GREMLIN Database
RLMM - Ribosomal RNA large subunit methyltransferase M
UniProt: P0ADR6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11794
Length: 366 (347)
Sequences: 451 (273)
Seq/√Len: 14.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
338_A348_V7.0001.00
246_Q250_D5.0121.00
300_E351_H4.9181.00
119_F123_F4.5221.00
208_R300_E4.5121.00
6_L20_I4.0101.00
171_F340_Q3.5280.99
107_V113_S3.5100.99
201_P205_W3.3910.99
208_R351_H3.1710.98
101_G146_P3.1530.98
216_V271_I2.9720.98
237_Y257_L2.9410.97
93_L96_V2.8210.97
243_P258_R2.7950.96
226_T230_V2.7070.96
335_Q353_R2.6990.96
31_G44_Y2.6540.95
104_R147_V2.6240.95
315_E318_H2.5190.94
125_V128_R2.4840.93
239_V264_F2.4310.92
200_I205_W2.4130.92
265_R297_W2.2420.89
202_A205_W2.2290.88
211_N233_N2.1960.88
107_V173_M2.1950.88
171_F176_P2.1910.87
323_I352_V2.1450.86
111_N114_K2.1010.85
197_H205_W2.1000.85
14_K37_E2.0960.85
32_F45_E2.0790.84
163_S168_N2.0710.84
16_C21_T2.0630.84
152_F158_C2.0600.84
123_F152_F2.0570.84
196_F278_M2.0470.84
10_P40_G2.0110.82
53_D164_Y1.9300.80
205_W210_A1.9250.79
280_E288_L1.8860.78
65_I313_Y1.8430.76
261_G278_M1.8140.75
338_A350_V1.7890.74
199_F300_E1.7730.73
147_V168_N1.7670.73
16_C67_A1.7210.71
12_F346_E1.7030.70
71_F161_G1.7000.70
244_M249_M1.6670.69
119_F155_P1.6640.68
124_T128_R1.6200.66
262_F285_V1.6190.66
86_I123_F1.6100.66
104_R169_S1.6020.65
320_L338_A1.5640.63
189_T228_Q1.5600.63
230_V251_T1.5440.62
123_F330_H1.5430.62
105_V120_C1.5330.62
41_Y239_V1.5270.61
93_L239_V1.5220.61
286_A290_A1.5160.61
47_Y221_C1.5150.61
320_L350_V1.5060.60
336_I352_V1.4650.58
185_P292_W1.4580.58
227_Y280_E1.4580.58
276_C346_E1.4580.58
311_K314_E1.4370.57
3_K43_I1.4370.57
14_K20_I1.4340.56
274_M301_T1.4330.56
110_T115_E1.4000.55
193_E205_W1.3950.54
176_P340_Q1.3830.54
46_C52_G1.3780.53
201_P206_D1.3730.53
217_D349_T1.3710.53
221_C227_Y1.3590.52
7_L114_K1.3570.52
201_P210_A1.3510.52
5_V71_F1.3440.52
26_Q50_D1.3420.51
123_F348_V1.3420.51
177_R345_R1.3350.51
286_A336_I1.3240.50
183_D289_M1.3220.50
214_W270_N1.3220.50
291_Q326_Q1.3200.50
63_S340_Q1.3080.50
187_R341_L1.3020.49
283_A322_Y1.2980.49
315_E319_N1.2970.49
202_A334_A1.2950.49
29_I54_K1.2910.49
40_G319_N1.2660.47
286_A323_I1.2640.47
251_T337_Q1.2630.47
84_D87_T1.2630.47
46_C51_D1.2620.47
290_A322_Y1.2500.46
181_P189_T1.2480.46
220_A343_H1.2470.46
22_D313_Y1.2340.45
9_R13_E1.2330.45
189_T227_Y1.2210.45
239_V257_L1.2160.44
235_W253_Q1.2140.44
234_M253_Q1.2060.44
80_L121_R1.2030.44
94_Q134_A1.2030.44
177_R343_H1.1860.43
192_L278_M1.1790.42
25_G31_G1.1780.42
107_V354_R1.1760.42
243_P256_W1.1650.42
34_R45_E1.1650.42
232_R287_A1.1620.42
52_G160_T1.1600.41
266_P292_W1.1600.41
201_P351_H1.1600.41
21_T25_G1.1580.41
260_D292_W1.1500.41
293_L352_V1.1470.41
227_Y251_T1.1440.41
29_I46_C1.1400.40
100_G202_A1.1350.40
33_A211_N1.1310.40
66_F345_R1.1260.40
52_G55_L1.1250.40
76_L159_Y1.1240.39
290_A338_A1.1200.39
196_F280_E1.1180.39
68_R345_R1.1160.39
226_T229_L1.1060.39
253_Q272_S1.1040.38
76_L157_C1.0900.38
16_C196_F1.0860.37
278_M281_K1.0810.37
270_N296_G1.0790.37
324_Q328_D1.0750.37
100_G148_V1.0680.37
119_F122_K1.0630.36
6_L16_C1.0590.36
181_P228_Q1.0590.36
327_L334_A1.0550.36
156_G239_V1.0520.36
55_L59_L1.0470.35
218_L305_L1.0180.34
33_A132_R1.0150.34
276_C280_E1.0040.33
227_Y231_K1.0000.33
320_L336_I0.9990.33
150_V158_C0.9910.33
86_I179_K0.9850.32
158_C221_C0.9840.32
178_L193_E0.9810.32
3_K76_L0.9740.32
293_L298_C0.9730.32
14_K18_A0.9730.32
260_D284_K0.9710.32
100_G136_V0.9700.32
111_N201_P0.9700.32
286_A352_V0.9680.32
38_N183_D0.9670.32
211_N234_M0.9660.31
20_I24_A0.9650.31
200_I206_D0.9640.31
122_K313_Y0.9590.31
213_M300_E0.9520.31
285_V350_V0.9420.30
154_A157_C0.9390.30
7_L173_M0.9360.30
201_P208_R0.9320.30
185_P266_P0.9310.30
69_Q106_E0.9280.30
227_Y279_V0.9280.30
9_R292_W0.9240.30
188_S338_A0.9210.29
241_N253_Q0.9190.29
69_Q114_K0.9160.29
101_G141_E0.9160.29
175_I178_L0.9140.29
11_G276_C0.9120.29
48_Q51_D0.9100.29
10_P256_W0.9080.29
205_W234_M0.8980.28
195_A345_R0.8970.28
20_I38_N0.8910.28
279_V344_D0.8900.28
249_M252_G0.8840.28
180_F189_T0.8780.27
133_D336_I0.8780.27
208_R353_R0.8760.27
139_N239_V0.8730.27
248_L254_V0.8630.27
263_K278_M0.8620.27
145_R165_S0.8620.27
24_A55_L0.8620.27
29_I58_E0.8560.26
179_K233_N0.8530.26
8_C13_E0.8510.26
213_M272_S0.8500.26
262_F284_K0.8490.26
304_N344_D0.8470.26
289_M301_T0.8460.26
128_R245_A0.8450.26
196_F234_M0.8410.26
293_L336_I0.8370.26
32_F37_E0.8330.25
276_C307_L0.8320.25
302_I339_R0.8320.25
217_D225_W0.8290.25
307_L345_R0.8280.25
316_V348_V0.8270.25
174_G345_R0.8220.25
52_G239_V0.8210.25
206_D210_A0.8190.25
298_C313_Y0.8190.25
205_W281_K0.8180.25
203_D332_I0.8170.25
212_G253_Q0.8140.25
89_I152_F0.8100.25
286_A322_Y0.8090.24
218_L292_W0.8080.24
26_Q42_V0.8060.24
201_P244_M0.8050.24
177_R346_E0.8010.24
52_G72_V0.8010.24
45_E205_W0.7960.24
206_D233_N0.7940.24
10_P25_G0.7900.24
193_E231_K0.7890.24
161_G345_R0.7850.24
74_G159_Y0.7810.23
68_R177_R0.7800.23
289_M318_H0.7780.23
202_A299_R0.7760.23
150_V289_M0.7740.23
45_E147_V0.7730.23
226_T340_Q0.7720.23
86_I202_A0.7700.23
201_P234_M0.7700.23
199_F337_Q0.7670.23
101_G138_A0.7650.23
107_V151_F0.7610.23
193_E315_E0.7610.23
188_S350_V0.7600.23
99_K198_V0.7580.22
199_F208_R0.7580.22
15_E350_V0.7570.22
68_R307_L0.7560.22
20_I29_I0.7520.22
113_S155_P0.7460.22
272_S319_N0.7430.22
185_P304_N0.7430.22
108_A151_F0.7420.22
191_K219_G0.7420.22
191_K222_P0.7420.22
191_K306_K0.7420.22
191_K223_G0.7420.22
191_K224_G0.7420.22
191_K240_D0.7420.22
277_D347_E0.7420.22
191_K277_D0.7420.22
306_K347_E0.7420.22
191_K347_E0.7420.22
240_D347_E0.7420.22
222_P306_K0.7420.22
222_P277_D0.7420.22
222_P240_D0.7420.22
219_G306_K0.7420.22
219_G277_D0.7420.22
219_G240_D0.7420.22
219_G347_E0.7420.22
219_G224_G0.7420.22
219_G223_G0.7420.22
222_P347_E0.7420.22
223_G240_D0.7420.22
240_D306_K0.7420.22
240_D277_D0.7420.22
224_G347_E0.7420.22
224_G306_K0.7420.22
224_G277_D0.7420.22
224_G240_D0.7420.22
223_G347_E0.7420.22
223_G306_K0.7420.22
223_G277_D0.7420.22
219_G222_P0.7420.22
277_D306_K0.7420.22
226_T274_M0.7390.22
47_Y172_Y0.7380.22
95_G206_D0.7380.22
57_R302_I0.7370.22
81_P86_I0.7350.22
40_G144_K0.7340.22
9_R266_P0.7330.22
51_D54_K0.7330.22
29_I78_Q0.7330.22
199_F351_H0.7300.21
80_L85_R0.7280.21
62_S337_Q0.7280.21
27_R339_R0.7250.21
181_P238_S0.7250.21
69_Q149_H0.7240.21
56_I70_W0.7230.21
43_I330_H0.7230.21
123_F130_A0.7220.21
265_R288_L0.7210.21
43_I159_Y0.7210.21
4_V95_G0.7210.21
22_D26_Q0.7180.21
32_F70_W0.7170.21
113_S285_V0.7160.21
7_L71_F0.7160.21
308_P312_R0.7140.21
279_V292_W0.7140.21
229_L275_V0.7130.21
290_A326_Q0.7090.21
146_P165_S0.7080.21
290_A323_I0.7080.21
41_Y51_D0.7080.21
185_P218_L0.7070.21
27_R46_C0.7050.20
105_V128_R0.7040.20
12_F259_E0.7040.20
179_K214_W0.7030.20
85_R309_M0.6970.20
156_G214_W0.6960.20
17_A42_V0.6950.20
185_P190_L0.6940.20
218_L266_P0.6900.20
172_Y314_E0.6900.20
205_W334_A0.6890.20
106_E163_S0.6890.20
283_A319_N0.6880.20
328_D332_I0.6870.20
74_G339_R0.6850.20
89_I202_A0.6850.20
197_H206_D0.6840.20
119_F265_R0.6830.20
303_F308_P0.6820.20
39_A153_I0.6810.20
40_G198_V0.6800.20
199_F205_W0.6790.20
249_M253_Q0.6760.19
34_R41_Y0.6740.19
263_K280_E0.6710.19
161_G248_L0.6620.19
289_M350_V0.6620.19
301_T352_V0.6610.19
85_R118_K0.6590.19
116_L121_R0.6580.19
178_L275_V0.6560.19
194_E224_G0.6550.19
191_K194_E0.6550.19
194_E277_D0.6550.19
194_E219_G0.6550.19
194_E222_P0.6550.19
194_E240_D0.6550.19
194_E223_G0.6550.19
194_E347_E0.6550.19
194_E306_K0.6550.19
314_E317_S0.6540.19
12_F221_C0.6530.19
176_P198_V0.6520.19
196_F255_T0.6520.19
70_W155_P0.6510.19
68_R308_P0.6510.19
330_H334_A0.6500.19
76_L160_T0.6500.19
25_G32_F0.6480.18
111_N115_E0.6470.18
72_V102_E0.6450.18
177_R276_C0.6440.18
180_F305_L0.6420.18
59_L321_A0.6410.18
266_P304_N0.6400.18
225_W349_T0.6400.18
93_L160_T0.6390.18
193_E342_Y0.6380.18
293_L327_L0.6380.18
149_H218_L0.6370.18
174_G177_R0.6360.18
66_F177_R0.6350.18
114_K152_F0.6340.18
109_D113_S0.6320.18
63_S302_I0.6320.18
216_V313_Y0.6300.18
279_V315_E0.6290.18
68_R276_C0.6280.18
25_G170_P0.6240.18
43_I73_V0.6240.18
65_I348_V0.6230.18
108_A114_K0.6230.18
260_D279_V0.6220.18
199_F248_L0.6200.18
217_D220_A0.6200.18
49_P57_R0.6180.18
79_H258_R0.6170.17
180_F188_S0.6160.17
121_R125_V0.6160.17
67_A171_F0.6150.17
323_I350_V0.6140.17
193_E197_H0.6140.17
262_F304_N0.6130.17
226_T275_V0.6130.17
17_A31_G0.6100.17
104_R353_R0.6090.17
241_N258_R0.6090.17
196_F210_A0.6080.17
221_C271_I0.6060.17
235_W267_T0.6040.17
227_Y260_D0.6040.17
6_L14_K0.6010.17
34_R154_A0.5990.17
266_P308_P0.5990.17
35_V231_K0.5980.17
83_E183_D0.5980.17
128_R141_E0.5970.17
319_N322_Y0.5960.17
57_R326_Q0.5950.17
76_L79_H0.5930.17
239_V340_Q0.5920.17
22_D302_I0.5920.17
35_V239_V0.5920.17
34_R333_N0.5900.17
104_R270_N0.5890.17
92_M95_G0.5880.17
67_A149_H0.5880.17
113_S117_L0.5880.17
110_T159_Y0.5870.17
83_E96_V0.5850.16
215_A314_E0.5850.16
201_P300_E0.5850.16
65_I129_A0.5810.16
221_C243_P0.5810.16
229_L256_W0.5800.16
35_V204_E0.5800.16
221_C279_V0.5800.16
161_G215_A0.5770.16
184_A220_A0.5760.16
127_L255_T0.5760.16
102_E202_A0.5750.16
152_F278_M0.5750.16
149_H303_F0.5750.16
279_V346_E0.5730.16
185_P262_F0.5710.16
189_T276_C0.5700.16
260_D312_R0.5690.16
16_C36_K0.5670.16
66_F349_T0.5660.16
73_V156_G0.5650.16
138_A141_E0.5640.16
72_V161_G0.5640.16
62_S94_Q0.5610.16
237_Y271_I0.5590.16
151_F173_M0.5590.16
39_A130_A0.5560.16
20_I132_R0.5550.16
101_G145_R0.5550.16
108_A188_S0.5540.16
100_G165_S0.5540.16
299_R334_A0.5490.15
227_Y278_M0.5490.15
218_L284_K0.5480.15
188_S279_V0.5480.15
262_F266_P0.5470.15
72_V94_Q0.5450.15
119_F288_L0.5410.15
200_I300_E0.5400.15
63_S91_G0.5400.15
126_P316_V0.5390.15
317_S320_L0.5380.15
7_L161_G0.5370.15
200_I210_A0.5360.15
204_E247_S0.5360.15
94_Q321_A0.5340.15
141_E145_R0.5340.15
73_V338_A0.5340.15
256_W279_V0.5320.15
110_T151_F0.5320.15
120_C152_F0.5310.15
58_E154_A0.5300.15
5_V323_I0.5300.15
77_L88_P0.5300.15
202_A207_E0.5290.15
26_Q153_I0.5280.15
174_G186_S0.5260.15
323_I334_A0.5260.15
292_W298_C0.5230.15
284_K312_R0.5220.15
96_V144_K0.5210.15
112_E115_E0.5200.15
204_E290_A0.5190.15
87_T325_A0.5190.15
262_F308_P0.5170.15
34_R257_L0.5170.15
321_A325_A0.5170.15
147_V150_V0.5150.14
292_W304_N0.5120.14
101_G152_F0.5120.14
105_V169_S0.5110.14
66_F341_L0.5110.14
86_I130_A0.5100.14
149_H163_S0.5100.14
184_A342_Y0.5100.14
119_F152_F0.5080.14
85_R242_G0.5080.14
51_D239_V0.5070.14
258_R322_Y0.5070.14
122_K271_I0.5070.14
301_T340_Q0.5060.14
102_E128_R0.5040.14
304_N309_M0.5030.14
228_Q232_R0.5020.14
41_Y340_Q0.5020.14
167_N199_F0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4aukA 2 0.9754 100 0.493 Contact Map
4v0qA 2 0.5656 99.8 0.844 Contact Map
4k6mA 2 0.571 99.7 0.859 Contact Map
3lkzA 1 0.582 99.7 0.861 Contact Map
3tm4A 1 0.8825 99.7 0.862 Contact Map
4r8rA 1 0.571 99.6 0.867 Contact Map
2px2A 1 0.5492 99.6 0.87 Contact Map
3tmaA 2 0.8443 99.6 0.873 Contact Map
2oxtA 1 0.582 99.5 0.874 Contact Map
2wa2A 1 0.5902 99.5 0.876 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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