GREMLIN Database
YGIW - Protein YgiW
UniProt: P0ADU5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13025
Length: 130 (125)
Sequences: 321 (250)
Seq/√Len: 22.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_R106_E4.6711.00
111_V120_I3.1221.00
107_I120_I2.5310.98
66_N104_T2.4540.98
90_D121_D2.3650.97
103_D127_K2.3270.97
4_F8_I2.2730.97
87_V107_I2.2670.97
76_Y89_I2.2410.96
38_G41_G2.1590.95
106_E126_R2.1520.95
68_V79_K2.0570.94
114_D118_V2.0550.94
81_A107_I1.9710.93
69_E77_V1.9060.91
75_L86_N1.9010.91
49_V78_F1.8130.89
55_L59_T1.7960.89
52_A107_I1.7730.88
61_V120_I1.7330.87
47_T51_S1.7080.86
70_R73_D1.6680.84
112_D122_V1.5560.80
57_D112_D1.4880.77
107_I125_I1.4630.76
10_V14_C1.3970.72
74_D90_D1.3960.72
16_A20_A1.3930.72
97_V105_V1.3870.71
77_V84_T1.3470.69
14_C17_P1.3420.69
10_V82_S1.3300.68
88_D121_D1.3090.67
89_I99_V1.3090.67
99_V105_V1.3010.66
39_F94_W1.2940.66
69_E119_E1.2850.65
53_K70_R1.2810.65
55_L111_V1.2810.65
97_V126_R1.2770.65
76_Y105_V1.2730.65
68_V77_V1.2220.61
108_Q124_Q1.1970.60
49_V82_S1.1890.59
8_I12_A1.1870.59
114_D117_S1.1830.59
67_I87_V1.1640.58
10_V13_L1.1630.58
67_I125_I1.1540.57
72_S123_K1.1360.56
48_T52_A1.1230.55
39_F113_K1.1180.55
66_N102_K1.1170.54
70_R74_D1.1080.54
37_G127_K1.1030.54
92_K110_E1.0870.52
49_V57_D1.0800.52
49_V52_A1.0730.51
72_S105_V1.0670.51
55_L79_K1.0640.51
58_D121_D1.0630.51
18_V23_Q1.0440.49
63_L85_I1.0420.49
11_M88_D1.0380.49
7_V12_A1.0360.49
38_G101_P1.0290.48
53_K66_N1.0280.48
38_G113_K1.0130.47
36_A92_K1.0100.47
56_R75_L1.0090.47
94_W103_D1.0050.47
67_I105_V0.9910.46
68_V127_K0.9760.45
24_G84_T0.9760.45
50_E54_S0.9670.44
94_W125_I0.9460.43
66_N79_K0.9380.42
75_L88_D0.9310.42
85_I120_I0.8970.40
50_E53_K0.8920.39
59_T111_V0.8910.39
87_V125_I0.8910.39
28_G67_I0.8890.39
90_D110_E0.8780.38
52_A59_T0.8720.38
46_V79_K0.8630.37
68_V88_D0.8620.37
105_V119_E0.8580.37
60_W71_I0.8460.36
69_E91_H0.8310.35
111_V114_D0.8270.35
32_T47_T0.8240.35
95_N127_K0.8200.35
92_K123_K0.8160.34
88_D118_V0.8130.34
79_K111_V0.8050.34
12_A17_P0.8040.34
79_K84_T0.8010.33
56_R118_V0.7980.33
55_L64_R0.7970.33
37_G40_Q0.7940.33
101_P113_K0.7910.33
110_E123_K0.7790.32
63_L83_G0.7730.32
34_S107_I0.7730.32
95_N98_T0.7680.31
15_S18_V0.7670.31
74_D91_H0.7510.30
37_G98_T0.7480.30
9_A106_E0.7470.30
113_K117_S0.7400.30
41_G61_V0.7380.30
76_Y87_V0.7340.29
28_G31_A0.7310.29
93_R122_V0.7280.29
69_E103_D0.7230.29
65_G80_D0.7200.29
14_C19_M0.7190.29
14_C18_V0.7170.29
72_S76_Y0.7170.29
42_P72_S0.7150.28
75_L115_W0.7100.28
64_R104_T0.7090.28
50_E71_I0.7080.28
116_N120_I0.7070.28
27_S97_V0.7060.28
52_A111_V0.7060.28
20_A126_R0.7000.28
26_F29_P0.6990.28
61_V76_Y0.6840.27
8_I15_S0.6760.26
114_D119_E0.6760.26
11_M14_C0.6640.26
36_A125_I0.6540.25
41_G76_Y0.6470.25
12_A36_A0.6460.25
36_A39_F0.6350.24
47_T94_W0.6330.24
46_V62_T0.6320.24
74_D110_E0.6310.24
9_A84_T0.6280.24
71_I77_V0.6240.24
64_R119_E0.6170.23
6_A9_A0.6150.23
19_M45_S0.6140.23
102_K114_D0.6080.23
4_F73_D0.6060.23
40_Q111_V0.6030.23
56_R68_V0.6000.22
56_R59_T0.5980.22
71_I94_W0.5940.22
91_H94_W0.5880.22
112_D121_D0.5860.22
107_I126_R0.5780.21
34_S82_S0.5770.21
23_Q75_L0.5760.21
93_R110_E0.5750.21
5_A19_M0.5750.21
63_L122_V0.5720.21
97_V103_D0.5650.21
4_F10_V0.5650.21
62_T106_E0.5560.20
29_P37_G0.5540.20
46_V107_I0.5540.20
35_Q127_K0.5520.20
88_D119_E0.5510.20
106_E120_I0.5480.20
72_S99_V0.5390.20
16_A19_M0.5390.20
28_G125_I0.5360.20
42_P88_D0.5340.19
27_S30_S0.5310.19
28_G32_T0.5280.19
89_I93_R0.5280.19
111_V115_W0.5280.19
76_Y93_R0.5210.19
52_A55_L0.5210.19
6_A30_S0.5180.19
6_A124_Q0.5140.19
48_T112_D0.5140.19
15_S46_V0.5130.19
54_S102_K0.5130.19
36_A111_V0.5130.19
37_G101_P0.5130.19
52_A120_I0.5110.18
55_L73_D0.5020.18
35_Q72_S0.5000.18
96_G99_V0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nnxA 1 0.7154 100 0.226 Contact Map
2pi2A 1 0.6769 96.9 0.846 Contact Map
4rmfA 2 0.6692 96.5 0.853 Contact Map
3nemA 2 0.6769 96.5 0.854 Contact Map
4gnxB 1 0.6462 96.5 0.854 Contact Map
1c0aA 1 0.6692 96.4 0.855 Contact Map
1x54A 2 0.6769 96.4 0.856 Contact Map
1wydA 2 0.6769 96.4 0.856 Contact Map
1n9wA 2 0.6231 96.3 0.856 Contact Map
2xgtA 2 0.6385 96.3 0.857 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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