GREMLIN Database
YGDH - LOG family protein YgdH
UniProt: P0ADR8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12373
Length: 454 (445)
Sequences: 341 (168)
Seq/√Len: 8.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
304_V312_R6.4721.00
415_K451_E6.1291.00
251_G329_M5.4301.00
370_M394_G5.2791.00
290_K293_A4.4790.99
303_V311_A4.1530.98
254_I265_L4.1100.98
52_K409_E4.0550.98
214_M235_M3.9940.97
272_L284_L3.8920.97
168_R191_E3.7140.96
426_M452_I3.5080.94
309_E312_R3.4720.94
316_R328_Q3.3760.93
150_M212_I3.3220.92
254_I286_L3.1410.90
265_L286_L3.0300.88
304_V309_E2.6690.80
337_K341_R2.6220.79
376_Y379_Q2.5410.77
174_L253_I2.5030.75
64_N75_E2.4940.75
212_I248_I2.4670.74
294_D297_R2.4460.74
38_S63_I2.4180.73
189_A192_A2.3900.72
192_A203_Q2.3740.71
167_A192_A2.3470.70
92_A172_N2.3430.70
141_A233_I2.3430.70
300_D315_Y2.3130.69
273_M314_H2.3000.69
200_G347_Y2.2970.69
5_I94_Q2.2870.68
423_M427_D2.2680.68
214_M358_D2.2270.66
105_L180_N2.1920.65
235_M437_H2.1790.64
268_L284_L2.1680.64
192_A228_L2.1640.64
41_V100_V2.1430.63
416_I422_I2.0520.60
276_A354_R1.9770.57
224_P286_L1.9090.54
17_L130_N1.8850.53
182_C222_A1.8810.53
13_M54_L1.8370.51
172_N191_E1.8270.50
182_C187_P1.7860.49
270_G386_A1.7680.48
92_A189_A1.7560.48
36_N69_E1.7300.46
92_A192_A1.7220.46
79_P224_P1.7180.46
270_G359_L1.7060.45
12_D89_I1.6890.45
106_F281_V1.6830.45
224_P265_L1.6800.44
178_E206_Y1.6790.44
43_N379_Q1.6610.44
127_H131_L1.6560.43
54_L371_A1.6460.43
34_F38_S1.6430.43
95_A203_Q1.6410.43
168_R172_N1.6330.43
8_L215_T1.6070.42
364_E403_V1.5830.41
92_A203_Q1.5690.40
57_R415_K1.5670.40
79_P265_L1.5620.40
120_L131_L1.5610.40
167_A199_V1.5520.39
211_F451_E1.5520.39
324_E328_Q1.5340.39
125_S128_I1.5220.38
51_S224_P1.5050.38
104_I135_I1.5040.37
120_L382_E1.5030.37
50_N88_R1.4830.37
101_L317_I1.4820.37
437_H442_P1.4730.36
106_F282_L1.4700.36
98_F132_V1.4690.36
200_G426_M1.4680.36
174_L416_I1.4650.36
394_G416_I1.4610.36
31_Y69_E1.4550.36
41_V414_Y1.4520.36
151_V368_E1.4450.35
294_D405_I1.4280.35
387_D390_R1.4250.35
212_I215_T1.4210.34
262_A400_V1.4160.34
275_P382_E1.4120.34
11_M432_G1.3990.34
167_A203_Q1.3940.33
358_D383_V1.3910.33
215_T320_D1.3810.33
120_L127_H1.3760.33
380_P420_K1.3750.33
26_A29_D1.3750.33
74_L101_L1.3740.33
347_Y405_I1.3710.33
107_V135_I1.3600.32
160_N165_L1.3540.32
72_V121_N1.3500.32
101_L315_Y1.3500.32
318_I328_Q1.3400.31
121_N127_H1.3240.31
282_L332_S1.3240.31
50_N214_M1.3200.31
5_I105_L1.3000.30
16_Q23_K1.2960.30
24_R29_D1.2870.30
141_A416_I1.2860.30
324_E327_R1.2810.29
100_V414_Y1.2810.29
310_N381_V1.2770.29
187_P222_A1.2630.29
124_N127_H1.2580.29
224_P254_I1.2570.29
203_Q228_L1.2540.28
69_E200_G1.2520.28
8_L12_D1.2470.28
96_N414_Y1.2420.28
391_A452_I1.2420.28
370_M416_I1.2390.28
50_N161_E1.2360.28
50_N235_M1.2270.28
92_A95_A1.2260.28
379_Q416_I1.2250.28
134_S191_E1.2230.27
34_F105_L1.2200.27
165_L168_R1.2180.27
92_A211_F1.2090.27
431_Q435_A1.2030.27
33_L215_T1.1990.27
45_G187_P1.1980.27
218_S224_P1.1980.27
168_R348_S1.1910.26
313_R372_N1.1780.26
167_A359_L1.1740.26
227_P402_E1.1720.26
98_F199_V1.1700.26
151_V329_M1.1670.26
391_A426_M1.1670.26
359_L443_G1.1610.25
26_A348_S1.1580.25
192_A211_F1.1570.25
43_N369_N1.1520.25
210_R397_A1.1490.25
19_V23_K1.1460.25
281_V332_S1.1410.25
44_S299_L1.1370.25
95_A172_N1.1340.25
199_V228_L1.1340.25
316_R324_E1.1340.25
64_N376_Y1.1330.25
151_V249_A1.1310.25
69_E347_Y1.1300.25
271_I346_A1.1260.24
55_L134_S1.1200.24
131_L134_S1.1180.24
162_N291_E1.1170.24
107_V227_P1.1150.24
95_A192_A1.1120.24
218_S382_E1.1110.24
359_L422_I1.1090.24
63_I150_M1.1090.24
9_G205_R1.1080.24
141_A285_I1.1070.24
107_V409_E1.0970.24
285_I328_Q1.0950.23
191_E348_S1.0950.23
310_N421_E1.0890.23
74_L275_P1.0890.23
172_N203_Q1.0820.23
101_L165_L1.0800.23
67_R387_D1.0790.23
48_T51_S1.0700.23
189_A203_Q1.0690.23
65_V366_S1.0640.23
52_K56_S1.0630.23
38_S59_E1.0590.22
168_R203_Q1.0560.22
306_T311_A1.0550.22
110_Q134_S1.0540.22
141_A231_E1.0530.22
36_N68_R1.0510.22
58_F320_D1.0510.22
99_A113_N1.0500.22
105_L452_I1.0430.22
30_L235_M1.0430.22
64_N200_G1.0320.22
209_S253_I1.0300.22
10_S94_Q1.0300.22
358_D390_R1.0250.21
180_N344_G1.0220.21
31_Y161_E1.0200.21
161_E165_L1.0200.21
39_L433_F1.0190.21
4_H199_V1.0190.21
377_P419_D1.0140.21
253_I294_D1.0110.21
92_A96_N1.0080.21
53_E405_I1.0070.21
210_R231_E1.0070.21
122_L127_H1.0050.21
69_E73_K1.0010.21
191_E211_F0.9990.21
165_L191_E0.9990.21
227_P270_G0.9980.21
407_A410_E0.9960.21
121_N361_M0.9940.21
54_L130_N0.9930.21
368_E421_E0.9930.21
36_N268_L0.9900.21
191_E218_S0.9890.21
167_A228_L0.9880.20
305_H425_R0.9840.20
5_I72_V0.9810.20
275_P333_M0.9760.20
92_A228_L0.9750.20
222_A400_V0.9710.20
290_K320_D0.9690.20
416_I452_I0.9670.20
111_I131_L0.9650.20
45_G414_Y0.9600.20
179_L271_I0.9570.20
319_I420_K0.9560.20
67_R339_N0.9520.20
76_L395_I0.9520.20
161_E265_L0.9500.19
249_A273_M0.9460.19
281_V339_N0.9460.19
161_E224_P0.9460.19
270_G321_D0.9430.19
44_S414_Y0.9390.19
41_V45_G0.9350.19
72_V113_N0.9350.19
380_P383_V0.9350.19
20_D24_R0.9290.19
106_F161_E0.9280.19
338_E402_E0.9260.19
24_R142_L0.9250.19
110_Q249_A0.9250.19
51_S54_L0.9240.19
55_L130_N0.9230.19
138_N392_F0.9210.19
301_E451_E0.9190.19
314_H410_E0.9140.19
341_R347_Y0.9120.19
81_E161_E0.9100.18
145_G349_F0.9100.18
167_A270_G0.9070.18
68_R344_G0.9060.18
46_S54_L0.9060.18
189_A259_V0.9060.18
404_G411_F0.9040.18
54_L426_M0.9020.18
94_Q191_E0.9000.18
72_V178_E0.8980.18
5_I286_L0.8970.18
54_L299_L0.8970.18
55_L249_A0.8970.18
123_D358_D0.8950.18
346_A356_A0.8900.18
403_V414_Y0.8890.18
215_T419_D0.8870.18
427_D449_C0.8860.18
32_Q36_N0.8850.18
69_E224_P0.8850.18
206_Y369_N0.8830.18
19_V187_P0.8820.18
294_D435_A0.8810.18
34_F352_S0.8800.18
26_A191_E0.8800.18
52_K55_L0.8760.18
73_K182_C0.8760.18
55_L110_Q0.8750.18
106_F192_A0.8740.18
168_R198_A0.8740.18
19_V62_D0.8680.17
298_V357_P0.8650.17
318_I390_R0.8650.17
214_M233_I0.8630.17
189_A265_L0.8610.17
208_D285_I0.8590.17
105_L333_M0.8580.17
13_M224_P0.8580.17
390_R445_A0.8570.17
206_Y285_I0.8550.17
101_L300_D0.8540.17
298_V432_G0.8480.17
316_R377_P0.8470.17
20_D67_R0.8450.17
96_N211_F0.8390.17
46_S50_N0.8390.17
329_M407_A0.8340.17
111_I452_I0.8330.17
9_G182_C0.8260.16
407_A411_F0.8210.16
143_H146_E0.8190.16
168_R211_F0.8190.16
138_N141_A0.8190.16
345_D443_G0.8190.16
227_P390_R0.8150.16
50_N150_M0.8150.16
54_L322_A0.8140.16
303_V306_T0.8140.16
375_L416_I0.8130.16
310_N375_L0.8130.16
215_T418_G0.8120.16
122_L131_L0.8120.16
138_N275_P0.8100.16
8_L11_M0.8100.16
215_T310_N0.8090.16
259_V451_E0.8080.16
97_L181_I0.8060.16
36_N337_K0.8060.16
68_R233_I0.8040.16
24_R425_R0.8020.16
414_Y425_R0.7930.16
84_F365_P0.7920.16
431_Q447_I0.7920.16
365_P397_A0.7910.16
81_E191_E0.7910.16
16_Q215_T0.7870.16
214_M259_V0.7860.16
198_A386_A0.7860.16
312_R316_R0.7860.16
191_E203_Q0.7850.16
211_F337_K0.7830.16
334_P338_E0.7830.16
30_L397_A0.7810.15
235_M452_I0.7810.15
278_K310_N0.7810.15
338_E342_D0.7810.15
36_N54_L0.7810.15
13_M299_L0.7800.15
89_I127_H0.7800.15
16_Q51_S0.7790.15
34_F339_N0.7780.15
379_Q414_Y0.7760.15
11_M382_E0.7750.15
279_D324_E0.7700.15
158_S320_D0.7700.15
54_L347_Y0.7690.15
104_I275_P0.7690.15
93_L135_I0.7680.15
347_Y424_R0.7680.15
135_I403_V0.7680.15
314_H317_I0.7680.15
6_S442_P0.7680.15
55_L107_V0.7670.15
281_V314_H0.7670.15
43_N48_T0.7670.15
138_N290_K0.7660.15
318_I324_E0.7660.15
161_E316_R0.7640.15
12_D65_V0.7630.15
114_T341_R0.7620.15
105_L231_E0.7600.15
174_L254_I0.7580.15
280_Q334_P0.7570.15
68_R73_K0.7550.15
150_M248_I0.7540.15
38_S265_L0.7540.15
312_R315_Y0.7540.15
82_E410_E0.7530.15
13_M348_S0.7480.15
205_R408_I0.7480.15
249_A254_I0.7470.15
95_A228_L0.7450.15
77_I337_K0.7440.15
377_P422_I0.7420.15
29_D332_S0.7410.15
287_T326_A0.7410.15
46_S143_H0.7400.15
67_R79_P0.7390.15
34_F347_Y0.7370.15
10_S231_E0.7360.15
104_I107_V0.7350.15
252_I259_V0.7310.14
5_I144_V0.7310.14
345_D441_L0.7300.14
95_A211_F0.7260.14
202_A228_L0.7260.14
67_R320_D0.7260.14
319_I322_A0.7250.14
253_I299_L0.7250.14
292_S379_Q0.7240.14
73_K104_I0.7230.14
337_K376_Y0.7230.14
198_A332_S0.7220.14
65_V199_V0.7210.14
134_S382_E0.7200.14
151_V251_G0.7180.14
146_E349_F0.7140.14
182_C205_R0.7130.14
369_N421_E0.7100.14
372_N413_P0.7100.14
403_V452_I0.7100.14
23_K105_L0.7100.14
215_T253_I0.7070.14
142_L421_E0.7070.14
54_L200_G0.7070.14
349_F355_I0.7070.14
28_S249_A0.7060.14
437_H444_S0.7020.14
78_N416_I0.7020.14
253_I271_I0.7020.14
161_E322_A0.7010.14
64_N69_E0.7000.14
74_L375_L0.6980.14
167_A189_A0.6980.14
11_M411_F0.6970.14
369_N372_N0.6970.14
70_R404_G0.6960.14
320_D442_P0.6960.14
427_D450_Y0.6950.14
96_N379_Q0.6950.14
65_V413_P0.6950.14
208_D416_I0.6930.14
125_S151_V0.6910.14
44_S359_L0.6910.14
44_S178_E0.6900.14
441_L444_S0.6900.14
92_A167_A0.6900.14
262_A270_G0.6900.14
95_A272_L0.6900.14
198_A202_A0.6890.14
17_L51_S0.6880.14
400_V405_I0.6860.14
83_A311_A0.6850.14
93_L199_V0.6850.14
254_I371_A0.6840.14
320_D380_P0.6830.14
326_A416_I0.6830.14
211_F415_K0.6820.13
88_R410_E0.6810.13
59_E150_M0.6810.13
198_A211_F0.6790.13
5_I200_G0.6780.13
178_E191_E0.6750.13
64_N421_E0.6730.13
94_Q337_K0.6730.13
60_N268_L0.6720.13
27_S91_R0.6710.13
23_K31_Y0.6700.13
259_V344_G0.6700.13
293_A344_G0.6680.13
74_L134_S0.6670.13
182_C262_A0.6600.13
74_L94_Q0.6600.13
130_N146_E0.6600.13
214_M222_A0.6590.13
5_I162_N0.6590.13
8_L89_I0.6590.13
23_K131_L0.6570.13
36_N73_K0.6570.13
98_F375_L0.6560.13
120_L275_P0.6560.13
10_S341_R0.6550.13
314_H332_S0.6550.13
50_N99_A0.6550.13
48_T106_F0.6520.13
307_L311_A0.6520.13
330_K333_M0.6510.13
279_D405_I0.6510.13
290_K407_A0.6470.13
53_E327_R0.6470.13
121_N124_N0.6460.13
46_S89_I0.6460.13
121_N131_L0.6460.13
89_I253_I0.6440.13
88_R323_A0.6440.13
21_M282_L0.6430.13
406_R416_I0.6430.13
346_A382_E0.6420.13
293_A297_R0.6420.13
26_A32_Q0.6410.13
88_R426_M0.6390.13
67_R218_S0.6380.13
23_K344_G0.6370.13
26_A198_A0.6370.13
333_M432_G0.6360.13
34_F69_E0.6360.13
109_G130_N0.6360.13
386_A390_R0.6360.13
99_A165_L0.6340.13
228_L299_L0.6330.13
235_M366_S0.6320.13
29_D110_Q0.6320.13
126_V431_Q0.6310.13
10_S101_L0.6310.13
211_F452_I0.6300.13
68_R303_V0.6300.13
168_R218_S0.6290.13
29_D200_G0.6280.12
94_Q101_L0.6260.12
324_E424_R0.6260.12
75_E418_G0.6250.12
24_R299_L0.6230.12
19_V407_A0.6230.12
172_N192_A0.6220.12
95_A106_F0.6210.12
167_A404_G0.6210.12
34_F64_N0.6190.12
20_D99_A0.6190.12
29_D298_V0.6180.12
38_S382_E0.6170.12
107_V235_M0.6150.12
291_E405_I0.6130.12
69_E392_F0.6120.12
104_I233_I0.6120.12
192_A359_L0.6100.12
300_D312_R0.6090.12
211_F262_A0.6080.12
169_R342_D0.6060.12
21_M452_I0.6050.12
169_R173_Q0.6040.12
13_M282_L0.6030.12
111_I120_L0.6030.12
368_E372_N0.6020.12
149_N212_I0.6020.12
211_F341_R0.6020.12
145_G447_I0.6010.12
270_G300_D0.6010.12
73_K189_A0.6000.12
182_C408_I0.5990.12
403_V407_A0.5980.12
135_I314_H0.5980.12
12_D105_L0.5960.12
50_N371_A0.5960.12
180_N349_F0.5960.12
215_T280_Q0.5950.12
56_S122_L0.5950.12
300_D317_I0.5940.12
246_V254_I0.5900.12
58_F445_A0.5890.12
130_N134_S0.5860.12
345_D356_A0.5840.12
72_V276_A0.5840.12
327_R337_K0.5830.12
123_D361_M0.5810.12
199_V414_Y0.5800.12
43_N227_P0.5750.12
150_M222_A0.5750.12
76_L89_I0.5750.12
309_E324_E0.5740.12
113_N301_E0.5730.12
235_M301_E0.5730.12
128_I422_I0.5710.12
328_Q424_R0.5700.11
356_A369_N0.5700.11
290_K330_K0.5690.11
72_V93_L0.5680.11
199_V230_N0.5660.11
199_V418_G0.5640.11
106_F228_L0.5630.11
303_V337_K0.5600.11
34_F98_F0.5580.11
5_I376_Y0.5580.11
92_A191_E0.5570.11
79_P281_V0.5570.11
249_A271_I0.5570.11
11_M298_V0.5560.11
328_Q420_K0.5550.11
150_M377_P0.5530.11
212_I419_D0.5520.11
227_P281_V0.5520.11
13_M46_S0.5520.11
4_H26_A0.5510.11
98_F418_G0.5500.11
19_V91_R0.5500.11
39_L182_C0.5500.11
206_Y402_E0.5490.11
169_R420_K0.5490.11
98_F160_N0.5490.11
90_I151_V0.5480.11
212_I259_V0.5480.11
357_P361_M0.5480.11
161_E254_I0.5470.11
51_S292_S0.5470.11
191_E224_P0.5460.11
17_L38_S0.5450.11
5_I416_I0.5450.11
34_F43_N0.5440.11
166_Y355_I0.5440.11
111_I165_L0.5430.11
195_K203_Q0.5420.11
105_L235_M0.5420.11
11_M272_L0.5420.11
79_P124_N0.5400.11
134_S224_P0.5400.11
105_L303_V0.5400.11
32_Q121_N0.5390.11
24_R134_S0.5380.11
347_Y419_D0.5380.11
211_F400_V0.5380.11
108_Y253_I0.5380.11
94_Q347_Y0.5370.11
13_M273_M0.5370.11
13_M44_S0.5360.11
320_D354_R0.5360.11
9_G441_L0.5360.11
41_V96_N0.5360.11
9_G345_D0.5350.11
25_T310_N0.5350.11
253_I331_K0.5340.11
72_V305_H0.5340.11
202_A315_Y0.5330.11
292_S409_E0.5330.11
178_E198_A0.5330.11
195_K205_R0.5320.11
17_L224_P0.5320.11
278_K343_T0.5320.11
324_E342_D0.5320.11
5_I417_N0.5300.11
47_L64_N0.5300.11
93_L167_A0.5290.11
293_A324_E0.5290.11
262_A443_G0.5280.11
48_T379_Q0.5270.11
291_E432_G0.5260.11
104_I414_Y0.5260.11
54_L211_F0.5260.11
34_F218_S0.5240.11
65_V94_Q0.5240.11
323_A327_R0.5240.11
64_N333_M0.5230.11
21_M64_N0.5230.11
87_G222_A0.5220.11
79_P218_S0.5200.11
8_L432_G0.5200.11
13_M29_D0.5200.11
356_A361_M0.5190.11
145_G379_Q0.5190.11
172_N272_L0.5180.11
166_Y287_T0.5170.11
23_K200_G0.5170.11
81_E290_K0.5150.11
307_L365_P0.5150.11
127_H218_S0.5150.11
13_M218_S0.5150.11
349_F447_I0.5140.11
69_E218_S0.5140.11
68_R280_Q0.5140.11
11_M425_R0.5110.11
88_R431_Q0.5110.11
31_Y343_T0.5110.11
285_I325_V0.5090.11
259_V268_L0.5090.11
337_K347_Y0.5060.10
50_N53_E0.5060.10
228_L414_Y0.5050.10
10_S16_Q0.5050.10
91_R346_A0.5050.10
74_L107_V0.5030.10
13_M382_E0.5030.10
9_G442_P0.5020.10
338_E421_E0.5020.10
161_E168_R0.5010.10
44_S54_L0.5010.10
25_T441_L0.5010.10
44_S100_V0.5000.10
122_L409_E0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bq9A 3 0.9824 100 0.369 Contact Map
3gh1A 3 0.9802 100 0.38 Contact Map
1ydhA 2 0.3877 99.9 0.9 Contact Map
5ajtA 2 0.4141 99.9 0.909 Contact Map
2a33A 2 0.3767 99.8 0.915 Contact Map
1wekA 5 0.4581 99.8 0.922 Contact Map
1t35A 5 0.3899 99.7 0.926 Contact Map
3sbxA 2 0.3767 99.7 0.928 Contact Map
1wehA 1 0.37 99.6 0.933 Contact Map
3quaA 2 0.3811 99.4 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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