99
14_L17_S1.4750.99
53_T71_K1.4620.99
75_T87_D1.3930.99
55_T71_K1.3830.99
124_T140_K1.3680.99
43_Q54_F1.3660.99
31_D34_Q1.3530.99
41_D56_G1.3520.99
73_V87_D1.3460.99
58_V72_V1.3440.99
34_Q63_G1.3130.99
52_V76_R1.3090.99
43_Q52_V1.2940.98
108_H128_Y1.2870.98
120_F144_L1.2760.98
11_N23_I1.2650.98
34_Q64_T1.2510.98
131_Q150_M1.2450.98
72_V86_I1.2040.97
122_V140_K1.2030.97
43_Q162_T1.1850.97
113_H122_V1.1820.97
92_P112_M1.1770.97
111_Q124_T1.1740.97
107_G127_A1.1590.97
115_E122_V1.1460.97
31_D62_Q1.1350.96
11_N14_L1.1230.96
76_R107_G1.1210.96
98_M104_P1.1050.96
54_F76_R1.0980.96
128_Y137_K1.0760.95
14_L20_A1.0700.95
128_Y135_N1.0520.94
37_H61_T1.0460.94
136_I152_A1.0350.94
107_G123_L1.0050.93
85_V113_H1.0040.93
28_V64_T1.0030.93
67_I88_G1.0010.93
127_A152_A0.9990.93
13_V18_L0.9920.92
11_N16_S0.9850.92
16_S22_S0.9790.92
59_I66_K0.9750.92
92_P110_S0.9720.92
77_P84_E0.9390.90
96_Y104_P0.9310.90
61_T68_N0.9280.90
133_D165_V0.9240.89
15_A18_L0.9180.89
38_I72_V0.9170.89
83_K86_I0.9000.88
30_G64_T0.8950.88
23_I26_F0.8820.87
119_D145_V0.8790.87
29_T96_Y0.8740.87
130_Q135_N0.8670.86
37_H163_V0.8540.85
68_N94_T0.8520.85
28_V31_D0.8500.85
87_D111_Q0.8480.85
51_V75_T0.8330.84
38_I162_T0.8300.84
43_Q47_M0.8240.83
142_T151_Q0.8180.83
38_I60_V0.8180.83
12_L15_A0.7960.81
31_D65_I0.7880.80
139_D155_D0.7820.80
92_P95_F0.7770.80
134_S150_M0.7740.79
22_S26_F0.7710.79
28_V34_Q0.7640.78
11_N19_L0.7600.78
93_A127_A0.7550.78
141_I152_A0.7530.77
70_D89_Y0.7460.77
64_T97_Q0.7440.77
92_P126_N0.7410.76
40_S54_F0.7370.76
89_Y111_Q0.7330.75
17_S20_A0.7310.75
95_F121_V0.7310.75
158_K162_T0.7190.74
137_K161_T0.7160.74
54_F162_T0.7150.74
65_I97_Q0.7150.74
91_K110_S0.7130.73
54_F72_V0.7120.73
43_Q50_N0.7100.73
60_V67_I0.7100.73
60_V83_K0.7070.73
138_G153_F0.7060.73
25_A28_V0.7020.72
78_G169_L0.6980.72
16_S23_I0.6910.71
67_I141_I0.6890.71
94_T108_H0.6890.71
62_Q131_Q0.6880.71
12_L16_S0.6870.71
63_G166_P0.6850.70
47_M148_Q0.6740.69
11_N26_F0.6700.69
76_R83_K0.6680.69
11_N18_L0.6660.68
17_S21_A0.6640.68
93_A109_A0.6630.68
158_K161_T0.6600.68
19_L23_I0.6590.68
87_D113_H0.6580.67
144_L151_Q0.6540.67
109_A112_M0.6450.66
105_V127_A0.6430.66
50_N78_G0.6420.65
51_V73_V0.6410.65
19_L26_F0.6400.65
83_K148_Q0.6370.65
96_Y106_E0.6330.64
22_S25_A0.6310.64
95_F148_Q0.6300.64
127_A144_L0.6290.64
152_A164_L0.6240.63
82_G86_I0.6200.63
42_Q151_Q0.6160.62
114_Y143_Y0.6110.62
45_L62_Q0.6090.61
11_N15_A0.6080.61
129_L150_M0.6030.61
129_L141_I0.6000.60
13_V138_G0.5970.60
39_E159_R0.5950.60
28_V98_M0.5950.60
50_N149_K0.5950.60
116_L131_Q0.5940.60
93_A150_M0.5920.59
43_Q92_P0.5900.59
115_E165_V0.5860.58
144_L149_K0.5810.58
118_K147_E0.5800.58
111_Q151_Q0.5800.58
15_A22_S0.5800.58
17_S168_Q0.5790.58
40_S164_L0.5760.57
52_V84_E0.5750.57
138_G141_I0.5740.57
105_V141_I0.5720.57
15_A120_F0.5670.56
14_L23_I0.5670.56
29_T64_T0.5670.56
112_M135_N0.5670.56
108_H130_Q0.5670.56
29_T109_A0.5660.56
127_A150_M0.5660.56
12_L21_A0.5640.56
97_Q152_A0.5630.55
17_S22_S0.5610.55
55_T66_K0.5610.55
40_S160_V0.5580.55
75_T84_E0.5550.54
21_A26_F0.5540.54
136_I150_M0.5530.54
39_E59_I0.5530.54
34_Q97_Q0.5500.54
165_V168_Q0.5490.54
67_I120_F0.5490.54
21_A81_Q0.5470.53
30_G33_D0.5460.53
47_M138_G0.5450.53
69_A129_L0.5450.53
76_R112_M0.5440.53
114_Y119_D0.5420.53
112_M123_L0.5410.53
45_L144_L0.5400.52
52_V129_L0.5390.52
54_F152_A0.5360.52
32_T62_Q0.5320.51
20_A23_I0.5310.51
85_V115_E0.5300.51
109_A127_A0.5290.51
72_V84_E0.5280.51
98_M137_K0.5260.51
41_D121_V0.5210.50
14_L21_A0.5200.50
117_A126_N0.5200.50
20_A157_G0.5180.50
30_G136_I0.5150.49
66_K96_Y0.5130.49
15_A158_K0.5120.49
14_L156_K0.5100.48
45_L107_G0.5090.48
79_G157_G0.5070.48
35_P62_Q0.5030.48
81_Q84_E0.5010.47
68_N93_A0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uu4A 1 0.7297 100 0.278 Contact Map
2r19A 3 0.773 100 0.309 Contact Map
4q35A 1 0.7946 99.7 0.599 Contact Map
3my2A 2 0.6541 98.9 0.73 Contact Map
2wtpA 2 0.4703 34.3 0.923 Contact Map
2vdaB 1 0.1459 12.1 0.938 Contact Map
4peuA 1 0.8054 6.8 0.944 Contact Map
4pj0O 1 0.6919 5.9 0.946 Contact Map
1kmoA 1 0.3351 5.4 0.947 Contact Map
4bz4A 4 0.8216 5.1 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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