GREMLIN Database
YGGN - Uncharacterized protein YggN
UniProt: P0ADS9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12705
Length: 239 (229)
Sequences: 302 (218)
Seq/√Len: 14.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_L69_Q4.2831.00
56_V63_Y3.9891.00
12_S236_G3.3300.99
66_N69_Q3.1490.98
66_N79_E2.9200.97
142_L175_M2.8600.97
31_D54_G2.5880.94
186_N189_Q2.5710.94
56_V73_A2.5670.94
34_V81_R2.5290.93
117_R198_L2.3430.90
8_A16_M2.3260.90
57_M62_Q2.2950.89
73_A102_L2.2850.89
90_G192_L2.2710.89
66_N218_K2.1500.86
64_S68_A2.1140.85
26_V154_A2.0940.84
184_G191_V2.0870.84
12_S71_E2.0310.82
94_R98_A2.0240.82
41_V76_Y2.0160.82
26_V202_I1.9490.80
51_T55_N1.9390.79
54_G77_Q1.8340.75
87_I131_M1.7960.74
195_L214_Q1.7910.73
54_G81_R1.7860.73
11_L15_A1.7680.72
7_L66_N1.7320.71
71_E75_D1.7190.70
80_L124_D1.7100.70
43_G227_L1.6960.69
97_K206_W1.6910.69
12_S16_M1.6900.69
34_V147_K1.6890.69
66_N93_S1.6650.68
144_F231_R1.6000.64
48_L77_Q1.5690.63
53_D62_Q1.5110.60
153_R182_K1.4980.59
32_V150_D1.4950.59
76_Y231_R1.4700.58
169_Q214_Q1.4620.57
24_C221_C1.4600.57
105_I172_I1.4480.56
104_K113_S1.4420.56
172_I176_G1.4130.55
34_V132_N1.3880.53
28_P231_R1.3840.53
161_N203_Q1.3800.53
49_V151_Q1.3770.53
69_Q234_L1.3690.52
7_L89_E1.3560.51
32_V208_K1.3490.51
91_A94_R1.3490.51
93_S216_F1.3410.51
172_I192_L1.3380.50
120_L151_Q1.3360.50
90_G97_K1.3270.50
106_I110_M1.3160.49
102_L148_A1.3120.49
65_L234_L1.3100.49
107_V117_R1.2990.48
184_G195_L1.2940.48
152_V170_D1.2890.48
11_L232_K1.2830.47
6_L218_K1.2810.47
86_W216_F1.2660.47
152_V156_G1.2650.46
84_L142_L1.2610.46
95_V103_D1.2600.46
129_E211_K1.2600.46
194_S217_G1.2560.46
152_V214_Q1.2350.45
124_D199_Q1.2270.44
89_E202_I1.2270.44
7_L218_K1.2210.44
44_E64_S1.2190.44
61_K76_Y1.2170.44
90_G206_W1.2160.44
32_V131_M1.2150.44
34_V89_E1.2130.44
120_L127_L1.2060.43
6_L14_T1.2010.43
57_M84_L1.1880.42
125_A150_D1.1850.42
88_D137_T1.1820.42
13_V203_Q1.1790.42
102_L233_A1.1700.41
23_Q155_E1.1650.41
128_K131_M1.1540.40
11_L84_L1.1500.40
41_V212_D1.1450.40
193_G215_Q1.1270.39
167_I171_S1.1230.39
6_L63_Y1.1230.39
50_I59_N1.1200.39
124_D182_K1.1190.39
65_L74_K1.1160.38
65_L85_P1.1140.38
34_V87_I1.1120.38
80_L114_S1.1090.38
60_G101_A1.1040.38
207_K223_R1.1030.38
157_Q161_N1.1020.38
7_L53_D1.0910.37
85_P91_A1.0740.36
58_Y63_Y1.0660.36
179_A225_V1.0610.36
7_L37_Q1.0560.35
158_Q202_I1.0490.35
49_V52_P1.0400.35
77_Q142_L1.0390.35
76_Y228_E1.0360.34
26_V121_T1.0320.34
9_A71_E1.0300.34
135_I149_I1.0290.34
106_I114_S1.0200.34
14_T19_H1.0190.34
6_L13_V1.0170.33
41_V230_S1.0030.33
78_A182_K1.0010.33
26_V232_K1.0010.33
49_V57_M0.9990.33
85_P234_L0.9940.32
169_Q173_N0.9910.32
27_T34_V0.9840.32
13_V63_Y0.9820.32
63_Y153_R0.9780.32
92_K175_M0.9710.31
148_A209_Q0.9650.31
20_A208_K0.9640.31
64_S74_K0.9490.30
30_D209_Q0.9490.30
55_N64_S0.9480.30
149_I231_R0.9450.30
195_L199_Q0.9380.30
164_M197_G0.9320.29
53_D67_A0.9300.29
63_Y82_S0.9240.29
65_L182_K0.9230.29
229_D236_G0.9230.29
55_N84_L0.9220.29
196_G202_I0.9180.29
192_L195_L0.9160.29
50_I155_E0.9130.29
145_H170_D0.9110.28
69_Q161_N0.8990.28
188_L209_Q0.8920.28
102_L127_L0.8890.28
159_L167_I0.8850.27
71_E78_A0.8840.27
125_A129_E0.8810.27
8_A41_V0.8790.27
61_K65_L0.8790.27
215_Q222_S0.8770.27
36_P64_S0.8750.27
158_Q208_K0.8740.27
88_D187_P0.8720.27
37_Q233_A0.8720.27
125_A229_D0.8720.27
80_L222_S0.8650.26
152_V166_G0.8590.26
53_D168_L0.8570.26
103_D123_L0.8530.26
96_E100_I0.8510.26
142_L198_L0.8450.26
70_R223_R0.8430.26
193_G211_K0.8430.26
75_D233_A0.8410.25
65_L147_K0.8400.25
96_E133_R0.8400.25
105_I166_G0.8390.25
19_H32_V0.8360.25
103_D198_L0.8290.25
77_Q135_I0.8280.25
216_F230_S0.8260.25
189_Q198_L0.8230.25
54_G84_L0.8200.25
186_N190_N0.8130.24
166_G197_G0.8120.24
119_R234_L0.8060.24
32_V56_V0.8060.24
63_Y109_E0.8020.24
173_N196_G0.7970.24
30_D83_T0.7950.24
98_A206_W0.7920.23
64_S229_D0.7890.23
65_L98_A0.7820.23
66_N101_A0.7800.23
17_T184_G0.7770.23
215_Q232_K0.7770.23
153_R160_V0.7750.23
208_K215_Q0.7700.23
125_A168_L0.7660.22
41_V147_K0.7600.22
68_A133_R0.7580.22
173_N176_G0.7560.22
73_A234_L0.7510.22
101_A169_Q0.7500.22
101_A141_G0.7500.22
27_T35_S0.7490.22
99_R194_S0.7460.22
72_Q230_S0.7430.22
53_D236_G0.7410.22
130_Q155_E0.7390.21
172_I199_Q0.7370.21
10_A14_T0.7320.21
51_T75_D0.7310.21
25_S182_K0.7270.21
74_K82_S0.7260.21
38_T139_S0.7260.21
74_K197_G0.7210.21
46_G50_I0.7150.21
16_M68_A0.7140.21
93_S214_Q0.7120.20
184_G234_L0.7120.20
39_V86_W0.7120.20
164_M172_I0.7090.20
128_K154_A0.7080.20
15_A138_R0.7050.20
65_L70_R0.7030.20
28_P149_I0.7020.20
58_Y234_L0.6990.20
90_G128_K0.6980.20
144_F224_V0.6960.20
84_L169_Q0.6950.20
18_A120_L0.6950.20
66_N95_V0.6900.20
55_N226_T0.6880.20
6_L9_A0.6850.20
163_A167_I0.6840.19
36_P81_R0.6820.19
64_S209_Q0.6800.19
164_M176_G0.6770.19
30_D136_E0.6760.19
178_K234_L0.6690.19
30_D77_Q0.6670.19
160_V233_A0.6660.19
22_Y152_V0.6640.19
35_S156_G0.6620.19
32_V61_K0.6550.18
224_V228_E0.6550.18
109_E157_Q0.6510.18
192_L214_Q0.6510.18
205_E220_V0.6500.18
8_A14_T0.6500.18
102_L160_V0.6470.18
7_L182_K0.6440.18
103_D148_A0.6410.18
9_A175_M0.6400.18
76_Y233_A0.6370.18
131_M145_H0.6370.18
131_M170_D0.6350.18
91_A183_S0.6350.18
30_D170_D0.6350.18
73_A114_S0.6330.18
83_T152_V0.6320.18
117_R152_V0.6320.18
188_L195_L0.6310.18
56_V196_G0.6290.18
164_M199_Q0.6270.18
79_E228_E0.6230.17
94_R231_R0.6220.17
31_D216_F0.6190.17
34_V167_I0.6190.17
142_L224_V0.6180.17
95_V217_G0.6160.17
27_T82_S0.6150.17
21_D232_K0.6130.17
30_D40_Q0.6120.17
16_M233_A0.6100.17
10_A207_K0.6070.17
41_V168_L0.6060.17
156_G172_I0.6010.17
149_I228_E0.6010.17
22_Y156_G0.6010.17
144_F206_W0.5950.17
164_M195_L0.5930.17
15_A64_S0.5920.16
78_A125_A0.5920.16
44_E200_S0.5880.16
97_K201_S0.5850.16
40_Q50_I0.5840.16
56_V214_Q0.5840.16
91_A100_I0.5830.16
99_R155_E0.5820.16
69_Q76_Y0.5820.16
164_M215_Q0.5820.16
66_N168_L0.5800.16
49_V91_A0.5800.16
195_L224_V0.5760.16
169_Q216_F0.5740.16
10_A79_E0.5710.16
23_Q132_N0.5700.16
28_P127_L0.5690.16
145_H224_V0.5690.16
57_M222_S0.5680.16
42_K120_L0.5660.16
66_N228_E0.5660.16
7_L233_A0.5650.16
191_V195_L0.5650.16
94_R153_R0.5600.16
76_Y80_L0.5600.16
10_A122_K0.5580.15
88_D102_L0.5530.15
146_Y209_Q0.5470.15
20_A171_S0.5450.15
71_E218_K0.5440.15
178_K209_Q0.5440.15
55_N229_D0.5410.15
16_M67_A0.5400.15
39_V148_A0.5400.15
139_S211_K0.5370.15
40_Q77_Q0.5370.15
105_I190_N0.5370.15
73_A201_S0.5360.15
57_M183_S0.5310.15
137_T140_D0.5270.15
138_R224_V0.5270.15
94_R163_A0.5240.15
157_Q214_Q0.5220.14
41_V48_L0.5210.14
86_W170_D0.5170.14
22_Y138_R0.5170.14
69_Q131_M0.5170.14
67_A218_K0.5130.14
61_K78_A0.5110.14
20_A50_I0.5110.14
66_N139_S0.5090.14
28_P216_F0.5080.14
9_A102_L0.5070.14
189_Q193_G0.5070.14
50_I229_D0.5050.14
16_M19_H0.5050.14
109_E201_S0.5030.14
9_A13_V0.5030.14
10_A13_V0.5020.14
94_R215_Q0.5020.14
61_K64_S0.5020.14
53_D80_L0.5010.14
101_A152_V0.5000.14
41_V69_Q0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zg1A 2 0.4393 84.2 0.926 Contact Map
3layA 5 0.2971 63.4 0.937 Contact Map
4q4gX 1 0 59 0.939 Contact Map
4wwfA 2 0.4519 31.8 0.948 Contact Map
4c46A 3 0.2301 30.4 0.949 Contact Map
4cgkA 3 0.6527 25.2 0.951 Contact Map
3ubcA 3 0.4937 24.4 0.951 Contact Map
3uv0A 2 0.3808 23.4 0.952 Contact Map
3tm9A 2 0.5481 22.4 0.952 Contact Map
3o39A 2 0.3975 21.9 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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