GREMLIN Database
YGGE - Uncharacterized protein YggE
UniProt: P0ADS6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11244
Length: 246 (226)
Sequences: 3219 (2615)
Seq/√Len: 174.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_D60_T3.4421.00
55_A61_A3.3241.00
37_S221_Q3.3001.00
96_D110_R2.8931.00
77_E83_K2.8321.00
53_V65_A2.8051.00
46_T146_G2.7611.00
121_Q124_K2.6891.00
34_G164_N2.5891.00
166_I170_Q2.4521.00
36_A157_A2.4371.00
85_D120_R2.3361.00
38_V157_A2.2471.00
31_V227_D2.1811.00
178_R232_L2.1071.00
38_V160_A1.9201.00
70_A74_S1.9031.00
64_Q67_E1.8871.00
40_A153_Y1.8821.00
54_A96_D1.8431.00
184_Y231_Q1.8311.00
74_S78_L1.8021.00
170_Q174_N1.7691.00
159_K174_N1.7481.00
155_D171_E1.7421.00
158_R172_L1.7411.00
43_D148_A1.7321.00
52_N139_E1.7231.00
55_A60_T1.7211.00
162_I228_V1.7201.00
162_I175_G1.7061.00
155_D167_H1.7051.00
67_E71_Q1.6571.00
160_A163_D1.6491.00
186_V228_V1.6311.00
39_D219_A1.6311.00
95_P106_L1.6301.00
45_A125_L1.6231.00
124_K127_S1.6201.00
165_A228_V1.6091.00
65_A111_A1.5981.00
182_P231_Q1.5961.00
44_I118_T1.5881.00
39_D221_Q1.5811.00
69_V115_V1.5651.00
167_H170_Q1.5501.00
130_D213_E1.5411.00
183_V228_V1.5231.00
149_Q152_A1.5211.00
54_A110_R1.5181.00
159_K163_D1.5021.00
38_V156_K1.4931.00
55_A64_Q1.4921.00
119_L128_L1.4881.00
73_I77_E1.4811.00
12_M15_S1.4681.00
156_K159_K1.4671.00
62_K66_D1.4451.00
158_R188_Y1.4221.00
9_A12_M1.4131.00
59_A63_K1.4131.00
52_N110_R1.4051.00
61_A111_A1.3971.00
44_I146_G1.3911.00
156_K160_A1.3891.00
157_A224_D1.3891.00
89_A116_E1.3841.00
29_H229_V1.3621.00
162_I176_F1.3561.00
17_M20_Q1.3491.00
97_Y108_G1.3421.00
32_T165_A1.3401.00
93_T111_A1.3301.00
75_F131_G1.3221.00
60_T64_Q1.3171.00
72_Y115_V1.3171.00
63_K67_E1.3161.00
9_A15_S1.2951.00
37_S223_D1.2941.00
73_I216_E1.2891.00
185_S229_V1.2881.00
62_K91_L1.2851.00
158_R171_E1.2811.00
196_S199_V1.2641.00
49_I132_A1.2541.00
98_D107_K1.2481.00
120_R148_A1.2371.00
168_Q188_Y1.2351.00
53_V64_Q1.2331.00
30_I232_L1.2311.00
58_A93_T1.2101.00
64_Q68_R1.1911.00
170_Q180_L1.1871.00
147_V222_F1.1871.00
71_Q74_S1.1531.00
98_D105_I1.1501.00
181_G232_L1.1481.00
29_H184_Y1.1431.00
159_K175_G1.1381.00
44_I148_A1.1321.00
97_Y104_S1.1321.00
122_L125_L1.1311.00
189_H225_Q1.1221.00
151_D164_N1.1211.00
69_V113_R1.1141.00
82_A85_D1.1121.00
48_A141_R1.0931.00
30_I178_R1.0921.00
172_L188_Y1.0901.00
40_A157_A1.0841.00
75_F79_N1.0821.00
113_R214_T1.0681.00
66_D213_E1.0551.00
166_I230_F1.0541.00
45_A119_L1.0460.99
183_V186_V1.0370.99
54_A107_K1.0350.99
163_D166_I1.0320.99
41_V219_A1.0210.99
146_G150_P1.0190.99
40_A147_V1.0160.99
127_S131_G1.0140.99
91_L111_A1.0130.99
14_I17_M1.0100.99
11_L15_S1.0100.99
15_S18_A1.0040.99
66_D70_A0.9990.99
10_A14_I0.9980.99
97_Y106_L0.9980.99
79_N131_G0.9920.99
53_V68_R0.9920.99
202_M206_A0.9880.99
73_I86_I0.9850.99
87_S218_A0.9850.99
176_F186_V0.9840.99
164_N167_H0.9800.99
95_P108_G0.9700.99
180_L230_F0.9690.99
171_E175_G0.9610.99
7_A10_A0.9590.99
50_E137_L0.9560.99
30_I181_G0.9530.99
28_P178_R0.9450.99
99_Y104_S0.9380.99
58_A111_A0.9350.99
42_P220_I0.9290.99
96_D107_K0.9150.99
166_I177_H0.9150.99
79_N128_L0.9110.99
157_A222_F0.9100.99
10_A13_G0.9020.99
206_A209_V0.9010.98
147_V153_Y0.8980.98
88_S113_R0.8900.98
44_I120_R0.8900.98
11_L14_I0.8900.98
94_Q110_R0.8900.98
60_T63_K0.8810.98
87_S116_E0.8640.98
50_E114_T0.8470.98
130_D134_K0.8320.97
14_I18_A0.8240.97
76_L117_V0.8240.97
162_I172_L0.8200.97
48_A144_S0.8190.97
9_A18_A0.8190.97
200_R203_K0.8190.97
19_A23_E0.8140.97
34_G165_A0.8080.97
158_R162_I0.8070.97
74_S77_E0.8060.97
65_A113_R0.8050.97
91_L113_R0.8000.97
9_A14_I0.7980.97
76_L128_L0.7950.97
99_Y102_G0.7940.97
12_M16_G0.7840.96
31_V229_V0.7830.96
59_A134_K0.7820.96
154_K158_R0.7820.96
172_L186_V0.7810.96
119_L125_L0.7790.96
202_M205_D0.7790.96
189_H227_D0.7780.96
188_Y224_D0.7750.96
195_P198_M0.7720.96
46_T144_S0.7700.96
7_A18_A0.7680.96
203_K206_A0.7670.96
98_D106_L0.7620.96
19_A24_L0.7550.96
77_E86_I0.7530.95
159_K171_E0.7500.95
201_M204_A0.7420.95
85_D118_T0.7420.95
160_A164_N0.7410.95
140_I143_V0.7390.95
198_M201_M0.7360.95
99_Y103_K0.7330.95
35_T223_D0.7220.94
84_K219_A0.7200.94
81_I117_V0.7170.94
106_L109_Y0.7150.94
131_G135_A0.7030.93
205_D208_P0.7020.93
196_S200_R0.7000.93
47_L119_L0.6990.93
92_R112_V0.6930.93
46_T116_E0.6910.93
18_A21_A0.6890.93
48_A142_S0.6880.93
32_T172_L0.6870.93
46_T118_T0.6840.93
48_A116_E0.6810.92
10_A18_A0.6810.92
36_A160_A0.6770.92
29_H185_S0.6770.92
50_E112_V0.6750.92
52_N112_V0.6730.92
173_A180_L0.6720.92
208_P211_A0.6710.92
28_P182_P0.6690.92
53_V61_A0.6660.92
35_T225_Q0.6630.91
81_I86_I0.6620.91
178_R183_V0.6610.91
32_T180_L0.6600.91
147_V220_I0.6600.91
8_L13_G0.6590.91
164_N168_Q0.6580.91
38_V153_Y0.6570.91
96_D108_G0.6570.91
181_G231_Q0.6540.91
105_I108_G0.6490.90
49_I117_V0.6470.90
48_A114_T0.6460.90
75_F78_L0.6430.90
86_I115_V0.6360.90
114_T141_R0.6360.90
199_V202_M0.6350.90
194_Q197_P0.6330.89
193_Y197_P0.6330.89
7_A16_G0.6320.89
203_K207_A0.6310.89
81_I128_L0.6310.89
21_A25_P0.6310.89
125_L215_Y0.6290.89
62_K126_N0.6270.89
20_Q24_L0.6210.88
132_A137_L0.6200.88
113_R215_Y0.6190.88
49_I137_L0.6180.88
184_Y229_V0.6180.88
132_A135_A0.6170.88
153_Y222_F0.6150.88
33_S225_Q0.6140.88
75_F135_A0.6130.88
50_E138_N0.6130.88
163_D175_G0.6080.87
72_Y137_L0.6080.87
73_I115_V0.6080.87
16_G21_A0.6060.87
178_R181_G0.6060.87
33_S227_D0.6020.87
9_A13_G0.6010.87
81_I85_D0.5960.86
186_V232_L0.5950.86
173_A232_L0.5950.86
8_L18_A0.5930.86
50_E141_R0.5930.86
83_K216_E0.5920.86
150_P154_K0.5910.86
13_G18_A0.5900.86
19_A22_N0.5900.86
91_L215_Y0.5860.85
162_I226_V0.5850.85
8_L11_L0.5830.85
188_Y226_V0.5810.85
153_Y157_A0.5780.85
27_G231_Q0.5780.85
200_R204_A0.5770.85
57_D61_A0.5760.84
16_G19_A0.5760.84
94_Q112_V0.5720.84
179_K182_P0.5720.84
8_L17_M0.5680.84
66_D91_L0.5680.84
151_D154_K0.5660.83
204_A207_A0.5660.83
158_R224_D0.5660.83
99_Y106_L0.5630.83
113_R213_E0.5620.83
8_L14_I0.5620.83
10_A17_M0.5600.83
8_L16_G0.5600.83
54_A106_L0.5590.83
73_I83_K0.5570.82
75_F128_L0.5560.82
205_D210_S0.5560.82
195_P199_V0.5560.82
95_P107_K0.5540.82
31_V185_S0.5530.82
66_D113_R0.5500.82
133_L140_I0.5460.81
32_T164_N0.5450.81
71_Q135_A0.5430.81
152_A156_K0.5420.81
204_A209_V0.5390.80
145_L218_A0.5380.80
14_I21_A0.5350.80
33_S189_H0.5340.80
61_A65_A0.5320.80
54_A108_G0.5310.79
66_D126_N0.5310.79
113_R126_N0.5310.79
126_N213_E0.5310.79
168_Q186_V0.5300.79
122_L145_L0.5300.79
7_A15_S0.5290.79
62_K113_R0.5260.79
13_G17_M0.5250.79
207_A210_S0.5240.79
201_M205_D0.5230.78
48_A89_A0.5200.78
119_L132_A0.5180.78
11_L18_A0.5140.77
11_L17_M0.5120.77
12_M18_A0.5090.77
86_I117_V0.5090.77
198_M203_K0.5090.77
69_V88_S0.5090.77
62_K213_E0.5070.76
88_S215_Y0.5060.76
224_D228_V0.5060.76
20_Q23_E0.5050.76
67_E179_K0.5030.76
62_K93_T0.5020.76
154_K188_Y0.5010.75
51_V68_R0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hvzA 5 0.8415 100 0.254 Contact Map
4n4rB 1 0.5691 77.5 0.917 Contact Map
2jnaA 2 0.3618 25.3 0.941 Contact Map
1y0gA 2 0.5163 23.5 0.942 Contact Map
3zbiC 1 0.1138 13.9 0.948 Contact Map
2pptA 2 0.5041 10.7 0.95 Contact Map
3u7vA 3 0.7927 9.3 0.952 Contact Map
2nocA 1 0.3984 9.1 0.952 Contact Map
4fybB 1 0.5 8.7 0.953 Contact Map
2aizP 1 0.4024 8.2 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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