GREMLIN Database
ZAPA - Cell division protein ZapA
UniProt: P0ADS2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12878
Length: 109 (95)
Sequences: 532 (386)
Seq/√Len: 39.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_D61_I3.7341.00
15_L55_F3.5571.00
33_D37_R3.1521.00
38_L54_V3.0171.00
4_Q24_R2.8071.00
35_N39_Q2.5901.00
49_N56_I2.4991.00
37_R40_D2.3541.00
38_L53_L2.1550.99
9_Q12_G2.1210.99
32_D35_N1.9770.99
34_L62_S1.9430.99
45_T53_L1.9040.98
38_L52_Q1.8500.98
41_L53_L1.7200.97
41_L57_A1.6080.95
5_P31_A1.5520.94
11_F39_Q1.5160.94
13_R55_F1.5120.94
51_E88_Q1.4660.93
21_P30_A1.4640.92
31_A86_L1.4410.92
34_L37_R1.4100.91
57_A61_I1.4000.91
30_A91_E1.3740.90
25_D32_D1.3460.89
74_D86_L1.2990.87
12_G50_T1.2880.87
20_P59_L1.2710.86
18_N56_I1.2450.85
12_G39_Q1.2390.84
60_N63_Y1.2260.84
50_T62_S1.1980.82
78_S90_I1.1950.82
23_Q26_A1.1760.81
20_P60_N1.1620.80
13_R17_V1.1560.80
20_P26_A1.1050.77
32_D69_K1.0950.76
13_R49_N1.0670.74
38_L41_L1.0590.74
8_I72_T1.0540.73
5_P51_E0.9940.69
78_S84_R0.9870.68
86_L97_Q0.9860.68
20_P94_L0.9850.68
15_L56_I0.9310.64
71_K95_L0.9250.63
26_A87_Q0.9250.63
13_R16_R0.8930.60
17_V63_Y0.8870.60
30_A44_R0.8850.60
79_M83_I0.8830.60
29_Q69_K0.8780.59
32_D53_L0.8740.59
13_R47_V0.8680.58
6_V31_A0.8660.58
12_G16_R0.8630.58
44_R53_L0.8590.57
87_Q90_I0.8560.57
15_L54_V0.8550.57
36_Q69_K0.8480.56
7_D87_Q0.8380.56
37_R63_Y0.8380.56
33_D57_A0.8320.55
52_Q62_S0.8310.55
12_G84_R0.8280.55
41_L45_T0.8080.53
86_L90_I0.7870.51
67_Q79_M0.7860.51
7_D14_S0.7840.51
21_P70_A0.7830.51
65_L68_E0.7830.51
45_T49_N0.7680.49
28_N31_A0.7680.49
5_P46_R0.7640.49
32_D47_V0.7500.48
41_L54_V0.7450.47
17_V59_L0.7410.47
42_K61_I0.7390.47
73_R80_E0.7380.46
75_Y93_A0.7330.46
22_D26_A0.7300.46
29_Q71_K0.7290.46
17_V48_T0.7240.45
71_K96_E0.7230.45
52_Q55_F0.7180.45
40_D84_R0.7150.44
8_I97_Q0.7100.44
82_R85_M0.7050.43
56_I66_A0.7010.43
81_Q84_R0.7000.43
54_V62_S0.6940.43
7_D68_E0.6860.42
87_Q91_E0.6840.42
51_E68_E0.6790.41
42_K45_T0.6740.41
36_Q61_I0.6660.40
30_A90_I0.6600.40
53_L84_R0.6510.39
33_D40_D0.6500.39
14_S55_F0.6470.38
61_I73_R0.6420.38
82_R87_Q0.6350.37
13_R63_Y0.6350.37
73_R91_E0.6270.37
68_E71_K0.6100.35
95_L98_G0.5970.34
10_I82_R0.5930.34
51_E57_A0.5890.34
14_S38_L0.5890.34
14_S89_T0.5880.33
70_A83_I0.5860.33
34_L40_D0.5790.33
15_L49_N0.5790.33
10_I41_L0.5710.32
10_I46_R0.5650.32
63_Y67_Q0.5610.31
19_C90_I0.5590.31
47_V79_M0.5540.31
5_P55_F0.5480.30
33_D66_A0.5440.30
15_L89_T0.5420.30
13_R82_R0.5420.30
26_A37_R0.5400.30
81_Q85_M0.5370.29
33_D65_L0.5360.29
81_Q95_L0.5320.29
17_V31_A0.5320.29
25_D28_N0.5250.29
40_D78_S0.5210.28
10_I42_K0.5180.28
57_A95_L0.5160.28
21_P25_D0.5160.28
49_N52_Q0.5120.28
24_R48_T0.5090.27
67_Q87_Q0.5080.27
7_D81_Q0.5080.27
13_R89_T0.5050.27
85_M88_Q0.5030.27
31_A81_Q0.5030.27
34_L48_T0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p1mA 4 0.9908 99.9 0.365 Contact Map
1t3uA 4 0.8624 99.9 0.417 Contact Map
3hnwA 2 0.9541 99.8 0.478 Contact Map
2mmvA 2 0.7339 99.8 0.512 Contact Map
1m1jB 2 0.8624 12.5 0.932 Contact Map
3h4pa 5 0.2936 10.7 0.934 Contact Map
3ppmA 2 0.3394 9.9 0.935 Contact Map
4ldrA 2 0.9266 8.8 0.936 Contact Map
1pl5A 2 0.6606 8.7 0.936 Contact Map
3mq0A 2 0.8716 8.4 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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