GREMLIN Database
YGIC - Putative acid--amine ligase YgiC
UniProt: P0ADT5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11165
Length: 386 (364)
Sequences: 1265 (866)
Seq/√Len: 45.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_A360_P5.4301.00
52_T353_S5.2641.00
99_S116_N4.1071.00
343_K346_D4.0831.00
65_K276_M3.9391.00
314_I338_F3.6951.00
42_L46_E3.2821.00
64_E68_A3.2521.00
56_H116_N3.2461.00
311_N326_G3.0161.00
300_V314_I2.8921.00
74_T83_W2.7221.00
51_V111_P2.6051.00
106_D109_G2.5761.00
65_K69_S2.5341.00
76_F268_A2.5321.00
43_A47_K2.5211.00
15_K18_E2.4301.00
40_L45_V2.4151.00
177_T208_I2.3791.00
27_Y376_M2.3011.00
259_A262_S2.2951.00
218_Q226_V2.2901.00
285_P289_A2.2891.00
153_S157_K2.2781.00
301_V313_S2.2721.00
26_M376_M2.2231.00
211_I227_I2.2041.00
127_A154_L2.1891.00
14_E17_H2.1091.00
175_H206_L2.0951.00
17_H24_H2.0931.00
74_T80_K2.0710.99
157_K361_A2.0640.99
257_E265_S2.0500.99
73_M87_R2.0360.99
190_Q193_Q2.0300.99
62_V276_M1.9630.99
271_P288_F1.9300.99
73_M83_W1.9160.99
288_F291_D1.8890.99
178_C205_F1.8860.99
55_L101_L1.8830.99
62_V272_L1.8700.99
72_L275_E1.8480.99
289_A294_P1.8270.99
37_Y383_I1.8170.99
66_V72_L1.7800.98
271_P334_I1.7700.98
193_Q203_T1.7560.98
368_D374_Q1.7460.98
66_V263_I1.7410.98
193_Q197_T1.7270.98
207_Y210_D1.7260.98
180_R209_D1.7240.98
114_L341_L1.6990.98
351_I365_I1.6880.98
176_L192_L1.6850.98
173_L202_A1.6760.98
206_L222_L1.6480.97
237_E307_R1.6300.97
159_I195_C1.6100.97
15_K137_D1.5990.97
343_K348_Y1.5700.96
14_E18_E1.5560.96
70_D73_M1.5460.96
299_Y315_I1.5370.96
86_V259_A1.5330.96
267_K302_K1.5320.96
159_I198_E1.5310.96
23_F188_T1.5300.96
48_L363_I1.5300.96
16_A21_F1.5130.96
197_T202_A1.5050.96
235_P307_R1.4970.95
297_E337_Q1.4900.95
240_L262_S1.4850.95
270_L286_A1.4770.95
52_T355_L1.4670.95
284_L289_A1.4670.95
202_A225_Q1.4640.95
115_E302_K1.4570.95
329_G332_G1.4550.95
351_I363_I1.4510.95
105_W111_P1.4370.94
178_C207_Y1.4350.94
15_K19_Y1.4330.94
62_V269_L1.4310.94
286_A290_E1.4170.94
101_L113_L1.4110.94
300_V312_V1.4070.94
42_L384_F1.3970.93
61_K277_F1.3910.93
174_L201_I1.3820.93
102_D302_K1.3800.93
33_C378_R1.3760.93
113_L270_L1.3710.93
230_L255_W1.3680.93
210_D222_L1.3670.93
213_L247_K1.3660.93
122_T233_L1.3610.92
320_T323_A1.3510.92
180_R207_Y1.3480.92
214_G220_T1.3360.92
63_V264_I1.3260.91
104_A114_L1.3260.91
102_D267_K1.3140.91
27_Y374_Q1.3120.91
175_H227_I1.3060.91
115_E267_K1.2990.90
298_K337_Q1.2920.90
291_D294_P1.2860.90
101_L355_L1.2850.90
204_E225_Q1.2750.90
175_H204_E1.2640.89
301_V335_V1.2590.89
164_E357_N1.2550.89
26_M374_Q1.2440.88
177_T230_L1.2390.88
161_R165_L1.2190.87
301_V333_M1.2170.87
220_T224_D1.2060.87
52_T103_L1.2060.87
59_C118_A1.2050.87
102_D336_Q1.2050.87
289_A292_D1.2030.87
162_F195_C1.2010.87
193_Q205_F1.1910.86
62_V65_K1.1910.86
51_V282_N1.1890.86
102_D115_E1.1820.86
56_H355_L1.1810.86
204_E223_Q1.1790.86
87_R91_L1.1750.85
69_S74_T1.1740.85
160_D164_E1.1720.85
354_W367_E1.1710.85
268_A304_I1.1660.85
285_P337_Q1.1620.85
121_P257_E1.1610.85
298_K316_E1.1590.85
272_L276_M1.1580.85
350_L373_T1.1570.85
232_K236_W1.1510.84
114_L339_H1.1410.84
181_D209_D1.1400.84
70_D87_R1.1330.83
84_S88_Q1.1280.83
72_L75_K1.1250.83
100_R362_G1.1220.83
83_W87_R1.1200.83
122_T308_E1.1190.82
176_L193_Q1.1190.82
64_E295_Q1.1180.82
274_W280_H1.1060.82
322_E371_L1.0920.81
257_E261_K1.0900.81
31_Y373_T1.0780.80
254_R287_Y1.0750.80
302_K336_Q1.0700.80
98_Y231_F1.0690.79
154_L362_G1.0590.79
100_R352_G1.0580.79
120_T308_E1.0570.79
267_K336_Q1.0540.78
184_E307_R1.0430.78
29_E52_T1.0380.77
22_N26_M1.0370.77
157_K359_Q1.0370.77
238_F383_I1.0290.77
158_L162_F1.0230.76
285_P288_F1.0210.76
173_L228_S1.0210.76
246_T250_D1.0110.76
19_Y137_D1.0100.75
38_Y367_E1.0070.75
348_Y370_A1.0050.75
58_M277_F0.9970.74
25_T29_E0.9920.74
227_I230_L0.9890.74
233_L307_R0.9860.74
316_E319_K0.9800.73
117_N267_K0.9740.73
368_D377_S0.9700.72
214_G218_Q0.9700.72
88_Q92_T0.9700.72
311_N325_E0.9680.72
78_I263_I0.9640.72
120_T126_E0.9620.72
175_H221_D0.9600.72
103_L113_L0.9560.71
120_T257_E0.9560.71
189_I205_F0.9550.71
315_I320_T0.9550.71
179_C209_D0.9550.71
227_I253_V0.9540.71
119_D232_K0.9490.71
119_D122_T0.9470.71
197_T323_A0.9470.71
85_F259_A0.9450.70
374_Q377_S0.9440.70
149_D384_F0.9440.70
185_D188_T0.9430.70
230_L259_A0.9420.70
248_L255_W0.9410.70
53_A359_Q0.9400.70
21_F125_Y0.9390.70
48_L353_S0.9330.69
377_S382_H0.9320.69
119_D237_E0.9300.69
126_E307_R0.9300.69
58_M210_D0.9290.69
284_L290_E0.9270.69
174_L229_N0.9170.68
204_E221_D0.9140.68
41_T44_Q0.9140.68
296_M315_I0.9130.68
77_R332_G0.9100.68
286_A289_A0.9090.67
55_L283_L0.9080.67
262_S305_F0.9040.67
186_R205_F0.9030.67
115_E336_Q0.9010.67
313_S320_T0.8980.66
285_P291_D0.8970.66
101_L116_N0.8960.66
166_R243_M0.8960.66
206_L210_D0.8950.66
53_A57_Q0.8940.66
230_L253_V0.8930.66
176_L189_I0.8910.66
302_K309_G0.8850.65
316_E340_P0.8810.65
47_K50_E0.8790.65
172_Q228_S0.8760.65
21_F26_M0.8750.64
161_R357_N0.8720.64
75_K290_E0.8710.64
117_N302_K0.8670.64
84_S295_Q0.8650.64
230_L239_M0.8610.63
285_P290_E0.8600.63
247_K250_D0.8580.63
235_P308_E0.8580.63
364_G379_F0.8540.63
347_S378_R0.8500.62
353_S360_P0.8490.62
112_K337_Q0.8490.62
127_A365_I0.8440.62
265_S307_R0.8430.62
56_H101_L0.8420.61
185_D307_R0.8400.61
104_A339_H0.8350.61
149_D153_S0.8340.61
56_H358_D0.8330.61
28_G376_M0.8330.61
82_T240_L0.8320.60
197_T203_T0.8310.60
165_L256_L0.8300.60
119_D126_E0.8300.60
186_R345_G0.8280.60
14_E216_K0.8270.60
26_M154_L0.8240.60
59_C264_I0.8240.60
300_V338_F0.8230.60
286_A291_D0.8230.60
184_E237_E0.8220.60
269_L303_P0.8130.59
322_E325_E0.8120.59
236_W255_W0.8120.59
94_Q259_A0.8080.58
342_P349_M0.8000.57
284_L288_F0.7960.57
81_H84_S0.7960.57
46_E384_F0.7870.56
21_F187_G0.7850.56
123_S364_G0.7840.56
194_D198_E0.7830.56
22_N183_V0.7820.56
120_T185_D0.7800.56
126_E184_E0.7780.55
103_L177_T0.7720.55
196_A280_H0.7690.54
218_Q228_S0.7680.54
17_H25_T0.7680.54
275_E324_A0.7670.54
178_C181_D0.7650.54
100_R302_K0.7640.54
89_S260_W0.7630.54
233_L308_E0.7590.54
164_E197_T0.7580.53
126_E257_E0.7570.53
126_E352_G0.7560.53
190_Q197_T0.7550.53
74_T77_R0.7530.53
72_L79_P0.7460.52
104_A113_L0.7380.51
174_L227_I0.7370.51
234_Y238_F0.7350.51
99_S355_L0.7350.51
62_V277_F0.7330.51
115_E309_G0.7320.51
101_L357_N0.7320.51
290_E293_H0.7320.51
251_A255_W0.7300.51
24_H28_G0.7290.51
206_L227_I0.7290.51
16_A125_Y0.7280.50
121_P308_E0.7280.50
154_L349_M0.7280.50
227_I318_G0.7250.50
58_M283_L0.7230.50
297_E334_I0.7220.50
319_K355_L0.7220.50
17_H109_G0.7210.50
202_A359_Q0.7200.50
31_Y34_E0.7200.50
96_S373_T0.7200.50
317_N320_T0.7190.50
247_K252_G0.7180.50
206_L223_Q0.7170.49
185_D235_P0.7170.49
149_D152_N0.7170.49
118_A264_I0.7160.49
15_K30_P0.7150.49
161_R164_E0.7110.49
204_E222_L0.7110.49
237_E284_L0.7090.49
49_E149_D0.7090.49
182_T377_S0.7090.49
160_D340_P0.7060.48
180_R210_D0.7040.48
227_I355_L0.7040.48
45_V363_I0.7040.48
160_D163_V0.7030.48
86_V263_I0.7020.48
122_T237_E0.6990.48
312_V338_F0.6960.47
288_F334_I0.6960.47
155_Q159_I0.6940.47
174_L228_S0.6940.47
119_D257_E0.6930.47
208_I334_I0.6920.47
194_D311_N0.6910.47
233_L237_E0.6900.47
270_L284_L0.6890.47
212_G220_T0.6890.47
18_E217_G0.6880.47
100_R267_K0.6850.46
246_T249_E0.6840.46
129_F155_Q0.6820.46
285_P293_H0.6810.46
165_L174_L0.6810.46
174_L177_T0.6740.45
315_I324_A0.6740.45
238_F305_F0.6730.45
336_Q366_R0.6700.45
178_C189_I0.6690.45
60_L264_I0.6690.45
102_D117_N0.6670.45
98_Y122_T0.6650.44
16_A130_F0.6650.44
48_L111_P0.6650.44
170_G312_V0.6640.44
370_A374_Q0.6620.44
23_F26_M0.6610.44
221_D225_Q0.6590.44
177_T205_F0.6570.44
84_S94_Q0.6570.44
176_L205_F0.6570.44
154_L157_K0.6570.44
152_N158_L0.6560.44
152_N156_E0.6540.43
295_Q335_V0.6490.43
165_L251_A0.6490.43
174_L315_I0.6480.43
229_N254_R0.6480.43
191_Y194_D0.6470.43
86_V272_L0.6460.43
77_R339_H0.6450.42
132_W152_N0.6450.42
52_T96_S0.6390.42
188_T307_R0.6380.42
155_Q191_Y0.6360.42
348_Y371_L0.6320.41
61_K369_R0.6310.41
318_G321_I0.6300.41
188_T308_E0.6300.41
338_F371_L0.6300.41
287_Y293_H0.6290.41
221_D368_D0.6280.41
267_K309_G0.6210.40
136_E152_N0.6190.40
115_E352_G0.6190.40
100_R119_D0.6140.40
18_E22_N0.6130.39
243_M246_T0.6110.39
86_V250_D0.6110.39
261_K367_E0.6110.39
119_D235_P0.6050.39
132_W150_Q0.6040.39
244_F253_V0.6030.38
127_A241_R0.6020.38
173_L217_G0.5980.38
179_C253_V0.5980.38
136_E224_D0.5970.38
353_S363_I0.5970.38
272_L275_E0.5970.38
188_T233_L0.5940.38
42_L49_E0.5930.38
93_H170_G0.5930.38
182_T375_D0.5930.38
66_V83_W0.5920.37
60_L358_D0.5920.37
145_P335_V0.5920.37
172_Q202_A0.5920.37
149_D194_D0.5910.37
320_T324_A0.5910.37
45_V49_E0.5900.37
119_D233_L0.5900.37
133_I263_I0.5880.37
258_P270_L0.5880.37
191_Y356_V0.5880.37
279_N282_N0.5860.37
120_T235_P0.5860.37
121_P184_E0.5850.37
92_T369_R0.5850.37
16_A28_G0.5850.37
160_D167_E0.5850.37
216_K252_G0.5830.37
134_W265_S0.5830.37
65_K68_A0.5820.37
18_E250_D0.5810.36
16_A20_G0.5810.36
124_L362_G0.5800.36
61_K312_V0.5790.36
112_K283_L0.5780.36
27_Y379_F0.5770.36
100_R117_N0.5770.36
226_V253_V0.5770.36
90_W123_S0.5770.36
55_L103_L0.5760.36
287_Y290_E0.5760.36
36_A380_Y0.5760.36
199_A281_P0.5760.36
220_T226_V0.5740.36
227_I303_P0.5730.36
118_A122_T0.5720.36
284_L292_D0.5720.36
40_L365_I0.5690.35
84_S249_E0.5690.35
227_I372_I0.5680.35
14_E19_Y0.5670.35
185_D352_G0.5670.35
218_Q263_I0.5660.35
44_Q47_K0.5650.35
190_Q198_E0.5630.35
138_Q145_P0.5630.35
143_N147_G0.5620.35
126_E235_P0.5620.35
120_T184_E0.5620.35
37_Y321_I0.5590.35
113_L243_M0.5560.34
188_T191_Y0.5550.34
240_L259_A0.5550.34
19_Y22_N0.5550.34
178_C253_V0.5530.34
92_T251_A0.5520.34
163_V166_R0.5500.34
96_S109_G0.5490.34
235_P305_F0.5480.34
287_Y291_D0.5480.34
134_W381_P0.5480.34
184_E308_E0.5460.33
134_W308_E0.5460.33
304_I331_E0.5450.33
153_S331_E0.5430.33
238_F242_E0.5420.33
163_V343_K0.5400.33
58_M128_A0.5400.33
60_L164_E0.5380.33
16_A300_V0.5380.33
51_V103_L0.5380.33
81_H249_E0.5370.33
378_R381_P0.5370.33
343_K349_M0.5360.33
266_N367_E0.5360.33
45_V105_W0.5360.33
69_S272_L0.5350.32
99_S357_N0.5350.32
329_G333_M0.5340.32
54_E57_Q0.5320.32
30_P35_D0.5310.32
66_V319_K0.5290.32
22_N27_Y0.5290.32
44_Q63_V0.5290.32
265_S303_P0.5280.32
55_L293_H0.5280.32
131_Q260_W0.5270.32
214_G217_G0.5270.32
317_N321_I0.5250.32
66_V73_M0.5240.31
254_R312_V0.5240.31
153_S361_A0.5230.31
274_W279_N0.5230.31
58_M293_H0.5220.31
47_K287_Y0.5210.31
120_T265_S0.5210.31
314_I333_M0.5200.31
194_D280_H0.5200.31
216_K320_T0.5190.31
228_S288_F0.5190.31
308_E373_T0.5190.31
373_T381_P0.5180.31
61_K65_K0.5180.31
18_E28_G0.5170.31
126_E185_D0.5150.31
43_A225_Q0.5130.31
298_K338_F0.5130.31
121_P235_P0.5130.31
315_I321_I0.5110.30
185_D270_L0.5100.30
341_L372_I0.5080.30
49_E105_W0.5080.30
122_T307_R0.5080.30
299_Y317_N0.5070.30
192_L233_L0.5060.30
64_E93_H0.5050.30
115_E366_R0.5050.30
43_A53_A0.5040.30
14_E41_T0.5030.30
86_V90_W0.5030.30
69_S72_L0.5020.30
188_T231_F0.5020.30
166_R201_I0.5020.30
126_E232_K0.5010.30
98_Y135_L0.5010.30
22_N125_Y0.5010.30
40_L344_F0.5010.30
33_C42_L0.5000.30
319_K324_A0.5000.30
19_Y130_F0.5000.30
100_R115_E0.5000.30
101_L131_Q0.5000.30
223_Q226_V0.5000.30
114_L208_I0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vobA 1 0.8705 100 0.182 Contact Map
2io8A 2 0.9663 100 0.206 Contact Map
3n6xA 2 0.9352 100 0.467 Contact Map
2hgsA 2 0.9637 99.3 0.844 Contact Map
3kalA 2 0.9663 99.3 0.845 Contact Map
1m0wA 2 0.9715 99.3 0.847 Contact Map
1gsaA 3 0.5285 99.1 0.861 Contact Map
3vpbA 3 0.5104 98.9 0.869 Contact Map
2wyoA 2 0.9585 98.8 0.875 Contact Map
3r5xA 2 0.5233 98.8 0.875 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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