YIGM - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

YIGM - Uncharacterized membrane protein YigM

UniProt:	P0ADP5	Sequences: MALLIITTILWAFSFSFYGEYLAGHVDSYFAVLVRVGLAALVFLPFLRTRGNSLKTVGLYMLVGAMQLGVMYMLSFRAYLYLTVSELLLFTVLTPLYITLIYDIMSKRRLRWGYAFSALLAVIGAGIIRYDQVTDHFWTGLLLVQLSNITFAIGMVGYKRLMETRPMPQHNAFAWFYLGAFLVAVIAWFLLGNAQKMPQTTLQWGILVFLGVVASGIGYFMWNYGATQVDAGTLGIMNNMHVPAGLLVNLAIWHQQPHWPTFITGALVILASLWVHRKWVAPRSSQTADDRRRDCALSE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11471
Length:	299 (280)
Sequences:	262 (147)
Seq/√Len:	8.8

ECOLI - YIGM

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
81_Y	143_L	3.835	0.97
70_V	193_N	3.528	0.96
230_D	276_H	3.144	0.92
88_L	245_G	2.960	0.89
224_Y	228_Q	2.912	0.88
63_V	157_G	2.795	0.86
258_H	261_T	2.644	0.83
202_L	206_I	2.593	0.81
244_A	248_V	2.436	0.77
79_Y	87_L	2.349	0.74
8_T	244_A	2.300	0.73
230_D	279_W	2.253	0.71
102_Y	163_E	2.237	0.71
47_L	175_W	2.154	0.67
68_L	219_Y	2.141	0.67
93_L	126_G	2.140	0.67
73_M	209_F	2.132	0.67
223_N	226_A	2.093	0.65
92_V	126_G	2.013	0.62
127_I	268_V	1.980	0.61
37_G	181_F	1.932	0.59
242_V	246_L	1.929	0.58
10_L	244_A	1.916	0.58
58_G	62_L	1.899	0.57
32_V	184_A	1.870	0.56
250_L	272_S	1.855	0.55
250_L	257_P	1.841	0.55
159_K	169_Q	1.841	0.55
52_N	175_W	1.841	0.55
71_M	75_S	1.805	0.53
49_T	175_W	1.794	0.53
71_M	144_V	1.779	0.52
114_Y	163_E	1.767	0.52
158_Y	239_N	1.764	0.52
144_V	150_T	1.759	0.51
30_F	204_W	1.735	0.50
209_F	246_L	1.731	0.50
117_S	275_V	1.727	0.50
6_I	10_L	1.726	0.50
210_L	216_G	1.719	0.50
246_L	250_L	1.706	0.49
159_K	183_V	1.704	0.49
138_W	159_K	1.684	0.48
66_M	70_V	1.672	0.48
193_N	197_M	1.657	0.47
209_F	213_V	1.645	0.46
16_S	248_V	1.639	0.46
241_H	244_A	1.623	0.45
89_L	137_F	1.606	0.45
158_Y	215_S	1.590	0.44
81_Y	93_L	1.575	0.43
117_S	276_H	1.552	0.42
68_L	71_M	1.549	0.42
29_Y	93_L	1.548	0.42
34_V	185_V	1.546	0.42
33_L	185_V	1.543	0.42
254_H	257_P	1.511	0.41
105_M	246_L	1.501	0.40
101_I	149_I	1.500	0.40
158_Y	223_N	1.489	0.40
129_R	245_G	1.485	0.40
71_M	219_Y	1.484	0.40
19_G	84_V	1.479	0.39
70_V	149_I	1.477	0.39
16_S	32_V	1.476	0.39
81_Y	246_L	1.458	0.39
85_S	254_H	1.443	0.38
88_L	152_A	1.439	0.38
146_L	150_T	1.437	0.38
10_L	260_P	1.435	0.38
93_L	242_V	1.431	0.37
249_N	253_W	1.430	0.37
93_L	141_L	1.429	0.37
102_Y	231_A	1.426	0.37
216_G	241_H	1.423	0.37
68_L	144_V	1.421	0.37
117_S	236_I	1.419	0.37
93_L	231_A	1.407	0.37
16_S	249_N	1.407	0.37
102_Y	114_Y	1.380	0.35
83_T	134_T	1.376	0.35
1_M	4_L	1.373	0.35
92_V	127_I	1.372	0.35
102_Y	276_H	1.351	0.34
92_V	242_V	1.333	0.34
114_Y	236_I	1.325	0.33
8_T	16_S	1.322	0.33
152_A	156_V	1.313	0.33
40_A	178_L	1.298	0.32
66_M	157_G	1.293	0.32
16_S	20_E	1.282	0.32
5_I	240_M	1.282	0.32
89_L	124_G	1.261	0.31
241_H	249_N	1.252	0.31
223_N	239_N	1.250	0.31
96_L	272_S	1.240	0.30
256_Q	261_T	1.239	0.30
6_I	221_M	1.236	0.30
104_I	120_L	1.235	0.30
9_I	62_L	1.227	0.30
71_M	150_T	1.215	0.29
144_V	219_Y	1.211	0.29
177_Y	221_M	1.201	0.29
84_V	176_F	1.188	0.28
115_A	250_L	1.183	0.28
215_S	219_Y	1.179	0.28
142_L	199_Q	1.175	0.28
79_Y	240_M	1.175	0.28
174_A	224_Y	1.171	0.28
16_S	241_H	1.164	0.27
248_V	255_Q	1.144	0.27
47_L	68_L	1.141	0.27
30_F	192_G	1.139	0.27
166_P	271_A	1.137	0.27
247_L	251_A	1.135	0.27
150_T	219_Y	1.132	0.26
12_A	96_L	1.132	0.26
96_L	119_L	1.125	0.26
123_I	126_G	1.123	0.26
102_Y	111_R	1.111	0.26
11_W	151_F	1.110	0.26
117_S	163_E	1.109	0.26
53_S	213_V	1.108	0.26
76_F	79_Y	1.106	0.26
212_V	270_L	1.105	0.26
123_I	268_V	1.102	0.25
143_L	177_Y	1.098	0.25
8_T	19_G	1.094	0.25
241_H	253_W	1.092	0.25
123_I	275_V	1.092	0.25
217_I	274_W	1.090	0.25
29_Y	75_S	1.087	0.25
102_Y	177_Y	1.083	0.25
3_L	224_Y	1.071	0.24
54_L	101_I	1.067	0.24
76_F	176_F	1.065	0.24
236_I	276_H	1.060	0.24
98_I	130_Y	1.059	0.24
176_F	218_G	1.053	0.24
120_L	221_M	1.052	0.24
78_A	174_A	1.052	0.24
152_A	245_G	1.043	0.24
117_S	221_M	1.042	0.24
4_L	14_S	1.039	0.23
74_L	80_L	1.039	0.23
11_W	14_S	1.038	0.23
71_M	223_N	1.037	0.23
29_Y	77_R	1.024	0.23
210_L	215_S	1.023	0.23
153_I	272_S	1.022	0.23
224_Y	227_T	1.021	0.23
28_S	59_L	1.019	0.23
16_S	219_Y	1.018	0.23
159_K	163_E	1.015	0.23
158_Y	226_A	1.013	0.23
137_F	197_M	1.011	0.23
103_D	273_L	1.009	0.23
112_W	281_A	1.009	0.23
124_G	128_I	1.008	0.22
99_T	103_D	0.998	0.22
91_T	144_V	0.994	0.22
102_Y	169_Q	0.993	0.22
96_L	118_A	0.991	0.22
7_T	221_M	0.990	0.22
53_S	263_I	0.990	0.22
61_M	227_T	0.985	0.22
231_A	242_V	0.985	0.22
26_V	218_G	0.983	0.22
75_S	114_Y	0.980	0.22
176_F	237_M	0.979	0.22
23_A	193_N	0.977	0.22
167_M	263_I	0.971	0.21
176_F	241_H	0.970	0.21
98_I	101_I	0.969	0.21
136_H	212_V	0.968	0.21
114_Y	127_I	0.953	0.21
117_S	233_T	0.946	0.21
127_I	134_T	0.945	0.21
247_L	263_I	0.940	0.21
224_Y	259_W	0.936	0.20
75_S	102_Y	0.931	0.20
183_V	239_N	0.927	0.20
16_S	176_F	0.927	0.20
1_M	14_S	0.922	0.20
59_L	196_K	0.922	0.20
16_S	84_V	0.917	0.20
215_S	240_M	0.912	0.20
84_V	249_N	0.910	0.20
182_L	200_T	0.905	0.20
16_S	253_W	0.899	0.19
73_M	133_V	0.894	0.19
68_L	80_L	0.894	0.19
68_L	150_T	0.887	0.19
54_L	70_V	0.884	0.19
92_V	269_I	0.880	0.19
167_M	182_L	0.875	0.19
39_A	128_I	0.872	0.19
209_F	214_A	0.869	0.19
26_V	88_L	0.868	0.19
188_W	227_T	0.868	0.19
178_L	275_V	0.867	0.19
117_S	153_I	0.861	0.18
48_R	247_L	0.860	0.18
5_I	157_G	0.855	0.18
4_L	11_W	0.854	0.18
28_S	50_R	0.845	0.18
5_I	233_T	0.841	0.18
30_F	188_W	0.839	0.18
150_T	242_V	0.839	0.18
30_F	251_A	0.833	0.18
102_Y	209_F	0.829	0.18
81_Y	137_F	0.827	0.18
99_T	232_G	0.823	0.17
220_F	226_A	0.822	0.17
60_Y	235_G	0.819	0.17
157_G	274_W	0.811	0.17
16_S	244_A	0.809	0.17
176_F	249_N	0.809	0.17
76_F	86_E	0.807	0.17
120_L	272_S	0.807	0.17
177_Y	216_G	0.805	0.17
9_I	37_G	0.804	0.17
93_L	227_T	0.803	0.17
75_S	209_F	0.798	0.17
63_V	210_L	0.796	0.17
75_S	231_A	0.792	0.17
205_G	245_G	0.791	0.17
75_S	235_G	0.783	0.16
188_W	240_M	0.782	0.16
37_G	98_I	0.781	0.16
215_S	223_N	0.780	0.16
98_I	261_T	0.778	0.16
16_S	85_S	0.776	0.16
170_H	220_F	0.775	0.16
93_L	127_I	0.774	0.16
89_L	188_W	0.773	0.16
120_L	178_L	0.769	0.16
195_Q	267_L	0.768	0.16
190_L	267_L	0.768	0.16
125_A	158_Y	0.762	0.16
16_S	88_L	0.760	0.16
98_I	269_I	0.758	0.16
34_V	37_G	0.758	0.16
150_T	215_S	0.755	0.16
77_R	268_V	0.755	0.16
10_L	25_H	0.752	0.16
178_L	266_A	0.752	0.16
91_T	129_R	0.749	0.16
111_R	276_H	0.748	0.16
96_L	275_V	0.747	0.16
32_V	36_V	0.745	0.16
75_S	146_L	0.741	0.16
36_V	233_T	0.740	0.15
236_I	240_M	0.740	0.15
16_S	76_F	0.739	0.15
106_S	111_R	0.738	0.15
23_A	205_G	0.738	0.15
16_S	21_Y	0.737	0.15
98_I	141_L	0.737	0.15
52_N	127_I	0.730	0.15
261_T	266_A	0.729	0.15
1_M	11_W	0.726	0.15
21_Y	253_W	0.726	0.15
134_T	137_F	0.724	0.15
75_S	159_K	0.720	0.15
43_F	174_A	0.718	0.15
105_M	143_L	0.713	0.15
21_Y	85_S	0.708	0.15
138_W	161_L	0.703	0.15
18_Y	222_W	0.699	0.15
40_A	181_F	0.698	0.15
196_K	251_A	0.698	0.15
73_M	240_M	0.697	0.15
98_I	258_H	0.697	0.15
96_L	146_L	0.697	0.15
92_V	273_L	0.690	0.14
124_G	217_I	0.690	0.14
8_T	84_V	0.686	0.14
80_L	268_V	0.685	0.14
71_M	215_S	0.683	0.14
44_L	212_V	0.682	0.14
113_G	228_Q	0.680	0.14
33_L	188_W	0.676	0.14
198_P	245_G	0.676	0.14
136_H	195_Q	0.675	0.14
132_Q	186_I	0.675	0.14
139_T	143_L	0.670	0.14
160_R	259_W	0.670	0.14
46_F	281_A	0.669	0.14
68_L	74_L	0.667	0.14
56_T	59_L	0.664	0.14
71_M	114_Y	0.664	0.14
16_S	245_G	0.663	0.14
61_M	252_I	0.663	0.14
105_M	119_L	0.661	0.14
159_K	162_M	0.661	0.14
31_A	129_R	0.659	0.14
51_G	212_V	0.657	0.14
177_Y	257_P	0.657	0.14
23_A	247_L	0.656	0.14
26_V	176_F	0.656	0.14
74_L	144_V	0.654	0.14
74_L	219_Y	0.647	0.14
212_V	261_T	0.646	0.13
42_V	196_K	0.645	0.13
88_L	253_W	0.643	0.13
42_V	103_D	0.642	0.13
48_R	202_L	0.640	0.13
36_V	42_V	0.639	0.13
10_L	164_T	0.639	0.13
88_L	118_A	0.637	0.13
186_I	267_L	0.637	0.13
186_I	189_F	0.637	0.13
116_F	126_G	0.635	0.13
26_V	121_A	0.635	0.13
110_L	250_L	0.634	0.13
16_S	255_Q	0.632	0.13
225_G	273_L	0.632	0.13
91_T	98_I	0.631	0.13
31_A	92_V	0.631	0.13
28_S	31_A	0.630	0.13
51_G	57_V	0.628	0.13
63_V	89_L	0.628	0.13
12_A	18_Y	0.627	0.13
44_L	78_A	0.626	0.13
181_F	252_I	0.626	0.13
187_A	191_L	0.625	0.13
235_G	268_V	0.624	0.13
76_F	249_N	0.624	0.13
10_L	276_H	0.624	0.13
268_V	281_A	0.623	0.13
209_F	248_V	0.622	0.13
9_I	28_S	0.621	0.13
13_F	18_Y	0.620	0.13
130_Y	230_D	0.620	0.13
81_Y	193_N	0.617	0.13
191_L	259_W	0.616	0.13
40_A	242_V	0.615	0.13
79_Y	115_A	0.614	0.13
244_A	255_Q	0.614	0.13
163_E	276_H	0.612	0.13
10_L	37_G	0.611	0.13
88_L	156_V	0.608	0.13
235_G	279_W	0.607	0.13
71_M	80_L	0.606	0.13
190_L	263_I	0.604	0.13
96_L	152_A	0.600	0.13
242_V	269_I	0.591	0.12
138_W	178_L	0.590	0.12
20_E	25_H	0.589	0.12
7_T	115_A	0.587	0.12
147_S	177_Y	0.585	0.12
70_V	191_L	0.584	0.12
114_Y	177_Y	0.583	0.12
159_K	231_A	0.583	0.12
117_S	230_D	0.582	0.12
233_T	268_V	0.580	0.12
118_A	156_V	0.578	0.12
60_Y	149_I	0.578	0.12
63_V	161_L	0.575	0.12
141_L	250_L	0.573	0.12
132_Q	183_V	0.573	0.12
98_I	217_I	0.573	0.12
74_L	150_T	0.570	0.12
59_L	281_A	0.568	0.12
101_I	178_L	0.567	0.12
9_I	230_D	0.567	0.12
42_V	118_A	0.566	0.12
86_E	176_F	0.565	0.12
70_V	203_Q	0.564	0.12
4_L	15_F	0.564	0.12
135_D	251_A	0.561	0.12
260_P	263_I	0.561	0.12
199_Q	270_L	0.560	0.12
112_W	274_W	0.555	0.12
247_L	274_W	0.555	0.12
70_V	178_L	0.552	0.12
29_Y	209_F	0.550	0.12
256_Q	266_A	0.547	0.12
159_K	165_R	0.547	0.12
111_R	114_Y	0.547	0.12
188_W	192_G	0.547	0.12
53_S	212_V	0.546	0.12
84_V	244_A	0.546	0.12
185_V	272_S	0.545	0.12
11_W	15_F	0.544	0.12
21_Y	198_P	0.542	0.12
89_L	143_L	0.540	0.12
117_S	143_L	0.536	0.11
165_R	270_L	0.536	0.11
118_A	152_A	0.535	0.11
138_W	266_A	0.531	0.11
155_M	235_G	0.530	0.11
97_Y	215_S	0.529	0.11
88_L	205_G	0.528	0.11
16_S	26_V	0.528	0.11
99_T	159_K	0.526	0.11
189_F	240_M	0.524	0.11
271_A	275_V	0.520	0.11
100_L	220_F	0.518	0.11
168_P	171_N	0.518	0.11
153_I	157_G	0.518	0.11
13_F	188_W	0.517	0.11
10_L	227_T	0.517	0.11
92_V	170_H	0.517	0.11
36_V	217_I	0.516	0.11
6_I	34_V	0.514	0.11
84_V	245_G	0.513	0.11
255_Q	258_H	0.510	0.11
111_R	268_V	0.510	0.11
16_S	22_L	0.509	0.11
215_S	241_H	0.509	0.11
119_L	136_H	0.507	0.11
52_N	260_P	0.506	0.11
79_Y	136_H	0.504	0.11
7_T	259_W	0.503	0.11
260_P	275_V	0.503	0.11
71_M	210_L	0.503	0.11
92_V	111_R	0.501	0.11
146_L	259_W	0.500	0.11

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2i68A	2	0.2575	97.6	0.939	Contact Map
3b5dA	2	0.3378	90	0.961	Contact Map
4n7wA	2	0.9197	5.8	0.983	Contact Map
4nv5A	1	0.5619	5.5	0.983	Contact Map
3wo6A	1	0.2341	5.3	0.983	Contact Map
2m20A	2	0.1472	4.4	0.984	Contact Map
2xq2A	2	0.709	3.9	0.984	Contact Map
3wajA	1	0.7993	3.2	0.985	Contact Map
4dxwA	3	0.3077	3.1	0.985	Contact Map
2kluA	1	0.1672	3	0.985	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0089 seconds.