GREMLIN Database
YIGM - Uncharacterized membrane protein YigM
UniProt: P0ADP5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11471
Length: 299 (280)
Sequences: 262 (147)
Seq/√Len: 8.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_Y143_L3.8350.97
70_V193_N3.5280.96
230_D276_H3.1440.92
88_L245_G2.9600.89
224_Y228_Q2.9120.88
63_V157_G2.7950.86
258_H261_T2.6440.83
202_L206_I2.5930.81
244_A248_V2.4360.77
79_Y87_L2.3490.74
8_T244_A2.3000.73
230_D279_W2.2530.71
102_Y163_E2.2370.71
47_L175_W2.1540.67
68_L219_Y2.1410.67
93_L126_G2.1400.67
73_M209_F2.1320.67
223_N226_A2.0930.65
92_V126_G2.0130.62
127_I268_V1.9800.61
37_G181_F1.9320.59
242_V246_L1.9290.58
10_L244_A1.9160.58
58_G62_L1.8990.57
32_V184_A1.8700.56
250_L272_S1.8550.55
250_L257_P1.8410.55
159_K169_Q1.8410.55
52_N175_W1.8410.55
71_M75_S1.8050.53
49_T175_W1.7940.53
71_M144_V1.7790.52
114_Y163_E1.7670.52
158_Y239_N1.7640.52
144_V150_T1.7590.51
30_F204_W1.7350.50
209_F246_L1.7310.50
117_S275_V1.7270.50
6_I10_L1.7260.50
210_L216_G1.7190.50
246_L250_L1.7060.49
159_K183_V1.7040.49
138_W159_K1.6840.48
66_M70_V1.6720.48
193_N197_M1.6570.47
209_F213_V1.6450.46
16_S248_V1.6390.46
241_H244_A1.6230.45
89_L137_F1.6060.45
158_Y215_S1.5900.44
81_Y93_L1.5750.43
117_S276_H1.5520.42
68_L71_M1.5490.42
29_Y93_L1.5480.42
34_V185_V1.5460.42
33_L185_V1.5430.42
254_H257_P1.5110.41
105_M246_L1.5010.40
101_I149_I1.5000.40
158_Y223_N1.4890.40
129_R245_G1.4850.40
71_M219_Y1.4840.40
19_G84_V1.4790.39
70_V149_I1.4770.39
16_S32_V1.4760.39
81_Y246_L1.4580.39
85_S254_H1.4430.38
88_L152_A1.4390.38
146_L150_T1.4370.38
10_L260_P1.4350.38
93_L242_V1.4310.37
249_N253_W1.4300.37
93_L141_L1.4290.37
102_Y231_A1.4260.37
216_G241_H1.4230.37
68_L144_V1.4210.37
117_S236_I1.4190.37
93_L231_A1.4070.37
16_S249_N1.4070.37
102_Y114_Y1.3800.35
83_T134_T1.3760.35
1_M4_L1.3730.35
92_V127_I1.3720.35
102_Y276_H1.3510.34
92_V242_V1.3330.34
114_Y236_I1.3250.33
8_T16_S1.3220.33
152_A156_V1.3130.33
40_A178_L1.2980.32
66_M157_G1.2930.32
16_S20_E1.2820.32
5_I240_M1.2820.32
89_L124_G1.2610.31
241_H249_N1.2520.31
223_N239_N1.2500.31
96_L272_S1.2400.30
256_Q261_T1.2390.30
6_I221_M1.2360.30
104_I120_L1.2350.30
9_I62_L1.2270.30
71_M150_T1.2150.29
144_V219_Y1.2110.29
177_Y221_M1.2010.29
84_V176_F1.1880.28
115_A250_L1.1830.28
215_S219_Y1.1790.28
142_L199_Q1.1750.28
79_Y240_M1.1750.28
174_A224_Y1.1710.28
16_S241_H1.1640.27
248_V255_Q1.1440.27
47_L68_L1.1410.27
30_F192_G1.1390.27
166_P271_A1.1370.27
247_L251_A1.1350.27
150_T219_Y1.1320.26
12_A96_L1.1320.26
96_L119_L1.1250.26
123_I126_G1.1230.26
102_Y111_R1.1110.26
11_W151_F1.1100.26
117_S163_E1.1090.26
53_S213_V1.1080.26
76_F79_Y1.1060.26
212_V270_L1.1050.26
123_I268_V1.1020.25
143_L177_Y1.0980.25
8_T19_G1.0940.25
241_H253_W1.0920.25
123_I275_V1.0920.25
217_I274_W1.0900.25
29_Y75_S1.0870.25
102_Y177_Y1.0830.25
3_L224_Y1.0710.24
54_L101_I1.0670.24
76_F176_F1.0650.24
236_I276_H1.0600.24
98_I130_Y1.0590.24
176_F218_G1.0530.24
120_L221_M1.0520.24
78_A174_A1.0520.24
152_A245_G1.0430.24
117_S221_M1.0420.24
4_L14_S1.0390.23
74_L80_L1.0390.23
11_W14_S1.0380.23
71_M223_N1.0370.23
29_Y77_R1.0240.23
210_L215_S1.0230.23
153_I272_S1.0220.23
224_Y227_T1.0210.23
28_S59_L1.0190.23
16_S219_Y1.0180.23
159_K163_E1.0150.23
158_Y226_A1.0130.23
137_F197_M1.0110.23
103_D273_L1.0090.23
112_W281_A1.0090.23
124_G128_I1.0080.22
99_T103_D0.9980.22
91_T144_V0.9940.22
102_Y169_Q0.9930.22
96_L118_A0.9910.22
7_T221_M0.9900.22
53_S263_I0.9900.22
61_M227_T0.9850.22
231_A242_V0.9850.22
26_V218_G0.9830.22
75_S114_Y0.9800.22
176_F237_M0.9790.22
23_A193_N0.9770.22
167_M263_I0.9710.21
176_F241_H0.9700.21
98_I101_I0.9690.21
136_H212_V0.9680.21
114_Y127_I0.9530.21
117_S233_T0.9460.21
127_I134_T0.9450.21
247_L263_I0.9400.21
224_Y259_W0.9360.20
75_S102_Y0.9310.20
183_V239_N0.9270.20
16_S176_F0.9270.20
1_M14_S0.9220.20
59_L196_K0.9220.20
16_S84_V0.9170.20
215_S240_M0.9120.20
84_V249_N0.9100.20
182_L200_T0.9050.20
16_S253_W0.8990.19
73_M133_V0.8940.19
68_L80_L0.8940.19
68_L150_T0.8870.19
54_L70_V0.8840.19
92_V269_I0.8800.19
167_M182_L0.8750.19
39_A128_I0.8720.19
209_F214_A0.8690.19
26_V88_L0.8680.19
188_W227_T0.8680.19
178_L275_V0.8670.19
117_S153_I0.8610.18
48_R247_L0.8600.18
5_I157_G0.8550.18
4_L11_W0.8540.18
28_S50_R0.8450.18
5_I233_T0.8410.18
30_F188_W0.8390.18
150_T242_V0.8390.18
30_F251_A0.8330.18
102_Y209_F0.8290.18
81_Y137_F0.8270.18
99_T232_G0.8230.17
220_F226_A0.8220.17
60_Y235_G0.8190.17
157_G274_W0.8110.17
16_S244_A0.8090.17
176_F249_N0.8090.17
76_F86_E0.8070.17
120_L272_S0.8070.17
177_Y216_G0.8050.17
9_I37_G0.8040.17
93_L227_T0.8030.17
75_S209_F0.7980.17
63_V210_L0.7960.17
75_S231_A0.7920.17
205_G245_G0.7910.17
75_S235_G0.7830.16
188_W240_M0.7820.16
37_G98_I0.7810.16
215_S223_N0.7800.16
98_I261_T0.7780.16
16_S85_S0.7760.16
170_H220_F0.7750.16
93_L127_I0.7740.16
89_L188_W0.7730.16
120_L178_L0.7690.16
195_Q267_L0.7680.16
190_L267_L0.7680.16
125_A158_Y0.7620.16
16_S88_L0.7600.16
98_I269_I0.7580.16
34_V37_G0.7580.16
150_T215_S0.7550.16
77_R268_V0.7550.16
10_L25_H0.7520.16
178_L266_A0.7520.16
91_T129_R0.7490.16
111_R276_H0.7480.16
96_L275_V0.7470.16
32_V36_V0.7450.16
75_S146_L0.7410.16
36_V233_T0.7400.15
236_I240_M0.7400.15
16_S76_F0.7390.15
106_S111_R0.7380.15
23_A205_G0.7380.15
16_S21_Y0.7370.15
98_I141_L0.7370.15
52_N127_I0.7300.15
261_T266_A0.7290.15
1_M11_W0.7260.15
21_Y253_W0.7260.15
134_T137_F0.7240.15
75_S159_K0.7200.15
43_F174_A0.7180.15
105_M143_L0.7130.15
21_Y85_S0.7080.15
138_W161_L0.7030.15
18_Y222_W0.6990.15
40_A181_F0.6980.15
196_K251_A0.6980.15
73_M240_M0.6970.15
98_I258_H0.6970.15
96_L146_L0.6970.15
92_V273_L0.6900.14
124_G217_I0.6900.14
8_T84_V0.6860.14
80_L268_V0.6850.14
71_M215_S0.6830.14
44_L212_V0.6820.14
113_G228_Q0.6800.14
33_L188_W0.6760.14
198_P245_G0.6760.14
136_H195_Q0.6750.14
132_Q186_I0.6750.14
139_T143_L0.6700.14
160_R259_W0.6700.14
46_F281_A0.6690.14
68_L74_L0.6670.14
56_T59_L0.6640.14
71_M114_Y0.6640.14
16_S245_G0.6630.14
61_M252_I0.6630.14
105_M119_L0.6610.14
159_K162_M0.6610.14
31_A129_R0.6590.14
51_G212_V0.6570.14
177_Y257_P0.6570.14
23_A247_L0.6560.14
26_V176_F0.6560.14
74_L144_V0.6540.14
74_L219_Y0.6470.14
212_V261_T0.6460.13
42_V196_K0.6450.13
88_L253_W0.6430.13
42_V103_D0.6420.13
48_R202_L0.6400.13
36_V42_V0.6390.13
10_L164_T0.6390.13
88_L118_A0.6370.13
186_I267_L0.6370.13
186_I189_F0.6370.13
116_F126_G0.6350.13
26_V121_A0.6350.13
110_L250_L0.6340.13
16_S255_Q0.6320.13
225_G273_L0.6320.13
91_T98_I0.6310.13
31_A92_V0.6310.13
28_S31_A0.6300.13
51_G57_V0.6280.13
63_V89_L0.6280.13
12_A18_Y0.6270.13
44_L78_A0.6260.13
181_F252_I0.6260.13
187_A191_L0.6250.13
235_G268_V0.6240.13
76_F249_N0.6240.13
10_L276_H0.6240.13
268_V281_A0.6230.13
209_F248_V0.6220.13
9_I28_S0.6210.13
13_F18_Y0.6200.13
130_Y230_D0.6200.13
81_Y193_N0.6170.13
191_L259_W0.6160.13
40_A242_V0.6150.13
79_Y115_A0.6140.13
244_A255_Q0.6140.13
163_E276_H0.6120.13
10_L37_G0.6110.13
88_L156_V0.6080.13
235_G279_W0.6070.13
71_M80_L0.6060.13
190_L263_I0.6040.13
96_L152_A0.6000.13
242_V269_I0.5910.12
138_W178_L0.5900.12
20_E25_H0.5890.12
7_T115_A0.5870.12
147_S177_Y0.5850.12
70_V191_L0.5840.12
114_Y177_Y0.5830.12
159_K231_A0.5830.12
117_S230_D0.5820.12
233_T268_V0.5800.12
118_A156_V0.5780.12
60_Y149_I0.5780.12
63_V161_L0.5750.12
141_L250_L0.5730.12
132_Q183_V0.5730.12
98_I217_I0.5730.12
74_L150_T0.5700.12
59_L281_A0.5680.12
101_I178_L0.5670.12
9_I230_D0.5670.12
42_V118_A0.5660.12
86_E176_F0.5650.12
70_V203_Q0.5640.12
4_L15_F0.5640.12
135_D251_A0.5610.12
260_P263_I0.5610.12
199_Q270_L0.5600.12
112_W274_W0.5550.12
247_L274_W0.5550.12
70_V178_L0.5520.12
29_Y209_F0.5500.12
256_Q266_A0.5470.12
159_K165_R0.5470.12
111_R114_Y0.5470.12
188_W192_G0.5470.12
53_S212_V0.5460.12
84_V244_A0.5460.12
185_V272_S0.5450.12
11_W15_F0.5440.12
21_Y198_P0.5420.12
89_L143_L0.5400.12
117_S143_L0.5360.11
165_R270_L0.5360.11
118_A152_A0.5350.11
138_W266_A0.5310.11
155_M235_G0.5300.11
97_Y215_S0.5290.11
88_L205_G0.5280.11
16_S26_V0.5280.11
99_T159_K0.5260.11
189_F240_M0.5240.11
271_A275_V0.5200.11
100_L220_F0.5180.11
168_P171_N0.5180.11
153_I157_G0.5180.11
13_F188_W0.5170.11
10_L227_T0.5170.11
92_V170_H0.5170.11
36_V217_I0.5160.11
6_I34_V0.5140.11
84_V245_G0.5130.11
255_Q258_H0.5100.11
111_R268_V0.5100.11
16_S22_L0.5090.11
215_S241_H0.5090.11
119_L136_H0.5070.11
52_N260_P0.5060.11
79_Y136_H0.5040.11
7_T259_W0.5030.11
260_P275_V0.5030.11
71_M210_L0.5030.11
92_V111_R0.5010.11
146_L259_W0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.2575 97.6 0.939 Contact Map
3b5dA 2 0.3378 90 0.961 Contact Map
4n7wA 2 0.9197 5.8 0.983 Contact Map
4nv5A 1 0.5619 5.5 0.983 Contact Map
3wo6A 1 0.2341 5.3 0.983 Contact Map
2m20A 2 0.1472 4.4 0.984 Contact Map
2xq2A 2 0.709 3.9 0.984 Contact Map
3wajA 1 0.7993 3.2 0.985 Contact Map
4dxwA 3 0.3077 3.1 0.985 Contact Map
2kluA 1 0.1672 3 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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