GREMLIN Database
YGIM - Uncharacterized protein YgiM
UniProt: P0ADT8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12434
Length: 206 (194)
Sequences: 560 (430)
Seq/√Len: 30.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
174_F180_V5.1291.00
68_A82_L4.8601.00
60_Q69_Q4.6281.00
39_G44_Y4.2581.00
56_V70_V3.8691.00
41_G44_Y3.7951.00
147_E152_Q3.3831.00
28_V70_V3.3291.00
189_L192_P3.0521.00
148_L151_A2.6861.00
59_L71_K2.6751.00
23_E57_T2.6411.00
58_L68_A2.5321.00
173_W180_V2.5301.00
101_Q106_T2.3780.99
109_L112_I2.3650.99
141_N144_L2.2500.99
72_D76_R2.1780.98
102_V105_L2.0450.98
173_W188_G2.0380.98
184_G192_P2.0230.97
91_L95_V1.9220.97
127_V130_S1.9120.96
162_L165_K1.9060.96
155_V158_A1.8960.96
94_R99_E1.8800.96
95_V98_L1.8530.96
116_W119_R1.7630.94
69_Q77_T1.7190.94
143_K147_E1.6680.93
175_M179_G1.6650.92
111_N115_T1.6430.92
181_L185_L1.5730.90
84_Q178_G1.5290.89
61_T82_L1.4840.87
180_V188_G1.4620.86
8_G15_S1.4620.86
130_S134_I1.4400.86
50_V125_Q1.4380.86
108_K113_D1.4280.85
88_E94_R1.4250.85
25_T55_E1.3960.84
100_N104_T1.3790.83
35_W46_L1.3620.82
40_P79_W1.3610.82
192_P204_W1.3560.82
128_A131_D1.3520.82
71_K77_T1.3460.81
36_V78_A1.3410.81
48_G76_R1.3370.81
30_D45_R1.3360.81
27_Y36_V1.3200.80
36_V80_I1.3190.80
124_Q134_I1.3150.80
56_V85_L1.3110.80
94_R97_D1.3020.79
106_T110_T1.2930.79
140_E145_K1.2920.79
28_V34_T1.2900.79
41_G65_T1.2850.78
98_L102_V1.2830.78
124_Q130_S1.2740.78
35_W48_G1.2660.77
28_V86_S1.2420.76
26_R58_L1.2210.75
180_V193_H1.1850.72
33_N49_T1.1780.72
176_Y192_P1.1600.71
185_L189_L1.1590.71
37_R46_L1.1550.70
34_T80_I1.1490.70
164_D167_R1.1390.69
131_D135_N1.1200.68
37_R83_K1.1080.67
57_T71_K1.1000.67
28_V56_V1.0960.66
8_G14_L1.0730.65
178_G187_L1.0640.64
44_Y81_P1.0590.64
126_K130_S1.0350.62
27_Y30_D1.0270.61
27_Y173_W1.0240.61
176_Y195_I1.0170.60
146_N157_A1.0100.60
119_R123_M1.0090.60
191_L194_L0.9980.59
78_A165_K0.9960.59
127_V134_I0.9960.59
96_P178_G0.9940.59
68_A85_L0.9810.58
133_V136_G0.9800.57
61_T68_A0.9750.57
35_W49_T0.9640.56
39_G45_R0.9560.56
131_D134_I0.9520.55
113_D117_N0.9420.54
174_F192_P0.9340.54
177_G184_G0.9280.53
78_A113_D0.9250.53
161_Q165_K0.9220.53
29_S40_P0.9170.52
52_A79_W0.9160.52
171_M176_Y0.9100.52
67_Y194_L0.8850.50
198_R204_W0.8810.50
9_L15_S0.8790.49
39_G189_L0.8740.49
40_P170_I0.8640.48
106_T156_D0.8560.48
79_W163_D0.8540.47
11_L202_D0.8500.47
124_Q135_N0.8490.47
10_T103_K0.8460.47
182_G189_L0.8400.46
117_N194_L0.8380.46
28_V111_N0.8330.46
111_N114_N0.8270.45
32_L45_R0.8250.45
115_T118_Q0.8240.45
176_Y182_G0.8200.45
130_S133_V0.8200.45
79_W141_N0.8190.45
174_F197_S0.8180.44
148_L191_L0.8150.44
139_E183_L0.8150.44
149_I160_V0.8130.44
104_T186_L0.8110.44
188_G191_L0.8110.44
82_L85_L0.8100.44
184_G189_L0.8060.44
38_S45_R0.7960.43
11_L14_L0.7930.43
181_L188_G0.7910.42
73_S77_T0.7870.42
185_L191_L0.7860.42
128_A132_S0.7830.42
16_A19_V0.7820.42
192_P196_P0.7750.41
86_S110_T0.7750.41
174_F193_H0.7720.41
186_L197_S0.7670.40
86_S150_V0.7600.40
8_G11_L0.7590.40
36_V66_N0.7590.40
95_V108_K0.7580.40
34_T123_M0.7520.39
161_Q166_Q0.7500.39
17_T34_T0.7460.39
31_E83_K0.7460.39
28_V80_I0.7450.39
21_H136_G0.7420.39
128_A135_N0.7400.38
9_L12_L0.7350.38
99_E103_K0.7350.38
107_D113_D0.7330.38
133_V138_K0.7300.38
59_L88_E0.7260.37
68_A123_M0.7230.37
116_W120_T0.7170.37
177_G188_G0.7110.36
98_L172_Q0.7100.36
69_Q198_R0.7050.36
134_I138_K0.7040.36
57_T115_T0.7030.36
37_R91_L0.7020.36
17_T23_E0.7010.35
183_L187_L0.7010.35
12_L20_S0.6960.35
37_R74_S0.6940.35
33_N37_R0.6910.35
33_N83_K0.6860.34
185_L188_G0.6860.34
54_E73_S0.6820.34
52_A90_S0.6790.34
183_L194_L0.6790.34
124_Q131_D0.6770.34
129_Q134_I0.6770.34
193_H197_S0.6680.33
124_Q127_V0.6670.33
35_W90_S0.6620.33
151_A181_L0.6610.33
140_E143_K0.6610.33
195_I203_R0.6590.32
175_M193_H0.6590.32
102_V111_N0.6560.32
168_T172_Q0.6560.32
106_T109_L0.6550.32
144_L182_G0.6530.32
30_D184_G0.6520.32
114_N187_L0.6510.32
103_K114_N0.6480.32
154_K159_S0.6480.32
59_L67_Y0.6460.32
182_G185_L0.6430.31
58_L174_F0.6380.31
176_Y181_L0.6330.31
149_I152_Q0.6330.31
180_V185_L0.6330.31
100_N118_Q0.6320.31
54_E132_S0.6320.31
30_D177_G0.6310.30
91_L141_N0.6300.30
135_N138_K0.6260.30
174_F177_G0.6250.30
129_Q133_V0.6250.30
71_K105_L0.6240.30
157_A188_G0.6240.30
110_T186_L0.6230.30
50_V72_D0.6220.30
165_K170_I0.6210.30
37_R195_I0.6190.30
50_V133_V0.6170.30
13_A18_A0.6170.30
105_L162_L0.6110.29
14_L18_A0.6070.29
10_T64_N0.6070.29
30_D52_A0.6070.29
9_L17_T0.6000.28
80_I161_Q0.6000.28
58_L65_T0.5940.28
101_Q110_T0.5940.28
55_E80_I0.5940.28
122_E159_S0.5930.28
140_E160_V0.5890.28
190_V194_L0.5880.28
51_N85_L0.5880.28
67_Y192_P0.5870.28
10_T14_L0.5860.28
57_T183_L0.5830.27
143_K153_K0.5820.27
60_Q79_W0.5800.27
112_I116_W0.5780.27
19_V24_E0.5750.27
174_F188_G0.5740.27
48_G83_K0.5710.27
187_L196_P0.5680.26
32_L49_T0.5610.26
12_L139_E0.5590.26
33_N48_G0.5590.26
91_L138_K0.5580.26
89_P141_N0.5560.26
58_L105_L0.5530.25
125_Q129_Q0.5530.25
24_E101_Q0.5520.25
125_Q131_D0.5510.25
157_A187_L0.5450.25
110_T150_V0.5450.25
37_R67_Y0.5450.25
54_E151_A0.5450.25
8_G13_A0.5420.25
127_V133_V0.5400.25
112_I199_K0.5400.25
49_T81_P0.5380.25
13_A16_A0.5370.24
32_L36_V0.5360.24
29_S79_W0.5340.24
78_A84_Q0.5320.24
51_N99_E0.5310.24
50_V70_V0.5310.24
181_L184_G0.5300.24
44_Y189_L0.5290.24
141_N171_M0.5280.24
47_V76_R0.5280.24
106_T185_L0.5270.24
194_L199_K0.5260.24
95_V102_V0.5260.24
33_N46_L0.5250.24
36_V175_M0.5240.24
140_E144_L0.5230.24
8_G190_V0.5210.24
20_S23_E0.5200.23
86_S100_N0.5190.23
18_A103_K0.5190.23
17_T107_D0.5180.23
86_S91_L0.5170.23
151_A184_G0.5170.23
88_E186_L0.5160.23
77_T104_T0.5140.23
45_R177_G0.5080.23
103_K186_L0.5080.23
9_L59_L0.5070.23
57_T176_Y0.5060.23
36_V155_V0.5060.23
15_S70_V0.5060.23
22_A143_K0.5050.23
44_Y69_Q0.5050.23
67_Y98_L0.5040.23
66_N159_S0.5030.23
37_R81_P0.5000.22
106_T114_N0.5000.22
19_V22_A0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kq8A 1 0.3398 99.3 0.749 Contact Map
2kt8A 1 0.3689 99.3 0.75 Contact Map
2krsA 1 0.3592 99.3 0.758 Contact Map
4krtA 1 0.3641 99 0.782 Contact Map
3npfA 2 0.7524 98.7 0.806 Contact Map
3h41A 1 0.9515 98.5 0.818 Contact Map
3m1uA 2 0.932 97.1 0.867 Contact Map
2hbwA 1 0.5437 96.9 0.871 Contact Map
3pe0A 1 0.5146 95.5 0.888 Contact Map
1v1cA 1 0.3058 95.2 0.89 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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