GREMLIN Database
YIID - Uncharacterized protein YiiD
UniProt: P0ADQ2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11853
Length: 329 (299)
Sequences: 115 (57)
Seq/√Len: 3.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
247_G312_V4.7130.87
27_E31_R4.6050.86
90_M133_F3.4910.65
219_L224_L3.0930.55
285_G310_Y3.0850.55
35_F225_F2.9260.51
30_E74_V2.7870.47
86_S207_M2.5780.42
66_D70_N2.4770.39
38_E42_K2.4560.39
98_D188_S2.3730.36
226_S292_M2.3480.36
89_F133_F2.3070.35
65_V71_L2.2910.35
287_K314_P2.2420.33
122_T171_G2.1850.32
205_T211_G2.1620.32
187_L204_I2.1060.30
136_L254_A2.0960.30
118_V187_L2.0670.29
205_T231_T2.0410.29
227_L231_T2.0070.28
174_C197_Q2.0070.28
129_A154_H1.9260.26
68_Q105_M1.9230.26
20_L257_R1.9220.26
71_L160_P1.9020.26
44_L56_D1.8800.25
75_G100_G1.8650.25
55_W171_G1.8340.25
125_A154_H1.8240.24
89_F106_A1.8140.24
80_N303_G1.8110.24
77_L188_S1.8080.24
80_N226_S1.7950.24
85_A252_A1.7810.24
89_F154_H1.7440.23
28_E292_M1.7070.22
90_M154_H1.7000.22
41_R261_P1.6550.21
59_A124_S1.6530.21
118_V194_R1.6400.21
105_M193_V1.6210.21
35_F133_F1.6120.20
254_A257_R1.6090.20
28_E194_R1.6070.20
141_Q225_F1.6040.20
173_W253_D1.6020.20
17_M192_G1.5830.20
181_W266_P1.5790.20
187_L211_G1.5790.20
34_Q193_V1.5760.20
85_A309_T1.5630.20
26_E176_Q1.5570.20
90_M125_A1.5550.20
63_M200_G1.5510.19
123_C154_H1.5340.19
232_G294_V1.5260.19
139_V194_R1.5140.19
124_S219_L1.5130.19
171_G192_G1.5110.19
232_G310_Y1.4740.18
203_F239_M1.4710.18
59_A290_V1.4650.18
175_A231_T1.4500.18
247_G254_A1.4460.18
59_A134_A1.4390.18
80_N253_D1.4350.18
215_P243_R1.4280.18
189_E205_T1.4240.17
226_S279_L1.4200.17
101_L236_I1.3950.17
298_G303_G1.3900.17
55_W122_T1.3890.17
111_S225_F1.3820.17
19_H161_V1.3770.17
44_L125_A1.3660.17
92_V294_V1.3640.17
46_Q154_H1.3390.16
193_V290_V1.3370.16
20_L278_D1.3320.16
125_A204_I1.3250.16
192_G198_Y1.3070.16
187_L210_T1.3050.16
195_I278_D1.2930.16
171_G242_E1.2890.15
205_T226_S1.2880.15
84_E198_Y1.2820.15
187_L192_G1.2800.15
167_I235_L1.2770.15
150_T312_V1.2750.15
156_L174_C1.2650.15
250_I314_P1.2640.15
240_L304_A1.2510.15
44_L149_T1.2470.15
57_A240_L1.2430.15
97_Q184_H1.2390.15
209_E219_L1.2370.15
107_M215_P1.2220.15
75_G200_G1.2210.15
278_D289_R1.2190.15
192_G199_T1.2090.14
39_M225_F1.2080.14
100_G200_G1.2080.14
84_E247_G1.2010.14
65_V262_I1.2010.14
92_V232_G1.1970.14
72_V275_L1.1920.14
64_V299_D1.1830.14
70_N99_K1.1800.14
212_N223_S1.1590.14
205_T304_A1.1570.14
41_R44_L1.1560.14
59_A130_V1.1490.14
38_E226_S1.1480.14
17_M187_L1.1440.14
18_Y226_S1.1420.14
118_V267_H1.1330.13
98_D138_F1.1310.13
86_S219_L1.1310.13
62_Q187_L1.1250.13
44_L133_F1.1190.13
227_L289_R1.1180.13
217_H298_G1.1170.13
184_H215_P1.1170.13
101_L249_I1.1140.13
133_F154_H1.1100.13
244_H289_R1.0970.13
192_G226_S1.0970.13
78_Y180_A1.0950.13
44_L71_L1.0910.13
254_A312_V1.0880.13
126_R132_F1.0870.13
25_T30_E1.0870.13
92_V249_I1.0830.13
56_D184_H1.0740.13
242_E277_G1.0740.13
205_T292_M1.0710.13
187_L194_R1.0630.13
81_A298_G1.0540.13
62_Q219_L1.0540.13
80_N173_W1.0530.13
138_F241_R1.0500.12
121_V150_T1.0480.12
138_F171_G1.0430.12
118_V198_Y1.0400.12
18_Y64_V1.0380.12
171_G199_T1.0270.12
24_Q71_L1.0260.12
122_T138_F1.0210.12
208_P211_G1.0120.12
32_Y159_K1.0050.12
34_Q204_I1.0030.12
55_W120_R1.0030.12
97_Q199_T0.9990.12
20_L215_P0.9990.12
274_A292_M0.9980.12
94_P179_Q0.9890.12
118_V204_I0.9870.12
260_K298_G0.9810.12
124_S224_L0.9810.12
235_L270_A0.9780.12
97_Q276_S0.9780.12
226_S238_L0.9700.12
90_M261_P0.9630.12
17_M198_Y0.9620.11
215_P250_I0.9590.11
20_L235_L0.9580.11
52_R252_A0.9560.11
158_I284_R0.9550.11
194_R199_T0.9540.11
35_F123_C0.9530.11
62_Q299_D0.9530.11
73_A100_G0.9510.11
63_M75_G0.9480.11
18_Y292_M0.9460.11
39_M52_R0.9420.11
52_R260_K0.9370.11
240_L248_T0.9360.11
46_Q241_R0.9350.11
59_A65_V0.9310.11
161_V183_E0.9300.11
33_Y196_Q0.9300.11
142_G303_G0.9260.11
178_Q197_Q0.9230.11
101_L292_M0.9210.11
157_M232_G0.9170.11
39_M45_H0.9170.11
44_L148_T0.9150.11
127_E225_F0.9100.11
94_P285_G0.9070.11
63_M100_G0.9070.11
29_L148_T0.9070.11
65_V289_R0.9060.11
218_T305_V0.9040.11
90_M207_M0.9030.11
122_T192_G0.8990.11
25_T63_M0.8990.11
31_R139_V0.8990.11
28_E246_G0.8900.11
72_V143_E0.8890.11
86_S133_F0.8870.11
59_A155_F0.8840.11
205_T227_L0.8820.11
138_F312_V0.8820.11
55_W198_Y0.8810.11
82_D257_R0.8800.11
104_L279_L0.8800.11
135_K195_I0.8760.11
57_A146_T0.8750.11
56_D199_T0.8740.11
22_V44_L0.8720.11
18_Y167_I0.8710.11
95_D300_E0.8690.11
138_F254_A0.8680.11
80_N198_Y0.8670.11
127_E295_E0.8580.10
80_N205_T0.8570.10
46_Q152_I0.8550.10
171_G198_Y0.8550.10
37_W131_E0.8540.10
89_F169_H0.8530.10
68_Q248_T0.8530.10
163_T226_S0.8500.10
182_Y292_M0.8500.10
24_Q34_Q0.8470.10
193_V229_T0.8400.10
102_G132_F0.8390.10
84_E236_I0.8390.10
17_M242_E0.8330.10
268_A297_F0.8310.10
79_I138_F0.8270.10
37_W137_G0.8270.10
20_L265_K0.8260.10
139_V315_A0.8210.10
105_M307_E0.8200.10
227_L313_L0.8200.10
18_Y106_A0.8180.10
57_A277_G0.8170.10
208_P217_H0.8150.10
154_H157_M0.8140.10
41_R127_E0.8120.10
262_I286_R0.8100.10
125_A152_I0.8070.10
123_C225_F0.8060.10
29_L33_Y0.8060.10
225_F253_D0.8030.10
187_L193_V0.8020.10
54_A86_S0.7980.10
54_A83_N0.7980.10
22_V161_V0.7980.10
240_L259_S0.7980.10
133_F189_E0.7970.10
156_L204_I0.7950.10
178_Q242_E0.7890.10
270_A292_M0.7880.10
170_R272_L0.7840.10
33_Y135_K0.7840.10
63_M277_G0.7820.10
85_A296_I0.7810.10
64_V226_S0.7800.10
170_R231_T0.7780.10
35_F309_T0.7750.10
98_D216_H0.7750.10
71_L215_P0.7730.10
57_A299_D0.7720.10
81_A167_I0.7660.10
218_T227_L0.7640.10
152_I193_V0.7630.10
252_A311_I0.7610.10
254_A311_I0.7610.10
244_H307_E0.7600.09
56_D123_C0.7580.09
207_M219_L0.7570.09
193_V299_D0.7550.09
118_V199_T0.7540.09
35_F287_K0.7520.09
30_E85_A0.7490.09
243_R272_L0.7430.09
62_Q86_S0.7420.09
183_E274_A0.7360.09
92_V157_M0.7350.09
250_I282_L0.7330.09
45_H225_F0.7310.09
72_V262_I0.7300.09
66_D142_G0.7290.09
237_W293_Q0.7290.09
204_I207_M0.7290.09
46_Q101_L0.7290.09
67_E108_T0.7280.09
89_F189_E0.7280.09
44_L150_T0.7250.09
56_D71_L0.7210.09
59_A160_P0.7200.09
218_T278_D0.7160.09
38_E118_V0.7110.09
28_E262_I0.7100.09
45_H250_I0.7080.09
52_R303_G0.7060.09
22_V207_M0.7050.09
59_A260_K0.7040.09
112_V133_F0.7010.09
38_E103_T0.7010.09
93_H261_P0.7000.09
19_H29_L0.6970.09
56_D197_Q0.6940.09
67_E315_A0.6920.09
225_F311_I0.6910.09
30_E205_T0.6890.09
89_F129_A0.6880.09
206_T257_R0.6870.09
144_I298_G0.6830.09
265_K305_V0.6820.09
18_Y59_A0.6820.09
131_E252_A0.6820.09
131_E218_T0.6820.09
133_F226_S0.6790.09
34_Q38_E0.6790.09
184_H203_F0.6780.09
125_A211_G0.6760.09
62_Q178_Q0.6740.09
178_Q199_T0.6730.09
114_R163_T0.6710.09
82_D190_K0.6700.09
187_L241_R0.6690.09
85_A140_N0.6660.09
224_L256_I0.6650.09
137_G240_L0.6640.09
103_T279_L0.6630.09
156_L207_M0.6610.09
62_Q206_T0.6600.09
181_W258_Y0.6560.09
135_K289_R0.6550.09
84_E189_E0.6540.09
227_L302_P0.6540.09
215_P242_E0.6490.09
84_E174_C0.6480.09
198_Y242_E0.6470.09
90_M311_I0.6460.09
178_Q313_L0.6460.09
292_M296_I0.6440.08
200_G268_A0.6440.08
215_P265_K0.6400.08
25_T135_K0.6380.08
44_L145_T0.6370.08
35_F55_W0.6350.08
133_F207_M0.6340.08
135_K296_I0.6340.08
27_E182_Y0.6340.08
194_R206_T0.6320.08
118_V193_V0.6310.08
93_H215_P0.6310.08
121_V299_D0.6300.08
125_A129_A0.6280.08
27_E121_V0.6270.08
148_T187_L0.6260.08
44_L275_L0.6260.08
225_F280_D0.6250.08
78_Y298_G0.6230.08
47_P294_V0.6210.08
289_R302_P0.6170.08
34_Q182_Y0.6160.08
129_A303_G0.6150.08
59_A283_A0.6140.08
212_N306_F0.6120.08
223_S306_F0.6120.08
55_W174_C0.6100.08
71_L125_A0.6070.08
106_A136_L0.6060.08
84_E192_G0.6060.08
231_T266_P0.6060.08
192_G242_E0.6050.08
89_F167_I0.6050.08
161_V168_L0.6010.08
89_F123_C0.6010.08
84_E167_I0.6000.08
239_M255_H0.6000.08
129_A256_I0.5990.08
121_V270_A0.5980.08
97_Q291_Q0.5940.08
44_L86_S0.5930.08
131_E153_R0.5920.08
93_H152_I0.5900.08
59_A131_E0.5830.08
29_L259_S0.5820.08
40_L88_R0.5810.08
121_V167_I0.5770.08
99_K157_M0.5770.08
25_T98_D0.5760.08
110_E159_K0.5750.08
26_E309_T0.5740.08
116_E190_K0.5740.08
41_R133_F0.5730.08
70_N267_H0.5720.08
54_A207_M0.5690.08
218_T248_T0.5680.08
99_K300_E0.5660.08
20_L206_T0.5660.08
41_R90_M0.5630.08
55_W123_C0.5620.08
203_F288_A0.5590.08
50_S77_L0.5580.08
120_R294_V0.5580.08
118_V192_G0.5560.08
180_A240_L0.5540.08
84_E171_G0.5530.08
29_L123_C0.5520.08
71_L105_M0.5510.08
150_T207_M0.5490.08
27_E67_E0.5490.08
25_T310_Y0.5390.08
94_P215_P0.5380.08
22_V150_T0.5370.08
287_K294_V0.5360.08
97_Q218_T0.5360.08
225_F265_K0.5360.08
193_V279_L0.5330.08
226_S270_A0.5310.08
125_A213_Q0.5310.08
57_A237_W0.5280.08
148_T225_F0.5280.08
204_I267_H0.5270.08
224_L250_I0.5270.08
63_M167_I0.5260.08
274_A295_E0.5250.08
41_R154_H0.5230.08
150_T270_A0.5220.08
19_H138_F0.5210.08
86_S213_Q0.5200.08
123_C133_F0.5200.08
44_L106_A0.5170.08
183_E296_I0.5170.08
32_Y212_N0.5130.07
32_Y223_S0.5130.07
64_V72_V0.5120.07
35_F153_R0.5110.07
65_V243_R0.5110.07
124_S303_G0.5110.07
22_V90_M0.5100.07
151_P203_F0.5040.07
204_I210_T0.5040.07
169_H303_G0.5040.07
121_V133_F0.5040.07
85_A135_K0.5020.07
52_R296_I0.5010.07
120_R237_W0.5010.07
163_T303_G0.5000.07
203_F279_L0.5000.07
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lmbA 2 0.462 99.9 0.864 Contact Map
1t82A 2 0.4529 99.9 0.867 Contact Map
3efaA 2 0.4407 99.8 0.872 Contact Map
1ro5A 5 0.4894 99.8 0.875 Contact Map
1kzfA 1 0.4772 99.8 0.875 Contact Map
3p2hA 1 0.4681 99.8 0.878 Contact Map
2jdcA 1 0.4195 99.8 0.88 Contact Map
1q2yA 1 0.4255 99.8 0.885 Contact Map
1xebA 2 0.4377 99.7 0.887 Contact Map
2g0bA 4 0.4954 99.7 0.889 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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